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WO2008012108A3 - Préparation de stilbènes polyhydroxylés - Google Patents

Préparation de stilbènes polyhydroxylés Download PDF

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Publication number
WO2008012108A3
WO2008012108A3 PCT/EP2007/006726 EP2007006726W WO2008012108A3 WO 2008012108 A3 WO2008012108 A3 WO 2008012108A3 EP 2007006726 W EP2007006726 W EP 2007006726W WO 2008012108 A3 WO2008012108 A3 WO 2008012108A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
claisen condensation
polyhydroxylated
stilbenes
via claisen
Prior art date
Application number
PCT/EP2007/006726
Other languages
English (en)
Other versions
WO2008012108A2 (fr
Inventor
Jonathan William Wiffen
Raymond Mccague
Original Assignee
Portela & Ca Sa
Jonathan William Wiffen
Raymond Mccague
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP06015770A external-priority patent/EP1884508A1/fr
Application filed by Portela & Ca Sa, Jonathan William Wiffen, Raymond Mccague filed Critical Portela & Ca Sa
Publication of WO2008012108A2 publication Critical patent/WO2008012108A2/fr
Publication of WO2008012108A3 publication Critical patent/WO2008012108A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/215—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C07C45/676—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton by elimination of carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne un procédé de préparation de stilbènes polyhydroxylés à partir d'un composé de la formule (I), de la formule (VI) ou de la formule (IX).
PCT/EP2007/006726 2006-07-28 2007-07-30 Préparation de stilbènes polyhydroxylés WO2008012108A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP06015772 2006-07-28
EP06015772.4 2006-07-28
EP06015770.8 2006-07-28
EP06015773 2006-07-28
EP06015773.2 2006-07-28
EP06015770A EP1884508A1 (fr) 2006-07-28 2006-07-28 Procédé de préparation de stilbènes polyhydroxylés par condensation de claisen

Publications (2)

Publication Number Publication Date
WO2008012108A2 WO2008012108A2 (fr) 2008-01-31
WO2008012108A3 true WO2008012108A3 (fr) 2008-05-22

Family

ID=38872461

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/006726 WO2008012108A2 (fr) 2006-07-28 2007-07-30 Préparation de stilbènes polyhydroxylés

Country Status (1)

Country Link
WO (1) WO2008012108A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109970517B (zh) * 2019-04-28 2021-09-17 杭州师范大学 一种白藜芦醇类化合物的制备方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2805795C (fr) 2004-01-20 2016-11-08 Brigham Young University Noveaux composes activant sirtuine et leurs methodes de preparation
FR2904311B1 (fr) * 2006-07-28 2013-01-11 Clariant Specialty Fine Chem F Nouveau procede de synthese de derives (e) stilbeniques perm permettant d'obtenir le resveratrol et le piceatannol
WO2010046926A2 (fr) * 2008-10-17 2010-04-29 Aptuit Laurus Pvt Ltd Nouveaux analogues de stilbene novel stilbene analogs
EP2785673B1 (fr) * 2011-12-01 2018-01-03 Laurus Labs Limited Procédé de préparation de composés polyhydroxystilbène par déprotection des éthers correspondants
CN104151232A (zh) * 2014-06-30 2014-11-19 北京万全德众医药生物技术有限公司 一种制备依托考昔的方法
CN111686817B (zh) * 2019-03-14 2024-02-09 上海博腾智拓医药科技有限公司 一种铜负载催化剂、其制备方法及应用
CN114195610B (zh) * 2022-01-05 2023-07-14 海南大学 一种e式内部烯烃类化合物的合成方法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CARDILE V ET AL: "Chemo-enzymatic synthesis and cell-growth inhibition activity of resveratrol analogues", BIOORGANIC CHEMISTRY, ACADEMIC PRESS INC., NEW YORK, NY, US, vol. 33, no. 1, February 2005 (2005-02-01), pages 22 - 33, XP004720666, ISSN: 0045-2068 *
G. VIJAY B. REDDY ET AL: "CLEAVAGE OF NONPHENOLIC BETA-1 DIARYLPROPANE LIGNIN MODEL DIMERS BY MANGANESE PEROXIDASE FROM PHANEROCHAETE CHRYSOSPORIUM", EUROPEAN JOURNAL OF BIOCHEMISTRY , 270(2), 284-292, vol. 270, no. 2, 2003, pages 284 - 292, XP002415071 *
ROBERTS ET AL: "THE PHOTOCHEMISTRY OF 1-(3,5-DIMETHOXYPHENYL)-2-(4-METHOXYPHENYL)ETHYL ETHANOATE IN ALCOHOL SOLVENTS: A SEARCH FOR CARBOCATION REARRANGEMENTS", CANADIAN JOURNAL OF CHEMISTRY, NATIONAL RESEARCH COUNCIL. OTTAWA, CA, vol. 81, no. 6, 2003, pages 709 - 722, XP009076767, ISSN: 0008-4042 *
TALVITIE ET AL: "ENRICHMENT, CHARACTERIZATION AND ABSOLUTE CONFIGURATION OF THE ENANTIOMERS OF 1-(3,5-DIMETHOXYPHENYL)-2-(4-METHOXYPHENYL)ETHANOL", ACTA CHEMICA SCANDINAVICA, MUNKSGAARD, COPENHAGEN, DK, vol. 50, no. 12, 1996, pages 1143 - 1146, XP009076763, ISSN: 0904-213X *
ZHANG ET AL: "SYNTHESIS OF RESVERATROL AND RESVERATROL TRINICOTINATE", JOURNAL OF CHINESE PHARMACEUTICAL SCIENCES, SCHOOL OF PHARMACEUTICAL SCIENCES, BEIJING MEDICAL UNIVERSITY,, CN, vol. 13, no. 1, 2004, pages 10 - 13, XP001248789, ISSN: 1003-1057 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109970517B (zh) * 2019-04-28 2021-09-17 杭州师范大学 一种白藜芦醇类化合物的制备方法

Also Published As

Publication number Publication date
WO2008012108A2 (fr) 2008-01-31

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