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WO2008028060A3 - Composés antitumoraux servant à inhiber le développement du cancer - Google Patents

Composés antitumoraux servant à inhiber le développement du cancer Download PDF

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Publication number
WO2008028060A3
WO2008028060A3 PCT/US2007/077273 US2007077273W WO2008028060A3 WO 2008028060 A3 WO2008028060 A3 WO 2008028060A3 US 2007077273 W US2007077273 W US 2007077273W WO 2008028060 A3 WO2008028060 A3 WO 2008028060A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
triterpenoidal
groups
triterpenoid
sapongenin
Prior art date
Application number
PCT/US2007/077273
Other languages
English (en)
Other versions
WO2008028060A2 (fr
WO2008028060B1 (fr
WO2008028060A9 (fr
Inventor
Pui-Kwong Chan
May Sung Mak
Original Assignee
Pacific Arrow Ltd
Pui-Kwong Chan
May Sung Mak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacific Arrow Ltd, Pui-Kwong Chan, May Sung Mak filed Critical Pacific Arrow Ltd
Priority to CN200780040744.4A priority Critical patent/CN101553497B/zh
Priority to EP07841638A priority patent/EP2061798A4/fr
Priority to PCT/US2008/002086 priority patent/WO2008133766A1/fr
Priority to EP08725693A priority patent/EP2121715A4/fr
Priority to JP2009550096A priority patent/JP2010519219A/ja
Priority to AU2008244648A priority patent/AU2008244648A1/en
Priority to SG2012011029A priority patent/SG178795A1/en
Priority to CN200880012065A priority patent/CN101772511A/zh
Priority to CA002676791A priority patent/CA2676791A1/fr
Publication of WO2008028060A2 publication Critical patent/WO2008028060A2/fr
Publication of WO2008028060A9 publication Critical patent/WO2008028060A9/fr
Publication of WO2008028060A3 publication Critical patent/WO2008028060A3/fr
Publication of WO2008028060B1 publication Critical patent/WO2008028060B1/fr
Priority to AU2009200988A priority patent/AU2009200988B2/en
Priority to US12/856,322 priority patent/US8586719B2/en
Priority to US13/841,053 priority patent/US9382285B2/en
Priority to US15/181,631 priority patent/US10213451B2/en
Priority to US16/285,634 priority patent/US11046724B2/en
Priority to US17/362,028 priority patent/US20220024961A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne une méthode visant à traiter le cancer en bloquant la migration, la métastase de cellules cancéreuses ou le développement de cancers tels que le cancer du sein, le cancer des leucocytes, le cancer du foie, le cancer des ovaires, le cancer de la vessie, le cancer de la prostate, le cancer de la peau, le cancer des os, le cancer du cerveau, la leucémie, le cancer du poumon, le cancer du côlon, le cancer du système nerveux central, le mélanome, le cancer du rein ou le cancer de l'utérus. Cette invention concerne également des utilisations de compositions renfermant une saponine triterpénoïdale, un triterpénoïde, un composé triterpénoïdal ou une sapongénine, contenant au moins deux groupes latéraux sélectionnés dans le groupe comprenant des groupes angéloyle, des groupes tigloyle et des groupes sénécioyle, lesdits groupes latéraux étant fixés au carbone 21, 22 et/ou 28 d'une saponine triterpénoïdale, d'un triterpénoïde, d'un composé triterpénoïdal ou d'autres squelettes de sapongénine.
PCT/US2007/077273 2003-10-09 2007-08-30 Composés antitumoraux servant à inhiber le développement du cancer WO2008028060A2 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
CN200780040744.4A CN101553497B (zh) 2006-09-01 2007-08-30 能抑止癌细胞生长的抗肿瘤化合物
EP07841638A EP2061798A4 (fr) 2006-09-01 2007-08-30 Composés antitumoraux servant à inhiber le développement du cancer
CA002676791A CA2676791A1 (fr) 2007-02-16 2008-02-15 Blocage de la migration ou de la metastase des cellules cancereuses par la modification de proteines d'adhesion et utilisations de nouveaux composes associes
EP08725693A EP2121715A4 (fr) 2007-02-16 2008-02-15 Blocage de la migration ou de la metastase des cellules cancereuses par la modification de proteines d'adhesion et utilisations de nouveaux composes associes
JP2009550096A JP2010519219A (ja) 2007-02-16 2008-02-15 接着タンパク質に影響を及ぼすことによる癌細胞の移動または転移の遮断およびその新規化合物の使用
PCT/US2008/002086 WO2008133766A1 (fr) 2007-02-16 2008-02-15 Blocage de la migration ou de la metastase des cellules cancereuses par la modification de proteines d'adhesion et utilisations de nouveaux composes associes
AU2008244648A AU2008244648A1 (en) 2007-02-16 2008-02-15 Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
SG2012011029A SG178795A1 (en) 2007-02-16 2008-02-15 Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
CN200880012065A CN101772511A (zh) 2007-02-16 2008-02-15 通过影响粘连蛋白质表达阻止癌细胞的转移和新化合物及其应用
AU2009200988A AU2009200988B2 (en) 2003-10-09 2009-03-10 Anti-tumor compounds for inhibiting cancer growth
US12/856,322 US8586719B2 (en) 2005-04-27 2010-08-13 Triterpenes for modulating gene expression and cell membrane, and as antiprotozoal agents
US13/841,053 US9382285B2 (en) 2004-09-07 2013-03-15 Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells
US15/181,631 US10213451B2 (en) 2004-09-07 2016-06-14 Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells
US16/285,634 US11046724B2 (en) 2004-09-07 2019-02-26 Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells
US17/362,028 US20220024961A1 (en) 2004-09-07 2021-06-29 Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84172706P 2006-09-01 2006-09-01
US60/841,727 2006-09-01
US89038007P 2007-02-16 2007-02-16
US60/890,380 2007-02-16

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2006/016158 Continuation-In-Part WO2006116656A2 (fr) 2003-10-09 2006-04-27 Composition contenant des saponines triterpeniques et des composes a groupes fonctionnels angeloyle destinee a inhiber l'insuffisance veineuse, le gonflement des jambes et les tumeurs
US11/683,198 Continuation-In-Part US8614197B2 (en) 2003-10-09 2007-03-07 Anti-tumor compounds with angeloyl groups

Related Child Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2008/002086 Continuation-In-Part WO2008133766A1 (fr) 2004-09-07 2008-02-15 Blocage de la migration ou de la metastase des cellules cancereuses par la modification de proteines d'adhesion et utilisations de nouveaux composes associes
AU2009200988A Division AU2009200988B2 (en) 2003-10-09 2009-03-10 Anti-tumor compounds for inhibiting cancer growth

Publications (4)

Publication Number Publication Date
WO2008028060A2 WO2008028060A2 (fr) 2008-03-06
WO2008028060A9 WO2008028060A9 (fr) 2008-07-17
WO2008028060A3 true WO2008028060A3 (fr) 2008-10-23
WO2008028060B1 WO2008028060B1 (fr) 2008-11-20

Family

ID=39136898

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/077273 WO2008028060A2 (fr) 2003-10-09 2007-08-30 Composés antitumoraux servant à inhiber le développement du cancer

Country Status (3)

Country Link
EP (1) EP2061798A4 (fr)
CN (1) CN101553497B (fr)
WO (1) WO2008028060A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524824B2 (en) 2003-09-04 2009-04-28 Pacific Arrow Limited Composition comprising Xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof
US7727561B2 (en) 2001-08-31 2010-06-01 Pacific Arrow Limited Composition comprising Xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof
US7488753B2 (en) 2003-10-09 2009-02-10 Pacific Arrow Limited Composition comprising triterpene saponins and compounds with angeloyl functional group, methods for preparing same and uses thereof
US8614197B2 (en) 2003-10-09 2013-12-24 Pacific Arrow Limited Anti-tumor compounds with angeloyl groups
US7514412B2 (en) 2003-10-09 2009-04-07 Pacific Arrow Limited Anticancer biangeloyl saponins
US9382285B2 (en) 2004-09-07 2016-07-05 Pacific Arrow Limited Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells
US8735558B2 (en) 2005-02-14 2014-05-27 Pacific Arrow Limited Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
US8586719B2 (en) 2005-04-27 2013-11-19 Pacific Arrow Limited Triterpenes for modulating gene expression and cell membrane, and as antiprotozoal agents
JP2010519219A (ja) * 2007-02-16 2010-06-03 パシフィック アロー リミテッド 接着タンパク質に影響を及ぼすことによる癌細胞の移動または転移の遮断およびその新規化合物の使用
US9499577B2 (en) 2009-07-16 2016-11-22 Pacific Arrow Limited Natural and synthetic compounds for treating cancer and other diseases
US20120277308A1 (en) 2010-07-16 2012-11-01 Pacific Arrow Limited compounds for treating cancer and other diseases
US9434677B2 (en) 2009-07-16 2016-09-06 Pacific Arrow Limited Natural and synthetic compounds for treating cancer and other diseases
CN114671923B (zh) * 2010-07-16 2025-02-11 太平洋艾瑞有限公司 可治疗癌症和其它疾病的新化合物
EP3061765B1 (fr) 2015-02-27 2018-01-31 Warszawski Uniwersytet Medyczny Dérivé de protoescigénine, son procédé de préparation, utilisation de ce composé et composition pharmaceutique comprenant ledit composé

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003037200A2 (fr) * 2001-10-31 2003-05-08 Centerpulse Spine-Tech, Inc. Connecteurs en tandem reglables destines a des dispositifs de correction de la colonne vertebrale et d'autres os et articulations
US6616943B2 (en) * 2001-08-31 2003-09-09 Fountain Silver Limited Composition comprising Wenguanguo extracts and methods for preparing same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4815558B2 (ja) * 2003-10-09 2011-11-16 パシフィック アロー リミテッド Ｘａｎｔｈｏｃｅｒａｓｓｏｒｂｉｆｏｌｉａ抽出物を含む組成物、該抽出物から単離された化合物、それらを調製する方法、およびそれらの使用
US7488753B2 (en) * 2003-10-09 2009-02-10 Pacific Arrow Limited Composition comprising triterpene saponins and compounds with angeloyl functional group, methods for preparing same and uses thereof
WO2006029221A2 (fr) * 2004-09-07 2006-03-16 Pacific Arrow Limited Composes antitumoraux comprenant des groupes angeloyl
TWI454269B (zh) * 2003-12-23 2014-10-01 Pacific Arrow Ltd 由文冠果（ｘａｎｔｈｏｃｅｒａｓ ｓｏｒｂｉｆｏｌｉａ）單離之化合物、其製備方法以及其用途
WO2006102483A2 (fr) * 2005-03-23 2006-09-28 The Regents Of The University Of California Modulation de l'aquaporine dans la modulation de l'angiogenese et la migration cellulaire

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6616943B2 (en) * 2001-08-31 2003-09-09 Fountain Silver Limited Composition comprising Wenguanguo extracts and methods for preparing same
WO2003037200A2 (fr) * 2001-10-31 2003-05-08 Centerpulse Spine-Tech, Inc. Connecteurs en tandem reglables destines a des dispositifs de correction de la colonne vertebrale et d'autres os et articulations

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
D'ACQUARICA ET AL.: "Isolation and structure elucidation of four new triterpenoid estersaponins from fruits of Pittosporum tobira AIT", TETRAHEDRON, vol. 58, 2002, pages 10127 - 10136, XP004396869 *
See also references of EP2061798A4 *
SEO ET AL.: "A New Triterpene Saponin from Pittosporum viridiflorum from the Madagascar Rainforest", JOURNAL OF NATURAL PRODUCTS, vol. 65, 2002, pages 65 - 68, XP002510555 *

Also Published As

Publication number Publication date
CN101553497A (zh) 2009-10-07
WO2008028060A2 (fr) 2008-03-06
CN101553497B (zh) 2013-03-27
EP2061798A4 (fr) 2009-11-11
WO2008028060B1 (fr) 2008-11-20
WO2008028060A9 (fr) 2008-07-17
EP2061798A2 (fr) 2009-05-27

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