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WO2008145840A3 - Use of 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxidopyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide for the treatment of spinal cord traumas - Google Patents

Use of 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxidopyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide for the treatment of spinal cord traumas Download PDF

Info

Publication number
WO2008145840A3
WO2008145840A3 PCT/FR2008/000533 FR2008000533W WO2008145840A3 WO 2008145840 A3 WO2008145840 A3 WO 2008145840A3 FR 2008000533 W FR2008000533 W FR 2008000533W WO 2008145840 A3 WO2008145840 A3 WO 2008145840A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxidopyridin
cyclopropylmethoxy
carboxamide
dichloro
pyridine
Prior art date
Application number
PCT/FR2008/000533
Other languages
French (fr)
Other versions
WO2008145840A2 (en
Inventor
Philippe Delay-Goyet
Badia Ferzaz
Jocelyne Lolivier
Original Assignee
Sanofi Aventis
Philippe Delay-Goyet
Badia Ferzaz
Jocelyne Lolivier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK08787962.3T priority Critical patent/DK2150253T3/en
Priority to EP08787962A priority patent/EP2150253B1/en
Priority to JP2010503548A priority patent/JP5386477B2/en
Priority to MX2009011285A priority patent/MX2009011285A/en
Priority to SI200830270T priority patent/SI2150253T1/en
Priority to NZ580483A priority patent/NZ580483A/en
Priority to AT08787962T priority patent/ATE503481T1/en
Priority to DE602008005873T priority patent/DE602008005873D1/en
Priority to EA200970969A priority patent/EA015355B1/en
Priority to MEP-2009-298A priority patent/ME00934B/en
Priority to PL08787962T priority patent/PL2150253T3/en
Application filed by Sanofi Aventis, Philippe Delay-Goyet, Badia Ferzaz, Jocelyne Lolivier filed Critical Sanofi Aventis
Priority to CA2684172A priority patent/CA2684172C/en
Priority to AU2008257321A priority patent/AU2008257321B2/en
Priority to CN2008800125419A priority patent/CN101674829B/en
Priority to BRPI0810446-8A2A priority patent/BRPI0810446A2/en
Publication of WO2008145840A2 publication Critical patent/WO2008145840A2/en
Publication of WO2008145840A3 publication Critical patent/WO2008145840A3/en
Priority to US12/573,316 priority patent/US8592443B2/en
Priority to IL201451A priority patent/IL201451A/en
Priority to MA32335A priority patent/MA31369B1/en
Priority to HK10108583.4A priority patent/HK1142000A1/xx
Priority to HR20110459T priority patent/HRP20110459T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

The invention relates to the use of 4-cyclopropylmethoxy-N-(3,5-dichloro-1-oxidopyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide for the preparation of a medicament for use in the treatment of spinal cord traumas.
PCT/FR2008/000533 2007-04-19 2008-04-16 Use of 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxidopyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide for the treatment of spinal cord traumas WO2008145840A2 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
PL08787962T PL2150253T3 (en) 2007-04-19 2008-04-16 Use of 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxidopyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide for the treatment of spinal cord traumas
JP2010503548A JP5386477B2 (en) 2007-04-19 2008-04-16 Use of 4-cyclopropylmethoxy-N- (3,5-dichloro-1-oxidepyridin-4-yl) -5- (methoxy) pyridine-2-carboxamide for treating spinal cord injury
MX2009011285A MX2009011285A (en) 2007-04-19 2008-04-16 Use of 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxidopyridin -4-yl)-5-(methoxy)pyridine-2-carboxamide for the treatment of spinal cord traumas.
SI200830270T SI2150253T1 (en) 2007-04-19 2008-04-16 Use of 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxidopyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide for the treatment of spinal cord traumas
NZ580483A NZ580483A (en) 2007-04-19 2008-04-16 Use of 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxidopyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide for the treatment of spinal cord traumas
AT08787962T ATE503481T1 (en) 2007-04-19 2008-04-16 USE OF 4-CYCLOPROPYLMETHOXY-N-(3,5-DICHLORO-1-OXIDOPYRIDINE-4-YL)-5-(METHOXY)-PYRIDI - 2-CARBOXAMIDE FOR THE TREATMENT OF SPINAL CORD INJURY
CA2684172A CA2684172C (en) 2007-04-19 2008-04-16 Use of 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxidopyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide for the treatment of spinal cord traumas
EP08787962A EP2150253B1 (en) 2007-04-19 2008-04-16 Use of 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxidopyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide for the treatment of spinal cord traumas
MEP-2009-298A ME00934B (en) 2007-04-19 2008-04-16 Use of 4-cyclopropylmethoxy-<i>n</i>-(3,5-dichloro-1-oxidopyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide for the treatment of spinal cord traumas
DK08787962.3T DK2150253T3 (en) 2007-04-19 2008-04-16 Use of 4-cyclopropylmethoxy-N- (3,5-dichloro-1-oxidopyridin-4-yl) -5- (methoxy) pyridine-2-carboxamide for the treatment of spinal cord injury
EA200970969A EA015355B1 (en) 2007-04-19 2008-04-16 Use of 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxidopyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide for the treatment of spinal cord traumas
DE602008005873T DE602008005873D1 (en) 2007-04-19 2008-04-16 USE OF 4-CYCLOPROPYLMETHOXY-N- (3,5-DICHLOR-1-OXIDOPYRIDIN-4-YL) -5- (METHOXY) -PYRIDINE-2-CARBOXAMIDE FOR THE TREATMENT OF BACKBONE INJURIES
AU2008257321A AU2008257321B2 (en) 2007-04-19 2008-04-16 Use of 4-cyclopropylmethoxy-N-(3,5-dichloro-1-oxidopyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide for the treatment of spinal cord traumas
CN2008800125419A CN101674829B (en) 2007-04-19 2008-04-16 4-cyclopropylmethoxy-N-(3,5-dichloro-1-epoxy-pyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide for the treatment of spinal cord trauma the use of
BRPI0810446-8A2A BRPI0810446A2 (en) 2007-04-19 2008-04-16 USE OF 4-CYPROPYLMETOXY-N- (3,5-DICLORO-1-OXIDOPYRIDIN-4-IL) - 5- (METHOD) PYRIDINE-2-CARBOXAMIDE FOR TREATMENT OF SPINAL CORD TRAUMS
US12/573,316 US8592443B2 (en) 2007-04-19 2009-10-05 Use of 4 cyclopropylmethoxy-N-(3,5 dichloro-1 oxido-pyridin-4 yl)-5-(methoxy)pyridine-2-carboxamide for the treatment of spinal cord traumas
IL201451A IL201451A (en) 2007-04-19 2009-10-11 Use of 4 - cyclopropylmethoxy - n - (3, 5 - dichloro - 1 - oxidopyridin - 4 - yl) - 5 - (methoxy) pyridine - 2 - carboxamide for the preparation of a medicament for the treatment of spinal cord traumas
MA32335A MA31369B1 (en) 2007-04-19 2009-11-10 USE OF 4-CYCLOPROPYLMETHOXY-N- (3,5-DICHLORO-1-OXYDO-PYRIDIN-4-YL) -5- (METHOXY) PYRIDINE-2-CARBOXAMIDE FOR THE TREATMENT OF TRAUMATISMS OF SPINAL CORD
HK10108583.4A HK1142000A1 (en) 2007-04-19 2010-09-10
HR20110459T HRP20110459T1 (en) 2007-04-19 2011-06-17 Use of 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxidopyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide for the treatment of spinal cord traumas

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0702851 2007-04-19
FR0702851A FR2915098B1 (en) 2007-04-19 2007-04-19 USE OF 4-CYCLOPROPYLMETHOXY-N- (3,5-DICHLORO-1-OXYDO-PYRIDIN-4-YL) -5- (METHOXY) PYRIDINE-2-CARBOXAMIDE FOR THE TREATMENT OF TRAUMATISMS OF SPINAL CORD

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/573,316 Continuation US8592443B2 (en) 2007-04-19 2009-10-05 Use of 4 cyclopropylmethoxy-N-(3,5 dichloro-1 oxido-pyridin-4 yl)-5-(methoxy)pyridine-2-carboxamide for the treatment of spinal cord traumas

Publications (2)

Publication Number Publication Date
WO2008145840A2 WO2008145840A2 (en) 2008-12-04
WO2008145840A3 true WO2008145840A3 (en) 2009-06-25

Family

ID=38779706

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2008/000533 WO2008145840A2 (en) 2007-04-19 2008-04-16 Use of 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxidopyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide for the treatment of spinal cord traumas

Country Status (33)

Country Link
US (1) US8592443B2 (en)
EP (1) EP2150253B1 (en)
JP (1) JP5386477B2 (en)
KR (1) KR101470043B1 (en)
CN (1) CN101674829B (en)
AR (1) AR066106A1 (en)
AT (1) ATE503481T1 (en)
AU (1) AU2008257321B2 (en)
BR (1) BRPI0810446A2 (en)
CA (1) CA2684172C (en)
CL (1) CL2008001134A1 (en)
CY (1) CY1111779T1 (en)
DE (1) DE602008005873D1 (en)
DK (1) DK2150253T3 (en)
EA (1) EA015355B1 (en)
ES (1) ES2363056T3 (en)
FR (1) FR2915098B1 (en)
HK (1) HK1142000A1 (en)
HR (1) HRP20110459T1 (en)
IL (1) IL201451A (en)
JO (1) JO2662B1 (en)
MA (1) MA31369B1 (en)
ME (1) ME00934B (en)
MX (1) MX2009011285A (en)
MY (1) MY146657A (en)
NZ (1) NZ580483A (en)
PA (1) PA8776601A1 (en)
PL (1) PL2150253T3 (en)
PT (1) PT2150253E (en)
SI (1) SI2150253T1 (en)
TW (1) TWI411435B (en)
UY (1) UY31033A1 (en)
WO (1) WO2008145840A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2915099B1 (en) 2007-04-19 2009-06-05 Sanofi Aventis Sa USE OF 4-CYCLOPROPYLMETHOXY-N- (3,5-DICHLORO-1-OXYDO-PYRIDIN-4-YL) -5- (METHOXY) PYRIDINE-2-CARBOXAMIDE FOR THE TREATMENT OF CRANIAL TRAUMATISM
RU2635094C2 (en) * 2012-11-28 2017-11-09 Санофи Method for production of 4-(cyclopropylmethoxy)-n-(3,5-dichloro-1-oxide-4-pyridyl)-5-methoxypyridine-2-carboxamide
KR20150087252A (en) * 2012-11-28 2015-07-29 사노피 METHOD OF PREPARATION OF CRYSTAL FORMS OF 4-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLORO-1-OXIDOPYRIDYN-4-yl)-5-METHOXYPYRIDINE-2-CARBOXAMIDE AND CRISTAL FORMS THEREOF
EP4281065A1 (en) 2021-01-20 2023-11-29 Alto Neuroscience, Inc. Enhancement of camp signaling as a combination drug strategy for the treatment of depression and related conditions
WO2025079694A1 (en) * 2023-10-12 2025-04-17 株式会社 メドレックス Percutaneous absorption composition

Citations (3)

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WO1995004045A1 (en) * 1993-07-28 1995-02-09 Rhone-Poulenc Rorer Limited Compounds as pde iv and tnf inhibitors
GB2406856A (en) * 2003-10-07 2005-04-13 Renovis Inc Novel amide compounds as ion channel ligands and uses thereof
US20070021451A1 (en) * 2005-07-20 2007-01-25 Hamamatsu University School Of Medicine Method for preventing or treating neurologic damage after spinal cord injury

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US4193926A (en) * 1974-03-20 1980-03-18 Schering Aktiengesellschaft 4-(Polyalkoxy phenyl)-2-pyrrolidones
GB9401460D0 (en) 1994-01-26 1994-03-23 Rhone Poulenc Rorer Ltd Compositions of matter
GB9507297D0 (en) 1995-04-07 1995-05-31 Rh Ne Poulenc Rorer Limited New composition of matter
US6196968B1 (en) 1997-06-02 2001-03-06 General Surgical Innovations, Inc. Direct vision subcutaneous tissue retractor and method for use
US6177077B1 (en) * 1999-02-24 2001-01-23 Edward L. Tobinick TNT inhibitors for the treatment of neurological disorders
CN1230433C (en) * 1999-12-23 2005-12-07 艾科斯有限公司 Cyclic AMP-specific phosphodiesterase inhibitors
CA2439691A1 (en) 2001-03-02 2002-09-12 Bristol-Myers Squibb Company Co-administration of melanocortin receptor agonist and phosphodiesterase inhibitor for treatment of cyclic-amp associated disorders
CA2490097A1 (en) 2002-07-02 2004-01-15 Merck Frosst Canada & Co. Di-aryl-substituted-ethane pyridone pde4 inhibitors
WO2004067006A1 (en) 2003-01-27 2004-08-12 Pharmacia Corporation Combination of a pde iv inhibitor and a tnf-alpha antagonist
EP1888528A2 (en) * 2005-06-10 2008-02-20 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors

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Publication number Priority date Publication date Assignee Title
WO1995004045A1 (en) * 1993-07-28 1995-02-09 Rhone-Poulenc Rorer Limited Compounds as pde iv and tnf inhibitors
GB2406856A (en) * 2003-10-07 2005-04-13 Renovis Inc Novel amide compounds as ion channel ligands and uses thereof
US20070021451A1 (en) * 2005-07-20 2007-01-25 Hamamatsu University School Of Medicine Method for preventing or treating neurologic damage after spinal cord injury

Non-Patent Citations (1)

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NIKULINA E ET AL: "The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 08 JUN 2004 UNITED STATES, vol. 101, no. 23, 8 June 2004 (2004-06-08), pages 8786 - 8790, XP007903694, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
EA200970969A1 (en) 2010-02-26
MA31369B1 (en) 2010-05-03
AU2008257321B2 (en) 2013-08-15
EA015355B1 (en) 2011-06-30
EP2150253A2 (en) 2010-02-10
HRP20110459T1 (en) 2011-07-31
EP2150253B1 (en) 2011-03-30
BRPI0810446A2 (en) 2014-10-14
SI2150253T1 (en) 2011-07-29
HK1142000A1 (en) 2010-11-26
FR2915098A1 (en) 2008-10-24
AR066106A1 (en) 2009-07-22
CA2684172A1 (en) 2008-12-04
KR20090130063A (en) 2009-12-17
JP5386477B2 (en) 2014-01-15
MX2009011285A (en) 2009-11-02
DE602008005873D1 (en) 2011-05-12
PL2150253T3 (en) 2011-08-31
ATE503481T1 (en) 2011-04-15
MY146657A (en) 2012-09-14
PT2150253E (en) 2011-06-17
IL201451A0 (en) 2010-05-31
UY31033A1 (en) 2008-11-28
JP2010524905A (en) 2010-07-22
US20100137370A1 (en) 2010-06-03
TW200911248A (en) 2009-03-16
TWI411435B (en) 2013-10-11
CN101674829B (en) 2012-01-18
CA2684172C (en) 2015-10-27
CN101674829A (en) 2010-03-17
AU2008257321A1 (en) 2008-12-04
FR2915098B1 (en) 2009-06-05
DK2150253T3 (en) 2011-07-25
PA8776601A1 (en) 2008-11-19
CL2008001134A1 (en) 2009-01-16
ES2363056T3 (en) 2011-07-19
CY1111779T1 (en) 2015-10-07
ME00934B (en) 2012-06-20
KR101470043B1 (en) 2014-12-05
NZ580483A (en) 2011-06-30
WO2008145840A2 (en) 2008-12-04
US8592443B2 (en) 2013-11-26
JO2662B1 (en) 2012-06-17
IL201451A (en) 2013-04-30

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