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WO2008107362A3 - Stabiliser and inhibitors of factor vii - Google Patents

Stabiliser and inhibitors of factor vii Download PDF

Info

Publication number
WO2008107362A3
WO2008107362A3 PCT/EP2008/052409 EP2008052409W WO2008107362A3 WO 2008107362 A3 WO2008107362 A3 WO 2008107362A3 EP 2008052409 W EP2008052409 W EP 2008052409W WO 2008107362 A3 WO2008107362 A3 WO 2008107362A3
Authority
WO
WIPO (PCT)
Prior art keywords
factor vii
inhibitors
stabiliser
blood coagulation
liquid formulations
Prior art date
Application number
PCT/EP2008/052409
Other languages
French (fr)
Other versions
WO2008107362A2 (en
Inventor
Florencio Zaragoza Doerwald
Original Assignee
Novo Nordisk Healthcare Ag
Florencio Zaragoza Doerwald
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk Healthcare Ag, Florencio Zaragoza Doerwald filed Critical Novo Nordisk Healthcare Ag
Publication of WO2008107362A2 publication Critical patent/WO2008107362A2/en
Publication of WO2008107362A3 publication Critical patent/WO2008107362A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to novel compounds with formula (I) useful as blood coagulation factor inhibitors. The compounds (I) may be used for treatment of thrombotic conditions or as stabilizers of liquid formulations of blood coagulation factors, in particular liquid formulations of FVIIa, Factor VII variants, or Factor VII derivatives.
PCT/EP2008/052409 2007-03-07 2008-02-28 Stabiliser and inhibitors of factor vii WO2008107362A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07103676 2007-03-07
EP07103676.8 2007-03-07

Publications (2)

Publication Number Publication Date
WO2008107362A2 WO2008107362A2 (en) 2008-09-12
WO2008107362A3 true WO2008107362A3 (en) 2008-10-23

Family

ID=38290139

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/052409 WO2008107362A2 (en) 2007-03-07 2008-02-28 Stabiliser and inhibitors of factor vii

Country Status (1)

Country Link
WO (1) WO2008107362A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011510043A (en) 2008-01-23 2011-03-31 ノボ ノルディスク ヘルス ケア アーゲー Novel blood coagulation factor inhibitor

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0987274A1 (en) * 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Factor VIIa Inhibitors
WO2000058346A1 (en) * 1999-03-30 2000-10-05 Sanofi-Synthelabo N-sulfonyl-dipeptide derivatives, production and use thereof in therapy
WO2002026774A2 (en) * 2000-09-27 2002-04-04 The Procter & Gamble Company Melanocortin receptor ligands
WO2004041302A1 (en) * 2002-11-06 2004-05-21 Novo Nordisk A/S Pharmaceutical composition comprising a tissue factor antagonist and a blood glucose regulator
WO2005016365A2 (en) * 2003-08-14 2005-02-24 Novo Nordisk Health Care Ag Liquid, aqueous pharmaceutical composition of factor vii polypeptides

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0987274A1 (en) * 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Factor VIIa Inhibitors
WO2000058346A1 (en) * 1999-03-30 2000-10-05 Sanofi-Synthelabo N-sulfonyl-dipeptide derivatives, production and use thereof in therapy
WO2002026774A2 (en) * 2000-09-27 2002-04-04 The Procter & Gamble Company Melanocortin receptor ligands
WO2004041302A1 (en) * 2002-11-06 2004-05-21 Novo Nordisk A/S Pharmaceutical composition comprising a tissue factor antagonist and a blood glucose regulator
WO2005016365A2 (en) * 2003-08-14 2005-02-24 Novo Nordisk Health Care Ag Liquid, aqueous pharmaceutical composition of factor vii polypeptides

Also Published As

Publication number Publication date
WO2008107362A2 (en) 2008-09-12

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