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WO2008119720A8 - 1-(1-cyclobutyl-4-piperidinyl)-1,3-dihydro-2h-benzimidazol-2-one derivatives which have activity on the m1 receptor and their use in medicine - Google Patents

1-(1-cyclobutyl-4-piperidinyl)-1,3-dihydro-2h-benzimidazol-2-one derivatives which have activity on the m1 receptor and their use in medicine Download PDF

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Publication number
WO2008119720A8
WO2008119720A8 PCT/EP2008/053600 EP2008053600W WO2008119720A8 WO 2008119720 A8 WO2008119720 A8 WO 2008119720A8 EP 2008053600 W EP2008053600 W EP 2008053600W WO 2008119720 A8 WO2008119720 A8 WO 2008119720A8
Authority
WO
WIPO (PCT)
Prior art keywords
benzimidazol
piperidinyl
cyclobutyl
dihydro
receptor
Prior art date
Application number
PCT/EP2008/053600
Other languages
French (fr)
Other versions
WO2008119720A1 (en
Inventor
David Gwyn Cooper
Ian Thomson Forbes
Vincenzo Garzya
Graham Walker
Paul Adrian Wyman
Original Assignee
Glaxo Group Ltd
David Gwyn Cooper
Ian Thomson Forbes
Vincenzo Garzya
Graham Walker
Paul Adrian Wyman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, David Gwyn Cooper, Ian Thomson Forbes, Vincenzo Garzya, Graham Walker, Paul Adrian Wyman filed Critical Glaxo Group Ltd
Publication of WO2008119720A1 publication Critical patent/WO2008119720A1/en
Publication of WO2008119720A8 publication Critical patent/WO2008119720A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of formula I or a salt thereof are provided wherein R4, R5, R6, Q, L and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders and cognitive impairments are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.
PCT/EP2008/053600 2007-03-29 2008-03-27 1-(1-cyclobutyl-4-piperidinyl)-1,3-dihydro-2h-benzimidazol-2-one derivatives which have activity on the m1 receptor and their use in medicine WO2008119720A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0706173.2A GB0706173D0 (en) 2007-03-29 2007-03-29 Compounds
GB0706173.2 2007-03-29

Publications (2)

Publication Number Publication Date
WO2008119720A1 WO2008119720A1 (en) 2008-10-09
WO2008119720A8 true WO2008119720A8 (en) 2009-01-08

Family

ID=38050492

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/053600 WO2008119720A1 (en) 2007-03-29 2008-03-27 1-(1-cyclobutyl-4-piperidinyl)-1,3-dihydro-2h-benzimidazol-2-one derivatives which have activity on the m1 receptor and their use in medicine

Country Status (2)

Country Link
GB (1) GB0706173D0 (en)
WO (1) WO2008119720A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY148504A (en) 2005-09-30 2013-04-30 Glaxo Group Ltd Compounds which have activity at m? receptor and their uses in medicine
US8288413B2 (en) 2005-09-30 2012-10-16 Glaxo Group Limited Benzimidazolones which have activity at M1 receptor
JP5209481B2 (en) 2005-09-30 2013-06-12 グラクソ グループ リミテッド Compounds having activity at the M1 receptor and their use in medicine
GB0718415D0 (en) 2007-09-20 2007-10-31 Glaxo Group Ltd Compounds
CN104177327B (en) * 2014-08-26 2016-03-23 上海应用技术学院 Preparation method of 6-amino-2-thiaspiro[3,3]heptane hydrochloride
CN104292208A (en) * 2014-09-09 2015-01-21 上海师范大学 7-phenyl-6,8-dioxaspiro[3.5]nonane-2-carboxylic acid and preparation method thereof
CN106045916B (en) * 2016-05-31 2018-08-31 江苏之江化工有限公司 A kind of synthetic method of imidazolone compounds
CN111320535B (en) * 2020-03-09 2022-04-01 苏州楚凯药业有限公司 Preparation method of 3- (benzyloxy) -1-cyclobutanone
CN113443986A (en) * 2020-03-27 2021-09-28 南京药石科技股份有限公司 Preparation method of intermediate for synthesizing 3-oxo-1-cyclobutanecarboxylic acid
US20250064833A1 (en) 2021-12-13 2025-02-27 Sage Therapeutics, Inc. Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators
CN117003644A (en) * 2022-04-29 2023-11-07 帕潘纳(北京)科技有限公司 Novel method for synthesizing 2-chloro-6-nitrotoluene

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU701127B2 (en) * 1994-10-27 1999-01-21 Merck & Co., Inc. Muscarine antagonists

Also Published As

Publication number Publication date
GB0706173D0 (en) 2007-05-09
WO2008119720A1 (en) 2008-10-09

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