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WO2008144690A3 - Compositions et procédés d'amélioration de l'absorption d'agents actifs - Google Patents

Compositions et procédés d'amélioration de l'absorption d'agents actifs Download PDF

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Publication number
WO2008144690A3
WO2008144690A3 PCT/US2008/064233 US2008064233W WO2008144690A3 WO 2008144690 A3 WO2008144690 A3 WO 2008144690A3 US 2008064233 W US2008064233 W US 2008064233W WO 2008144690 A3 WO2008144690 A3 WO 2008144690A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
active agent
agent absorption
enhancing active
Prior art date
Application number
PCT/US2008/064233
Other languages
English (en)
Other versions
WO2008144690A2 (fr
Inventor
Chung Shih
Original Assignee
Nexus Pharma Inc
Chung Shih
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/805,202 external-priority patent/US8426466B2/en
Application filed by Nexus Pharma Inc, Chung Shih filed Critical Nexus Pharma Inc
Priority to EP08755962.1A priority Critical patent/EP2150243A4/fr
Publication of WO2008144690A2 publication Critical patent/WO2008144690A2/fr
Publication of WO2008144690A3 publication Critical patent/WO2008144690A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des compositions et procédés d'amélioration de l'absorption d'agents actifs à travers la muqueuse de sujets animaux. Des compositions ayant des liaisons biodégradables sont incluses, conférant une diminution de probabilité de toxicité. L'invention concerne également des procédés d'utilisation et des formes galéniques appropriées.
PCT/US2008/064233 2007-05-21 2008-05-20 Compositions et procédés d'amélioration de l'absorption d'agents actifs WO2008144690A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08755962.1A EP2150243A4 (fr) 2007-05-21 2008-05-20 Compositions et procédés d'amélioration de l'absorption d'agents actifs

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/805,202 2007-05-21
US11/805,202 US8426466B2 (en) 2006-05-22 2007-05-21 Compositions and methods for enhancing active agent absorption
US409907P 2007-11-21 2007-11-21
US61/004,099 2007-11-21

Publications (2)

Publication Number Publication Date
WO2008144690A2 WO2008144690A2 (fr) 2008-11-27
WO2008144690A3 true WO2008144690A3 (fr) 2009-02-26

Family

ID=40122287

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/064233 WO2008144690A2 (fr) 2007-05-21 2008-05-20 Compositions et procédés d'amélioration de l'absorption d'agents actifs

Country Status (2)

Country Link
EP (1) EP2150243A4 (fr)
WO (1) WO2008144690A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103384534B (zh) * 2011-02-25 2015-09-30 隆萨有限公司 用于蛋白质药物偶联物的支链联接体
US9796962B2 (en) 2013-08-07 2017-10-24 Kyoto University Method for generating pancreatic hormone-producing cells

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817624A (en) * 1995-06-05 1998-10-06 Alza Corporation Permeation enhancer compositions for increased absorption of therapeutic proteins through the colonic membrane
WO2001054514A1 (fr) * 2000-01-27 2001-08-02 Aqua Solution Inc. Composition pour administration intestinale
WO2003057170A2 (fr) * 2002-01-07 2003-07-17 Emisphere Technologies, Inc. Insulinotherapie par voie orale
CN1857727A (zh) * 2006-03-13 2006-11-08 新疆维吾尔自治区畜牧科学院兽医研究所 动物皮肤渗透剂

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773647A (en) 1997-02-07 1998-06-30 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817624A (en) * 1995-06-05 1998-10-06 Alza Corporation Permeation enhancer compositions for increased absorption of therapeutic proteins through the colonic membrane
WO2001054514A1 (fr) * 2000-01-27 2001-08-02 Aqua Solution Inc. Composition pour administration intestinale
WO2003057170A2 (fr) * 2002-01-07 2003-07-17 Emisphere Technologies, Inc. Insulinotherapie par voie orale
CN1857727A (zh) * 2006-03-13 2006-11-08 新疆维吾尔自治区畜牧科学院兽医研究所 动物皮肤渗透剂

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MENG, B. ET AL.: "Hypoglycemic effect of insulin W/O microemulsions following intestinal administration to rats.", ZHONGGUO YAOKE DAXUE XUEBAO., vol. 37, no. 4, 2006, pages 304 - 307, ISSN: 1000-5048 *
See also references of EP2150243A4 *

Also Published As

Publication number Publication date
WO2008144690A2 (fr) 2008-11-27
EP2150243A2 (fr) 2010-02-10
EP2150243A4 (fr) 2013-08-21

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