WO2008114736A1 - 生体組織補填材とその製造方法 - Google Patents
生体組織補填材とその製造方法 Download PDFInfo
- Publication number
- WO2008114736A1 WO2008114736A1 PCT/JP2008/054772 JP2008054772W WO2008114736A1 WO 2008114736 A1 WO2008114736 A1 WO 2008114736A1 JP 2008054772 W JP2008054772 W JP 2008054772W WO 2008114736 A1 WO2008114736 A1 WO 2008114736A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- filling material
- body tissue
- porous carrier
- tissue filling
- hyaluronic acid
- Prior art date
Links
- 239000000463 material Substances 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 4
- 108010010803 Gelatin Proteins 0.000 abstract 2
- 229920000159 gelatin Polymers 0.000 abstract 2
- 239000008273 gelatin Substances 0.000 abstract 2
- 235000019322 gelatine Nutrition 0.000 abstract 2
- 235000011852 gelatine desserts Nutrition 0.000 abstract 2
- 238000001035 drying Methods 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 238000005470 impregnation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Composite Materials (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
生着および修復能に優れた生体組織補填材を提供し、そのような生体組織補填材を簡易に製造することができる製造方法を提供する。ゼラチンからなる多孔質担体の表面に、硫酸化ヒアルロン酸からなるコーティングを施した生体組織補填材を提供する。また、ゼラチンからなる多孔質担体に硫酸化ヒアルロン酸溶液を滴下して含浸させるステップ（Ｓ３）と、硫酸化ヒアルロン酸溶液が含浸された多孔質担体を凍結させるステップ（Ｓ４）と、凍結した多孔質担体を乾燥させるステップ（Ｓ５）とを含む生体組織補填材の製造方法を提供する。
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/529,622 US20100278877A1 (en) | 2007-03-16 | 2008-03-14 | Body tissue filling material and method for production thereof |
| EP08722168A EP2127688A4 (en) | 2007-03-16 | 2008-03-14 | BODY FABRIC REFILL MATERIAL AND MANUFACTURING METHOD THEREFOR |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007-069160 | 2007-03-16 | ||
| JP2007069160A JP5088864B2 (ja) | 2007-03-16 | 2007-03-16 | 生体組織補填材とその製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2008114736A1 true WO2008114736A1 (ja) | 2008-09-25 |
Family
ID=39765844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2008/054772 WO2008114736A1 (ja) | 2007-03-16 | 2008-03-14 | 生体組織補填材とその製造方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20100278877A1 (ja) |
| EP (1) | EP2127688A4 (ja) |
| JP (1) | JP5088864B2 (ja) |
| WO (1) | WO2008114736A1 (ja) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101594552B1 (ko) | 2008-04-04 | 2016-02-17 | 유니버시티 오브 유타 리서치 파운데이션 | 알킬화된 반합성 글리코사미노글리코산 에테르 및 이의 제조 및 사용 방법 |
| EP2688402B1 (en) | 2011-03-23 | 2018-10-24 | University of Utah Research Foundation | Means for treating or preventing urological inflammation |
| WO2014165513A2 (en) * | 2013-04-02 | 2014-10-09 | The Regents Of The University Of California | Ethylsulfonated hyaluronic acid biopolymers and methods of use thereof |
| US11337994B2 (en) | 2016-09-15 | 2022-05-24 | University Of Utah Research Foundation | In situ gelling compositions for the treatment or prevention of inflammation and tissue damage |
| CN111228653A (zh) | 2018-11-13 | 2020-06-05 | 格莱科米拉治疗公司 | 用电离辐射加强癌症治疗的方法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996010426A1 (fr) | 1994-09-30 | 1996-04-11 | Yamanouchi Pharmaceutical Co., Ltd. | Greffon osteoplastique |
| JPH09510493A (ja) * | 1994-03-23 | 1997-10-21 | フィディア・アドヴァンスト・バイオポリマーズ・ソシエタ・ア・レスポンサビリタ・リミタータ | 新規なヘパリン様硫酸化多糖類 |
| WO2003011353A1 (fr) | 2001-07-30 | 2003-02-13 | Japan Tissue Engineering Co., Ltd | Materiau de base de regeneration de tissu, materiau implantaire et procede de production correspondant |
| JP2003245338A (ja) * | 2002-02-26 | 2003-09-02 | Kyocera Corp | 関節軟骨修復材 |
| WO2006037592A1 (en) * | 2004-10-08 | 2006-04-13 | Fidia Advanced Biopolymers S.R.L. | Biomaterials consisting of sulphated hyaluronic acid and gellan to be used in the prevention of spinal adhesions |
| WO2007137674A1 (en) * | 2006-05-31 | 2007-12-06 | Fidia Farmaceutici S.P.A. | Sulphated hyaluronic acid for treating degenerative osteoarthritis |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0971961T3 (da) * | 1997-04-04 | 2003-03-24 | Fidia Advanced Biopolymers Srl | N-sulfaterede hyaluronsyreforbindelser, derivater deraf og en fremgangsmåde til deres fremstilling |
| ITPD980149A1 (it) * | 1998-06-17 | 1999-12-17 | Fidia Advanced Biopolymers Srl | Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la |
| JP3536295B2 (ja) * | 1999-01-21 | 2004-06-07 | ニプロ株式会社 | 縫合可能な組織再生誘導型癒着防止膜 |
| DE10053053A1 (de) * | 2000-10-19 | 2002-05-16 | Knoell Hans Forschung Ev | Pharmazeutische Formulierungen zur Hemmung von entzündlichen Arthritiden |
| AU2004272432B2 (en) * | 2003-09-12 | 2011-01-06 | Seikagaku Corporation | Polysaccharide pseudo-sponge |
| WO2006083328A2 (en) * | 2004-09-15 | 2006-08-10 | Massachusetts Institute Of Technology | Biologically active surfaces and methods of their use |
-
2007
- 2007-03-16 JP JP2007069160A patent/JP5088864B2/ja active Active
-
2008
- 2008-03-14 WO PCT/JP2008/054772 patent/WO2008114736A1/ja active Application Filing
- 2008-03-14 US US12/529,622 patent/US20100278877A1/en not_active Abandoned
- 2008-03-14 EP EP08722168A patent/EP2127688A4/en not_active Withdrawn
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09510493A (ja) * | 1994-03-23 | 1997-10-21 | フィディア・アドヴァンスト・バイオポリマーズ・ソシエタ・ア・レスポンサビリタ・リミタータ | 新規なヘパリン様硫酸化多糖類 |
| WO1996010426A1 (fr) | 1994-09-30 | 1996-04-11 | Yamanouchi Pharmaceutical Co., Ltd. | Greffon osteoplastique |
| WO2003011353A1 (fr) | 2001-07-30 | 2003-02-13 | Japan Tissue Engineering Co., Ltd | Materiau de base de regeneration de tissu, materiau implantaire et procede de production correspondant |
| JP2003245338A (ja) * | 2002-02-26 | 2003-09-02 | Kyocera Corp | 関節軟骨修復材 |
| WO2006037592A1 (en) * | 2004-10-08 | 2006-04-13 | Fidia Advanced Biopolymers S.R.L. | Biomaterials consisting of sulphated hyaluronic acid and gellan to be used in the prevention of spinal adhesions |
| WO2007137674A1 (en) * | 2006-05-31 | 2007-12-06 | Fidia Farmaceutici S.P.A. | Sulphated hyaluronic acid for treating degenerative osteoarthritis |
Non-Patent Citations (2)
| Title |
|---|
| HAMILTON D.W. ET AL.: "The response of primary articular chondrocytes to micrometric surface topography and sulphated hyaluronic acid-based matrices", CELL BIOLOGY INTERNATIONAL, vol. 29, no. 8, 2005, pages 605 - 615, XP005012056 * |
| See also references of EP2127688A4 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2127688A1 (en) | 2009-12-02 |
| JP5088864B2 (ja) | 2012-12-05 |
| US20100278877A1 (en) | 2010-11-04 |
| EP2127688A4 (en) | 2013-01-02 |
| JP2008228812A (ja) | 2008-10-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2009111306A3 (en) | Coated embolization device | |
| WO2010017558A3 (en) | Composite material compositions and methods | |
| IL184189A0 (en) | Process for the preparation of optically active (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine | |
| WO2008114736A1 (ja) | 生体組織補填材とその製造方法 | |
| TW200733460A (en) | Method for preparing functional film | |
| WO2008116096A3 (en) | Porous orthapedic materials coated with demineralized bone matrix | |
| WO2010093130A3 (ko) | 생체 비활성 재료의 표면 개질방법 | |
| WO2009059165A3 (en) | Endoprosthesis coating | |
| TWI370160B (en) | Conductive polymer coating composition, method of preparing coating film using the conductive polymer coating composition, and coating film prepared using the method | |
| WO2010043979A3 (en) | Auto-sealant matrix for tissue repair | |
| WO2011054516A3 (en) | Methods and compositions for producing tobacco products containing hydrogel capsules coated for low permeability and physical integrity | |
| WO2013148762A3 (en) | Expandable tissue thickness compensator | |
| WO2006105239A3 (en) | Polyurethane encapsulated fertilizer | |
| WO2006020708A3 (en) | Biologically-active adhesive articles and methods of manufacture | |
| WO2009130229A3 (en) | An article and a method of making an article | |
| WO2010029344A3 (en) | Hyaluronic acid cryogel - compositions, uses, processes for manufacturing | |
| EP4302788A3 (en) | Hemostatic sponge | |
| WO2008091742A3 (en) | Pre-molded clip structure | |
| WO2011107807A3 (en) | Collagen gel for bonding porous collagen- based materials with non- porous collagen- based materials | |
| WO2010041014A3 (en) | Preparation of nanostructured microporous composite foams | |
| WO2012066506A3 (en) | Method for fabricating a microneedle | |
| EP1995032A4 (en) | MOLDED OBJECT PRETREATMENT METHOD, AGGLOMERATED ARTICLE AND PRODUCTION METHOD THEREOF, COATED ARTICLE, AND PRODUCTION METHOD THEREOF | |
| WO2010123728A3 (en) | Method of making and using activated carbon-containing coated substrates and the products made therefrom | |
| WO2007121912A3 (de) | Schichtförmige wundauflage | |
| WO2007126769A3 (en) | Method of making a coated medical device with a porous coating |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 08722168 Country of ref document: EP Kind code of ref document: A1 |
|
| WWE | Wipo information: entry into national phase |
Ref document number: 12529622 Country of ref document: US Ref document number: 2008722168 Country of ref document: EP |
|
| NENP | Non-entry into the national phase |
Ref country code: DE |