WO2008023268A3 - Modèle d'un cancer prolongé exprimant de façon conditionnelle un oncogène chez la souris - Google Patents
Modèle d'un cancer prolongé exprimant de façon conditionnelle un oncogène chez la souris Download PDFInfo
- Publication number
- WO2008023268A3 WO2008023268A3 PCT/IB2007/003288 IB2007003288W WO2008023268A3 WO 2008023268 A3 WO2008023268 A3 WO 2008023268A3 IB 2007003288 W IB2007003288 W IB 2007003288W WO 2008023268 A3 WO2008023268 A3 WO 2008023268A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bcr
- mouse model
- abl oncogene
- relates
- conditionally expressing
- Prior art date
Links
- 108700020796 Oncogene Proteins 0.000 title abstract 2
- 208000032839 leukemia Diseases 0.000 title abstract 2
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 title 1
- 238000010172 mouse model Methods 0.000 title 1
- 230000009261 transgenic effect Effects 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012636 effector Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/20—Animal model comprising regulated expression system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/005—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB
- C12N2830/006—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB tet repressible
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Biophysics (AREA)
- Animal Husbandry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne le développement du cancer, de façon plus précise, de la leucémie. En particulier, l'invention concerne des animaux transgéniques comprenant, dans leur génome, un oncogène humain qui peut être régulé de façon exogène par une substance effectrice. L'invention concerne en outre des animaux transgéniques comprenant, dans leur génome, le gène BCR-ABLp 190. De plus, l'invention concerne l'utilisation des mammifères non humains transgéniques de l'invention pour la découverte et le développement de composés pour la prévention et/ou le traitement du cancer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06017630.2 | 2006-08-24 | ||
EP06017630 | 2006-08-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008023268A2 WO2008023268A2 (fr) | 2008-02-28 |
WO2008023268A3 true WO2008023268A3 (fr) | 2008-07-31 |
Family
ID=39107179
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2007/003288 WO2008023268A2 (fr) | 2006-08-24 | 2007-08-23 | Modèle d'un cancer prolongé exprimant de façon conditionnelle un oncogène chez la souris |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008023268A2 (fr) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991007489A1 (fr) * | 1989-11-22 | 1991-05-30 | Childrens Hospital Of Los Angeles | Animaux transgeniques bcr/abl utilises comme modeles de la leucemie myelogene chronique positive et lymphoplastique aigue du chromosome de philadelphie |
-
2007
- 2007-08-23 WO PCT/IB2007/003288 patent/WO2008023268A2/fr active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991007489A1 (fr) * | 1989-11-22 | 1991-05-30 | Childrens Hospital Of Los Angeles | Animaux transgeniques bcr/abl utilises comme modeles de la leucemie myelogene chronique positive et lymphoplastique aigue du chromosome de philadelphie |
US5849996A (en) * | 1989-11-22 | 1998-12-15 | Childrens Hospital Of Los Angeles | BCR/ABL transgenic animals as models for Philadelphia chromosome positive chronic myelogenous and acute lymphoblastic leukemia |
Non-Patent Citations (6)
Title |
---|
BRAIN JULIA M ET AL: "The kinase inhibitor STI571 reverses the Bcr-Abl induced point mutation frequencies observed in pre-leukemic P190Bcr-Abl transgenic mice.", LEUKEMIA RESEARCH, vol. 26, no. 11, November 2002 (2002-11-01), pages 1011 - 1016, XP002480384, ISSN: 0145-2126 * |
CHOO Y ET AL: "IN VIVO REPRESSION BY A SITE-SPECIFIC DNA-BINDING PROTEIN DESIGNED AGAINST AN ONCOGENIC SEQUENCE", NATURE, NATURE PUBLISHING GROUP, LONDON, vol. 372, 15 December 1994 (1994-12-15), pages 642 - 645, XP000986225, ISSN: 0028-0836 * |
COBALEDA C ET AL: "In vivo inhibition by a site-specific catalytic RNA subunit of RNase P designed against the BCR-ABL oncogenic products: A novel approach for cancer treatment", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, vol. 95, no. 3, 1 February 2000 (2000-02-01), pages 731 - 737, XP002239466, ISSN: 0006-4971 * |
GARCÍA-HERNÁNDEZ B ET AL: "Retroviral vector design for gene therapy of cancer: specific inhibition and tagging of BCR-ABLp190 cells.", MOLECULAR MEDICINE (CAMBRIDGE, MASS.) JAN 1996, vol. 2, no. 1, January 1996 (1996-01-01), pages 125 - 133, XP001013586, ISSN: 1076-1551 * |
PEREZ-CARO M ET AL: "Sustained leukaemic phenotype after inactivation of BCR-ABLp190 in mice", ONCOGENE, vol. 26, no. 12, March 2007 (2007-03-01), pages 1702 - 1713, XP002480386, ISSN: 0950-9232 * |
VITALE-CROSS LYNN ET AL: "Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis", CANCER RESEARCH, vol. 64, no. 24, 15 December 2004 (2004-12-15), pages 8804 - 8807, XP002480385, ISSN: 0008-5472 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008023268A2 (fr) | 2008-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL195411A0 (en) | Real time, on the fly, distribution of pre-selected electronic content | |
AP2414A (en) | Fungicidal aqueous compositions for seed treatment. | |
HK1096555A1 (en) | Tissue products derived from animals lacking any expression of functional alpha 1,3 galactosyltransferase -13 | |
EP1910507A4 (fr) | Preparations de cire pour produits lignocellulosiques, procedes pour leur fabrication et produits formes a partir desdites preparations | |
WO2007141274A3 (fr) | Molécules de liaison humaines présentant une activité bactéricide contre les staphylocoques et leurs utilisations | |
WO2009077443A3 (fr) | Azolylméthyloxiranes, leur utilisation et agents les contenant | |
GB2443287B (en) | Methods, compositions and formulations for the treatment of thyroid eye disease | |
WO2010078324A3 (fr) | Compositions pour animaux de compagnie comprenant de l'acide lipoïque et leurs procédés d'utilisation | |
AP2012006217A0 (en) | Soybean transgenic event mon 87708 and methods of use thereof. | |
WO2007117511A3 (fr) | Préparations alimentaires contenant de l'acide docosahexaénoïque | |
EP2384439A4 (fr) | Hydrogels réticulés avec des nanoparticules d'or | |
WO2009077500A3 (fr) | Azolylméthyloxiranes, leur utilisation et agents les contenant | |
WO2009077471A3 (fr) | Azolylméthyloxiranes, leur utilisation et agents les contenant | |
PH12008500597A1 (en) | Use of lactate esters for improving the action of agricultural pesticides | |
WO2007080621A8 (fr) | Animaux transgéniques non humains luminescents, leur progéniture, leurs dérivés cellulaires et leurs applications | |
GB0605715D0 (en) | Treatment of laminitis | |
GB0623716D0 (en) | Manufacture of animal feed supplements | |
WO2008011990A3 (fr) | Mélanges insecticides synergiques | |
WO2008023268A3 (fr) | Modèle d'un cancer prolongé exprimant de façon conditionnelle un oncogène chez la souris | |
FR2946881B1 (fr) | Activite multimodale d'oligonucleotides g-quartet et compositions microbicides. | |
GB0606868D0 (en) | Animal deterrent | |
GB0507490D0 (en) | Treatment of animal parasites | |
WO2009038089A1 (fr) | Agent anti-fatigue contenant de la sésamine et de la vitamine e | |
SI2010514T1 (sl) | 3-(piridin-2-il)-(1,2,4)-triazini uporabni kot fungicidi | |
EP2063950A4 (fr) | Cathéter de guidage renforcé |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07825546 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
NENP | Non-entry into the national phase |
Ref country code: RU |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 07825546 Country of ref document: EP Kind code of ref document: A2 |