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WO2008153040A1 - マイクロチップおよびこれを用いた分析方法 - Google Patents

マイクロチップおよびこれを用いた分析方法 Download PDF

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Publication number
WO2008153040A1
WO2008153040A1 PCT/JP2008/060648 JP2008060648W WO2008153040A1 WO 2008153040 A1 WO2008153040 A1 WO 2008153040A1 JP 2008060648 W JP2008060648 W JP 2008060648W WO 2008153040 A1 WO2008153040 A1 WO 2008153040A1
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WO
WIPO (PCT)
Prior art keywords
microchip
sample
section
same
introducing
Prior art date
Application number
PCT/JP2008/060648
Other languages
English (en)
French (fr)
Inventor
Hisao Kawaura
Original Assignee
Nec Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nec Corporation filed Critical Nec Corporation
Publication of WO2008153040A1 publication Critical patent/WO2008153040A1/ja

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/142—Preventing evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Electrochemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

　再現性よく短時間で試料を分離する測定精度の高いマイクロチップを提供する。 　マイクロチップは、基板１０２と、該基板１０２の表面に形成された試料溶液の通る流路とを備える。流路は、試料溶液を分離する解析部１０３と、解析部１０３に隣接し、試料溶液を導入させる試料導入部１０４とを備える。試料導入部１０４の表面は、疎水面１０６と、親水性領域とを含み、親水性領域は、解析部１０３の表面と接して親水面１０５を形成している。
PCT/JP2008/060648 2007-06-14 2008-06-11 マイクロチップおよびこれを用いた分析方法 WO2008153040A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-157848 2007-06-14
JP2007157848A JP2008309642A (ja) 2007-06-14 2007-06-14 マイクロチップおよびこれを用いた分析方法

Publications (1)

Publication Number Publication Date
WO2008153040A1 true WO2008153040A1 (ja) 2008-12-18

Family

ID=40129645

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/060648 WO2008153040A1 (ja) 2007-06-14 2008-06-11 マイクロチップおよびこれを用いた分析方法

Country Status (2)

Country Link
JP (1) JP2008309642A (ja)
WO (1) WO2008153040A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014173935A (ja) * 2013-03-07 2014-09-22 Toshiba Corp 半導体マイクロ分析チップ及びその製造方法
JPWO2014045482A1 (ja) * 2012-09-19 2016-08-18 日本電気株式会社 分析チップ、及び分析装置
JP2016212090A (ja) * 2015-05-13 2016-12-15 アークレイ株式会社 分析用具および分析システム

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5948248B2 (ja) * 2010-11-01 2016-07-06 コニカミノルタ株式会社 マイクロチップ、及び、マイクロチップの製造方法
JP2015222177A (ja) * 2012-09-19 2015-12-10 シャープ株式会社 チップ、分析装置および分析システム
JP7276798B2 (ja) * 2017-09-22 2023-05-18 国立研究開発法人理化学研究所 マイクロ流路デバイス及びその製造方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004069430A (ja) * 2002-08-05 2004-03-04 Mitsubishi Kagaku Iatron Inc 電気泳動用チップ、その製造方法、及び物質の分離方法
JP2004077305A (ja) * 2002-08-19 2004-03-11 Nec Corp 検出装置
WO2005124332A1 (ja) * 2004-06-15 2005-12-29 Nec Corporation 電気泳動チップおよび電気泳動装置、ならびに電気泳動方法
JP2006250622A (ja) * 2005-03-09 2006-09-21 Shimadzu Corp キャピラリープレートを用いた電気泳動方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004069430A (ja) * 2002-08-05 2004-03-04 Mitsubishi Kagaku Iatron Inc 電気泳動用チップ、その製造方法、及び物質の分離方法
JP2004077305A (ja) * 2002-08-19 2004-03-11 Nec Corp 検出装置
WO2005124332A1 (ja) * 2004-06-15 2005-12-29 Nec Corporation 電気泳動チップおよび電気泳動装置、ならびに電気泳動方法
JP2006250622A (ja) * 2005-03-09 2006-09-21 Shimadzu Corp キャピラリープレートを用いた電気泳動方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2014045482A1 (ja) * 2012-09-19 2016-08-18 日本電気株式会社 分析チップ、及び分析装置
JP2014173935A (ja) * 2013-03-07 2014-09-22 Toshiba Corp 半導体マイクロ分析チップ及びその製造方法
JP2016212090A (ja) * 2015-05-13 2016-12-15 アークレイ株式会社 分析用具および分析システム
JP2018072350A (ja) * 2015-05-13 2018-05-10 アークレイ株式会社 分析システム

Also Published As

Publication number Publication date
JP2008309642A (ja) 2008-12-25

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