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WO2008152422A3 - Binding proteins specific for insulin-like growth factors and uses thereof-909 - Google Patents

Binding proteins specific for insulin-like growth factors and uses thereof-909 Download PDF

Info

Publication number
WO2008152422A3
WO2008152422A3 PCT/GB2008/050436 GB2008050436W WO2008152422A3 WO 2008152422 A3 WO2008152422 A3 WO 2008152422A3 GB 2008050436 W GB2008050436 W GB 2008050436W WO 2008152422 A3 WO2008152422 A3 WO 2008152422A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding proteins
insulin
growth factors
proteins specific
specific
Prior art date
Application number
PCT/GB2008/050436
Other languages
French (fr)
Other versions
WO2008152422A2 (en
Inventor
Vahe Bedian
Susan Ann Cartlidge
Gadi Gazit-Bornstein
Olivia Raeber
David William Tonge
Xiao-Dong Yang
Original Assignee
Astrazeneca Ab
Astrazeneca Uk Ltd
Vahe Bedian
Susan Ann Cartlidge
Gadi Gazit-Bornstein
Olivia Raeber
David William Tonge
Xiao-Dong Yang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Astrazeneca Uk Ltd, Vahe Bedian, Susan Ann Cartlidge, Gadi Gazit-Bornstein, Olivia Raeber, David William Tonge, Xiao-Dong Yang filed Critical Astrazeneca Ab
Publication of WO2008152422A2 publication Critical patent/WO2008152422A2/en
Publication of WO2008152422A3 publication Critical patent/WO2008152422A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Binding proteins, such as antibodies directed to IGF-II with cross-reactivity to IGF-I and uses of such antibodies are described.
PCT/GB2008/050436 2007-06-12 2008-06-11 Binding proteins specific for insulin-like growth factors and uses thereof-909 WO2008152422A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94333107P 2007-06-12 2007-06-12
US60/943,331 2007-06-12

Publications (2)

Publication Number Publication Date
WO2008152422A2 WO2008152422A2 (en) 2008-12-18
WO2008152422A3 true WO2008152422A3 (en) 2009-03-12

Family

ID=39671449

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/050436 WO2008152422A2 (en) 2007-06-12 2008-06-11 Binding proteins specific for insulin-like growth factors and uses thereof-909

Country Status (1)

Country Link
WO (1) WO2008152422A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20090368A1 (en) 2007-06-19 2009-04-28 Boehringer Ingelheim Int ANTI-IGF ANTIBODIES
GEP20146119B (en) 2008-12-12 2014-07-25 Boehringer Ingelheim Int Anti-igf antibodies
AU2011282423B2 (en) 2010-07-22 2015-05-14 Schrader, Sabariah Cross-protective pathogen protection, methods and compositions thereof
US20140255413A1 (en) 2013-03-07 2014-09-11 Boehringer Ingelheim International Gmbh Combination therapy for neoplasia treatment
EP3082859A4 (en) * 2013-12-19 2017-07-19 Medlmmune, LLC Compositions and methods for treating sarcoma
CN114984192A (en) * 2022-06-29 2022-09-02 重庆大学 Application of recombinant protein IGF1-24 in preparation of medicine for treating respiratory dysfunction

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1505075A1 (en) * 2002-04-30 2005-02-09 Kyowa Hakko Kogyo Co., Ltd. Antibody to human insulin-like growth factor
WO2005016970A2 (en) * 2003-05-01 2005-02-24 Imclone Systems Incorporated Fully human antibodies directed against the human insulin-like growth factor-1 receptor
EP1661582A1 (en) * 2003-08-21 2006-05-31 Kyowa Hakko Kogyo Co., Ltd. Cancer metastasis inhibitor
WO2007070432A2 (en) * 2005-12-13 2007-06-21 Astrazeneca Ab Binding proteins specific for insulin-like growth factors and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1505075A1 (en) * 2002-04-30 2005-02-09 Kyowa Hakko Kogyo Co., Ltd. Antibody to human insulin-like growth factor
WO2005016970A2 (en) * 2003-05-01 2005-02-24 Imclone Systems Incorporated Fully human antibodies directed against the human insulin-like growth factor-1 receptor
EP1661582A1 (en) * 2003-08-21 2006-05-31 Kyowa Hakko Kogyo Co., Ltd. Cancer metastasis inhibitor
WO2007070432A2 (en) * 2005-12-13 2007-06-21 Astrazeneca Ab Binding proteins specific for insulin-like growth factors and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GOYA MASATO ET AL: "Growth inhibition of human prostate cancer cells in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice by a ligand-specific antibody to human insulin-like growth factors", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, vol. 64, no. 17, 1 January 2004 (2004-01-01), pages 6252 - 6258, XP002982679, ISSN: 0008-5472 *

Also Published As

Publication number Publication date
WO2008152422A2 (en) 2008-12-18

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