+

WO2008125927A3 - Microfluidic system with actuators - Google Patents

Microfluidic system with actuators Download PDF

Info

Publication number
WO2008125927A3
WO2008125927A3 PCT/IB2007/055104 IB2007055104W WO2008125927A3 WO 2008125927 A3 WO2008125927 A3 WO 2008125927A3 IB 2007055104 W IB2007055104 W IB 2007055104W WO 2008125927 A3 WO2008125927 A3 WO 2008125927A3
Authority
WO
WIPO (PCT)
Prior art keywords
actuator
sample
actuators
configuration
microfluidic system
Prior art date
Application number
PCT/IB2007/055104
Other languages
French (fr)
Other versions
WO2008125927A2 (en
Inventor
Murray F Gillies
Toonder Jacob M J Den
Marc W G Ponjee
Mark T Johnson
Original Assignee
Koninkl Philips Electronics Nv
Murray F Gillies
Toonder Jacob M J Den
Marc W G Ponjee
Mark T Johnson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninkl Philips Electronics Nv, Murray F Gillies, Toonder Jacob M J Den, Marc W G Ponjee, Mark T Johnson filed Critical Koninkl Philips Electronics Nv
Publication of WO2008125927A2 publication Critical patent/WO2008125927A2/en
Publication of WO2008125927A3 publication Critical patent/WO2008125927A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3038—Micromixers using ciliary stirrers to move or stir the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/54—Heating or cooling apparatus; Heat insulating devices using spatial temperature gradients
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/20—Other positive-displacement pumps
    • F04B19/24—Pumping by heat expansion of pumped fluid
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04D—NON-POSITIVE-DISPLACEMENT PUMPS
    • F04D33/00—Non-positive-displacement pumps with other than pure rotation, e.g. of oscillating type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1861—Means for temperature control using radiation
    • B01L2300/1872—Infrared light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0484—Cantilevers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

The invention relates to microfluidic system (100), particularly a biosensor, for manipulating a sample in a sample chamber (1). The device comprises at least one actuator (10) that reversibly changes its spatial configuration if it is heated and/or cooled. The actuator (10) may particularly be arranged adjacent to an associated heating element (20) of a 5 heating array that is used to establish a predetermined spatial and/or temporal temperature profile in the sample chamber (1). The configuration change of the actuator (10) can be used to move the sample fluid or to control its passage through fluid channels. A plurality of actuators (10) may optionally be provided that undergo their configuration changes at different temperatures, particularly temperatures within a range that is passed during a 10 reaction like PCR.
PCT/IB2007/055104 2006-12-19 2007-12-14 Microfluidic system with actuators WO2008125927A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06126460 2006-12-19
EP06126460.2 2006-12-19

Publications (2)

Publication Number Publication Date
WO2008125927A2 WO2008125927A2 (en) 2008-10-23
WO2008125927A3 true WO2008125927A3 (en) 2009-01-29

Family

ID=39864427

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/055104 WO2008125927A2 (en) 2006-12-19 2007-12-14 Microfluidic system with actuators

Country Status (1)

Country Link
WO (1) WO2008125927A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3658841B1 (en) * 2017-11-22 2024-03-27 Hewlett-Packard Development Company, L.P. Temperature-controlling microfluidic devices

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030156991A1 (en) * 2001-10-23 2003-08-21 William Marsh Rice University Optomechanically-responsive materials for use as light-activated actuators and valves
US20060069425A1 (en) * 2004-09-24 2006-03-30 Searete Llc, A Limited Liability Corporation Of The Stste Of Delaware Ciliated stent-like-system
WO2006087655A1 (en) * 2005-02-21 2006-08-24 Koninklijke Philips Electronics N.V. Micro-fluidic systems based on actuator elements

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030156991A1 (en) * 2001-10-23 2003-08-21 William Marsh Rice University Optomechanically-responsive materials for use as light-activated actuators and valves
US20060069425A1 (en) * 2004-09-24 2006-03-30 Searete Llc, A Limited Liability Corporation Of The Stste Of Delaware Ciliated stent-like-system
WO2006087655A1 (en) * 2005-02-21 2006-08-24 Koninklijke Philips Electronics N.V. Micro-fluidic systems based on actuator elements

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANQUETIL P A ET AL: "Artificial Muscle Technology: Physical Principles and Naval Prospects", IEEE JOURNAL OF OCEANIC ENGINEERING, IEEE SERVICE CENTER, PISCATAWAY, NJ, US, vol. 29, no. 3, 1 July 2004 (2004-07-01), pages 706 - 728, XP011121556, ISSN: 0364-9059 *

Also Published As

Publication number Publication date
WO2008125927A2 (en) 2008-10-23

Similar Documents

Publication Publication Date Title
Hsieh et al. Enhancement of thermal uniformity for a microthermal cycler and its application for polymerase chain reaction
US10226772B2 (en) Combined thermal devices for thermal cycling
JP2017207523A5 (en)
CN101287845B (en) Method and device for conducting biochemical or chemical reactions at multiple temperatures
EP3160649B1 (en) Floating thermal contact enabled pcr
NZ605885A (en) Methods for rapid multiplexed amplification of target nucleic acids
WO2008027398A3 (en) Rapid thermocycler
WO2007150043A3 (en) Systems and methods for cooling in a thermal cycler
WO2007090405A3 (en) Control of a system with a large thermal capacity
US20100159582A1 (en) Disposable multiplex polymerase chain reaction (pcr) chip and device
US20110207632A1 (en) Temperature control device with a flexible temperature control surface
Jafek et al. Instrumentation for xPCR Incorporating qPCR and HRMA
WO2008030914A3 (en) Device for carrying out chemical or biological reactions
WO2009058376A3 (en) Temperature control module using gas pressure to control thermal conductance between liquid coolant and component body
EP2290356A3 (en) Differential scanning calorimeter (DSC) with temperature controlled furnace
CN101104842A (en) Instrument for heating and cooling
Bu et al. A temperature control method for shortening thermal cycling time to achieve rapid polymerase chain reaction (PCR) in a disposable polymer microfluidic device
WO2008002991A3 (en) Low-mass sample block with rapid response to temperature change
EP4410428A3 (en) Microfluidic device and methods for digital assays in biological analyses
WO2008035293A3 (en) A micro-fluidic device for the use in biochips or biosystems
WO2006094057A3 (en) Heating hydrocarbon process flow using flameless oxidation burners
US11666910B2 (en) Microfluidic devices
WO2009019658A3 (en) Integrated microfluidic device with local temperature control
WO2008125927A3 (en) Microfluidic system with actuators
ATE473424T1 (en) LEVEL SENSOR AND ASSOCIATED OPERATING AND MANUFACTURING METHOD AND CORRESPONDING USE

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07873374

Country of ref document: EP

Kind code of ref document: A2

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载