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WO2008108323A1 - インフルエンザ治療剤 - Google Patents

インフルエンザ治療剤 Download PDF

Info

Publication number
WO2008108323A1
WO2008108323A1 PCT/JP2008/053738 JP2008053738W WO2008108323A1 WO 2008108323 A1 WO2008108323 A1 WO 2008108323A1 JP 2008053738 W JP2008053738 W JP 2008053738W WO 2008108323 A1 WO2008108323 A1 WO 2008108323A1
Authority
WO
WIPO (PCT)
Prior art keywords
influenza
drug
treatment
prevention
disclosed
Prior art date
Application number
PCT/JP2008/053738
Other languages
English (en)
French (fr)
Inventor
Makoto Yamashita
Yoshihiro Kawaoka
Original Assignee
Daiichi Sankyo Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2009502568A priority Critical patent/JP5286251B2/ja
Priority to SI200830440T priority patent/SI2123271T1/sl
Priority to CN2008800149108A priority patent/CN101715343B/zh
Priority to AT08721158T priority patent/ATE526960T1/de
Priority to CA002680415A priority patent/CA2680415A1/en
Priority to PL08721158T priority patent/PL2123271T3/pl
Priority to DK08721158.7T priority patent/DK2123271T3/da
Priority to ES08721158T priority patent/ES2372996T3/es
Application filed by Daiichi Sankyo Company, Limited filed Critical Daiichi Sankyo Company, Limited
Priority to EP08721158A priority patent/EP2123271B1/en
Priority to US12/449,909 priority patent/US20100204314A1/en
Publication of WO2008108323A1 publication Critical patent/WO2008108323A1/ja
Priority to HK10103858.3A priority patent/HK1137142A1/xx
Priority to HR20110861T priority patent/HRP20110861T1/hr
Priority to US14/010,784 priority patent/US20140018418A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

　Ｈ５Ｎ１型インフルエンザの治療剤または予防剤を提供する。 　一般式（I）で表される化合物を有効成分として含有するＨ５Ｎ１型インフルエンザの治療剤または予防剤。 ［式中、Ｒ1、Ｒ2：Ｈ、アルカノイル；Ｘ：ハロゲン原子、ＯＨ、アルコキシ、アルカノイルオキシ；Ｒ3：Ｈ、アルキル。Ｒ1、Ｒ2：Ｈ；Ｘ：ＯＨ；Ｒ3：Ｈを除く。］
PCT/JP2008/053738 2007-03-07 2008-03-03 インフルエンザ治療剤 WO2008108323A1 (ja)

Priority Applications (13)

Application Number Priority Date Filing Date Title
DK08721158.7T DK2123271T3 (da) 2007-03-07 2008-03-03 Lægemiddel til behandling af influenza
CN2008800149108A CN101715343B (zh) 2007-03-07 2008-03-03 流感治疗药
AT08721158T ATE526960T1 (de) 2007-03-07 2008-03-03 Arzneimittel zur behandlung von grippe
CA002680415A CA2680415A1 (en) 2007-03-07 2008-03-03 Neuraminic acid derivatives useful in the treatment of influenza
PL08721158T PL2123271T3 (pl) 2007-03-07 2008-03-03 Lek do leczenia grypy
JP2009502568A JP5286251B2 (ja) 2007-03-07 2008-03-03 インフルエンザ治療剤
US12/449,909 US20100204314A1 (en) 2007-03-07 2008-03-03 Drug for treatment of influenza
ES08721158T ES2372996T3 (es) 2007-03-07 2008-03-03 Fármaco para el tratamiento de gripe.
EP08721158A EP2123271B1 (en) 2007-03-07 2008-03-03 Drug for treatment of influenza
SI200830440T SI2123271T1 (sl) 2007-03-07 2008-03-03 Zdravilo za zdravljenje influence
HK10103858.3A HK1137142A1 (en) 2007-03-07 2010-04-21 Drug for treatment of influenza
HR20110861T HRP20110861T1 (hr) 2007-03-07 2011-11-21 Lijek za liječenje gripe
US14/010,784 US20140018418A1 (en) 2007-03-07 2013-08-27 Methods of treating or preventing h5n1 influenza

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007056872 2007-03-07
JP2007-056872 2007-03-07

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/010,784 Division US20140018418A1 (en) 2007-03-07 2013-08-27 Methods of treating or preventing h5n1 influenza

Publications (1)

Publication Number Publication Date
WO2008108323A1 true WO2008108323A1 (ja) 2008-09-12

Family

ID=39738201

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053738 WO2008108323A1 (ja) 2007-03-07 2008-03-03 インフルエンザ治療剤

Country Status (17)

Country Link
US (2) US20100204314A1 (ja)
EP (1) EP2123271B1 (ja)
JP (2) JP5286251B2 (ja)
KR (1) KR101473028B1 (ja)
CN (1) CN101715343B (ja)
AT (1) ATE526960T1 (ja)
CA (1) CA2680415A1 (ja)
CY (1) CY1112201T1 (ja)
DK (1) DK2123271T3 (ja)
ES (1) ES2372996T3 (ja)
HK (1) HK1137142A1 (ja)
HR (1) HRP20110861T1 (ja)
PL (1) PL2123271T3 (ja)
PT (1) PT2123271E (ja)
SI (1) SI2123271T1 (ja)
TW (1) TWI424841B (ja)
WO (1) WO2008108323A1 (ja)

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US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
JP5986745B2 (ja) 2008-07-15 2016-09-06 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ Ｐｔｆｅ様のアルミニウム・コート・ガラススライド上のグリカンアレイおよび関連する方法
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10338069B2 (en) 2010-04-12 2019-07-02 Academia Sinica Glycan arrays for high throughput screening of viruses
KR101915647B1 (ko) 2010-05-10 2018-11-06 아카데미아 시니카 항-인플루엔자 활성을 가진 자나미비르 포스포네이트 동족체 및 인플루엔자 바이러스의 오셀타미비르 감수성을 확인하는 방법
KR101971311B1 (ko) * 2011-12-16 2019-04-22 다이이찌 산쿄 가부시키가이샤 뉴라민산 유도체의 제조 방법
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
EP2885311B1 (en) 2012-08-18 2020-01-01 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
WO2014210397A1 (en) 2013-06-26 2014-12-31 Academia Sinica Rm2 antigens and use thereof
US9981030B2 (en) 2013-06-27 2018-05-29 Academia Sinica Glycan conjugates and use thereof
KR102298172B1 (ko) 2013-09-06 2021-09-06 아카데미아 시니카 변화된 글리코실 그룹을 갖는 당지질을 사용한 인간 iNKT 세포 활성화
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
TW201620939A (zh) 2014-01-16 2016-06-16 中央研究院 治療及檢測癌症之組合物及方法
JP6562942B2 (ja) 2014-03-27 2019-08-28 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 反応性標識化合物およびその使用
KR20230033737A (ko) 2014-05-27 2023-03-08 아카데미아 시니카 증진된 항체 효능을 위한 범용 당형태에 관한 조성물 및 방법
KR20240096599A (ko) 2014-05-27 2024-06-26 아카데미아 시니카 항-ｃｄ20 글리코항체 및 이의 용도
JP7062361B2 (ja) 2014-05-27 2022-05-06 アカデミア シニカ 抗ｈｅｒ２糖操作抗体群およびその使用
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
KR102494193B1 (ko) 2014-05-28 2023-01-31 아카데미아 시니카 항-ｔｎｆ-알파 글리코항체 및 이의 용도
JP6899321B2 (ja) 2014-09-08 2021-07-07 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 糖脂質を使用するヒトｉＮＫＴ細胞活性化
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
WO2016118191A1 (en) 2015-01-24 2016-07-28 Academia Sinica Novel glycan conjugates and methods of use thereof
CA3016170A1 (en) 2016-03-08 2017-09-14 Academia Sinica Methods for modular synthesis of n-glycans and arrays thereof
JP7213549B2 (ja) 2016-08-22 2023-01-27 シーエイチオー ファーマ インコーポレイテッド 抗体、結合性断片、および使用の方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10109981A (ja) 1996-08-13 1998-04-28 Sankyo Co Ltd ノイラミン酸化合物
JPH10330373A (ja) * 1996-07-22 1998-12-15 Sankyo Co Ltd ノイラミン酸誘導体
JP2002012590A (ja) 2000-04-25 2002-01-15 Sankyo Co Ltd ノイラミン酸化合物の水和物及び結晶
US6340702B1 (en) 1996-07-22 2002-01-22 Sankyo Company, Limited Neuraminic acid derivatives, their preparation and their medical use
US6451766B1 (en) 1996-07-22 2002-09-17 Sankyo Company, Limited Neuraminic acid derivatives, their preparation and their medical use
US6844363B2 (en) 2000-04-25 2005-01-18 Sankyo Company, Limited Hydrates of a neuraminic acid compound and crystalline forms thereof
JP2007056872A (ja) 2005-08-22 2007-03-08 Delphi Technologies Inc カムシャフトとタイミングギアとの間のタイミングを制御するためのフェーザ

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PT823428E (pt) * 1996-07-22 2002-04-29 Sankyo Co Derivados do acido neuraminico sua preparacao e sua utilizacao em medicina

Patent Citations (8)

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JPH10330373A (ja) * 1996-07-22 1998-12-15 Sankyo Co Ltd ノイラミン酸誘導体
JP3209946B2 (ja) 1996-07-22 2001-09-17 三共株式会社 ノイラミン酸誘導体
US6340702B1 (en) 1996-07-22 2002-01-22 Sankyo Company, Limited Neuraminic acid derivatives, their preparation and their medical use
US6451766B1 (en) 1996-07-22 2002-09-17 Sankyo Company, Limited Neuraminic acid derivatives, their preparation and their medical use
JPH10109981A (ja) 1996-08-13 1998-04-28 Sankyo Co Ltd ノイラミン酸化合物
JP2002012590A (ja) 2000-04-25 2002-01-15 Sankyo Co Ltd ノイラミン酸化合物の水和物及び結晶
US6844363B2 (en) 2000-04-25 2005-01-18 Sankyo Company, Limited Hydrates of a neuraminic acid compound and crystalline forms thereof
JP2007056872A (ja) 2005-08-22 2007-03-08 Delphi Technologies Inc カムシャフトとタイミングギアとの間のタイミングを制御するためのフェーザ

Non-Patent Citations (7)

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Title
HIROKAWA SHOTEN: "Molecular Design", vol. 7, 1990, article "Development of Pharmaceuticals", pages: 163 - 198
LE Q MAI ET AL.: "Avian flu: isolation of drug- resistant H5N1 virus.", NATURE, vol. 437, no. 7062, 2005, pages 1108, XP008112478 *
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See also references of EP2123271A4

Also Published As

Publication number Publication date
SI2123271T1 (sl) 2012-05-31
US20140018418A1 (en) 2014-01-16
JP6012076B2 (ja) 2016-10-25
EP2123271A4 (en) 2010-03-17
KR101473028B1 (ko) 2014-12-15
ES2372996T3 (es) 2012-01-30
HRP20110861T1 (hr) 2011-12-31
US20100204314A1 (en) 2010-08-12
CA2680415A1 (en) 2008-09-12
EP2123271A1 (en) 2009-11-25
KR20090129414A (ko) 2009-12-16
EP2123271B1 (en) 2011-10-05
PL2123271T3 (pl) 2012-03-30
TWI424841B (zh) 2014-02-01
HK1137142A1 (en) 2010-07-23
PT2123271E (pt) 2011-12-20
JP2013139483A (ja) 2013-07-18
JPWO2008108323A1 (ja) 2010-06-17
CN101715343A (zh) 2010-05-26
ATE526960T1 (de) 2011-10-15
JP5286251B2 (ja) 2013-09-11
TW200848018A (en) 2008-12-16
DK2123271T3 (da) 2012-01-23
CY1112201T1 (el) 2015-12-09
CN101715343B (zh) 2012-09-26

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