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WO2008013988A3 - Method of treating a condition associated with phosphorylation of task-1 - Google Patents

Method of treating a condition associated with phosphorylation of task-1 Download PDF

Info

Publication number
WO2008013988A3
WO2008013988A3 PCT/US2007/016999 US2007016999W WO2008013988A3 WO 2008013988 A3 WO2008013988 A3 WO 2008013988A3 US 2007016999 W US2007016999 W US 2007016999W WO 2008013988 A3 WO2008013988 A3 WO 2008013988A3
Authority
WO
WIPO (PCT)
Prior art keywords
task
phosphorylation
treating
condition associated
subject
Prior art date
Application number
PCT/US2007/016999
Other languages
French (fr)
Other versions
WO2008013988A2 (en
WO2008013988A9 (en
Inventor
Steven J Feinmark
Richard B Robinson
Original Assignee
Univ Columbia
Steven J Feinmark
Richard B Robinson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2006/029544 external-priority patent/WO2007014347A2/en
Priority claimed from US11/498,343 external-priority patent/US8097650B2/en
Application filed by Univ Columbia, Steven J Feinmark, Richard B Robinson filed Critical Univ Columbia
Priority to EP07836321A priority Critical patent/EP2068628A4/en
Publication of WO2008013988A2 publication Critical patent/WO2008013988A2/en
Publication of WO2008013988A9 publication Critical patent/WO2008013988A9/en
Publication of WO2008013988A3 publication Critical patent/WO2008013988A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

This invention provides methods and compositions for treating a condition associated with phosphorylation of TASK-I in a subject comprising administering to the subject an amount of an agent effective to overcome the phosphorylation dependent loss of TASK-I function so as to thereby treat the condition. In a specific embodiment of the invention the agent is a TREK-I agonist.
PCT/US2007/016999 2006-07-27 2007-07-27 Method of treating a condition associated with phosphorylation of task-1 WO2008013988A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07836321A EP2068628A4 (en) 2006-07-27 2007-07-27 METHOD OF TREATING DISEASE ASSOCIATED WITH PHOSPHORYLATION OF TASK-I

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
USPCT/US2006/029544 2006-07-27
PCT/US2006/029544 WO2007014347A2 (en) 2005-07-27 2006-07-27 Method of treating a condition associated with phosphorylation of task-1
US11/498,343 US8097650B2 (en) 2005-07-27 2006-08-02 Method of treating a condition associated with phosphorylation of TASK-1
US11/498,343 2006-08-02

Publications (3)

Publication Number Publication Date
WO2008013988A2 WO2008013988A2 (en) 2008-01-31
WO2008013988A9 WO2008013988A9 (en) 2008-04-10
WO2008013988A3 true WO2008013988A3 (en) 2008-12-18

Family

ID=38982134

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/016999 WO2008013988A2 (en) 2006-07-27 2007-07-27 Method of treating a condition associated with phosphorylation of task-1

Country Status (2)

Country Link
EP (1) EP2068628A4 (en)
WO (1) WO2008013988A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020028485A1 (en) * 1998-01-27 2002-03-07 Meadows Helen Jane Novel compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001275414A1 (en) * 2000-06-16 2002-01-02 Smith Kline Beecham Corporation Method for the prevention or reduction of cardiovascular events associated with coronary intervention
DE10332685A1 (en) * 2003-07-18 2005-02-17 Bayer Healthcare Ag Use of a modulator of specific potassium channels, expressed preferentially in the atrium, for treatment and prevention of arrhythmia, coronary disease and hypertension
WO2007014347A2 (en) * 2005-07-27 2007-02-01 The Trustees Of Columbia University In The City Of New York Method of treating a condition associated with phosphorylation of task-1

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020028485A1 (en) * 1998-01-27 2002-03-07 Meadows Helen Jane Novel compounds

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEMIN ET AL.: "Cross-talk between the mechano-gated K2p channel TREK-1 and the actin cytoskeleton", EMBO J., vol. 24, no. 1, January 2005 (2005-01-01), pages 44 - 53, XP008103203 *
NINIO ET AL.: "Dietary Fish Oil Protects Against Stretch-Induced Vulnerability to Atrial Fibrillation in a Rabbit Model", JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, vol. 16, no. 11, May 2005 (2005-05-01), pages 1189 - 1194, XP008103200 *
See also references of EP2068628A4 *

Also Published As

Publication number Publication date
EP2068628A2 (en) 2009-06-17
WO2008013988A2 (en) 2008-01-31
WO2008013988A9 (en) 2008-04-10
EP2068628A4 (en) 2009-11-04

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