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WO2008140251A3 - Inhibiteurs de la cyclooxygénase-2 - Google Patents

Inhibiteurs de la cyclooxygénase-2 Download PDF

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Publication number
WO2008140251A3
WO2008140251A3 PCT/KR2008/002677 KR2008002677W WO2008140251A3 WO 2008140251 A3 WO2008140251 A3 WO 2008140251A3 KR 2008002677 W KR2008002677 W KR 2008002677W WO 2008140251 A3 WO2008140251 A3 WO 2008140251A3
Authority
WO
WIPO (PCT)
Prior art keywords
disorder
cyclooxygenase
inhibitors
5dione
cox
Prior art date
Application number
PCT/KR2008/002677
Other languages
English (en)
Other versions
WO2008140251A2 (fr
Inventor
Jae Yeol Lee
Dong Joon Choo
Kyung Tae Lee
Jong Taik Moon
Ji Young Jeon
Original Assignee
Univ Kyung Hee Univ Ind Coop Group
Jae Yeol Lee
Dong Joon Choo
Kyung Tae Lee
Jong Taik Moon
Ji Young Jeon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020080014364A external-priority patent/KR100989141B1/ko
Application filed by Univ Kyung Hee Univ Ind Coop Group, Jae Yeol Lee, Dong Joon Choo, Kyung Tae Lee, Jong Taik Moon, Ji Young Jeon filed Critical Univ Kyung Hee Univ Ind Coop Group
Publication of WO2008140251A2 publication Critical patent/WO2008140251A2/fr
Publication of WO2008140251A3 publication Critical patent/WO2008140251A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention porte sur des dérivées du IH-pyrrole ou du furan-2,5dione et sur une composition pharmaceutique inhibitrice de la cyclooxygénase-2 (COX-2), et plus spécifiquement sur une telle composition traitant ou prévenant l'inflammation, les troubles allergiques, la dermatose inflammatoire, les troubles immunologiques, les troubles neurodégénératifs, l'arthrite, la douleur ou la fièvre.
PCT/KR2008/002677 2007-05-14 2008-05-14 Inhibiteurs de la cyclooxygénase-2 WO2008140251A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2007-0046489 2007-05-14
KR20070046489 2007-05-14
KR10-2008-0014364 2008-02-18
KR1020080014364A KR100989141B1 (ko) 2007-05-14 2008-02-18 시클로옥시게나제-2 저해제

Publications (2)

Publication Number Publication Date
WO2008140251A2 WO2008140251A2 (fr) 2008-11-20
WO2008140251A3 true WO2008140251A3 (fr) 2009-01-15

Family

ID=40002753

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2008/002677 WO2008140251A2 (fr) 2007-05-14 2008-05-14 Inhibiteurs de la cyclooxygénase-2

Country Status (1)

Country Link
WO (1) WO2008140251A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101429181A (zh) * 2008-12-18 2009-05-13 毛近隆 对羟基苯丙烯酸衍生物及其应用
CN101538256B (zh) * 2009-04-28 2014-05-21 沈阳药科大学 3，4-二芳基呋喃-2，5-二酮类衍生物与3，4-二芳基-1h-吡咯-2，5-二酮类衍生物及其用途
CN103951594B (zh) * 2009-12-18 2015-04-22 山东中医药大学 一种中药活性成分阿魏酸的衍生物、合成及其应用
JP2013014534A (ja) * 2011-07-04 2013-01-24 Daicel Corp ベンゾイルギ酸化合物、及びその製造方法
CN103804108B (zh) * 2012-11-15 2016-08-03 沈阳药科大学 一种制备伯胺的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996013483A1 (fr) * 1994-10-27 1996-05-09 Merck Frosst Canada Inc. Derives de stilbene utilisables comme inhibiteurs de la cyclo-oxygenase 2
US5648373A (en) * 1992-02-11 1997-07-15 Smithkline Beecham Corporation CoA-IT and PAF inhibitors
WO1998041521A1 (fr) * 1997-03-19 1998-09-24 Merck Patent Gmbh Antagonistes des recepteurs d'endotheline
WO2003039539A2 (fr) * 2001-11-09 2003-05-15 Merck Patent Gmbh Utilisation d'antagonistes du recepteur de l'endotheline dans le traitement de maladies tumorales

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648373A (en) * 1992-02-11 1997-07-15 Smithkline Beecham Corporation CoA-IT and PAF inhibitors
WO1996013483A1 (fr) * 1994-10-27 1996-05-09 Merck Frosst Canada Inc. Derives de stilbene utilisables comme inhibiteurs de la cyclo-oxygenase 2
WO1998041521A1 (fr) * 1997-03-19 1998-09-24 Merck Patent Gmbh Antagonistes des recepteurs d'endotheline
WO2003039539A2 (fr) * 2001-11-09 2003-05-15 Merck Patent Gmbh Utilisation d'antagonistes du recepteur de l'endotheline dans le traitement de maladies tumorales

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
KALGUTKAR A.S. ET AL.: "Design, Synthesis and Biochemical Evaluation of N-Substituted Maleimides as Inhibitors of Prostaglandin Endoperoxide Synthases", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, no. 4, 2006, pages 1271 - 1281 *
KRISHNA REDDY K.V.S.R. ET AL.: "Isolation and characterization of process-related impurities in rofecoxib", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 29, no. 1-2, 2002, pages 355 - 360 *
PEIFER C. ET AL.: "Design, Synthesis, and Biological Evaluation of 3,4-Diarylmaleimides as Angiogenesis Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, no. 4, 2006, pages 1271 - 1281, XP002660940, DOI: doi:10.1021/JM0580297 *
REDDY L.R. AND COREY E.J.: "Facile air oxidation of the conjugate base of rofecoxib (Vioxx), a possible contrubutor to chronic human toxicity", TETRAHEDRON LETTERS, vol. 46, 2005, pages 927 - 929 *
SMITH P.A.S. ET AL.: "The Chemistry of 3-(alpha-Cyanobenzylidene)-1-phenyltriazenes and Their Conversion to Diarylmaleimides and Phenanthrene-9,10-dicarboximides", JOURNAL OF ORGANIC CHEMISTRY, vol. 55, no. 10, 1990, pages 3351 - 3362, XP002507240, DOI: doi:10.1021/jo00297a066 *
TATTABIRAMAN V.R. ET AL.: "Synthesis of 3,4-diaryl-substituted maleic anhydrides/maleimides via unusal oxidative cyclization of phenacyl esters/amides", SYNLETT., vol. 6, 2002, pages 947 - 951 *

Also Published As

Publication number Publication date
WO2008140251A2 (fr) 2008-11-20

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