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WO2008154350A3 - Use of tight junction agonists to suppress immune responses - Google Patents

Use of tight junction agonists to suppress immune responses Download PDF

Info

Publication number
WO2008154350A3
WO2008154350A3 PCT/US2008/066057 US2008066057W WO2008154350A3 WO 2008154350 A3 WO2008154350 A3 WO 2008154350A3 US 2008066057 W US2008066057 W US 2008066057W WO 2008154350 A3 WO2008154350 A3 WO 2008154350A3
Authority
WO
WIPO (PCT)
Prior art keywords
tight junction
immune responses
suppress immune
agonists
junction agonists
Prior art date
Application number
PCT/US2008/066057
Other languages
French (fr)
Other versions
WO2008154350A2 (en
Inventor
Amir Tamiz
Niranjan Pandey
Blake Paterson
Original Assignee
Alba Therapeutics Corp
Amir Tamiz
Niranjan Pandey
Blake Paterson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alba Therapeutics Corp, Amir Tamiz, Niranjan Pandey, Blake Paterson filed Critical Alba Therapeutics Corp
Publication of WO2008154350A2 publication Critical patent/WO2008154350A2/en
Publication of WO2008154350A3 publication Critical patent/WO2008154350A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention provides materials and methods to suppress an excessive or undesired immune response. In some embodiments, agonists of biological pathways responsible for opening and closing tight junctions (e.g., tight junction agonists) are used in compositions with antigens to suppress an immune response to the antigen.
PCT/US2008/066057 2007-06-08 2008-06-06 Use of tight junction agonists to suppress immune responses WO2008154350A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94297807P 2007-06-08 2007-06-08
US60/942,978 2007-06-08

Publications (2)

Publication Number Publication Date
WO2008154350A2 WO2008154350A2 (en) 2008-12-18
WO2008154350A3 true WO2008154350A3 (en) 2009-02-26

Family

ID=40130444

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/066057 WO2008154350A2 (en) 2007-06-08 2008-06-06 Use of tight junction agonists to suppress immune responses

Country Status (1)

Country Link
WO (1) WO2008154350A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4338297A (en) * 1980-02-19 1982-07-06 Michael Jacob G Polypeptide active pollen immunosuppressant fraction
US20050119171A1 (en) * 2001-08-10 2005-06-02 Genset S.A. Human cdnas and proteins and uses thereof
US20060165722A1 (en) * 2005-01-14 2006-07-27 University Of Maryland, Baltimore Peptides for delivery of mucosal vaccines
US20060276399A1 (en) * 1998-08-03 2006-12-07 University Of Maryland - Baltimore Peptide antagonists of zonulin and methods for use of the same
US20070122423A1 (en) * 2001-08-17 2007-05-31 Glaxosmithkline Biologicals Sa Derp1 and proderp1 allergen derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4338297A (en) * 1980-02-19 1982-07-06 Michael Jacob G Polypeptide active pollen immunosuppressant fraction
US20060276399A1 (en) * 1998-08-03 2006-12-07 University Of Maryland - Baltimore Peptide antagonists of zonulin and methods for use of the same
US20050119171A1 (en) * 2001-08-10 2005-06-02 Genset S.A. Human cdnas and proteins and uses thereof
US20070122423A1 (en) * 2001-08-17 2007-05-31 Glaxosmithkline Biologicals Sa Derp1 and proderp1 allergen derivatives
US20060165722A1 (en) * 2005-01-14 2006-07-27 University Of Maryland, Baltimore Peptides for delivery of mucosal vaccines

Also Published As

Publication number Publication date
WO2008154350A2 (en) 2008-12-18

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