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WO2008152099A3 - Aryl/hétarylamides en tant que modulateurs du récepteur ep2 - Google Patents

Aryl/hétarylamides en tant que modulateurs du récepteur ep2 Download PDF

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Publication number
WO2008152099A3
WO2008152099A3 PCT/EP2008/057396 EP2008057396W WO2008152099A3 WO 2008152099 A3 WO2008152099 A3 WO 2008152099A3 EP 2008057396 W EP2008057396 W EP 2008057396W WO 2008152099 A3 WO2008152099 A3 WO 2008152099A3
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WO
WIPO (PCT)
Prior art keywords
receptor
aryl
hetarylamides
modulators
hetarylamide
Prior art date
Application number
PCT/EP2008/057396
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English (en)
Other versions
WO2008152099A2 (fr
Inventor
Bernd Buchmann
Nico Braeuer
Marcus Koppitz
Olaf Peters
Knut Eis
Laak Antonius Ter
Bernhard Lindenthal
Gernot Langer
Tim Wintermantel
Original Assignee
Bayer Schering Pharma Ag
Bernd Buchmann
Nico Braeuer
Marcus Koppitz
Olaf Peters
Knut Eis
Laak Antonius Ter
Bernhard Lindenthal
Gernot Langer
Tim Wintermantel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag, Bernd Buchmann, Nico Braeuer, Marcus Koppitz, Olaf Peters, Knut Eis, Laak Antonius Ter, Bernhard Lindenthal, Gernot Langer, Tim Wintermantel filed Critical Bayer Schering Pharma Ag
Priority to EP08760936A priority Critical patent/EP2167077A2/fr
Publication of WO2008152099A2 publication Critical patent/WO2008152099A2/fr
Publication of WO2008152099A3 publication Critical patent/WO2008152099A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/42—Oxazoles
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    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
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    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D495/04—Ortho-condensed systems

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Abstract

La présente invention porte sur des dérivés d'aryle/hétarylamide de la formule générale (I), sur un procédé pour leur préparation et sur l'utilisation de ceux-ci dans la fabrication de compositions pharmaceutiques pour le traitement de troubles et d'indications associés au récepteur EP2.
PCT/EP2008/057396 2007-06-13 2008-06-12 Aryl/hétarylamides en tant que modulateurs du récepteur ep2 WO2008152099A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08760936A EP2167077A2 (fr) 2007-06-13 2008-06-12 Aryle/hétarylamides en tant que modulateurs du récepteur ep2

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07090121.0 2007-06-13
EP07090121A EP2002834A1 (fr) 2007-06-13 2007-06-13 Aryle/hétarylamides en tant que modulateurs du récepteur EP2

Publications (2)

Publication Number Publication Date
WO2008152099A2 WO2008152099A2 (fr) 2008-12-18
WO2008152099A3 true WO2008152099A3 (fr) 2009-04-09

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PCT/EP2008/057396 WO2008152099A2 (fr) 2007-06-13 2008-06-12 Aryl/hétarylamides en tant que modulateurs du récepteur ep2

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US (1) US20090023741A1 (fr)
EP (2) EP2002834A1 (fr)
WO (1) WO2008152099A2 (fr)

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US7989459B2 (en) 2006-02-17 2011-08-02 Pharmacopeia, Llc Purinones and 1H-imidazopyridinones as PKC-theta inhibitors
WO2010008777A2 (fr) * 2008-06-23 2010-01-21 Ligand Pharmaceuticals Inc. Pyridines azabicycliques condensées
EP2149554A1 (fr) * 2008-07-30 2010-02-03 Bayer Schering Pharma Aktiengesellschaft Indolylamides en tant que modulateurs du récepteur EP2
EP2149552A1 (fr) * 2008-07-30 2010-02-03 Bayer Schering Pharma AG Dérivés de benzamide 5,6 substitués en tant que modulateurs du récepteur EP2
WO2010017179A1 (fr) 2008-08-04 2010-02-11 Chdi, Inc. Certains inhibiteurs de kynurénine-3-monooxygénase, compositions pharmaceutiques, et procédés d'utilisation de ceux-ci
CA2738929A1 (fr) * 2008-10-17 2010-04-22 Boehringer Ingelheim International Gmbh Composes indole a substitution heteroaryle utilises comme inhibiteurs de mmp-13
JP5592388B2 (ja) * 2008-10-31 2014-09-17 メルク・シャープ・アンド・ドーム・コーポレーション 疼痛治療用のｐ２ｘ３受容体アンタゴニスト技術分野
KR101082414B1 (ko) 2009-04-20 2011-11-10 충북대학교 산학협력단 신규한 나프탈렌 유도체 화합물 및 이를 유효성분으로 포함하는 면역 증강용 약제학적 조성물
GB0910003D0 (en) 2009-06-11 2009-07-22 Univ Leuven Kath Novel compounds for the treatment of neurodegenerative diseases
DE102009049662A1 (de) 2009-10-13 2011-04-14 Bayer Schering Pharma Aktiengesellschaft 2,5-Disubstituierte 2H-Indazole als EP2-Rezeptor-Antagonisten
TW201139370A (en) * 2009-12-23 2011-11-16 Lundbeck & Co As H Processes for the manufacture of a pharmaceutically active agent
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