WO2008146005A3 - Freeze drying of target substances - Google Patents
Freeze drying of target substances Download PDFInfo
- Publication number
- WO2008146005A3 WO2008146005A3 PCT/GB2008/001835 GB2008001835W WO2008146005A3 WO 2008146005 A3 WO2008146005 A3 WO 2008146005A3 GB 2008001835 W GB2008001835 W GB 2008001835W WO 2008146005 A3 WO2008146005 A3 WO 2008146005A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- target substance
- freeze
- chamber
- carrier
- freeze drying
- Prior art date
Links
- 239000013076 target substance Substances 0.000 title abstract 8
- 238000004108 freeze drying Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 abstract 5
- 238000001816 cooling Methods 0.000 abstract 2
- 238000007710 freezing Methods 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Drying Of Solid Materials (AREA)
Abstract
In a process for freeze drying a target substance, the target substance is carried by a carrier, which is passed into a freeze chamber (31) to reduce the temperature of the target substance, and then on to a dryer chamber (32). Vacuum/ reduced pressure is applied during the process, during a final portion of the freeze process when the target substance and carrier are present in the freeze chamber (31); and/or when the target substance and carrier are transferred from the freeze chamber (31) to the dryer chamber (32). Vacuum/reduced pressure is also applied when the target substance and carrier are present in the dryer chamber. The process enables the freezing process to commence at temperatures close to the collapse temperature of the target substance and to maintain that temperature while compensating for evaporative cooling, thus giving the fastest and most efficient freeze drying cycle, resulting in a slower cooling rate producing structures that are optimal for use.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0710379.9 | 2007-05-31 | ||
| GB0710379A GB0710379D0 (en) | 2007-05-31 | 2007-05-31 | Freeze drying of target substances |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2008146005A2 WO2008146005A2 (en) | 2008-12-04 |
| WO2008146005A3 true WO2008146005A3 (en) | 2009-05-07 |
Family
ID=38289592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/GB2008/001835 WO2008146005A2 (en) | 2007-05-31 | 2008-05-30 | Freeze drying of target substances |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB0710379D0 (en) |
| WO (1) | WO2008146005A2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2379604C1 (en) * | 2008-12-17 | 2010-01-20 | Александр Михайлович Костин | Low-temperature vacuum material dehydration and drying device |
| CN104677057B (en) * | 2015-03-03 | 2017-02-01 | 华南理工大学 | Method and equipment for adopting variable-frequency alternating current electric field for assisting freeze drying of drug liposome powder |
| CN116136356B (en) * | 2021-11-16 | 2025-04-11 | 青岛海尔生物医疗股份有限公司 | Method, device and system for program-controlled drying of freezing system |
| GB202212257D0 (en) * | 2022-08-23 | 2022-10-05 | Stow Roger Valentine | Drying apparatus and associated drying process |
| CN117026679A (en) * | 2022-10-08 | 2023-11-10 | 中煤（北京）印务有限公司 | Method and equipment for preventing excessive deformation of printing paper |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3192645A (en) * | 1959-10-07 | 1965-07-06 | Leybold Aulagen Holding A G | Apparatus and method for vacuum freeze drying substances in a tunnel dryer having sealing locks |
| US3242575A (en) * | 1960-11-05 | 1966-03-29 | Manaresi Alessandra | Lyophilization apparatus |
| US4104807A (en) * | 1976-04-10 | 1978-08-08 | Boehringer Mannheim Gmbh | Machine for the continuous preparation and packaging of freeze-dried materials |
| US4501719A (en) * | 1981-05-04 | 1985-02-26 | Marquest Medical Products, Inc. | Tray apparatus for freeze-drying biologicals having a predetermined unit dosage |
| US4597188A (en) * | 1985-03-04 | 1986-07-01 | Trappler Edward H | Freeze dry process and structure |
| US5964043A (en) * | 1995-03-18 | 1999-10-12 | Glaxo Wellcome Inc. | Freeze-drying process and apparatus |
| WO2003056319A2 (en) * | 2001-12-21 | 2003-07-10 | Oxford Biosensors Limited | Micro-band electrode |
| US20040043042A1 (en) * | 2001-12-03 | 2004-03-04 | Johnson Audrey M. | Microscale lyophilization and drying methods for the stabilization of molecules |
| WO2006000823A2 (en) * | 2004-06-29 | 2006-01-05 | Oxford Biosensors Limited | Composition and electrochemical sensor for detecting ischaemia |
| US20070000145A1 (en) * | 2004-08-27 | 2007-01-04 | Dynax Corporation | Method for drying and storing activated aluminum fine particles |
| WO2007066132A1 (en) * | 2005-12-09 | 2007-06-14 | Oxford Biosensors Limited | Freeze drying of target substances |
-
2007
- 2007-05-31 GB GB0710379A patent/GB0710379D0/en not_active Ceased
-
2008
- 2008-05-30 WO PCT/GB2008/001835 patent/WO2008146005A2/en active Application Filing
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3192645A (en) * | 1959-10-07 | 1965-07-06 | Leybold Aulagen Holding A G | Apparatus and method for vacuum freeze drying substances in a tunnel dryer having sealing locks |
| US3242575A (en) * | 1960-11-05 | 1966-03-29 | Manaresi Alessandra | Lyophilization apparatus |
| US4104807A (en) * | 1976-04-10 | 1978-08-08 | Boehringer Mannheim Gmbh | Machine for the continuous preparation and packaging of freeze-dried materials |
| US4501719A (en) * | 1981-05-04 | 1985-02-26 | Marquest Medical Products, Inc. | Tray apparatus for freeze-drying biologicals having a predetermined unit dosage |
| US4597188A (en) * | 1985-03-04 | 1986-07-01 | Trappler Edward H | Freeze dry process and structure |
| US5964043A (en) * | 1995-03-18 | 1999-10-12 | Glaxo Wellcome Inc. | Freeze-drying process and apparatus |
| US20040043042A1 (en) * | 2001-12-03 | 2004-03-04 | Johnson Audrey M. | Microscale lyophilization and drying methods for the stabilization of molecules |
| WO2003056319A2 (en) * | 2001-12-21 | 2003-07-10 | Oxford Biosensors Limited | Micro-band electrode |
| WO2006000823A2 (en) * | 2004-06-29 | 2006-01-05 | Oxford Biosensors Limited | Composition and electrochemical sensor for detecting ischaemia |
| US20070000145A1 (en) * | 2004-08-27 | 2007-01-04 | Dynax Corporation | Method for drying and storing activated aluminum fine particles |
| WO2007066132A1 (en) * | 2005-12-09 | 2007-06-14 | Oxford Biosensors Limited | Freeze drying of target substances |
Also Published As
| Publication number | Publication date |
|---|---|
| GB0710379D0 (en) | 2007-07-11 |
| WO2008146005A2 (en) | 2008-12-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2008146005A3 (en) | Freeze drying of target substances | |
| WO2007095033A3 (en) | Lyophilization system and method | |
| IL178046A0 (en) | An improved process for producing chlorinated sucrose | |
| TW288985B (en) | ||
| ATE471404T1 (en) | HOUSEHOLD APPLIANCE WITH HEAT PUMP | |
| PL357860A1 (en) | Interketaled graphite compounds capable to expand, method of obtaining them and their applications | |
| WO2004045815A3 (en) | Apparatus and method for the heat treatment of lignocellulosic material | |
| NZ597210A (en) | Rebaudioside a composition and method for purifying rebaudioside a | |
| TW200616891A (en) | Method for producing manganese fluoride | |
| WO2002081059A3 (en) | Method for the regeneration of humidity-laden process air and arrangement for carrying out said method | |
| WO2009148557A3 (en) | Indirect drying method using two temperature zones | |
| WO2009062931A3 (en) | High vacuum pump for pumping high temperature saturated steam | |
| WO2009060471A3 (en) | Microwave assisted process for synthesis of molecular sieves from pseudo and/or dry gels | |
| CN102952025B (en) | Preparation method of (S)-1-amino-3-chloro-2-propyl alcohol hydrochloride | |
| MY187861A (en) | Method and system for drying biomass | |
| CN106255860B (en) | The controlled nucleation of the pressure difference ice crystal distribution come autocondensation frost is utilized in the refrigerating process of freeze-drying circulation | |
| GB2519321B (en) | Drying apparatus and method of drying material | |
| US20150040420A1 (en) | Controlled nucleation during freezing step of freeze drying cycle using pressure differential water vapor co2 ice crystals | |
| WO2012025378A3 (en) | Method for drying textiles, and dryer | |
| WO2006102176A3 (en) | Process for preparing crystalline form i of olanzapine | |
| WO2009004653A3 (en) | Process for preparing an amorphous form of (2s,3s,5s)-2-(2,6- dimethylphenoxyacetyl)-amino-3-hydroxy-5-(2-(1-tetrahydropyrimid-2-only)-3-methylbutanoyl)-amino-1,6-diphenyl hexane and product thereof | |
| WO2006010742A3 (en) | Domestic refrigerating appliance with an evacuatable storage compartment | |
| KR100246245B1 (en) | Refrigerator-free freeze-drying system | |
| RU2187056C1 (en) | Method of freezing out steam from gas-steam mixture | |
| CN214892196U (en) | Freeze dryer with external hanging device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 08750727 Country of ref document: EP Kind code of ref document: A2 |
|
| NENP | Non-entry into the national phase |
Ref country code: DE |
|
| 32PN | Ep: public notification in the ep bulletin as address of the adressee cannot be established |
Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 14/04/2010) |
|
| 122 | Ep: pct application non-entry in european phase |
Ref document number: 08750727 Country of ref document: EP Kind code of ref document: A2 |