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WO2008027379A3 - Indicateurs d'activité sirtuine et procédés d'utilisation de ceux-ci - Google Patents

Indicateurs d'activité sirtuine et procédés d'utilisation de ceux-ci Download PDF

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Publication number
WO2008027379A3
WO2008027379A3 PCT/US2007/018916 US2007018916W WO2008027379A3 WO 2008027379 A3 WO2008027379 A3 WO 2008027379A3 US 2007018916 W US2007018916 W US 2007018916W WO 2008027379 A3 WO2008027379 A3 WO 2008027379A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
sirtuin
indicators
subject
sirtuin activity
Prior art date
Application number
PCT/US2007/018916
Other languages
English (en)
Other versions
WO2008027379A2 (fr
Inventor
Jill Milne
Peggy Romero
Lei Jin
Original Assignee
Sirtris Pharmaceuticals Inc
Jill Milne
Peggy Romero
Lei Jin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sirtris Pharmaceuticals Inc, Jill Milne, Peggy Romero, Lei Jin filed Critical Sirtris Pharmaceuticals Inc
Publication of WO2008027379A2 publication Critical patent/WO2008027379A2/fr
Publication of WO2008027379A3 publication Critical patent/WO2008027379A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des procédés pour suivre la modulation de la sirtuine chez un sujet, par exemple, durant le traitement thérapeutique avec un composé modulateur de sirtuine. Les procédés comprennent la détermination du taux d'acétylation d'un ou de plusieurs nouveaux substrats de sirtuine dans un échantillon biologique provenant dudit sujet. La présente invention concerne en outre des procédés pour identifier des composés qui modulent l'activité d'une protéine sirtuine en utilisant un ou plusieurs nouveaux substrats de sirtuine.
PCT/US2007/018916 2006-08-29 2007-08-28 Indicateurs d'activité sirtuine et procédés d'utilisation de ceux-ci WO2008027379A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84102906P 2006-08-29 2006-08-29
US60/841,029 2006-08-29

Publications (2)

Publication Number Publication Date
WO2008027379A2 WO2008027379A2 (fr) 2008-03-06
WO2008027379A3 true WO2008027379A3 (fr) 2008-07-17

Family

ID=39052418

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/018916 WO2008027379A2 (fr) 2006-08-29 2007-08-28 Indicateurs d'activité sirtuine et procédés d'utilisation de ceux-ci

Country Status (1)

Country Link
WO (1) WO2008027379A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110007235A (ko) 2008-05-01 2011-01-21 서트리스 파마슈티컬즈, 인코포레이티드 시르투인 조절제로서의 퀴놀린 및 관련 유사체
KR20110036602A (ko) 2008-07-03 2011-04-07 서트리스 파마슈티컬즈, 인코포레이티드 시르투인 조절제로서의 벤즈이미다졸 및 관련 유사체
CA2738794C (fr) 2008-09-29 2016-01-05 Sirtris Pharmaceuticals, Inc. Analogues de chromenone en tant que modulateurs de sirtuine
US8980852B2 (en) * 2008-10-10 2015-03-17 Yansong Gu Methods for treating obesity
WO2011059839A1 (fr) 2009-10-29 2011-05-19 Sirtris Pharmaceuticals, Inc. Pyridines bicycliques et analogues en tant que modulateurs de la sirtuine
WO2013074948A1 (fr) 2011-11-16 2013-05-23 Resveratrol Partners, Llc Compositions contenant du resvératrol et des nucléotides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060025337A1 (en) * 2003-07-01 2006-02-02 President And Fellows Of Harvard College Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
WO2006076681A2 (fr) * 2005-01-13 2006-07-20 Sirtris Pharmaceuticals, Inc. Compositions nouvelles pour le traitement des troubles de la neurodegenerescence et de la coagulation du sang

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060025337A1 (en) * 2003-07-01 2006-02-02 President And Fellows Of Harvard College Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
WO2006076681A2 (fr) * 2005-01-13 2006-07-20 Sirtris Pharmaceuticals, Inc. Compositions nouvelles pour le traitement des troubles de la neurodegenerescence et de la coagulation du sang

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PORCU M ET AL: "The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER, HAYWARTH, GB, vol. 26, no. 2, February 2005 (2005-02-01), pages 94 - 103, XP002406159, ISSN: 0165-6147 *

Also Published As

Publication number Publication date
WO2008027379A2 (fr) 2008-03-06

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