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WO2008141511A8 - A HUMAN ANTI-TNFα MONOCLONAL ANTIBODY AND THE USE THEREOF - Google Patents

A HUMAN ANTI-TNFα MONOCLONAL ANTIBODY AND THE USE THEREOF Download PDF

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Publication number
WO2008141511A8
WO2008141511A8 PCT/CN2007/070044 CN2007070044W WO2008141511A8 WO 2008141511 A8 WO2008141511 A8 WO 2008141511A8 CN 2007070044 W CN2007070044 W CN 2007070044W WO 2008141511 A8 WO2008141511 A8 WO 2008141511A8
Authority
WO
WIPO (PCT)
Prior art keywords
tnfα
antibody
human anti
human
monoclonal antibody
Prior art date
Application number
PCT/CN2007/070044
Other languages
French (fr)
Chinese (zh)
Other versions
WO2008141511A1 (en
Inventor
Qingfa Liu
Original Assignee
Human Antibodomics Shanghai In
Qingfa Liu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Antibodomics Shanghai In, Qingfa Liu filed Critical Human Antibodomics Shanghai In
Priority to PCT/CN2007/070044 priority Critical patent/WO2008141511A1/en
Publication of WO2008141511A1 publication Critical patent/WO2008141511A1/en
Publication of WO2008141511A8 publication Critical patent/WO2008141511A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A protein specifically binding to human TNFα (tumor necrosis factor α) is disclosed, i.e. human anti-TNFα monoclonal antibody derived from human B cells. The light and heavy chain of the antibody have the amino acid sequence as shown in SEQ ID NO: 3 and SEQ ID NO: 4, respectively. Also disclosed are the encoded sequences of the human anti- TNFα antibody, its Fab antibody and the peglated Fab antibody. The present invention further provides the uses of the antibodies in the preparation of the medicament for treatment of TNFα-related inflammation.
PCT/CN2007/070044 2007-05-22 2007-05-22 A HUMAN ANTI-TNFα MONOCLONAL ANTIBODY AND THE USE THEREOF WO2008141511A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2007/070044 WO2008141511A1 (en) 2007-05-22 2007-05-22 A HUMAN ANTI-TNFα MONOCLONAL ANTIBODY AND THE USE THEREOF

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2007/070044 WO2008141511A1 (en) 2007-05-22 2007-05-22 A HUMAN ANTI-TNFα MONOCLONAL ANTIBODY AND THE USE THEREOF

Publications (2)

Publication Number Publication Date
WO2008141511A1 WO2008141511A1 (en) 2008-11-27
WO2008141511A8 true WO2008141511A8 (en) 2009-07-09

Family

ID=40031397

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2007/070044 WO2008141511A1 (en) 2007-05-22 2007-05-22 A HUMAN ANTI-TNFα MONOCLONAL ANTIBODY AND THE USE THEREOF

Country Status (1)

Country Link
WO (1) WO2008141511A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101896502B (en) 2009-03-20 2012-10-17 刘庆法 Anti-human TNFα monoclonal antibody, molecular evolution and its application
CN102167741B (en) * 2010-02-25 2014-05-14 上海百迈博制药有限公司 A fully human anti-TNF-α monoclonal antibody, its preparation method and use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040136989A1 (en) * 2002-07-19 2004-07-15 Abbott Laboratories S.A. Treatment of vasculitides using TNFalpha inhibitors
EP1578799B8 (en) * 2002-12-02 2011-03-23 Amgen Fremont Inc. Antibodies directed to tumor necrosis factor and uses thereof
CN100393748C (en) * 2003-11-06 2008-06-11 上海中信国健药业有限公司 Human tumour necrosin antibody, its preparation and medicinal composition
KR100772800B1 (en) * 2003-11-17 2007-11-01 주식회사유한양행 Variable regions of monoclonal antibodies that recognize human tumor necrosis factor α and genes encoding them
CN101111521B (en) * 2004-12-29 2011-08-24 株式会社柳韩洋行 Tumor necrosis factor-α specific humanized antibody

Also Published As

Publication number Publication date
WO2008141511A1 (en) 2008-11-27

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