+

WO2008105260A1 - Therapeutic agent for ameliorating prognosis after lower limb amputation surgery - Google Patents

Therapeutic agent for ameliorating prognosis after lower limb amputation surgery Download PDF

Info

Publication number
WO2008105260A1
WO2008105260A1 PCT/JP2008/052694 JP2008052694W WO2008105260A1 WO 2008105260 A1 WO2008105260 A1 WO 2008105260A1 JP 2008052694 W JP2008052694 W JP 2008052694W WO 2008105260 A1 WO2008105260 A1 WO 2008105260A1
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic agent
ameliorating
prognosis
lower limb
limb amputation
Prior art date
Application number
PCT/JP2008/052694
Other languages
French (fr)
Japanese (ja)
Inventor
Yutaka Mizushima
Masahiro Murakami
Original Assignee
Ltt Bio-Pharma Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ltt Bio-Pharma Co., Ltd. filed Critical Ltt Bio-Pharma Co., Ltd.
Priority to CN2008800063978A priority Critical patent/CN101622003B/en
Publication of WO2008105260A1 publication Critical patent/WO2008105260A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed is a therapeutic agent for ameliorating the prognosis after lower limb amputation surgery which is induced by severe peripheral arterial disease. The therapeutic agent comprises a prostaglandin E1 (PGE1) derivative shown by the formula (I) (AS-013) as an active ingredient. Preferably, the therapeutic agent takes a dosage form of a preparation for intravenous or local administration. More preferably, the preparation for injection takes a dosage form of a liposome preparation having the active ingredient AS-013 embedded in a lipid particle.
PCT/JP2008/052694 2007-02-28 2008-02-19 Therapeutic agent for ameliorating prognosis after lower limb amputation surgery WO2008105260A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2008800063978A CN101622003B (en) 2007-02-28 2008-02-19 Therapeutic agent for ameliorating prognosis after lower limb amputation surgery

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-049363 2007-02-28
JP2007049363 2007-02-28

Publications (1)

Publication Number Publication Date
WO2008105260A1 true WO2008105260A1 (en) 2008-09-04

Family

ID=39721096

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/052694 WO2008105260A1 (en) 2007-02-28 2008-02-19 Therapeutic agent for ameliorating prognosis after lower limb amputation surgery

Country Status (2)

Country Link
CN (1) CN101622003B (en)
WO (1) WO2008105260A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0710833A (en) * 1991-04-16 1995-01-13 Yutaka Mizushima Prostaglandin analog, its fat emulsion and its use
WO1999009992A1 (en) * 1997-08-27 1999-03-04 Yoshitomi Pharmaceutical Industries, Ltd. Neovascularization promoters
WO1999011268A1 (en) * 1997-08-28 1999-03-11 Yoshitomi Pharmaceutical Industries, Ltd. Neovascularization promoters and neovascularization potentiators

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0710833A (en) * 1991-04-16 1995-01-13 Yutaka Mizushima Prostaglandin analog, its fat emulsion and its use
WO1999009992A1 (en) * 1997-08-27 1999-03-04 Yoshitomi Pharmaceutical Industries, Ltd. Neovascularization promoters
WO1999011268A1 (en) * 1997-08-28 1999-03-11 Yoshitomi Pharmaceutical Industries, Ltd. Neovascularization promoters and neovascularization potentiators

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ITO M.: "Heisokusei Domyaku Kokasho -Gainen.Bunrui.Shindan.Chiryo-", SHINJIDAI NO TONYOBYOGAKU (4) - BYOIN.SHINDAN.CHIRYO KENKYU NO SHINPO-, KABUSHIKI KASIHA NIPPON RINSHOSHA, 28 October 2002 (2002-10-28), pages 334 *

Also Published As

Publication number Publication date
CN101622003A (en) 2010-01-06
CN101622003B (en) 2012-03-21

Similar Documents

Publication Publication Date Title
NZ586751A (en) Use of CDDO methyl ester (methyl 2-cyano-3,12-dioxoleana-1,9(11)-dien-28-oate) for the treatment of renal diseases and for improving kigney function
NZ589445A (en) Rasagiline for parkinson's disease modification
BRPI0509863A (en) drug release to the eye fundus
WO2007017135A3 (en) Process for the preparation of olmesartan medoxomil
WO2008027557A3 (en) Topiramate compositions and methods of enhancing its bioavailability
EP1834637A4 (en) Preventive/therapeutic composition for free radical disease
WO2008069941A3 (en) Modified release ibuprofen solid oral dosage form
WO2010088000A3 (en) Antifibrotic compounds and uses thereof
AR047993A1 (en) PHARMACEUTICAL COMPOSITION THAT PIMOBENDAN INCLUDES
WO2012021107A3 (en) A liposomal formulation for ocular drug delivery
UA96575C2 (en) Process for the preparation of olmesartan medoxomil
BR112012016783A2 (en) "Uses of the naltrexone compound or pharmaceutically acceptable salt thereof to bupropion or pharmaceutically acceptable salt thereof or composition thereof and methods for providing therapy"
WO2009028605A1 (en) Prophylactic or alleviating agent for peripheral nerve disorder induced by anti-cancer agent
BR0210293A (en) An aqueous pharmaceutical preparation of cilostazol for parenteral use
WO2012012305A3 (en) Combination therapy using a ruthenium complex
WO2008008701A3 (en) Substituted cyclopentane derivatives as therapeutic agents
WO2010075315A3 (en) Topical formulations of flap inhibitors for administration to an eye
EA201171087A1 (en) METHODS OF ADMINISTRATION (4aR, 10aR) -1-n-PROPIL-1,2,3,4,4a, 5,10,10a-OCTAGHYDROBENZO [g] KHINOLIN-6,7-DIOLA AND RELATED COMPOUNDS THROUGH THE IMMABLE SHELL OF THE CAVITY SLIM OF THE NOSE OR SKIN AND PHARMACEUTICAL COMPOSITIONS ON THEIR BASIS
WO2007145863A3 (en) Sustained release formulation of naltrexone
WO2008008882A3 (en) Glucocorticoid receptor modulator and methods of use
WO2008133297A1 (en) Therapeutic or prophylactic agent for dyskinesia
WO2007133796A3 (en) Methods and compositions for treatment of sleep apnea comprising administration of an endothelin antagonist
EA022988B9 (en) Phenylketone carboxylate compounds and pharmaceutical uses thereof
WO2011049979A3 (en) Injectable formulations for intra- articular or peri-articular administration
PH12013500711A1 (en) Acylbenzene derivative

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880006397.8

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08711518

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08711518

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: JP

点击 这是indexloc提供的php浏览器服务,不要输入任何密码和下载