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WO2008147360A1 - Compositions, procédés, dispositifs et systèmes de soins oraux - Google Patents

Compositions, procédés, dispositifs et systèmes de soins oraux Download PDF

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Publication number
WO2008147360A1
WO2008147360A1 PCT/US2007/012901 US2007012901W WO2008147360A1 WO 2008147360 A1 WO2008147360 A1 WO 2008147360A1 US 2007012901 W US2007012901 W US 2007012901W WO 2008147360 A1 WO2008147360 A1 WO 2008147360A1
Authority
WO
WIPO (PCT)
Prior art keywords
component
oral care
dentifrice
toothbrush
composition
Prior art date
Application number
PCT/US2007/012901
Other languages
English (en)
Inventor
Paul Albert Sagel
Marc Philip Ortins
Vadim Denishenko
Philip Maurice Braun
Original Assignee
The Gillette Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Gillette Company filed Critical The Gillette Company
Priority to AU2007354332A priority Critical patent/AU2007354332A1/en
Priority to BRPI0721760-9A priority patent/BRPI0721760A2/pt
Priority to MX2009012690A priority patent/MX2009012690A/es
Priority to CA2686944A priority patent/CA2686944C/fr
Priority to PCT/US2007/012901 priority patent/WO2008147360A1/fr
Priority to CN200780052932A priority patent/CN101668493A/zh
Priority to KR1020097024576A priority patent/KR20100005145A/ko
Priority to EP07795577A priority patent/EP2148632A1/fr
Priority to JP2010508349A priority patent/JP2010526638A/ja
Priority to US12/125,199 priority patent/US20090070949A1/en
Publication of WO2008147360A1 publication Critical patent/WO2008147360A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C17/00—Devices for cleaning, polishing, rinsing or drying teeth, teeth cavities or prostheses; Saliva removers; Dental appliances for receiving spittle
    • A61C17/02—Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication
    • A61C17/028—Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication with intermittent liquid flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C17/00—Devices for cleaning, polishing, rinsing or drying teeth, teeth cavities or prostheses; Saliva removers; Dental appliances for receiving spittle
    • A61C17/16—Power-driven cleaning or polishing devices
    • A61C17/22—Power-driven cleaning or polishing devices with brushes, cushions, cups, or the like
    • A61C17/225—Handles or details thereof
    • A61C17/227—Handles or details thereof with reservoirs, e.g. for toothpaste
    • A—HUMAN NECESSITIES
    • A46—BRUSHWARE
    • A46B—BRUSHES
    • A46B11/00—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water
    • A—HUMAN NECESSITIES
    • A46—BRUSHWARE
    • A46B—BRUSHES
    • A46B11/00—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water
    • A46B11/001—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water with integral reservoirs
    • A—HUMAN NECESSITIES
    • A46—BRUSHWARE
    • A46B—BRUSHES
    • A46B15/00—Other brushes; Brushes with additional arrangements
    • A46B15/0002—Arrangements for enhancing monitoring or controlling the brushing process
    • A—HUMAN NECESSITIES
    • A46—BRUSHWARE
    • A46B—BRUSHES
    • A46B15/00—Other brushes; Brushes with additional arrangements
    • A46B15/0002—Arrangements for enhancing monitoring or controlling the brushing process
    • A46B15/0004—Arrangements for enhancing monitoring or controlling the brushing process with a controlling means
    • A46B15/0008—Arrangements for enhancing monitoring or controlling the brushing process with a controlling means with means for controlling duration, e.g. time of brushing
    • A—HUMAN NECESSITIES
    • A46—BRUSHWARE
    • A46B—BRUSHES
    • A46B15/00—Other brushes; Brushes with additional arrangements
    • A46B15/0002—Arrangements for enhancing monitoring or controlling the brushing process
    • A46B15/0038—Arrangements for enhancing monitoring or controlling the brushing process with signalling means
    • A46B15/004—Arrangements for enhancing monitoring or controlling the brushing process with signalling means with an acoustic signalling means, e.g. noise
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C17/00—Devices for cleaning, polishing, rinsing or drying teeth, teeth cavities or prostheses; Saliva removers; Dental appliances for receiving spittle
    • A61C17/16—Power-driven cleaning or polishing devices
    • A61C17/22—Power-driven cleaning or polishing devices with brushes, cushions, cups, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C17/00—Devices for cleaning, polishing, rinsing or drying teeth, teeth cavities or prostheses; Saliva removers; Dental appliances for receiving spittle
    • A61C17/16—Power-driven cleaning or polishing devices
    • A61C17/22—Power-driven cleaning or polishing devices with brushes, cushions, cups, or the like
    • A61C17/221—Control arrangements therefor

Definitions

  • This invention relates to oral care compositions, methods, devices, and systems.
  • the invention features oral care treatments, including multi-component oral care compositions, methods of oral care, including protocols for the delivery of multiple components to the oral cavity, and oral care devices, kits, and systems.
  • FIG 1 is a side perspective view of an embodiment of an oral care system.
  • FIG 2 A is a front perspective view of an embodiment of an oral care device.
  • FIG 2B is a rear perspective view of the oral care device of FIG 2A.
  • FIG 3 A is a transparent front view of the oral care device of FlG 2 A.
  • FIG 3 B is a transparent rear view of the oral care device of FIG 2 A.
  • FIGS. 4A and 4B are rear and front views, respectively, of the head and neck of another oral care device embodiment with the neck shown as transparent.
  • FIG 5 is a rear view of the head and neck of another oral care device embodiment with the neck shown as transparent.
  • FIGS. 6 and 7 are front perspective views of two brush embodiments.
  • FIG 8 A is a side perspective view of an embodiment of a docking station.
  • FIG 8B is a transparent side perspective view of the docking station of FIG. 8A.
  • FIG 9 illustrates a docking station embodiment
  • FIG 10 illustrates another docking station embodiment.
  • FIG 11 is a perspective view of an embodiment of an oral care system.
  • FIG 12 is a perspective view of base portion B of the docking station shown in FIG 11.
  • FIG. 13 is a cross-sectional view of a dual compartmented dispenser suitable for use with the present invention.
  • FIG 14 is a cross-sectional view of two dispensers suitable for use with the present invention.
  • FIG 15 is a front view of a dispensing toothbrush suitable for use with the present invention.
  • FIG 16 is a schematic representation of an oral care system in accordance with the present invention.
  • FIG 17 is a schematic representation of electrical components suitable for use with the present invention.
  • oral care treatments involving delivery of two or more oral care compositions, parts of a composition, materials, formulations, or ingredients (referred to collectively below as "components") to the oral cavity will be discussed below.
  • components can be delivered from a variety of oral care devices, such as a manual toothbrush, an electric toothbrush, a package, or dispenser.
  • the components can be delivered simultaneously or sequentially.
  • the two components when mixed together, during delivery or in the oral cavity, react or otherwise interact together to form an oral care composition, for example the dual component dentifrices described in U.S. Patent No.
  • a component may be a dentifrice or a mouthwash.
  • a component may be a dentifrice or a mouthwash.
  • the components may be in any form that can be delivered by the desired delivery device, e.g., a Newtonian or non-Newtonian fluid, a liquid, a paste or a gel.
  • a dispensing device having a microprocessor controller.
  • a toothbrush a stationary or moving head (or moving portions of the head) may be used.
  • suitable toothbrushes having heads (or portions the head, including bristles or elements) which rotate, oscillate, reciprocate, translate, vibrate, etc., as described in U.S. Application Nos. 09/993,167; 10/036,613; 10/114,870; 10/128,018; 10/208,213; and 10/830,693; and U.S. Patent No. 5,378,153.
  • toothbrushes having light emitting diodes may be used, including toothbrushes which emit light (including blue light), as described in U.S. Application Nos. 10/832,168; 10/847,429; 10/842,302; 10/887,644; 10/887,667; and 10/888,206.
  • Suitable toothbrushes may or may not comprise bristles or cleaning elements.
  • dispensers such as a multi-compartmented package, can be used with the present invention as discussed further below. Examples of suitable devices will be discussed in detail in the Oral Care Devices section, below.
  • the components can be delivered to the oral cavity simultaneously or sequentially.
  • both components may be delivered during a single oral care session, e.g., a single brushing session or other single treatment session (single use, start to finish, by a particular user, typically about 0.1 to 5 minutes), or alternatively the components may be delivered individually over multiple oral care sessions.
  • a single oral care session e.g., a single brushing session or other single treatment session (single use, start to finish, by a particular user, typically about 0.1 to 5 minutes)
  • the components may be delivered individually over multiple oral care sessions.
  • Many combinations are possible, for example delivery of both components during a first oral care session and delivery of only one of the components during a second oral care session. Examples of possible delivery sequences and regimens are discussed below. Simultaneous Delivery
  • the simplest case is simultaneous, continuous delivery of equal amounts of the two components or a constant ratio of the components during a single oral care session.
  • the ratio can be between about 1 :20 and about 20:1.
  • the regimens of the present invention may be suitable, for example, when it is desired to deliver two components which do not react with one another, but are incompatible formulation- wise.
  • the two components may be provided separately, with binder systems having different pH levels, and then delivered simultaneously to the oral cavity. Brushing duration is sufficiently short so that the components will not be inactivated.
  • Another use for simultaneous, continuous delivery is systems that include two components that react relatively slowly, and that will remain in the oral cavity after brushing to be absorbed by the teeth and or gums.
  • delivery can be simultaneous and continuous, but the ratio of the two components can be varied during brushing.
  • the change in the relative amounts can be linear, or can be non-linear, e.g., a large burst of toothpaste initially, to have enough paste to begin brushing, with a small amount of mouthwash, followed almost immediately by a significantly reduced amount of paste and increased amount of mouthwash.
  • the components and their ratios can also be selected to provide the user with a brushing experience that goes from initially soothing to an intensely clean/refreshing mouthfeel.
  • two components may be simultaneously delivered during different periods of a single oral care session (e.g., during the seconds 1-5 and seconds 60-65 of a 120 second oral care session) or two components may be simultaneously delivered during different sessions (e.g., every other session).
  • Sequential delivery during a single oral care session may take various forms.
  • two components are delivered in alternation, as either a few relatively long duration cycles during brushing (A B A B), or many rapid-fire alternations (A B A B A B A B A B . . . . A B).
  • treatments that lend themselves well to this type of delivery are remineralization, and treatment with a peroxide and an activator for the peroxide.
  • the preferred cycle time will depend on the chemistry used, and may be optimized for a given chemical reaction. For example, in the case of a peroxide and activator, the cycle time may be relatively long, e.g., 15 seconds, to allow the peroxide and activator to react.
  • Other chemistries e.g., remineralization systems such as those discussed herein (see the Compositions section below) may be used with faster cycle times, for example 5 seconds or less.
  • two or more components are delivered one after the other during a single oral care session, with no subsequent alternating delivery in that oral care session (A followed by B).
  • a dentifrice may be delivered initially, to initiate brushing and provide cleansing, followed by a mouthrinse, fluoride treatment, or temporary sealant.
  • Other options include a peroxide followed by an activator or a dentifrice to enhance fluoridation; a copper dentifrice followed by chlorite; an anti-gingivitis treatment followed by anti-inflammatory treatment; or a pair of components having different flavors, to provide a sensory signal to the user.
  • the flavor change may indicate, for example, that the user should brush longer or can terminate brushing, or that the user should change the mode of brushing, e.g., to a higher or lower brush speed.
  • the delivery device includes a clock function, and is programmed to deliver a predetermined treatment at a predetermined time of day or range of times.
  • Different components, different ratios, or a different sequence of components may be delivered, depending on the time of day. For example, one component may be delivered in the morning, and a second, different component may be delivered in the evening, e.g., two different dentifrices or a mouthwash and dentifrice.
  • two components e.g., a dentifrice and a mouthrinse, may be delivered in the morning, and dentifrice only may be delivered in the evening.
  • This clock-based approach could allow the user to have two different sensory experiences, to receive two different active ingredients, or to receive an active ingredient only once a day (morning or evening only) while brushing twice a day.
  • some treatment regimens may involve delivery of a specialized treatment, for example a prescription medicine, according to a prescribed treatment protocol, e.g., morning or evening only, every other day (morning and/or evening), or once per week (morning and/or evening).
  • a prescribed treatment protocol e.g., morning or evening only, every other day (morning and/or evening), or once per week (morning and/or evening).
  • the delivery device can be programmed to deliver the precise dosage at a desired time during brushing. Toothpaste may be delivered at other times, and, if desired, may be delivered simultaneously with the specialized treatment.
  • the specialized treatment may be a prescription toothpaste, with standard over-the-counter toothpaste being dispensed in between prescribed uses of the prescription toothpaste.
  • Another approach that is useful over multiple oral care sessions is a "counting" feature, whereby the delivery device is programmed to deliver one of the components every x number of oral care sessions. For example, if multiple users utilize the same toothbrush handle, the delivery device may be programmed to recognize a particular user's replaceable toothbrush head, e.g., by RFID, and count only the sessions of that user.
  • the delivery device may include both a clock feature and a volume-monitoring feature that accumulates data over multiple oral care sessions, for example so that only a predetermined volume of one or both of the components is delivered within a given time period (e.g., less than x grams of component A over a 24 hour period).
  • the volume-monitoring feature may also be used to meter a precise dosage of a component over a single oral care session. Volume-monitoring is desirable, for example, when a component raises toxicity or other safety concerns at higher than normal dosages. For instance, in the case of fluoride treatments for children it is important that the child not receive too much fluoride, due to the risk of fluorosis.
  • the dosage delivered can be measured by any suitable method, such as by accurately calibrating the device and then calculating the dosage indirectly based on the number of pumping cycles.
  • the delivery device may be used to precisely control the dosage of a particular active, while allowing a second composition, such as a standard dentifrice, to be delivered as needed.
  • the delivery device may be programmed to accumulate data regarding brushing time and/or the amount of each component dispensed, for example to allow the user and/or the user's dentist or other clinician to track the user's compliance with a prescribed treatment protocol. This information can be displayed on an LCD display on the delivery device.
  • the delivery device e.g., a power toothbrush
  • the device can be programmed to allow each user to select a desired component for use during that user's oral care session. For example, different users may prefer different flavors of toothpaste, or may require toothpastes with particular performance attributes such as whitening vs. sensitivity reduction.
  • a toothbrush it may be configured so that the two components are delivered to different toothbrush heads.
  • a first head e.g., a standard power toothbrush head
  • a first component is delivered, e.g., a dentifrice
  • a second head is in place (e.g., a pic, tongue scrape, or gingival brush)
  • another component is delivered, e.g., a mouthrinse.
  • the toothbrushe may be configured to automatically recognize the different heads, e.g., by RFID identification or by mechanical means such as a pin setting. Oral care devices having RFID identification of various heads are described in published U.S. Application No. 2002/0129454, the full disclosure of which is incorporated herein by reference.
  • Delivery according to any of the treatment regimens discussed herein may be intermittent, i.e., with pauses during which no delivery will occur. It is noted that even “continuous" delivery may be intermittent in the sense that the pumping mechanism of the delivery device may operate in a pulsing manner. However, additional and/or longer pauses may be included in the treatment regimen by programming the delivery device accordingly.
  • a first component may be dispensed over a period of about 0.2, 0.4, 0.6, 0.8, 1, 1.2, 1.5, 1.8, 2, 4, 6, 8, 10, 15, 30, 60, 90, or 120 seconds and about 0.05, 0.1, 0.15, 0.2, 0.25, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.2, 1.4, 1.5, 1.6, 1.8, or 2 grams (or about 0.05, 0.1, 0.15, 0.2, 0.25, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.2, 1.4, 1.5, 1.6, 1.8, 2, 5, 7, 10, 12, 15, 20, 25, or 30 mis) of a first component may be dispensed over a period of about 0.2, 0.4, 0.6, 0.8, 1, 1.2, 1.5, 1.8, 2, 4, 6, 8, 10, 15, 30, 60, 90, or 120 seconds and about 0.05, 0.1, 0.15, 0.2, 0.25, 0.3, 0.4, 0.5, 0.6,
  • the first and/or second component may be dispensed by about 1, 2, 3, 4 or 10 or more actuations of the pump.
  • a first and second component may be dispensed in ratios (first component/second component) of about 90/10, 80/20, 70/30, 60/40, 50/50, 40/60, 30/70, 20/80, or 10/90.
  • ratios can be between about 1 :20 and about 20:1.
  • the first and second components may be dispensed simultaneously or sequentially (such that the second component may be dispensed about 0.2, 0.4, 0.6, 0.8, 1 , 1.2, 1.5, 1.8, 2, 4, 6, 8, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 75, 90, 105, or 120, seconds after the first component).
  • the second component may be dispensed during a second brushing session, following a first brushing session, wherein at least about 4, 6, 8, 10, or 12 hours separate the beginning of the second brushing session from the end of the first brushing session.
  • the second component can be dispensed during the same oral care regimen but after a time interval has lapsed between use of the first component and use of the second component. For instance, a dentifrice (the first component) might be used for 2 minutes and a rinse (the second component) might be applied several seconds or minutes after completing use of the dentifrice.
  • a brushing session there may be several sequences which include various combinations of the above mentioned weights, volumes, and times.
  • the sequences may be simultaneous or sequential, and may include pauses as discussed above. For example, within a 2 minute brushing session, a first sequence may include a volume of a first component and a volume of a second component being dispensed simultaneously, then a second sequence may include a volume of a first component being dispensed, then a period of time without dispensing may occur, then a third sequence may include a volume of the second component being dispensed, then a period of time without dispensing may occur, then a fourth sequence may include a volume of the first component being dispensed. Delivery Devices
  • a wide variety of oral care devices can be used to dispense the components of the present invention, including manual toothbrush, electric toothbrushes, and a variety of other packages (e.g., hand pumps, etc.) and devices.
  • oral care devices that is capable of delivering two components simultaneously.
  • an embodiment of an oral care system 10 includes an oral care device 12, in this case a toothbrush, and a docking station 14 that holds the oral care device 12 in an upright position within a receiving portion of the docking station.
  • Oral care device 12 is a power toothbrush having a motorized head, and is designed to discharge two components, such as a dentifrice and a mouthwash, during the brushing cycle.
  • the docking station 14 is designed to recharge batteries that are located within the oral care device, and to refill the oral care device with the components.
  • oral care device 12 includes a separable housing 16 consisting of three interconnected components 152, 154 and 156. As assembled, the oral care device 12 includes a distal portion 18 at which a head 20 is located and a proximal portion 22 at which a handle 24 is located. Connecting handle 24 and head 20 is neck 26. Head 20 is sized to fit within a user's mouth for brushing, while the handle 24 is graspable by a user and facilitates manipulation of the head 20 during use.
  • inlets 28 are positioned near an end surface 30 at the proximal portion 22 of the oral care device.
  • the inlets 28 are matable with corresponding outlets 280 (Fig. 8A) located at the docking station 14 for refilling the oral care device.
  • Oral care device 12 includes motors 34 and 36.
  • Motor 34 drives a pumping assembly 38 that transfers a pair of components along respective passageways (only one of which, passageway 40, is visible in Figs. 3 A and 3B) toward the distal portion 18 of the oral care device 12.
  • the pumping assembly 38 may transfer each component through the respective passageway by compressing a portion of tubes 514 and 516 (Fig. 4A) with a compression element, as described in U.S. Serial No. 10/861,253, the full disclosure of which is incorporated herein by reference.
  • a rechargeable battery 44 is electrically coupled to the motors.
  • a suitable rechargeable battery is a Li Ion UR 14500P, available from Sanyo.
  • the oral care device includes a pair of tubes 514 and 516 to direct the two fluid streams within the oral care device.
  • each of the tubes 514 and 516 is connected to the head at a location offset from a longitudinal axis 531 perpendicular to an axis of rotation 518 of the movable head 20.
  • one of the tubes may be connected to the head at the axis of rotation and the other connected at a location offset from the axis of rotation.
  • tubes 550 and 552 are fluidly connected to each other downstream of the pumping assembly and upstream of a fluid outlet at the head. This embodiment may be advantageous where it is desirable to mix the components within the passageways at a time just prior to delivery to a brushing surface.
  • the oral care device 12 includes two passageways, as discussed above (e.g., the tubes 514 and 516 in Figs. 4A and 4B). However, in some cases a single passageway may be used, for example where the two components can mix upstream of the head, close to separate chambers in which the two components are stored.
  • the oral care device 12 includes a control circuit or controller 400 that is electrically connected to the motors 34 and 36, and that generally governs operation of the motors.
  • a user interface 402 provides external interaction with controller 400.
  • the user interface 402 includes on and off buttons 404 and 406 and a fluid level switch 408, all of which are accessible from exterior of the housing 16 (see Fig. 2A).
  • the controller can be programmed as desired, as one example, the controller is designed such that depressing button 404 initiates motors 34 and 36, and depressing button 406 initiates only one of the motors, such as motor 36.
  • depressing button 404 or 405 both head movement and fluid flow can be initiated, with button 404 actuating one stream and button 405 actuating the other stream.
  • depressing button 406 only one of fluid flow and head movement can be initiated.
  • Depressing button 404 or 406 can also halt the associated motor(s) subsequent to initiation.
  • a user can, for example, brush without delivery of either component, and can rinse the oral care device 12 while the head rotates.
  • the fluid level switches 408, 409 allow a user to choose between preselected rates of fluid delivery, such as high, medium and low rates.
  • Three LED's 410 can selectively illuminate to indicate a selected fluid delivery level.
  • an LCD display can be included to convey a fluid delivery level and/or can be used to display other information such as level of fluid in the oral care device 12 and/or status of battery charge.
  • the controller 400 may also be programmed to adjust a paste delivery level subsequent to initiation of the motor 34.
  • the controller is programmed such that a relatively large bolus of the two components is delivered soon after motor 34 is initiated, e.g., to have enough paste to begin brushing, and then the level of delivery is decreased, e.g., to a lower delivery level throughout the remaining portion of the brushing cycle.
  • the level of paste delivery may be decreased, for example, by intermittent bursts of fluid and/or by slower rates of fluid delivery.
  • the controller may be programmed to provide three delivery settings, low, medium and high. In one embodiment, at the low delivery setting, the controller is programmed to deliver a bolus by activating the motor 34 for about seven seconds.
  • the controller intermittently activates the motor 34 for about 0.75 seconds and deactivates motor 34 for about 2.4 seconds (i.e., cycles the motor on and off at these intervals).
  • the controller is programmed to deliver a bolus by activating the motor 34 for about seven seconds, and then to cycle the motor on for about 0.75 seconds and off for about 1.63 seconds.
  • the controller is programmed to deliver a bolus by activating the motor 34 for about seven seconds and then to cycle the motor on for about 0.75 seconds and off for about 1.2 seconds.
  • more or fewer user interface controls can be used to initiate various functions.
  • the motor 36 moves (e.g., translates linearly) the pivoting drive shaft 42, which in turn moves (e.g., oscillates rotationally) the rotatable head 20.
  • the drive shaft 42 is connected to the rotatable head 20 using an offset design that facilitates placement of a fluid outlet at the head 20 and a tube 82 (or pair of tubes, if the two streams of material are to be kept separate) forming a portion of the fluid passageways within the neck 26 of the housing 16. This offset design is described in further detail in U.S. Serial No. 10/861,253.
  • Movement of the rotatable head 20 may be accomplished, in part, by use of a cam and follower system that translates rotational output of the motor 36 into linear motion used to drive the drive shaft 42 backward and forward.
  • a cam and follower system that translates rotational output of the motor 36 into linear motion used to drive the drive shaft 42 backward and forward.
  • head 20 includes a base 136 that has an opening 124 through which a valve 122, e.g., a duckbill valve as shown, extends outwardly.
  • a valve 122 e.g., a duckbill valve as shown
  • the distal end of the tube 82 forms the fluid outlet without use of a valve attached thereto.
  • two valves may be used, or a dual duckbill valve such as that described in U.S. Serial No. 11/114,987, filed on April 26, 2005, the complete disclosure of which is incorporated herein by reference.
  • Extending from the base 136 is an array of bristle tufts 138. Although each tuft 138 is shown as a solid mass in the drawings, the tufts are actually each made up of a great mass of individual plastic bristles.
  • Applicants refer to pending U.S. Application number 10/666,497, filed September 9, 2003, the disclosure of which is hereby incorporated by reference in its entirety.
  • oral care device 12 When not in use, oral care device 12 can be coupled with docking station 14. Docking station 14 can be connected to an electrical outlet (not shown) or other suitable power supply. Referring to Figs. 8 A and 8B, docking station 14 is formed to hold oral care device 12 within the receiving portion 273 in an upright position.
  • the receiving portion 273 includes a floor 275 extending between a vertical recess 295 formed in housing 291 and housing extension 297.
  • the recess 295 is contoured to receive a portion of oral care device 12.
  • the docking station 14 includes a reactive device, e.g., a sensor (not shown) that detects an input upon receipt of the oral care device by the docking station and, in response to this input, sends a signal to a controller, the details of which will be described in greater detail below.
  • a reactive device e.g., a sensor (not shown) that detects an input upon receipt of the oral care device by the docking station and, in response to this input, sends a signal to a controller, the details of which will be described in greater detail below.
  • the docking station 14 includes a multi-chamber fluid reservoir 274 the two chambers of which are coupled with tubes 276 to outlets 280.
  • the fluid reservoir 274 is formed as an integral part of a separable, replaceable portion 301 of the docking station 14.
  • replaceable two pouches 303 illustrated by Fig. 10
  • the upper portion 301 of the docking station is removable, to allow the consumer to easily remove the pouches 303 when their contents are exhausted, or when the user wishes to use a different product, and insert a replacement pouch. Referring to Fig.
  • the docking station includes a pump assembly 282. Details of the refilling mechanism in the docking station are provided in U.S. Serial No. 10/861 ,253.
  • a pair of leads 336, 338 are exposed within the receiving portion 273 of the docking station 14. Leads 336, 338, are positioned to contact a pair of contacts 340, 342 (Fig. 2A) on the oral care device 12 when the oral care device 12 is placed within the receiving portion 173. This contact will electrically couple the oral care device 12 and the docking station 14, so that the power source to which the docking station is connected can recharge the rechargeable batteries within the oral care device.
  • Contacts 340, 342 are electrically connected with the rechargeable batteries, allowing power to flow from the docking station to the batteries.
  • Oral care system 600 that is suitable for sequential delivery of two components is shown in FIG 1 1.
  • Oral care system 600 includes an oral care device 602, in the form of a toothbrush, and a docking station 604.
  • the oral care device 602 is connected to the docking station 604 by a length of tubing 605, only a very small portion of which is shown in FIG 11.
  • Tubing 605 is flexible and is long enough to allow the user to easily manipulate the oral care device, e.g., about 2.5 to 3.5 feet long.
  • Tubing 605 may be connected to the oral care device at any desired location, e.g., the head or handle, as will be discussed below.
  • Oral care device 602 includes a handle 606 and a detachable head/neck portion 608.
  • the handle 606 does not include a pumping mechanism or a pump motor, as these components are provided in the docking station as will be discussed below.
  • the handle 606 does contain a motor and other components necessary to drive the head, and may contain two fluid passageways.
  • the docking station 604 includes a tower portion T and a base portion B.
  • the tower portion contains two reservoirs (not shown), and is removable from the base portion so that the user can refill or replace the reservoirs.
  • the base portion B shown in detail in FIG 12, carries two pumps 610, 612, which receive the two components from the reservoirs through tubes 614, 616 and deliver it to downstream portions 618, 620 of the tubes. After the tubes exit the docking station, they may be wrapped or otherwise contained in a single sheath to form the tubing 605 shown in FIG 11.
  • Pumps 610 and 612 are driven independently, by motors 622, 624. Firing of the motors is driven by a controller, e.g., one or more microprocessors, which may be mounted on printed circuit boards 626, 628.
  • the handle will contain tubing defining two fluid paths. If the tubing 605 enters the oral care device at the base or in the handle, the handle will contain tubing defining two fluid paths. If the tubing 605 enters the oral care device at the head, a standard handle containing only the head drive components may be used. Any desired type of reservoir may be used to contain the two components in the oral care devices described above. Suitable reservoirs are described in U.S. Serial No. 10/861 ,253, incorporated by reference above.
  • the delivery device can be provided in the form of a dual compartmented dispenser which can be used alone or in combination with the electric toothbrush previously described.
  • a dual compartmented dispenser 700 having a first outlet 705 and a second outlet 710 is illustrated.
  • the dispenser 700 has a first compartment 715 storing a first component and a second compartment 720 storing a second component.
  • the first compartment 715 is in fluid communication with the first outlet 705 via tube 722
  • the second compartment 720 is in fluid communication with the second outlet 710 via tube 724.
  • the first and second compartments 715 and 720 are not fluid communication with each other downstream so that the first and second components do not mix substantially mix, co-mingle or are otherwise dispensed together.
  • a piston-type pump 726 can be used to pump the first component from the first compartment 715 while separate piston-type pump 728 can be used to pump the second component from the second compartment 720.
  • the pumps 726 and 728 can be biased by springs 730 and 732.
  • One or more valves 736 can be provided to facilitate the action of the piston-type pump.
  • the valves 736 can be provide as check-valves to allow a fluid to travel in only one direction.
  • the first and second compartments can have the same or similar capacities. In another embodiment, the first and second compartments have different capacities, which can be useful where the amounts of the first and second components that are dispensed during an oral care regimen are different.
  • An orifice 734 can be provided, to meter the dosage of the first or second components for each stroke of the piston pump. Dosages can also be controlled by the size (e.g., bore) and/or stroke of the piston pump.
  • the first and second compartments 715 and 720 can be provided as replaceable cartridges that releaseably engage the housing 734 of the dispenser 700.
  • the compartments 715 and 720 might threadably engage the housing the 734.
  • the compartments 715 and 720 can be provided with different threads (pitch or size) so that each compartment is properly paired with the piston pump or orifice if there is different dosing or metering between the first component and the second component.
  • a first outlet and second outlet is illustrated, a single piston-type pump and outlet can also be provided, wherein the single piston- type pump and outlet can be placed in selective fluid communication with either the first or second compartments.
  • Any of the components, dosing, or regimens, in whole or part, described herein can be used with the dispenser 700. While the dispenser 700 is one dispensing device suitable for use with the present invention, it will be appreciated that other dispensing devices can be used.
  • a user dispenses the first component onto a toothbrush and proceeds with applying the first component to the oral cavity as part of a brushing regimen.
  • the user sequentially dispenses the second component onto the toothbrush and applies the second component to the oral cavity as part of the brushing regimen.
  • the user may rinse the brush and/or his/her oral cavity prior to application of the second component to the toothbrush.
  • the toothbrush may contain a timer that activates a signal upon expiration of a predetermined time period to alert the user when it is time to switch between the first component and the second component or when to complete usage of the second component.
  • the second component is applied to a toothbrush or the oral cavity within about 15, 30, 45, 60, 120, 180, 240, 300, 360, 420, seconds or 10, 15, or 20 minutes of the first component being applied to a toothbrush or the oral cavity.
  • dispenser 700 has been illustrated as comprising a first and second compartment, it will be appreciated that more than two compartments can be provided.
  • the dispenser 700 can be provided in wide variety of shapes, sizes, and configurations.
  • the first component and second component can be provided in completely separate packages, which may be bundled together as a kit.
  • a first component provided as a dentifrice could be provided in a first dentifrice dispenser 800 and a second component provided as a dentifrice could be provided in a second separate dentifrice dispenser 805.
  • the first and second dispensers may be the same or different, and, for simplicity, have been shown comprising the same structures as the dispenser 700 (Fig. 13).
  • a user could dispense a first amount from the first dentifrice package onto a toothbrush and, after brushing for a period of time with the first component, dispense an amount of the second component from the second dentifrice package onto the same toothbrush and complete the brushing regimen with the second component.
  • the first and second dentifrice packages could be provided in visually distinct shapes, sizes, or color(s) so that a user can easily differentiate between the two.
  • the first and second dentifrice packages might also be provided with graphics, text, icons, or numeric characters to differentiate between the two.
  • the first and second dentifrice packages can meter the first and second components so that a particular dose is delivered resulting in application of a controlled ratio between the first and second components.
  • the delivery device can be provided in the form of an oral care device that can dispense a liquid, such as a mouth rinse.
  • the oral care device can be provided in the form of a toothbrush, some examples of which are described in USPNs 6,331,088; 6,047,429; 6,689,078; and 6,739,782.
  • the toothbrush may be provided with movable bristle holders and/or static or non-movable bristle holders.
  • the toothbrush head may be releasably attached to the toothbrush handle. Referring to Fig. 15, an example of a fluid dispensing toothbrush suitable for use with the present invention will now be described.
  • the toothbrush 900 has a handle 905, head 910, and liquid reservoir 915 disposed in the handle.
  • the liquid reservoir 915 can be a replaceable single use reservoir or refillable by a user of the toothbrush.
  • the liquid reservoir 915 is in liquid communication with one or more outlets 920 disposed in the head 910.
  • the outlet 920 is connected to the liquid reservoir 915 by conduit 925.
  • a pump 930 is provided to pump or pressurize a liquid 913 within the liquid reservoir 915.
  • the pump 930 can be provided in a variety of forms as known in the art. For example, a piston pump as described in USPN 6,689,078 can be used.
  • the pump 930 can be an air pump that is used to pressurize the liquid in the reservoir 915. Once pressurized, the liquid may exit the reservoir when a valve 935 is opened.
  • the valve 935 may be opened or actuated by depressing a button (not shown) on the handle 905.
  • a first component or composition preferably in the form of a dentifrice although other forms may be used, can be applied by a user to the tufts of bristles 945 (or other tooth cleaning elements) of the head 910 of the toothbrush 900.
  • the first component can include any of the ingredients (and combinations thereof) described herein and/or other ingredients known in the art.
  • the first component is then applied to the hard and/or soft tissues of an oral cavity as the toothbrush is used.
  • a second component or composition preferably in the form of a liquid or rinse, can then be selectively applied to all or portions of the oral cavity by the toothbrush 900 at the beginning, during, or end (or combinations thereof) of a tooth brushing regimen by a user actuating or opening the valve 935.
  • the second component can include any of the ingredients (and combinations thereof) described herein and/or other ingredients known in the art.
  • one or more of the devices described herein can be used with a display 950 having a screen 952.
  • Various arrangements are also further described in US S/Ns 60/859,226 field November 15, 2006; 60/920,698 filed March 29, 2007; and 60/912,111 filed April 16, 2007.
  • a system 955 comprising one or more oral care products such as dispensing toothbrush 900, a manual or electric toothbrush 958, a packaged dentifrice 960, a packaged rinse 965, and dual compartmented dispenser 700 are illustrated.
  • Examples of some manual or electric toothbrushes 955 suitable for use with the present invention are described in USPNs 5,974,615; 5,930,858; 6,006,394; 6,108,869; 5,943,723; 6,308,367; 2003/0101,526; 2003/0154,567; 6,536,068; 2002/0129454; and 5,987,688. While certain devices and products are illustrated in Fig. 16 for simplicity, it will be appreciated that a variety of oral care devices may be used with the system 955, including other oral care devices and products described in this application.
  • the oral care products can communicate using data links 970, 972, 974, 976, and 978 with the display 950, or an intermediary device which is then in data communication with the display 950.
  • the one or more oral care products, displays, and/or system components described herein can be bundled together for distribution or sale to a user as a kit.
  • the system 955 may also be connected to a network 982 via a data link 984.
  • the network 982 can comprise one or more computers, servers and clients, or electronic devices 985.
  • the oral care products and devices of the system 955 can use a variety of methods and devices to store, transmit and/or communicate data between the devices/products and the display 950.
  • the term "data" is intended to refer to any digital or analog information in any form that is transferred or communicated.
  • Data may include any data actively transmitted by a data transmitter and/or data that is passively detected by a data reader.
  • Data may include ones and zeroes if the data that is communicated is digital.
  • data could be a series of digits, such as "12345678", wherein each digit could represent information about a characteristic of an oral care device (e.g., for a manual toothbrush, the first digit could represent the brushing time in minutes, the second digit could represent the number of months until the brush should be replaced, the third and fourth digits could represent a type unique reward, etc.).
  • Data may include the arrangement of optical elements (e.g., a bar code) that represents information.
  • Data may include the presence or absence of electromagnetic energy (e.g., such as a magnetic field) and the like.
  • the data may be stored, interpreted, decoded, or analyzed by a processor 986, shown in Fig. 17. For instance, where the data is a series of digits, such as "12345678", the processor 986 and/or associated memory 987 could comprise a set of instructions that would be able to decode or interpret the data to determine what information is represented by the data.
  • a data transmitter is a device or component that actively transmits data to a data reader.
  • a radio frequency identification tag, or RFDD tag is one example of a data transmitter.
  • a data communicator is a device or component that may or may not actively transmit data but which has data that is capable of being detected. While a data transmitter, such as an RFDD tag, is a type of date communicator, a data communicator need not necessarily actively transmit data. Examples of data communicators that contain data that that may be detected or read by a data reader but which do not actively transmit data include a bar code (wherein the bar code reader is the data reader), a spotcode, or a hall effect magnet (wherein the hall effect sensor is the data reader).
  • data communicators are intended to encompass a wide variety of devices and arrangements for the transmission, communication, and/or detection of a variety of analog or digital data, including the mere detection of the presence of a data communicator.
  • data communication is intended to encompass all the methods and forms by which data may be transmitted, communicated, and/or detected by a devices of the present invention, including data readers, data transmitters, data communicators, as well as data communication between a two components such as a display and any of the oral care products.
  • the data stored and/or transmitted or communicated by the RFID tag or other data transmitters/communicators can be quite varied.
  • Some of the categories of data includes product identification data (e.g., the brand name or product name) and product usage or regimen data (e.g., usage time, such as 1 minute regimen for a rinse, text or graphical instructions concerning product usage, information concerning the sequence of usage, etc.), one or more rewards, and component or product replacement data (e.g., number of times or length of time that a component or product can be used before it should be replaced).
  • product identification data e.g., the brand name or product name
  • product usage or regimen data e.g., usage time, such as 1 minute regimen for a rinse
  • text or graphical instructions concerning product usage e.g., such as 1 minute regimen for a rinse
  • one or more rewards e.g., number of times or length of time that a component or product can be used before it should be replaced.
  • component or product replacement data e.g., number of times or
  • each of the oral care products can be provided with an RFID tag 988 that can transmit usage or regimen data to a reader 990 associated with the display 950.
  • the usage data can be used as an input for a count-up or count-down timer that is displayed on the display 950.
  • the oral care product containing the RFED tag need only be placed in sufficient proximity to the reader 990 to power-up the RFLD tag.
  • an oral care regimen can comprise placing the dentifrice package 960 (which can be any package, including a tube containing the dentifrice or an outer package such as a paper box) and the rinse package 965 in data communication with the display 950 (or an intermediary component that is in data communication with the display 950) in order to communicate data concerning the dentifrice (e.g., the amount of time to apply the dentifrice to the oral cavity) and rinse to the display 950.
  • the dentifrice is applied to the head 910 of the toothbrush 900 and the liquid rinse is loaded into the liquid reservoir 913.
  • the toothbrush 900 is then placed in data communication with the display 950, which initiates a timer whose time interval is displayed on the display 950 and which is set according to the data communicated by the RFID tag associated with the dentifrice package 960.
  • the display 950 can display or send one or more audible and/or visual signals at the beginning, during, or at the end of the time interval indicating that the rinse 965 should be dispensed by the user of the toothbrush 900 based upon data communicated to the reader 990 by the data communicator of the packaged rinse 965.
  • the timer can initiate a second time interval that is displayed on the display 950 that can communicate either a time interval for dispensing the rinse to the oral cavity in order to approximate a dosing of the rinse and/or a time interval for use of the rinse in the oral cavity that approximates an application period.
  • the second time interval can be set according to data communicated by the RFED tag (or other data communicator) associated with the rinse package 965.
  • the dentifrice or first time interval can be between about 30 seconds and 3 minutes and the liquid rinse or second time interval can be between about 30 seconds and 3 minutes.
  • the length of the time intervals can be varied depending upon the intended interaction between the dentifrice and the liquid rinse.
  • the steps described herein can be performed in a variety of sequences and some steps may not need to be performed for each oral care or tooth brushing cycle. For example, it may not be necessary to refill the liquid reservoir 913 each time, and it may only be necessary to place the dentifrice and rinse packages in data communication with the display 950 once, such as the first time the dentifrice and rinse are used. Thereafter, the data communicated by the RFED tags can be stored in the memory 987 until deleted or replaced, such as when new dentifrice and rinse packages are purchased and first used.
  • the display 950 could also display other information, such as a visual guide to assist with application of the dentifrice or rinse to all four quadrants of the oral cavity. For example, a representation of the each quadrant of an oral cavity can be displayed on the display 950 to indicate when or for how long the dentifrice, rinse, or brushing action should be applied to that quadrant of the oral cavity.
  • the dual compartmented dispenser 700 and/or the toothbrush 958 can be placed in data communication with the display 950.
  • the dual compartmented dispenser 700 can be provided with one or more data communicators. In some embodiments, there maybe one data communicator associated with each compartment.
  • the data communication with the display 950 can initiate a timer.
  • the display 950 can then display a count-up or count-down time interval based upon the data that is transmitted by the data communicator of the toothbrush 958 and/or the compartmented dispenser 700.
  • the data communicator such as RFDD tag 988, might communicate data representing the amount of time that the oral care composition of the first compartment 715 should be used.
  • the RFED tag 988 might also communicate data representing the amount of time that oral care composition of the second compartment should be used.
  • the RFDD tag 988 might communicate that the oral care composition of the first compartment 715 should be applied to an oral cavity for 1 minute and that the oral care composition of the second compartment 720 should be applied to the oral cavity for 2 minutes.
  • the display 950 can display a first time interval or timer for 1 minute.
  • the display 950 can display a signal or reminder to apply the second oral care composition from the second compartment 720 to the head of the toothbrush 958 (and/or additional actions, such are rinsing the toothbrush and/or the oral cavity prior to application of the second oral care composition, etc.) followed by application of the second oral care composition from the second compartment 720 to the oral cavity.
  • the display 950 can display a second time interval or period, such as the aforementioned 2 minutes, for application of the second oral care composition to the oral cavity.
  • the second time interval can be initiated by placing the toothbrush 958 in data communication with the display 950, by user activation of a switch, button, or other control on or associated with the display 950, or automatically after a pre-determined period of time.
  • the display 950 can provide an audio and/or visual signal that the second time interval has lapsed. After lapse of the second time interval, use of the second oral care composition may cease.
  • other information can be displayed by the display 950 that is associated with the compartmented package 700 and/or the oral care compositions stored therein (e.g., instructional information, regimen or usage information (including historical user information), rewards, educational information, coupons, etc.).
  • Two component oral care compositions are described below. In some instances, it is beneficial or necessary to deliver two components to the mouth of a user separately, or to maintain two components of an oral care composition separate until use and then allow them to mix during delivery or in the oral cavity. This may be the case, for example, where the two components would react with and/or neutralize each other if stored together, or where ingredients in the two components are active at different pH levels, as discussed above in the Methods section. Examples of various two component compositions and their uses follow. As noted below, several of the compositions described may in some cases be provided as a single component which may be delivered sequentially or simultaneously with any other desired component, such as a standard dentifrice or mouthwash according to the methods discussed above.
  • compositions can be advantageously delivered in whole or part using the methods and devices described above.
  • methods and devices described above are equally suitable for delivering two unrelated components, e.g., a dentifrice and a mouthwash, two different flavored dentifrices, etc., as well as other two component compositions not mentioned below.
  • the hard and soft tissues of the mouth are covered with microbial populations that contain bacteria with different metabolic capabilities.
  • the Gram-positive bacteria within these microbial populations readily catabolize carbohydrates to produce acids which attack the hard tissues of the oral cavity, resulting in the formation of dental caries lesions (cavities).
  • the Gram-negative bacteria, especially the anaerobes readily metabolize various amino acids contained in salivary (and to lesser extent other) peptides and proteins in the oral cavity to form end-products which favor the formation of oral malodor and periodontitis.
  • Oral malodor clinically referred to as halitosis
  • halitosis can be caused by the putrefactive activity of these microorganisms on dental plaque, debris adhering to mucous membranes and salivary cellular elements to produce volatile sulfur compounds — primarily hydrogen sulfide, methyl mercaptan and traces of methyl sulfide.
  • the two-component oral care compositions can reduce oral malodor, improve breath freshness, and/or prevent plaque accumulation.
  • the first component of the oral care composition includes a metal salt, e.g., a copper salt such as Cu (II), and the second component of the oral care composition includes an oxidizer, e.g., a chlorite salt.
  • the two components are kept separate until use or until just before use, for example in two compartments of a delivery device such as those described above.
  • the components can be applied by a user in a single step, for example using a device described herein, rather than as a two step process such as first brushing one's teeth using a dentifrice and then using an oral care rinse.
  • such compositions can reduce malodor with a two fold approach.
  • the metal salt can lower the concentration of volatile sulfur compounds (VSC) by precipitating the VSC as metal sulfides.
  • VSC volatile sulfur compounds
  • the oxidizer oxidizes malodorous compounds, including amines and sulfides, to nonvolatile and thus, non-odorous forms.
  • the oxidizers and metal salts, especially Cu (II) salts have antibacterial activity which can also have an anti-carries effect on the user.
  • the two component composition can provide enhanced efficacy relative to the use of a single component oral care product (e.g., dentifrice or mouth rinse alone), or even in some instances using an oral care regime of a dentifrice followed by a mouthrinse. Accordingly, in some embodiments, a lower amount of active ingredient is applied in the two component compositions relative to what would be applied in a single component system in order to obtain substantially equivalent efficacy, or conversely the same amount of active ingredient will provide greater efficacy.
  • a single component oral care product e.g., dentifrice or mouth rinse alone
  • a lower amount of active ingredient is applied in the two component compositions relative to what would be applied in a single component system in order to obtain substantially equivalent efficacy, or conversely the same amount of active ingredient will provide greater efficacy.
  • the first component includes a copper salt, capable of releasing Cu(II) ions in solution.
  • suitable copper salts include copper gluconate, copper chlorate, copper chloride, copper fluoride, and copper nitrate.
  • the copper salt is present in the first component at a concentration of from about 50 to 10,000 ppm, or about 200 to about 2000 ppm, for example, 500 to about 1000 ppm.
  • Suitable oxidizing agents include chlorite salts, hydrogen peroxide, and perborates, perchlorates, peroxyacids, and hyperchlorates.
  • the second component includes a chlorite salt, capable of releasing chlorite ions in solution.
  • a suitable chlorite salts include sodium chlorite.
  • the chlorite is present in the second component at a concentration of from about 100 to 10,000 ppm, or about 1000 to about 4000 ppm, for example, from about 1600 to about 2400 ppm.
  • Each of the two components of the oral care composition can be independently formulated as a dentifrice or as a mouth rinse.
  • the components may be delivered simultaneously or sequentially to the mouth of the user.
  • the first and second components can be delivered using a delivery device such as those described above.
  • Each component of the oral care composition can be delivered in a single bolus, or alternatively can be delivered continuously during the brushing period of the user, for example at of rate of from about 0.01 mL/min to about 20 mL/min, or about 0.15 mL/min to about 1 mL/min over a two minute brushing period, or from about 0.15 mL/min to about 0.5 mL/min.
  • both components of the oral care composition are delivered as a mouth rinse.
  • Each component can be singularly administered, or alternatively, the two components can be mixed immediately before use. In general, from about 15 mL to about 30 mL of total mouth rinse is used for about 30 seconds, for example in a 1 : 1 ratio of components.
  • one component can be administered as a dentifrice and the other as a mouth rinse.
  • the components can be administered simultaneously or sequentially.
  • the ratio of first and second component can be varied during administration of the oral care composition.
  • the oral care composition can be administered using an oral care device described herein such that the oral care composition is initially administered in a ratio of first component to second component of about 80:20 and throughout administration, the ratio of the first component to second component changes to about 20:80.
  • oral care compositions that can improve oral malodor include dual component dentifrices described in U.S. Patent No. 6,375,933, which is incorporated herein by reference in its entirety. These dentifrices include zinc and chlorite ion releasable compounds included in separate, semi-solid aqueous components.
  • the first component includes a zinc salt as the source of zinc ions and a chlorite salt as a source of chlorite ions in an orally acceptable vehicle having a substantially neutral pH of about 6.0 to 7.5, e.g., about 6.8.
  • the second component has an acid pH of from about 2.0 to about 6.0, preferably about 4.0 to about 5.5.
  • Mixing and combination of the two components of the oral care composition provides a pH of the final product of no greater than 6.5, preferably about 5.8 to about 6.4, thereby generating chlorine dioxide.
  • the two components are preferably formulated with water, humectants, surfactant and abrasive to have similar physical characteristics, with an acid compound has been added to the acid component to adjust the pH to the desired acidity.
  • Suitable zinc ion releasable compounds are generally water soluble zinc salts including zinc nitrate, zinc citrate, zinc chloride, zinc sulfate, zinc bicarbonate and zinc oxalate with zinc nitrate being preferred.
  • the zinc salt is generally incorporated in the neutral pH dentifrice component at a concentration of about 0.25 to about 10% by weight and preferably about 0.5 to about 2.0% by weight.
  • Chlorite ion releasable compounds include alkali metal chlorites, alkaline earth metal chlorites, and any other transition metals, inner transition metal chlorites and/or polymeric salts. Water soluble chlorite salts are preferred.
  • Suitable metal chlorites include calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite and potassium chlorite. Mixtures of two or more sources of chlorite may also be used.
  • the chlorite ion releasable salt is generally incorporated in the neutral pH dentifrice component at a concentration of about 0.5 to abut 5% by weight and preferably about 0.1 to about 1% by weight.
  • the acidic dentifrice component of the dentifrice composition contains an acid or mixture of acids to acidulate and thereby activate the chlorite compound present in the neutral dentifrice component, releasing chlorine dioxide when the two components are combined prior to use.
  • Acidic compounds which can be present in the acidic dentifrice component of the present invention include both mineral and organic acids, such as, sulfuric acid, hydrochloric acid, malic acid, alginic acid, citric acid, succinic acid, lactic acid, tartaric acid, potassium bitartrate, acid sodium citrate, phosphoric acid, and sodium acid phosphate.
  • Acid phosphates are preferred, including phosphoric acid, or salts of phosphoric acid containing the PO4 ion, as such acids or acid salts thereof, such as sodium phosphate monobasic, not only provide the necessary acidity, but also provide phosphate ions, to inhibit any tooth enamel demineralization which may occur with the application of the two component dentifrice to the teeth.
  • the preferred acid, phosphoric acid is commercially available as a liquid at 85% concentration.
  • the acid is added to the dentifrice component in an amount to maintain the pH of the dentifrice at a pH of about 2.0 to about 6.0 and preferably about 4.0 to about 5.5 when the neutral and acidic dentifrice components of the present invention are combined, the pH of the combined compositions is between about 5.8 to about 6.4.
  • the composition may also include pyrophosphate salts having anticalculus efficacy, for example water soluble salts such as dialkali or tetraalkali metal pyrophosphate salts such as Na 4 P 2 O 7 (TSPP), K 4 P 2 O 7 , Na 2 K 2 P 2 O 7 , Na 2 H 2 P 2 O 7 and K 2 H 2 P 2 O 7 .
  • pyrophosphate salts may include the water soluble alkali metal tripolyphosphates such as sodium tripolyphosphate and potassium tripolyphosphate.
  • the pyrophosphate salts may be incorporated at a concentration of about 0.05 to about 2.0% by weight, and preferably about 0.5 to about 2% by weight, while polyphosphate salts may be incorporated at a concentration of about 1.0 to about 7.0% by weight.
  • Tooth whitening efficacy of a peroxide-containing dentifrice component can be substantially heightened by first applying to the teeth an aqueous rinse component having an alkaline pH, and subsequently applying the peroxide dentifrice to the teeth.
  • the alkaline rinse tends to activate and promote the rapid release of oxygen from the peroxide contained in the dentifrice.
  • Such sequential administration can be performed using the methods and devices described above.
  • the delivery device can be programmed to deliver the alkaline rinse and peroxide dentifrice sequentially, either as a single application of rinse followed by a single application of dentifrice, or in alternation (rinse, dentifrice, rinse, dentifrice, etc.).
  • the aqueous rinse component includes about 70% to about 95% of water or a combination of water and ethanol, and preferably about 65% to 95% water and about 0% to 35% ethanol.
  • the peroxide compound is included in an amount sufficient to allow release of sufficient oxygen during brushing of teeth to effect whitening thereof.
  • the peroxide compound comprises from about 5 to about 15% by weight of the component.
  • suitable peroxide compounds used to prepare the dentifrice components used in the practice of the present invention include calcium peroxide, hydrogen peroxide and peroxides including urea peroxide, glyceryl peroxide, benzoyl peroxide and the like.
  • a preferred peroxide compound is urea peroxide.
  • Metal ion chelating agents when included in the peroxide dentifrice component, can contribute to the chemical stability of the peroxide component when an abrasive such as calcined alumina or calcium pyrophosphate is also present in the dentifrice.
  • suitable metal ion chelating agents include alkali metal stannates such as sodium and potassium stannate, ethylenediaminetetracetic acid (EDTA) and its salts.
  • EDTA ethylenediaminetetracetic acid
  • the metal ion chelating agents are incorporated in the dentifrice components at a concentration of about 0.01 to about 1% by weight.
  • the pH is adjusted to a range between about 3.0 and about 8 and preferably about between about 5 and about 7 with an acid such as phosphoric acid.
  • oral care compositions that can promote improved flavor include those described in U.S. Patent No. 6,696,047, which is hereby incorporated by reference in its entirety.
  • Some two component oral compositions containing chlorite are stable against loss of chlorite via conversion to chlorine dioxide as well as against degradation of other composition ingredients such as flavors and sweeteners.
  • it is particularly important for oral care compositions that the flavor components do not degrade as consumer acceptability of the product is significantly influenced by the flavor and taste of the product.
  • aqueous components are formulated at a basic pH so as to not undergo a substantial change in pH during storage. In some embodiments, when the two components are mixed the resulting compositions also do not exhibit the penetrating and unpleasant odor of chlorine dioxide, which could alter the flavor characteristics of the product.
  • the first component may include chlorite ion; and the second component may include a pharmaceutically-acceptable topical, oral carrier and comprising no chlorite.
  • the first component can also include pharmaceutically-acceptable topical oral carriers which are compatible with chlorite ion.
  • the first component also includes one (or more) compatible binder(s), a buffer and/or a preservative.
  • the second component, which comprises no chlorite includes flavorant, surfactant, fluoride ion, humectant, and/or abrasive.
  • the two components can be delivered simultaneously, and can be combined during dispensing, for example at a 1 :1 volume to volume ratio to form the composition.
  • the concentration of chlorite ion in the composition can depend on the type of composition (e.g., toothpaste or mouth rinse) used to apply the chlorite ion to the gingival/mucosal tissue and/or the teeth, due to differences in efficiency of the compositions contacting the tissue and teeth, and due also to the amount of the composition generally used.
  • the concentration may also depend on the disease or condition being treated.
  • the mouth rinse to be taken into the oral cavity have a concentration of chlorite ion in the range of from about 0.02% to about 0.5%, more preferably from about 0.10% to about 0.30% by weight of the composition.
  • mouth rinse compositions of the present invention deliver about 3.75 to about 30.0 mg of chlorite ion to the oral cavity when approximately 15 ml of the rinse is used.
  • the concentration of chlorite ion is in the range of from about 0.5% to about 3.0%, by weight of the composition.
  • the above concentrations of chlorite ion represents the concentration of chlorite ion after the components are mixed together to form the composition.
  • the concentration of chlorite ion in the chlorite containing component will vary depending on the amount of the second or additional components to be mixed with the chlorite-containing component to obtain the final composition.
  • whole body health can be promoted in humans and animals by using one or two component topical oral compositions comprising a safe and effective amount of chlorite ion in admixture with a pharmaceutically acceptable carrier, said compositions being effective in controlling bacterial-mediated diseases and conditions present in the oral cavity and inhibiting the spread into the bloodstream of oral pathogenic bacteria and associated bacterial toxins and resultant inflammatory cytokines and mediators.
  • topical oral compositions comprising a safe and effective amount of chlorite ion in admixture with a pharmaceutically acceptable carrier, said compositions being effective in controlling bacterial-mediated diseases and conditions present in the oral cavity and inhibiting the spread into the bloodstream of oral pathogenic bacteria and associated bacterial toxins and resultant inflammatory cytokines and mediators.
  • topical oral compositions can be used for promoting whole body health in humans and animals, said compositions comprising a safe and effective amount of chlorite ion in admixture with a pharmaceutically acceptable carrier, and effectively controlling bacterial-mediated diseases and conditions present in the oral cavity and inhibiting spread into the bloodstream of pathogenic bacteria, associated bacterial toxins and resultant inflammatory cytokines and mediators.
  • compositions include methods of use of these compositions by topical application to the oral cavity, to promote and/or enhance whole body health in humans and other animals. More particularly, the compositions can be used to reduce the risk in the development of cardiovascular disease, stroke, atherosclerosis, diabetes, severe respiratory infections, premature births and low birth weight (as well as postpartum dysfunction in neurologic and developmental functions), and associated risk of mortality.
  • compositions are used to treat and prevent diseases and conditions of the oral cavity including periodontal disease, thereby promoting and/or enhancing enhanced whole body health for the individual being treated, as evidenced by the following health indices or biomarkers: 1) reduction in risk of development of heart attack, stroke, diabetes, respiratory infections, low birth weight infants, and post-partum dysfunction in neurologic/developmental function and associated increased risk of mortality;
  • compositions promote overall body health by controlling bacteria-mediated diseases and conditions present in the oral cavity and thus, preventing the spread of bacteria, bacterial toxins and endotoxins and inflammatory mediators/cytokines into the bloodstream and other parts of the body.
  • the oral care compositions include therapeutic rinses, especially mouth rinses, as well as toothpastes, tooth gels, tooth powders, non-abrasive gels (including subgingival gels) comprising:
  • compositions (b) a pharmaceutically-acceptable topical, oral carrier; wherein the final composition is essentially free of chlorine dioxide or chlorous acid and wherein the composition is essentially free of hypochlorite ions or hypochlorite salts and has a final pH greater than 7, preferably greater than 7.5, and even more preferably from about 8 to 12.
  • the chlorite ion agent is incorporated in the present compositions in an amount to comprise from about 0.02% to about 6.0%, by weight of chlorite ion.
  • essentially free of chlorous acid or chlorine dioxide as used herein is meant a composition which comprises very low levels, e.g. less than about 2 ppm, preferably less than about 1 ppm of chlorine dioxide or chlorous acid, using known analytical methods for measuring chlorine dioxide or chlorous acid including highly specific electron spin resonance (ESR) spectroscopy.
  • ESR electron spin resonance
  • the present compositions further comprise one or more additional therapeutic agents selected from the group consisting of: antimicrobial/antiplaque agents, biofilm inhibiting agents, anti-inflammatory agents (including cyclo-oxygenase inhibitors and lipoxygenase inhibitors), H2-antagonists, metalloproteinase inhibitors, cytokine receptor antagonists, lipopolysaccharide complexing agents, tissue growth factors, immunostimulatory agents, cellular redox modifiers (antioxidants), analgesics, hormones, vitamins, and minerals.
  • additional therapeutic agents selected from the group consisting of: antimicrobial/antiplaque agents, biofilm inhibiting agents, anti-inflammatory agents (including cyclo-oxygenase inhibitors and lipoxygenase inhibitors), H2-antagonists, metalloproteinase inhibitors, cytokine receptor antagonists, lipopolysaccharide complexing agents, tissue growth factors, immunostimulatory agents, cellular redox modifiers (antioxidants), analgesics, hormone
  • compositions can include a first component that comprises a chlorite ion and a second component comprising the additional therapeutic agent.
  • the chlorite ion as an essential ingredient in the compositions and methods described.
  • the chlorite ion can come from any type of chlorite salt. Examples include alkali metal chlorites, alkaline earth metal chlorites, and any other transition metals, inner transition metal chlorites and/or polymeric salts. Water soluble chlorite salts are preferred. Examples of suitable metal chlorites include calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite and potassium chlorite. Sodium chlorite and potassium chlorite are preferred. Sodium chlorite is particularly preferred. Mixtures of two or more sources of chlorite may also be used.
  • the level of chlorite ion is greater than about 0.005%, 0.01%, 0.02%, 0.4%, 0.6%, 0.75%, and/or less than about 2%, 1.5%, or 1% by weight of the composition.
  • the level of chlorite ion is greater than about 0.02%, preferably greater than about 0.075%, more preferably greater than about 0.15%, by weight of the composition.
  • compositions comprise from about 0.1% to about 6%, of chlorite ion, by weight of the composition.
  • Chlorite salts are available from various suppliers as sodium chlorite.
  • Sodium chlorite is commercially available as a technical grade powder or flake, and as an aqueous liquid concentrate in a range of concentrations.
  • Example of sources of sodium chlorite include: sodium chlorite available from Aragonesas and from Vulcan. These sources generally have no more than 4% sodium chlorate as well.
  • the source of chlorite ion has high purity, e.g. 70% or greater.
  • the compositions of the present invention are essentially free of hypochlorite metal salt or hypochlorite ion, dichloroisocyanurate, or salts thereof.
  • the level of chlorite ion is measured by ' gradient separation of inorganic and organic acid anions using Ion Pac ASII exchange column, available from Dionex Corporation, Sunnyvale, Calif.
  • compositions of the present invention preferably comprise low levels of chlorine dioxide or chlorous acid, or are essentially free of chlorine dioxide or chlorous acid (i.e., have less than about 2 ppm, preferably less than about 1 ppm of chlorine dioxide or chlorous acid).
  • the level of chlorine dioxide or chlorous acid is measured within about 2 to 3 minutes after the two components are mixed together.
  • the pH of the final composition is generally greater than 7, preferably greater than 7.5, more preferably from 8 to 12; still more preferably the pH is from 9 to 10.
  • dentifrices having improved sensory attributes are described, for example, in U.S. Patent No. 5,820,854, which is incorporated herein by reference in its entirety. These dentifrices may be provided and delivered as a single component, or as two component compositions.
  • the sensory attributes of a dentifrice with a high ionic strength can be improved sensory by the addition of polyoxyethylene.
  • the dentifrice provides an increased foam volume, increased foam viscosity, and a smooth teeth feeling.
  • the polyoxyethylene may be present in a second dentifrice component which is dispensed side-by-side with the high ionic strength dentifrice component.
  • the polyoxyethlene may be included in the high ionic strength dentifrice component, and the second stream dispensed by a delivery device may be a different component, e.g., a mouthrinse or another type of dentifrice.
  • the polyoxyethylene may have a molecular weight of from about 100,000 to about 10,000,000 or about 200,000 to about 7,000,000.
  • a dual component dentifrice includes a first dentifrice component having an ionic strength of from about 1 ,000 ⁇ mho to about 50,000 ⁇ mho and comprising from about 0.1% to about 8% of a polyoxyethylene having a molecular weight of from about 100,000 to about 10,000,000 or about 200,000 to about 7,000,000 and from about 92% to about 99.5% of one or more aqueous carriers; and a second dentifrice component.
  • the dentifrice includes a first dentifrice component having an ionic strength of from about 1,000 ⁇ mho to about 50,000 ⁇ mho; and a second dentifrice component comprising from about 0.1% to about 8% of a polyoxyethylene having a molecular weight of from about 100,000 to about 10,000,000 or about 200,000 to about 7,000,000 and from about 92% to about 99.9% of one or more aqueous carriers.
  • polyoxyethylenes examples include those having a molecular weight of from about 100,000 to about 10,000,000 or about 200,000 to about 7,000,000. Preferably, the molecular weights will be from about 600,000 to about 2,000,000, and more preferably from about 800,000 to about 1,000,000.
  • Polyox is the tradename for a high molecular weight polyoxyethylene produced by Union Carbide.
  • the polyoxyethylene is generally present in an amount of from about 0.1% to about 8%, preferably from about 0.2% to about 5%, and more preferably from about 0.3% to about 2%, by weight of the dentifrice component. High ionic strength in a dentifrice will occur when the dentifrice contains ingredients having an ionic character.
  • ingredients with ionic character include materials such as salts and surfactants.
  • Dentifrices with high salt levels and/or high surfactant levels will have a high ionic strength. Ionic strength of a dentifrice is measured by conductivity of the dilute slurry. The slurry is a 3:1 water to dentifrice slurry.
  • the dentifrice will have an ionic strength of from about 5,000 ⁇ mho to about 40,000 ⁇ mho and more preferably from about 10,000 ⁇ mho to about 25,000 ⁇ mho.
  • the total salt level of dentifrices with high ionic strength is generally from about 4% to about 70%, preferably from about 6% to about 60%, and more preferably from about 8% to about 50%.
  • Subsurface dental enamel cay be remineralized by the sequential application of certain soluble salts yielding ions which will react to form a desirable remineralizing precipitate.
  • Salt solutions such as calcium and phosphate salt solutions, cay be sequentially applied to dental enamel to effect remineralization.
  • Subsurface remineralization of tooth enamel with a desirable precipitate cay be accomplished by a process utilizing a first component comprising a water-soluble compound capable of acting as a source of the cation of the desirable precipitate, and a second component comprising a water-soluble compound capable of acting as a source of the anion of the desirable precipitate.
  • the process comprises the steps of: (1) applying one of the above components to the surface of a tooth, and thereafter, (2) applying the other component to the surface of the tooth, whereby the desired ion of the other component diffuses into the demineralized subsurface and forms the desirable precipitate with the ions of the first component, thus effecting remineralization of the demineralized subsurface.
  • the duration of step (1) may be selected to allow the desired ion to diffuse into the demineralized subsurface.
  • a component including a reactant solution of a soluble salt is placed in contact with the tooth surface nearest to the demineralized subsurface.
  • this first reactant solution are selected cations which diffuse through the tooth surface to its demineralized subsurface.
  • a second component including a reactant solution containing selected anions is placed in contact with the tooth surface nearest the demineralized subsurface. The anions diffuse through the tooth surface to the demineralized subsurface where they come in contact with the cations previously deposited and form a precipitate which is bound to the tooth structure.
  • the tooth's subsurface is remineralized.
  • Concentrations of the cationic and anionic solutions may be from 0.005 to 10% or the limit of solubility of the salt, with from about 0.05 to about 5% preferred. Excess salt can be present, if desired. More than one cation may be employed in the cationic solution. Equivalent concentrations in the cationic and anionic solutions are not necessary since in each step an excess of the reactant is required in order to promote diffusion into the tooth's demineralized subsurface. Similarly, more than one anion may be employed in the anionic solution. There is a visible effect on "white spots" after as few as eight sequential applications, and it is contemplated that several sequential applications will be employed to achieve the most beneficial results.
  • a therapeutic amount of the desired cations and anions may be employed in the oral cavity.
  • the amount of solution placed in the mouth should generally contain at least about 0.001 g. of desired cations and about 0.001 g. of desired anions and preferably contains more than about 0.1 g. of desired cations and about 0.1 g. of desired anions and/or less about 1O g of the desired cations/anions and/or less than about 5g of the desired cations/anions, or less than about 2g of the desired cations/anions.
  • the length of time of contact between the salt solutions and the tooth's surface is not critical, it is necessary for the length of time to be great enough to allow diffusion of the ions through the tooth's surface to the demineralized subsurface. It is believed that at least ten seconds . is required for this diffusion.
  • Each solution should have a pH of from about 3 to about 10 before and after the precipitation reaction, and be otherwise compatible in the oral environment.
  • the ions must not combine prematurely in the solution to form a precipitate, but must be able to diffuse through the surface of the tooth to a demineralized subsurface area and be able to form an insoluble salt with ions of the other solution.
  • the solutions and the insoluble precipitates are preferably not colored, and, or course, have acceptable levels of toxicity (i.e., the particular ions, in the amounts used in the remineralization process, must be non-toxic).
  • the remineralized subsurface can be made to be more resistant to demineralization than was the original enamel. If remineralization is carried out in the presence of either a heavy metal ion or fluoride ion, the remineralized enamel is more resistant to demineralization than was the original enamel. If both ions are present, the remineralized enamel is even more resistant to demineralization.
  • concentration of salt containing heavy metal ion and fluoride ion in their respective solutions may be from about 0.005 to about 10%, e.g., from about 0.005 to about 0.1%.
  • Suitable heavy metal ions are aluminum, manganese, tin, zinc, indium, and rare earth metals such as lanthanum and cerium.
  • the remineralizing cationic solution contains from about 0.005 to about 10%, preferably about 1%, of a soluble calcium salt yielding calcium ions and from about 0.005 to about 10%, preferably from about 0.005 to 0.1% of a soluble indium salt yielding indium ions.
  • the remineralizing anionic solution contains from about 0.005 to about 10%, preferably about 1%, of soluble phosphate salt yielding phosphate ions and from about 0.005 to about 10%, preferably from about 0.005 to about 0.1% of a soluble fluoride salt yielding fluoride ions.
  • the resulting precipitate is a calcium phosphate or hydroxyl apatite, the natural constituent of tooth enamel, with incorporated indium and fluoride ions. Not only does this process result in remineralized enamel, but the remineralized enamel is more resistant to subsequent demineralization than was the original enamel.
  • Suitable soluble fluoride and indium salts include, but are not limited to, sodium fluoride, zinc fluoride, betaine fluoride, alanine stannous fluoride, hexylamine fluoride, indium chloride, indium sulfate, and indium nitrate.
  • the anions which give desirable insoluble precipitates include phosphate, fatty acid groups having from 8 to 18 carbon atoms, fluoride, fluorophosphate, silica fluoride, sulfate, tartrate, sorbate, alkyl sulfonates having from 6 to 18 carbon atoms, carbonates, etc. Mixtures of these anions are desirable.
  • Cations which give desirable insoluble precipitates include the heavy metal ions referred to hereinbefore, and calcium and magnesium. Mixtures of these cations are desirable.
  • Suitable soluble salts of the cations used in this invention include the halide, e.g., chloride, nitrate, sulfate, acetate and gluconate salts of the desired cation.
  • suitable soluble salts of the anions of this invention include alkali metal (e.g., sodium and potassium), ammonium, and low molecular weight substituted ammonium salts.
  • low molecular weight substituted ammonium salts are those where one or more of the hydrogen atoms on the ammonium ion is substituted with a 1-3 carbon atom, alkyl or hydroxy alkyl group such as methyl, ethyl, propyl, hydroxyethyl, 2- hydroxypropyl, or 3-hydroxypropyl, e.g., the mono-, di-, or triethanolammonium salts or the mono-, di-, or triethylammonium salts.
  • precipitates are calcium phosphate compounds with small amounts of indium and fluoride incorporated therein.
  • the following precipitates disclose not only desirable remineralizing precipitates but, of course, also the cations and anions necessary to form the precipitates. It will be recognized by one skilled in the art that some of these precipitates can be formed by first forming an original precipitate which then further reacts to form the indicated precipitate. For example, a hydroxide may form first and then react further to form the corresponding oxide.
  • Preferred precipitates are: calcium phosphates; ZnNtLjPO 4 ; InPO 4 ; rare earth phosphates such as lanthanum, cerium and samarium phosphate; rare earth fluorides such as lanthanum, cerium, praseodymium, neodymium, and samarium fluorides; magnesium alkyl sulfonate wherein the alkyl group has from 10 to 22 carbon atoms; magnesium stearate; calcium stearate; zinc stearate; and aluminum phosphates.
  • the components of the precipitate can be sequentially delivered to the surface of the tooth by means of two separate delivery vehicles, each containing one component, e.g., a mouthwash and a toothpaste.
  • the components of the precipitate can be delivered using an oral care device described herein.
  • Desensitizing dentifrice compositions are formulated to eliminate or reduce the discomfort and pain associated with dentinal hypersensitivity.
  • Such compositions include two- component desensitizing dental compositions containing potassium salt desensitizing agents.
  • the dental compositions can include two semi-solid aqueous components: a first component buffered to maintain an alkaline pH of at least about 9.0 and preferably about 9.0 to about 12.0, and a second component maintained at a pH of 6.5 to 7.5 with a phosphate salt buffer ingredient. At least one of the components contains a fluoride ion-releasing salt and a potassium-releasable salt compound in an orally acceptable vehicle, the fluoride compound being present at a concentration sufficient to release about 2500 to 8800 parts per million (ppm) fluoride from the compound.
  • ppm parts per million
  • the two components are preferably combined in approximately equal weight proportions, so that about one-half of the concentration of any particular ingredient within either component will be present when the components are combined and applied to the teeth, as by brushing. Both components are preferably formulated to have similar physical characteristics, so that the two components may be simultaneously delivered in the desired predetermined amounts.
  • a buffering agent is incorporated, which is normally prepared using a vehicle which contains water, humectant, surfactant and an abrasive.
  • the buffering agent is preferably a mixture of mono- and dibasic sodium phosphate salts and is incorporated in dentifrice component at a concentration of about 5 to about 10% by weight and preferably about 6 to about 10% by weight of in the component.
  • the dentifrice component having an alkaline pH is prepared using a vehicle having a composition similar to that of the buffered neutral pH component.
  • An alkaline agent such as an alkali metal compound including sodium hydroxide, potassium hydroxide, sodium bicarbonate, sodium carbonate, N-sodium silicate (a 3.22 weight ratio of sodium silicate in 34.6% water available from PQ Corporation) is incorporated in the alkaline component in amounts in the range of about 0.5 to about 15% by weight, preferably about 1.0 to about 8% by weight and most preferably at about 1.0 to about 5.0% by weight of the component. Mixtures of the above alkali metal compounds can also be used.
  • the fluoride ion-releasing salts are characterized by their ability to release fluoride ions in water. It is preferable to employ a water soluble fluoride salt providing about 1000 to about 9000 ppm of fluoride ion, and preferably about 2500 to about 8800 ppm of fluoride ion.
  • Suitable examples of fluoride ion-releasing salts include water soluble inorganic metal salts, for example, sodium fluoride, potassium fluoride, sodium monofluorophosphate, stannous fluoride and sodium fluorosilicate. Sodium fluoride, sodium monofluorophosphate and stannous fluoride are preferred fluoride ion releasing salts.
  • the source of desensitizing potassium ion is generally a water soluble potassium salt including potassium nitrate, potassium citrate, potassium chloride, potassium bicarbonate and potassium oxalate with potassium nitrate being preferred.
  • the potassium salt is generally incorporated in one or more of the dentifrice components at a concentration of about 1 to about 20% by weight and preferably about 3 to about 10% by weight.
  • Some oral care compositions are capable of reducing plaque and gingivitis while at the same time not incurring significant staining. Staining can be reduced by the use of a dual component composition containing pyrophosphate ions and stannous compounds, e.g., with stannous fluoride and another stannous compound in one component and pyrophosphate ions in another. Both components generally include a pharmaceutically acceptable carrier.
  • Stannous fluoride is the first essential component of the stannous components. This material is present in the stannous composition at a level of from about 0.05% to about 1.1%, preferably from about 0.4% to about 0.95%. It should be recognized that separate soluble stannous and fluoride salts may be used to form stannous fluoride in-situ as well as adding the salt directly. Suitable salts for forming stannous fluoride in-situ include stannous chloride and sodium fluoride among many others.
  • a second stannous compound is generally included in the stannous component.
  • the second stannous compound is a stannous salt of an alpha hydroxy acid, phytic acid, EDTA, glycine and mixtures thereof.
  • the second stannous compound is stannous gluconate.
  • These materials are known stannous chelates and may be provided to the present compositions as the chelate or as separate soluble stannous salts and the chelate formed in-situ such as with stannous fluoride.
  • Suitable alpha hydroxy-acids include gluconic acid, citric acid, malic acid, tartaric acid and lactic acids.
  • Such salts include stannous chloride and stannous fluoride.
  • the second stannous compound is generally present in the present components at a level of from about 0.1% to about 11%, preferably from about 2% to about 4%.
  • the second component is a component containing or capable of providing an effective amount of pyrophosphate ions.
  • the pyrophosphate ion can be, for example, pyrophosphate acid or any of the readily water soluble pyrophosphate salts.
  • Such salts include any of the alkali metal salts such as sodium, potassium and lithium and also including ammonium.
  • the amount of pyrophosphate ions is any effective amount generally from about 1 % to about 15%, preferably from about 1% to about 10%, most preferably from about 3% to about 7%.
  • the components can be applied to the oral cavity in safe and effective amounts. These amounts (e.g. from about 0.3 to about 15 g), if it is a toothpaste or mouthwash, are kept in the mouth for from about 15 to about 60 seconds.
  • the components can be used in any order but it is preferable that the stannous component be used first.
  • hydrogen or urea peroxide is dissolved in a nontoxic gel for use in combination with a separately stored but substantially simultaneously dispensed paste containing sodium bicarbonate, table (or another suitable) salt, and, preferably, additional cleansing, anticaries and polishing agents as well as an effective concentration of flavoring substances.
  • Controlled quantities of the gel and paste can be simultaneously released onto the toothbrush and immediately applied to the teeth and gums.
  • Control of the peroxide, salt, and NaHCO 3 quantities delivered may be thus effected by specification of the opening of the orifice and the active ingredient concentration in each tube (or pump compartment).
  • immediate mixing of the products takes place followed by the rapid evolution of active oxygen and carbon dioxide.
  • the effervescence accompanying release of active oxygen activates the flavor contained in the bicarbonate paste and produces a lasting highly refreshing taste in the mouth which is unlike any other flavor provided by existing toothpastes or gels.
  • the hydrogen peroxide gel may contain the following ingredients in the following amounts -H 2 O 2 : about 1.0-10.0% and preferably about 3.0-6.5%; Acrylic acid copolymer: about 0.05-1.20% and, preferably, about 0.3-0.8%; nonionic cellulose gum: about 0.1-1.5% and, preferably, about 0.3-0.8%; neutralizing agent (rriethanolamine, diisopropanolamine, NaOH, KOH): an amount sufficient to raise the gel pH to about 3.0-6.0. The balance is purified (distilled or deionized) water.
  • the sodium bicarbonate paste contains sodium bicarbonate, sodium chloride, purified (distilled or deionized) water and a thickener/stabilizer such as cellulose gum and magnesium- aluminum silicate, as essential ingredients.
  • a bodying agent is added, such a sorbitol, glycerin or a glycol.
  • cleansing agents such as calcium sulfate, calcium phosphate and hydrated aluminum oxide, as well as a foaming agent such as sodium lauryl sulfate (which also enhances the peroxide-bicarbonate-salt action) may be added.
  • the constituents and quantities for the bicarbonate paste are as follows: sodium bicarbonate: about 10-50% and preferably 20-40%; polyol: about 5-30% and preferably, 15- 25%; cellulose gum: about 1-3% and preferably 1.2-1.8%; sodium chloride: about 1-6% and preferably about 2-4%; polishing agent/cleanser: about 1-40%, preferably about 1.5-30%; foaming agent: about 0.1-2.5% and preferably about 0.2-0.5%; flavoring agent(s): to taste, less than about 1%; preservatives: about 0.1-0.5%.
  • the balance is purified water.
  • the paste and the gel are preferably used in substantially equal proportions, by volume.
  • gingival bleeding may be inhibited, and the texture and consistency of gingival and periodontal tissues improved, by delivering to the oral cavity a first component comprising from about 0.1 to about 10% by weight of zinc salt in a pharmaceutically acceptable carrier, and a second component comprising from about 1 to about 80% by weight of a bicarbonate salt in a pharmaceutically acceptable carrier, and agitating the combination of first and second compositions within the mouth against the gingival and periodontal tissues, or brushing gingival and periodontal surfaces surrounding the teeth simultaneously with a combination of the first and second components.
  • a first component comprising from about 0.1 to about 10% by weight of zinc salt in a pharmaceutically acceptable carrier
  • a second component comprising from about 1 to about 80% by weight of a bicarbonate salt in a pharmaceutically acceptable carrier
  • the first component can also include a peroxygen compound.
  • a peroxygen compound can also include ascorbic or citric acids in place of the peroxygen compound.
  • This combination of zinc and bicarbonate salts can deliver a very potent inhibitory effect against gingival and periodontal tissue damage.
  • Such effect requires the zinc and bicarbonate salts to be separately packaged prior to their introduction into the oral cavity. For example in an oral care device described herein.
  • the first component includes a salt capable of delivering zinc ions.
  • a salt capable of delivering zinc ions.
  • zinc ion is meant that the zinc-atom portion of a molecule of the zinc compound in the solid or undissociated state, is capable of being dissociated into simple or complex zinc ions, especially when dispersed in an aqueous medium.
  • examples of the compounds that may be employed are zinc salts of the following inorganic ions: borate, bromide, carbonate, hexofluorosilicate, pyrophosphate, silicate, sulphate and titanate.
  • Organic anions are those having from 2 to 22 carbon atoms with a charged group selected from carboxylate, sulphonate, sulphate and phosphate.
  • Specific examples include, but are not limited to, acetate, benzoate, citrate, glycinate, lactate, phenolsulphonate, salicylate, tartrate, acetylacetonate, maleate, succinate, ascorbate, and gluconate.
  • the zinc salts will generally be present in oral care compositions in an amount from about 0.05 to about 10%, preferably between about 0.2 and 5%, optimally between about 0.8 and 3% by weight.
  • the first component may be a gel and the second composition may be in the form of an opaque paste.
  • the gel will include a peroxygen compound such as hydrogen peroxide, urea peroxide, calcium peroxide and the salts of perborate, persilicate, perphosphate and percarbonate.
  • the amount of the peroxygen compound may range from about 0.1 to about 10% by weight. In terms of active weight hydrogen peroxide, the amount will range from about 0.5 to about 5%, preferably from about 0.8 to about 4%, optimally between about 1 and 3% by weight.
  • the first component may contain a C 2 -C20 carboxylic acid.
  • Illustrative acids include citric, malic, lactic and ascorbic acids. Levels of the acids may range in amounts similar to that of the peroxygen compound, i.e. from about 0.1 to about 10% by weight. Citric acid is most preferred. When present, these acids will either be in liquid, gel or paste type compositions.
  • the pH of the first component will be held between about 3.2 and 5.0, preferably from 4.0 to 4.5.
  • the bicarbonate-containing second component may also contain a fluoride anticaries compound selected from the same fluoride compounds in essentially identical amounts to those described hereinabove with respect to the first composition. Especially preferred is sodium fluoride.
  • Bicarbonate salts will be present in alkali metal form, examples of which are sodium and potassium. Typically, the concentration of bicarbonate salt will range from about 0.5 to about 80%, preferably from about 5 to about 50%, optimally between about 8 and about 20% by weight.
  • the pH of the bicarbonate composition may range from about 7.0 to about 9.5, most preferably about 8.0 to 9.0.
  • the bicarbonate composition When the bicarbonate composition is in toothpaste or gel form, there will typically be included a natural or synthetic thickening agent in an amount from about 0.1 to 10%, preferably about 0.5 to 5% by weight. Relative weight amounts of the first composition to that of the second composition will range from about 1 :2 to 2: 1 , preferably about 1 :1.
  • Oral care compositions and components formulated as a dentifrice generally include a binder, a carrier, and an active ingredient.
  • the dentifrice may also include one or more of the following: a surfactant and/or detergent, a thickening agent, a polishing agent, a carrier, a humectant, a salt, etc. Examples of suitable dentifrice ingredients are described below.
  • the binder system generally, is a primary factor that determines the rheological characteristics of the oral care composition.
  • the binder also acts to keep any solid phase of an oral care component suspended, thus preventing separation of the solid phase portion of the oral care component from the liquid phase portion.
  • the binder can provide body or thickness to the oral care composition.
  • a binder can also provide a thickening function to an oral care composition.
  • binders include sodium carboxymethyl-cellulose, cellulose ether, xanthan gum, carrageenan, sodium alginate, carbopol, or silicates such as hydrous sodium lithium magnesium silicate.
  • suitable binders include polymers such as hydroxypropyl methylcellulose, hydroxyethyl cellulose, guar gum, tragacanth gum, karaya gum, arabic gum, Irish moss, starch, and alginate.
  • the binder can include a clay, for example, a synthetic clay such as a hectorite, or a natural clay.
  • Each of the binders can be used alone or in combination with other binders.
  • the dentifrice may includes one or more surfactants or detergents to provide a desirable foaming quality.
  • Surfactants generally include anionic, nonionic, cationic and zwitterionic or amphoteric compositions.
  • surfactants include soaps, sulfates (e.g., sodium lauryl sulfate and sodium dodecyl benzene sulfonate), sodium lauryl sarcosinate, sorbitan esters of fatty acids, sulfobetaines (e.g., cocamidopropylbatine), and D-glucopyranoside Cio-i6 alkyl oligomeric.
  • the surfactants include sodium lauryl sulphate, cocamidopropyl betaine, and D-glucopyranoside Cio-Ci ⁇ alkyl oligomeric.
  • surfactants are present in an amount from about 0.2 to about 8% by weight (e.g., from about 1 to about 5% or from about 1.5 to about 3.5%).
  • Thickening agents include sodium lauryl sulphate, cocamidopropyl betaine, and D-glucopyranoside Cio-Ci ⁇ alkyl oligomeric.
  • thickening agents examples include thickening silica, polymers, clays, and combinations thereof.
  • Thickening silica for example, SILODENT 15 hydrated silica, in the amount between about 4% to about 8% by weight (e.g., about 6%) provide desirable in- mouth characteristics.
  • the phrase "in-mouth characteritics" as described herein relates to the body and thickness of the dentifrice as it foams in the mouth of a user.
  • polishing agents include abrasives, such as carbonates (e.g., sodium bicarbonate, calcium carbonate) water-colloidal silica, precipitated silicas (e.g., hydrated silica), sodium aluminosilicates, silica grades containing alumina, hydrated alumina, dicalcium phosphates, insoluble sodium metaphosphate, and magnesiums (e.g., trimagnesium phosphate).
  • a suitable amount of polishing agent is an amount that safely provides good polishing and cleaning and which, when combined with other ingredients gives a smooth, flowable, and not excessively gritty composition. In general, when polishing agents are included, they are present in an amount from about 5% to about 50% by weight (e.g., from about 5% to about 35%, or from about 7% to about 25%).
  • Examples of carriers include water, polyethylene glycol, glycerin, polypropylene glycol, starches, sucrose, alcohols (e.g., methanol, ethanol, isopropanol, etc.), or combinations thereof. Examples of combinations include various water and alcohol combinations and various polyethylene glycol and polypropylene glycol combinations.
  • the amount of carrier included is determined based on the concentration of the binder system along with the amount of dissolved salts, surfactants, and dispersed phase.
  • humectants are polyols.
  • examples of humectants include glycerin, sorbitol propyleneglycol, xylitol, lactitol, polypropylene glycol, polyethylene glycol, hydrogenated corn syrup and mixtures thereof.
  • humectants when included they can be present in an amount from about 10% to about 60% by weight.
  • buffers and salts include primary, secondary, or tertiary alkali metal phosphates, citric acid, sodium citrate, sodium saccharin, tetrasodium pyrophosphate, sodium hydroxide, and the like. Active ingredients
  • Dentifrices may include active ingredients, for example, to prevent cavities, to whiten teeth, to freshen breath, to deliver oral medication, and to provide other therapeutic and cosmetic benefits such as those described above.
  • active ingredients include the following: anti-caries agents (e.g., water soluble fluoride salts, fluorosilicates, fluorozirconates, fluorostannites, fluoroborates, fluorotitanates, fluorogermanates, mixed halides and casine); anti- tarter agents; anti-calculus agents (e.g.
  • potassium peroxydiphosphate potassium peroxydiphosphate
  • anti-plaque agents gum protecting agents (e.g., vegetable oils such as sunflower oil, rape seed oil, soybean oil and safflower oil, and other oils such as silicone oils and hydrocarbon oils).
  • the gum protection agent may be an agent capable of improving the permeability barrier of the gums.
  • wound healing agents e.g., urea, allantoin, panthenol, alkali metal thiocyanates, chamomile-based actives and acetylsalicylic acid derivatives, ibuprofen, flurbiprofen, aspirin, indomethacin etc.
  • tooth buffering agents e.g., urea, allantoin, panthenol, alkali metal thiocyanates, chamomile-based actives and acetylsalicylic acid derivatives, ibuprofen, flurbiprofen, aspirin, indomethacin etc.
  • reminieralization agents e.g., anti-inflammatory agents; anti-malodor agent; breath freashing agents; and agents for the treatment of oral conditions such as gingivitis or periodontitis.
  • dentifrices may include effervescing systems such as sodium bicarbonate citric acid systems, or color change systems.
  • Dentifrices may also include one or more of the following: phenolic compounds (e.g., phenol and its homologues, including 2 -methyl-phenol, 3-methyl-phenol. 4-methyl-phenol, 4- ethyl-phenol, 2,4-dimethol-phenol, and 3,4-dimethol -phenol); sweetening agents (e.g., sodium saccharin, sodium cyclamate, sucrose, lactose, maltose, and fructose); flavors (e.g., peppermint oil, spearmint oil, eucalyptus oil, aniseed oil, fennel oil, caraway oil, methyl acetate, cinnamaldehyde, anethol, vanillin, thymol and other natural or nature-identical essential oils or synthetic flavors); preservatives (e.g., p-hydroxybenzoic acid methyl, ethyl, or propyl ester, sodium sorbate, sodium benzoate, bromochlor
  • compositions and components discussed herein may be provided in the form of mouthrinses or mouthwashes.
  • ingredients of such mouthwashes and mouthrinses typically include one or more of water (from about 45% to about 95%), ethanol (from about 0% to about 25%), a humectant (from about 0% to about 50%), a surfactant (from about 0.01% to about 7%), a flavoring agent (from about 0.04% to about 2%), a sweetening agent (from about 0.1% to about 3%), and a coloring agent (from about 0.001% to about 0.5%).
  • Such mouthwashes and mouthrinses may also include one or more of an anticaries agent (from about 0.05% to about 0.3% as fluoride ion) and an anticalculus agent (from about 0.1% to about 3%).
  • compositions and components discussed herein may also be in the form of dental solutions and irrigation fluids.
  • Ingredients of such dental solutions generally include one or more of water (from about 90% to about 99%), preservative (from about 0.01% to about 0.5%), thickening agent (from 0% to about 5%), flavoring agent (from about 0.04% to about 2%), sweetening agent (from about 0.1% to about 3%), and surfactant (from 0% to about 5%).
  • Some examples of rinses that may be used with the present invention are described in U.S. 6,440,395 to Libin; U.S. 6,355,229 to Adamy; U.S. 6,344,184 to Rolla; U.S. 6,117,417 to Wicks et al.; U.S.
  • first component/composition and a second component/composition which can be either simultaneously or sequentially (i.e., the second component following the first component) delivered by wide variety of devices and/or packages, some of which have been described herein, are set forth in Table 1 below.
  • the first and second components of Table 1 can be delivered using any of the regimens, dosages, steps, or methods, in whole or part, described herein and may be provided in variety of forms, including but not limited to a dentifrice, rinse, gel, liquid, or paste.

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  • Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Brushes (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne des traitements de soins oraux parmi lesquels des compositions de soins oraux multi-composants et des procédés d'apport de telles compositions à la cavité orale. Des dispositifs et des systèmes de soins oraux pour l'implémentation de tels traitements sont également proposés.
PCT/US2007/012901 2007-05-31 2007-05-31 Compositions, procédés, dispositifs et systèmes de soins oraux WO2008147360A1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
AU2007354332A AU2007354332A1 (en) 2007-05-31 2007-05-31 Oral care compositions, methods, devices and systems
BRPI0721760-9A BRPI0721760A2 (pt) 2007-05-31 2007-05-31 composiÇÕes para tratamento bucal, mÉtodos, dispositivos e sistemas
MX2009012690A MX2009012690A (es) 2007-05-31 2007-05-31 Composiciones, metodos, dispositivos y sistemas para el cuidado bucal.
CA2686944A CA2686944C (fr) 2007-05-31 2007-05-31 Compositions, procedes, dispositifs et systemes de soins oraux
PCT/US2007/012901 WO2008147360A1 (fr) 2007-05-31 2007-05-31 Compositions, procédés, dispositifs et systèmes de soins oraux
CN200780052932A CN101668493A (zh) 2007-05-31 2007-05-31 口腔护理组合物、方法、装置和系统
KR1020097024576A KR20100005145A (ko) 2007-05-31 2007-05-31 구강 케어 조성물, 방법, 장치 및 시스템
EP07795577A EP2148632A1 (fr) 2007-05-31 2007-05-31 Compositions, procédés, dispositifs et systèmes de soins oraux
JP2010508349A JP2010526638A (ja) 2007-05-31 2007-05-31 口腔ケア用の組成物、方法、器具、及びシステム
US12/125,199 US20090070949A1 (en) 2007-05-31 2008-05-22 Oral Care Compositions, Methods, Devices and Systems

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CA (1) CA2686944C (fr)
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WO2014068431A1 (fr) * 2012-11-02 2014-05-08 Braun Gmbh Irrigateur oral
WO2015009876A1 (fr) * 2013-07-16 2015-01-22 Colgate-Palmolive Company Système et procédé de fabrication d'une formulation de soin bucco-dentaire
USD723912S1 (en) 2012-11-30 2015-03-10 Colgate-Palmolive Company Container
WO2015087176A1 (fr) * 2013-12-12 2015-06-18 Koninklijke Philips N.V. Brosse à dents ayant un système de sélection tactile variable, et son procédé de fonctionnement
USD736701S1 (en) 2012-11-30 2015-08-18 Colgate-Palmolive Company Case with battery charger for electric toothbrush
USD757439S1 (en) 2012-11-30 2016-05-31 Colgate-Palmolive Company Electric toothbrush handle
USD767896S1 (en) 2015-02-27 2016-10-04 Colgate-Palmolive Company Electric toothbrush
US9931186B2 (en) 2013-03-15 2018-04-03 Koninklijke Philips N.V. Oral care appliance using a jet-type fluid flow and mechanical action
US9961985B2 (en) 2012-11-30 2018-05-08 Colgate-Palmolive Company Case for powered toothbrush and system
US10226314B2 (en) 2013-12-12 2019-03-12 Koninklijke Philips N.V. Toothbrush with variable touch selection system and method of operation thereof
US10517704B2 (en) 2017-02-03 2019-12-31 Dyson Technology Limited Dental treatment appliance
US10582764B2 (en) 2016-11-14 2020-03-10 Colgate-Palmolive Company Oral care system and method
JP2020039892A (ja) * 2015-07-08 2020-03-19 ウォーター・ピック，インク． 歯ブラシ用ハンドルおよび口腔洗浄デバイス
WO2020161597A1 (fr) * 2019-02-07 2020-08-13 Willo 32 Sas Cartouche et unité de base destinées à être utilisées dans un appareil de soins buccodentaires
US10835028B2 (en) 2016-11-14 2020-11-17 Colgate-Palmolive Company Oral care system and method
US11043141B2 (en) 2016-11-14 2021-06-22 Colgate-Palmolive Company Oral care system and method
US11076940B2 (en) 2016-11-04 2021-08-03 Dyson Technology Limited Cleaning appliance
CN113598517A (zh) * 2021-07-05 2021-11-05 上海文芙达实业有限公司 个人清洁用具及组合
US11213120B2 (en) 2016-11-14 2022-01-04 Colgate-Palmolive Company Oral care system and method
US11361672B2 (en) 2016-11-14 2022-06-14 Colgate-Palmolive Company Oral care system and method
US11413125B2 (en) 2015-05-15 2022-08-16 Dyson Technology Limited Cleaning appliance
US11439226B2 (en) * 2020-03-12 2022-09-13 Cynthia Drakes Automatic mascara applicator apparatus
US11980518B2 (en) 2018-07-16 2024-05-14 Dyson Technology Limited Cleaning appliance

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ES2532334T3 (es) * 2011-07-25 2015-03-26 Braun Gmbh Utensilio de higiene bucodental y dispositivo de higiene bucodental
KR101410048B1 (ko) * 2013-03-21 2014-06-20 안승희 구강살균세정기
JP6475101B2 (ja) * 2015-06-18 2019-02-27 オムロンヘルスケア株式会社 電動歯ブラシ及び電動歯ブラシの作動方法
GB2559107B (en) * 2016-11-04 2019-05-08 Dyson Technology Ltd Cleaning appliance
KR101822645B1 (ko) * 2017-07-28 2018-01-26 주식회사 블루레오 구강 세정기
KR101989415B1 (ko) * 2017-08-17 2019-06-25 주식회사 에스알생활건강 칫솔 자세 감지 장치
KR102506599B1 (ko) * 2018-02-06 2023-03-06 주식회사 엘지생활건강 해바라기유를 포함하는 구강질환 예방 또는 치료용 조성물
CN113081351B (zh) * 2021-04-08 2022-08-23 读书郎教育科技有限公司 一种智能清新口气的装置及方法
CN115381572B (zh) * 2021-05-25 2025-04-08 广东美西科技有限公司 口腔护理设备的控制方法、装置、电子设备及存储介质

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Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014068431A1 (fr) * 2012-11-02 2014-05-08 Braun Gmbh Irrigateur oral
USD798060S1 (en) 2012-11-30 2017-09-26 Colgate-Palmolive Company Electric toothbrush handle
US9961985B2 (en) 2012-11-30 2018-05-08 Colgate-Palmolive Company Case for powered toothbrush and system
USD723912S1 (en) 2012-11-30 2015-03-10 Colgate-Palmolive Company Container
USD736701S1 (en) 2012-11-30 2015-08-18 Colgate-Palmolive Company Case with battery charger for electric toothbrush
USD757439S1 (en) 2012-11-30 2016-05-31 Colgate-Palmolive Company Electric toothbrush handle
USD758966S1 (en) 2012-11-30 2016-06-14 Colgate-Palmolive Company Case with battery charger for electric toothbrush
US9931186B2 (en) 2013-03-15 2018-04-03 Koninklijke Philips N.V. Oral care appliance using a jet-type fluid flow and mechanical action
US11622924B2 (en) 2013-07-16 2023-04-11 Colgate-Palmolive Company System and method for making an oral care formulation
WO2015009876A1 (fr) * 2013-07-16 2015-01-22 Colgate-Palmolive Company Système et procédé de fabrication d'une formulation de soin bucco-dentaire
WO2015087176A1 (fr) * 2013-12-12 2015-06-18 Koninklijke Philips N.V. Brosse à dents ayant un système de sélection tactile variable, et son procédé de fonctionnement
US10080633B2 (en) 2013-12-12 2018-09-25 Koninklijke Philips N.V. Toothbrush with variable touch selection system and method of operation thereof
US10226314B2 (en) 2013-12-12 2019-03-12 Koninklijke Philips N.V. Toothbrush with variable touch selection system and method of operation thereof
USD767896S1 (en) 2015-02-27 2016-10-04 Colgate-Palmolive Company Electric toothbrush
US11413125B2 (en) 2015-05-15 2022-08-16 Dyson Technology Limited Cleaning appliance
JP2020039892A (ja) * 2015-07-08 2020-03-19 ウォーター・ピック，インク． 歯ブラシ用ハンドルおよび口腔洗浄デバイス
US11076940B2 (en) 2016-11-04 2021-08-03 Dyson Technology Limited Cleaning appliance
US10582764B2 (en) 2016-11-14 2020-03-10 Colgate-Palmolive Company Oral care system and method
US11043141B2 (en) 2016-11-14 2021-06-22 Colgate-Palmolive Company Oral care system and method
US10835028B2 (en) 2016-11-14 2020-11-17 Colgate-Palmolive Company Oral care system and method
US11213120B2 (en) 2016-11-14 2022-01-04 Colgate-Palmolive Company Oral care system and method
US11361672B2 (en) 2016-11-14 2022-06-14 Colgate-Palmolive Company Oral care system and method
US11602216B2 (en) 2016-11-14 2023-03-14 Colgate-Palmolive Company Oral care system and method
US10517704B2 (en) 2017-02-03 2019-12-31 Dyson Technology Limited Dental treatment appliance
US11980518B2 (en) 2018-07-16 2024-05-14 Dyson Technology Limited Cleaning appliance
US11104565B2 (en) 2019-02-07 2021-08-31 Willo 32 Sas Cartridge and a base unit for use in an oral care appliance
WO2020161597A1 (fr) * 2019-02-07 2020-08-13 Willo 32 Sas Cartouche et unité de base destinées à être utilisées dans un appareil de soins buccodentaires
US11649150B2 (en) 2019-02-07 2023-05-16 Willo 32 Sas Cartridge and a base unit for use in an oral care appliance
US11439226B2 (en) * 2020-03-12 2022-09-13 Cynthia Drakes Automatic mascara applicator apparatus
CN113598517A (zh) * 2021-07-05 2021-11-05 上海文芙达实业有限公司 个人清洁用具及组合

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EP2148632A1 (fr) 2010-02-03
CN101668493A (zh) 2010-03-10
CA2686944C (fr) 2013-11-19
KR20100005145A (ko) 2010-01-13
AU2007354332A1 (en) 2008-12-04
BRPI0721760A2 (pt) 2013-07-02
CA2686944A1 (fr) 2008-12-04
MX2009012690A (es) 2009-12-11
JP2010526638A (ja) 2010-08-05

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