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WO2008037366A3 - Solid state forms ab of acetyl salicylic acid - Google Patents

Solid state forms ab of acetyl salicylic acid Download PDF

Info

Publication number
WO2008037366A3
WO2008037366A3 PCT/EP2007/008054 EP2007008054W WO2008037366A3 WO 2008037366 A3 WO2008037366 A3 WO 2008037366A3 EP 2007008054 W EP2007008054 W EP 2007008054W WO 2008037366 A3 WO2008037366 A3 WO 2008037366A3
Authority
WO
WIPO (PCT)
Prior art keywords
salicylic acid
solid state
acetyl salicylic
state forms
formulation
Prior art date
Application number
PCT/EP2007/008054
Other languages
French (fr)
Other versions
WO2008037366A2 (en
Inventor
Roland Boese
Andrew D Bond
Gautam R Desiraju
Sascha Redder
Original Assignee
Sciconcept Gmbh
Roland Boese
Andrew D Bond
Gautam R Desiraju
Sascha Redder
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE200610045780 external-priority patent/DE102006045780A1/en
Application filed by Sciconcept Gmbh, Roland Boese, Andrew D Bond, Gautam R Desiraju, Sascha Redder filed Critical Sciconcept Gmbh
Publication of WO2008037366A2 publication Critical patent/WO2008037366A2/en
Publication of WO2008037366A3 publication Critical patent/WO2008037366A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/14—Acetic acid esters of monohydroxylic compounds
    • C07C69/145—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
    • C07C69/157—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols containing six-membered aromatic rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3563—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor
    • G01N2021/3572—Preparation of samples, e.g. salt matrices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3581—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared light; using Terahertz radiation
    • G01N21/3586—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared light; using Terahertz radiation by Terahertz time domain spectroscopy [THz-TDS]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a new form of acetyl salicylic acid designated as Form AB as well as processes for their preparation and formulation comprising it. Also, the invention relates to solid state forms of acetyl salicylic acid Form AB, in particular Form AB-A, as well as processes for their preparation and formulation comprising them.
PCT/EP2007/008054 2006-09-26 2007-09-17 Solid state forms ab of acetyl salicylic acid WO2008037366A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102006045780.3 2006-09-26
DE200610045780 DE102006045780A1 (en) 2006-09-26 2006-09-26 Mixed crystals of Form I and Form II of acetylsalicylic acid
EPPCT/EP2006/010698 2006-11-08
PCT/EP2006/010698 WO2008037289A1 (en) 2006-09-26 2006-11-08 Form ab of acetyl salicyclic acid

Publications (2)

Publication Number Publication Date
WO2008037366A2 WO2008037366A2 (en) 2008-04-03
WO2008037366A3 true WO2008037366A3 (en) 2008-09-12

Family

ID=38963121

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/008054 WO2008037366A2 (en) 2006-09-26 2007-09-17 Solid state forms ab of acetyl salicylic acid

Country Status (1)

Country Link
WO (1) WO2008037366A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4509497A1 (en) 2023-08-17 2025-02-19 Ruhr-Universität Bochum Method for producing acetylsalicylic acid nicotinamide cocrystals and acetylsalicylic acid nicotinamide cocrystals with improved solubility

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BOND, ANDREW D. ET AL: "On the polymorphism of aspirin: crystalline aspirin as intergrowths of two "polymorphic" domains", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 46, no. 4, 2007, pages 618 - 622, XP002438564 *
BOND, ANDREW D. ET AL: "On the polymorphism of aspirin: crystalline aspirin as intergrowths of two "polymorphic" domains", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 46, no. 4, 2007, pages S1 - S12, XP002438565 *
BUNDGAARD, HANS: "Influence of an acetylsalicylic anhydride impurity on the rate of dissolution of acetylsalicylic acid", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 26, no. 7, 1974, pages 535 - 540, XP009101555 *
JERSLEV, BODIL ET AL: "Organic solid-phase analysis. I. On the alleged polymorphism of acetylsalicylic acid", ARCHIV FOR PHARMACI OG CHEMI, SCIENTIFIC EDITION, vol. 9, no. 2-3, 1981, pages 61 - 69, XP009101556 *
KOLEVA ET AL: "Polymorphs of Aspirin - Solid-state IR-LD spectroscopic and quantitative determination in solid mixtures", JOURNAL OF MOLECULAR STRUCTURE, ELSEVIER, AMSTERDAM, NL, vol. 800, no. 1-3, 10 November 2006 (2006-11-10), pages 23 - 27, XP005758520, ISSN: 0022-2860 *
P. MANICKE ET AL.: "Zur Darstellung der Acetylsalicylsäure, des Acetanilids und des p-Acetphenetidins", ARCH. PHARM., 1926, pages 322 - 324, XP002484512 *
VISHWESHWAR, PEDDY ET AL: "The Predictably Elusive Form II of Aspirin", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 127, no. 48, 2005, pages 16802 - 16803, XP002438562 *
VISHWESHWAR, PEDDY ET AL: "The Predictably Elusive Form II of Aspirin", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 127, no. 48, 2005, pages S1 - S6, XP002438563 *

Also Published As

Publication number Publication date
WO2008037366A2 (en) 2008-04-03

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