+

WO2008100651A3 - Préparation de darifénacine et ses sels - Google Patents

Préparation de darifénacine et ses sels Download PDF

Info

Publication number
WO2008100651A3
WO2008100651A3 PCT/US2008/050388 US2008050388W WO2008100651A3 WO 2008100651 A3 WO2008100651 A3 WO 2008100651A3 US 2008050388 W US2008050388 W US 2008050388W WO 2008100651 A3 WO2008100651 A3 WO 2008100651A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
darifenacin
salts
reaction
salt
Prior art date
Application number
PCT/US2008/050388
Other languages
English (en)
Other versions
WO2008100651A2 (fr
Inventor
Srinivas Katkam
Pattabhiramayya Vaddadi
Vishnuvardhan Sunkara
Muralimohan Muttavarapu
Lalitha Dattatray Kulkarni
Rajeshwar Reddy Sagyam
Jaya Prakash Pitta
Ravinder Buchnikonda
Sridhar Munagala
Original Assignee
Reddys Lab Ltd Dr
Reddys Lab Inc Dr
Srinivas Katkam
Pattabhiramayya Vaddadi
Vishnuvardhan Sunkara
Muralimohan Muttavarapu
Lalitha Dattatray Kulkarni
Rajeshwar Reddy Sagyam
Jaya Prakash Pitta
Ravinder Buchnikonda
Sridhar Munagala
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reddys Lab Ltd Dr, Reddys Lab Inc Dr, Srinivas Katkam, Pattabhiramayya Vaddadi, Vishnuvardhan Sunkara, Muralimohan Muttavarapu, Lalitha Dattatray Kulkarni, Rajeshwar Reddy Sagyam, Jaya Prakash Pitta, Ravinder Buchnikonda, Sridhar Munagala filed Critical Reddys Lab Ltd Dr
Priority to EP08772573A priority Critical patent/EP2109601A2/fr
Publication of WO2008100651A2 publication Critical patent/WO2008100651A2/fr
Publication of WO2008100651A3 publication Critical patent/WO2008100651A3/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne plusieurs procédés et composés associés à la darifénacine et/ou à ses sels. L'invention concerne par exemple un procédé de préparation d'une base libre de darifénacine : Formule ou de son sel. Le procédé comprend la mise en réaction de la 3-(S)-(cyanodiphénylméthyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)éthyl] pyrrolidine de formule (IV) ou un de ses sels : Formule (IV) avec une base efficace pour transformer le groupement nitrile du composé de formule (IV) en groupement amide de la darifénacine dans un solvant organique, à condition que le solvant ne soit pas le 2-méthyl-butan-2-ol et que la réaction produise une quantité inférieure à environ 0,5 % du composé de formule (Ic) : Formule (Ic) dans la masse réactionnelle, telle que mesurée par HPLC. L'invention concerne également plusieurs modes de réalisation et plusieurs variantes.
PCT/US2008/050388 2007-01-05 2008-01-07 Préparation de darifénacine et ses sels WO2008100651A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08772573A EP2109601A2 (fr) 2007-01-05 2008-01-07 Préparation de darifénacine et ses sels

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IN34/CHE/2007 2007-01-05
IN34CH2007 2007-01-05
US89471107P 2007-03-14 2007-03-14
US60/894,711 2007-03-14
IN2060CH2007 2007-09-13
IN2060/CHE/2007 2007-09-13

Publications (2)

Publication Number Publication Date
WO2008100651A2 WO2008100651A2 (fr) 2008-08-21
WO2008100651A3 true WO2008100651A3 (fr) 2008-11-20

Family

ID=39277318

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/050388 WO2008100651A2 (fr) 2007-01-05 2008-01-07 Préparation de darifénacine et ses sels

Country Status (2)

Country Link
EP (1) EP2109601A2 (fr)
WO (1) WO2008100651A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109641822B (zh) * 2016-08-12 2022-03-11 拜耳作物科学股份公司 制备取代苯乙烯衍生物的方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008126106A2 (fr) * 2007-04-16 2008-10-23 Manne Satyanarayana Reddy Procédés nouveaux et perfectionnés pour la préparation d'intermédiaires de darifénacine, de la darifénacine et de ses sels pharmaceutiquement acceptables
WO2009007853A2 (fr) * 2007-06-08 2009-01-15 Actavis Group Ptc Ehf Nouveaux polymorphes de la base libre de darifénacine et son sel d'hydrobromure
WO2009010846A2 (fr) * 2007-07-13 2009-01-22 Medichem, S.A. Forme amorphe du bromhydrate de darifénacine et ses procédés de préparation
JP2012041277A (ja) * 2010-08-13 2012-03-01 Kaneka Corp 1,3位−2置換ピロリジン化合物またはその塩の改良された製造法
CN101973971A (zh) * 2010-09-26 2011-02-16 山东邹平大展新材料有限公司 一种制备5-卤代乙基-2,3-二氢苯并呋喃的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5096890A (en) * 1989-03-17 1992-03-17 Pfizer Inc. Pyrrolidine derivatives
WO2003080599A1 (fr) * 2002-03-26 2003-10-02 Novartis International Pharmaceutical Ltd. Hydrate stable d'antagoniste de recepteur muscarinique
WO2007076158A2 (fr) * 2005-12-27 2007-07-05 Teva Pharmaceutical Industries Ltd. Procedes de preparation de bromhydrate de darifenacine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5096890A (en) * 1989-03-17 1992-03-17 Pfizer Inc. Pyrrolidine derivatives
US5096890B1 (en) * 1989-03-17 1995-03-28 Pfizer Pyrrolidine derivatives
WO2003080599A1 (fr) * 2002-03-26 2003-10-02 Novartis International Pharmaceutical Ltd. Hydrate stable d'antagoniste de recepteur muscarinique
US6930188B2 (en) * 2002-03-26 2005-08-16 Novartis International Pharmaceutical, Ltd. Stable hydrate of a muscarinic receptor antagonist
WO2007076158A2 (fr) * 2005-12-27 2007-07-05 Teva Pharmaceutical Industries Ltd. Procedes de preparation de bromhydrate de darifenacine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109641822B (zh) * 2016-08-12 2022-03-11 拜耳作物科学股份公司 制备取代苯乙烯衍生物的方法

Also Published As

Publication number Publication date
EP2109601A2 (fr) 2009-10-21
WO2008100651A2 (fr) 2008-08-21

Similar Documents

Publication Publication Date Title
GB0719180D0 (en) New process
NZ602754A (en) Substituted 1,3-benzothiazepines useful in treating metabolic disorders
WO2008100651A3 (fr) Préparation de darifénacine et ses sels
NO20091242L (no) Fremgangsmate for fremstilling av biarylsubstituerte 4-aminosmorsyre eller derivater derav og deres anvendelse ved fremstilling av NEP-inhibitorer
NZ592533A (en) METHOD FOR THE PREPARATION OF N-(5-CHLORO-2-PYRIDINYL)-2-[[4-[(DIMETHYLAMINO) IMINOMETHYL] BENZOYL] AMINO]-5-METHOXY-BENZAMIDE, A FACTOR Xa INHIBITOR
CA2565660A1 (fr) Composes aryl- ou heteroarylamides ortho-substitues
HRP20150305T1 (hr) Postupak za pripravu intermedijera spojeva korisnih kao modulatori opioid receptora
MX2009003739A (es) Derivados de hidrobenzamida como inhibidores de hsp90.
NZ600119A (en) Process and intermediates for the preparation of 5-biphenyl-4-yl-2-methylpentanoic acid derivatives
DE602006008962D1 (de) Verfahren zur herstellung von valsartan
MX2009003257A (es) Procedimiento para la sintesis de derivados de fenoxi diaminopirimidina.
MY145466A (en) 3-alkyl-5- (4-alkyl-5-oxo-tetrahydrofutran-2-yl) pyrrolidin-2-one derivatives as intermediates in the synthesis of renin inhibitors
WO2009127948A8 (fr) Composés aryl carboxamides à 5 éléments de 4-[3-(aryloxy)benzylidène]-3-méthyl pipéridine utiles comme inhibiteurs de la faah
ZA200802048B (en) An improved process for preparing oxazolidine protected aminodiol compounds useful as intermediates to florfenicol
CA2356188A1 (fr) Technique de preparation de 5-cyanophtalide
WO2009154754A3 (fr) Synthèse de dérivés de morpholine deutérés
WO2011025982A3 (fr) Composés tétracycline
WO2008047388A3 (fr) Procédé amélioré de préparation de ranolazine
EP2318362A2 (fr) Composés de 3-(phénoxyphénylméthyl)pyrrolidine
WO2006103696A3 (fr) Procede de fabrication de levetiracetam et racemisation de (r) et (s)-2-amino butynamide, et derives acides correspondants
ZA201003751B (en) Process for the synthesis of propargylated aminoindan derivatives
NO20082005L (no) Syntese av renininhibitorer omfattende en cyklotilfoyelsesreaksjon
WO2008126106A8 (fr) Procédés nouveaux et perfectionnés pour la préparation d'intermédiaires de darifénacine, de la darifénacine et de ses sels pharmaceutiquement acceptables
BRPI0409016A (pt) processos para preparação de um produto de reação, de uma composição farmacêutica, de uma composição agroquìmica, de uma composição de limpeza, de uma composição de tinta e de um refrigerante ou lubrificante
NO20070845L (no) Fremgangsmate for fremstilling av losartan

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08772573

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 3902/CHENP/2009

Country of ref document: IN

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008772573

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务,不要输入任何密码和下载