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WO2008153762A3 - Formulations s-nitrosothiol et systèmes d'entreposage - Google Patents

Formulations s-nitrosothiol et systèmes d'entreposage Download PDF

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Publication number
WO2008153762A3
WO2008153762A3 PCT/US2008/006640 US2008006640W WO2008153762A3 WO 2008153762 A3 WO2008153762 A3 WO 2008153762A3 US 2008006640 W US2008006640 W US 2008006640W WO 2008153762 A3 WO2008153762 A3 WO 2008153762A3
Authority
WO
WIPO (PCT)
Prior art keywords
nitrosothiol
formulations
storage systems
nitrosoglutathione
provides stable
Prior art date
Application number
PCT/US2008/006640
Other languages
English (en)
Other versions
WO2008153762A2 (fr
Inventor
Douglas L Looker
Wayne F Beyer
Original Assignee
N30 Pharmaceuticals Llc
Douglas L Looker
Wayne F Beyer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by N30 Pharmaceuticals Llc, Douglas L Looker, Wayne F Beyer filed Critical N30 Pharmaceuticals Llc
Publication of WO2008153762A2 publication Critical patent/WO2008153762A2/fr
Publication of WO2008153762A3 publication Critical patent/WO2008153762A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Cette invention concerne un S-nitrosothiol stable, tel que le S-nitrosoglutathione, des formulations assurant un entreposage durable de S-nitrosothiols. Elle concerne également des formulations stables comprenant le S-nitrosothiol, telles que le S-nitrosoglutathione; et des méthodes de traitement de patients nécessitant le S-nitrosothiol, tel qu'un traitement à base de S-nitrosoglutathione et/ou d'acide nitrique.
PCT/US2008/006640 2007-05-25 2008-05-23 Formulations s-nitrosothiol et systèmes d'entreposage WO2008153762A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93173007P 2007-05-25 2007-05-25
US60/931,730 2007-05-25

Publications (2)

Publication Number Publication Date
WO2008153762A2 WO2008153762A2 (fr) 2008-12-18
WO2008153762A3 true WO2008153762A3 (fr) 2009-07-23

Family

ID=39869946

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/006640 WO2008153762A2 (fr) 2007-05-25 2008-05-23 Formulations s-nitrosothiol et systèmes d'entreposage

Country Status (1)

Country Link
WO (1) WO2008153762A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5795165B2 (ja) 2007-11-15 2015-10-14 ルイジアナ ステイト ユニヴァーシティー 慢性虚血における亜硝酸塩の使用
WO2010147742A2 (fr) 2009-06-18 2010-12-23 Theravasc Inc. Utilisation de sels de nitrates dans le traitement d'un endommagement tissulaire
CA2777066C (fr) 2009-10-14 2020-02-18 TheraVasc, LLC Formulations pharmaceutiques de nitrite et utilisations de celle-ci
WO2013103925A2 (fr) * 2012-01-05 2013-07-11 Guilford Frederick Timothy Glutathione réduite encapsulée dans un liposome pour le traitement du cancer, autres utilisations et méthodes
DK2958573T3 (da) 2013-02-20 2019-08-05 The Board Of Supervisors Of The Louisiana State Univ Mechanical And Agricultural College Farmaceutiske formuleringer af nitrit og anvendelser deraf
GB201505347D0 (en) * 2015-03-27 2015-05-13 Salupont Consulting Ltd Sterilisation of s-nitrosothiols
ITUB20154719A1 (it) 2015-10-21 2017-04-21 Glano Tech Ltd Formulazione per il rilascio di ossido nitrico
EP3419683B1 (fr) * 2016-02-25 2021-10-06 The Regents of The University of Michigan Formulations générant de l'oxyde nitrique et kits
CN112004531B (zh) 2018-03-01 2023-11-24 密歇根大学董事会 两部分的生成一氧化氮的局部组合物
US10716805B2 (en) 2018-03-19 2020-07-21 Glanotech Limited Formulation for release of nitric oxide

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4900719A (en) * 1988-08-05 1990-02-13 The Ohio State University Nitrosothiols as hypotensive agents
WO1999030716A1 (fr) * 1997-12-16 1999-06-24 Alcon Laboratories, Inc. Utilisation de generateurs d'oxyde nitrique pour le traitement de syndromes de l'oeil sec
WO2007076053A2 (fr) * 2005-12-21 2007-07-05 Nitrox, Llc Formulations stables de s-nitrosothiol

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4900719A (en) * 1988-08-05 1990-02-13 The Ohio State University Nitrosothiols as hypotensive agents
WO1999030716A1 (fr) * 1997-12-16 1999-06-24 Alcon Laboratories, Inc. Utilisation de generateurs d'oxyde nitrique pour le traitement de syndromes de l'oeil sec
WO2007076053A2 (fr) * 2005-12-21 2007-07-05 Nitrox, Llc Formulations stables de s-nitrosothiol

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ARTHUR KREZEL ET AL: "Contrasting effects of metal ions on S-Nitrosoglutathione, Related to Coordination Equilibria: GSNO Decomposition Assisted by Ni(II) vs Stability Increase in the Presence of Zn(II) and Cd(II)", CHEM. RES. TOXICOL., vol. 17, 2004, pages 392 - 403, XP002530569 *
ZHENGUO LIU ET AL: "S-Transnitrosation Reactions Are Involved in the Metabolic Fate and Biological Actions of Nitric oxide", THE J. OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 284, no. 2, 1998, pages 526 - 534, XP002530570 *

Also Published As

Publication number Publication date
WO2008153762A2 (fr) 2008-12-18

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