WO2008033990A3 - Compositions and methods for modulating the notch signal transduction pathway - Google Patents
Compositions and methods for modulating the notch signal transduction pathway Download PDFInfo
- Publication number
- WO2008033990A3 WO2008033990A3 PCT/US2007/078375 US2007078375W WO2008033990A3 WO 2008033990 A3 WO2008033990 A3 WO 2008033990A3 US 2007078375 W US2007078375 W US 2007078375W WO 2008033990 A3 WO2008033990 A3 WO 2008033990A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- signal transduction
- p180nack
- polypeptide
- methods
- modulating
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000019491 signal transduction Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 102000005650 Notch Receptors Human genes 0.000 abstract 3
- 108010070047 Notch Receptors Proteins 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The present invention relates to a p180NACK polypeptide which binds to Notch and modulates Notch-mediated signal transduction. Nucleic acid molecules encoding the p180NACK polypeptide, antibodies that selectively bind the p180NACK polypeptide, and iRNA molecules which inhibit the expression of the p180NACK polypeptide are provided, as are methods for identifying agents which modulate the expression or activity of the p180NACK polypeptide. A method for modulating Notch-mediated signal transduction using agents of the invention is also provided.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82577306P | 2006-09-15 | 2006-09-15 | |
| US60/825,773 | 2006-09-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2008033990A2 WO2008033990A2 (en) | 2008-03-20 |
| WO2008033990A3 true WO2008033990A3 (en) | 2008-11-06 |
Family
ID=39184584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2007/078375 WO2008033990A2 (en) | 2006-09-15 | 2007-09-13 | Compositions and methods for modulating the notch signal transduction pathway |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2008033990A2 (en) |
-
2007
- 2007-09-13 WO PCT/US2007/078375 patent/WO2008033990A2/en active Application Filing
Non-Patent Citations (3)
| Title |
|---|
| "Glycine-Glutamine bioactive peptide", SIGMA CHEMICAL 1993 CATALOG, pages 1089 * |
| DATABASE GENBANK [online] September 2006 (2006-09-01), CARCINI ET AL.: "Unnamed Protein Product", Database accession no. (BAC29528) * |
| TANAKA ET AL.: "Pragmin, a Novel Effector of Rnd2 GTPase, Stimulates RhoA Activity", J. BIOL. CHEM., vol. 281, 2006, pages 10355 - 10364, XP002501195 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008033990A2 (en) | 2008-03-20 |
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