+

WO2008011625A3 - Dispositifs à micro-aiguille(s) et procédés d'administration de médicament ou de retrait de fluide - Google Patents

Dispositifs à micro-aiguille(s) et procédés d'administration de médicament ou de retrait de fluide Download PDF

Info

Publication number
WO2008011625A3
WO2008011625A3 PCT/US2007/074123 US2007074123W WO2008011625A3 WO 2008011625 A3 WO2008011625 A3 WO 2008011625A3 US 2007074123 W US2007074123 W US 2007074123W WO 2008011625 A3 WO2008011625 A3 WO 2008011625A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
microneedle devices
drug delivery
drug
base substrate
Prior art date
Application number
PCT/US2007/074123
Other languages
English (en)
Other versions
WO2008011625A2 (fr
Inventor
Mark R Prausnitz
Jeong Woo Lee
Original Assignee
Georgia Tech Researh Corp
Mark R Prausnitz
Jeong Woo Lee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgia Tech Researh Corp, Mark R Prausnitz, Jeong Woo Lee filed Critical Georgia Tech Researh Corp
Publication of WO2008011625A2 publication Critical patent/WO2008011625A2/fr
Publication of WO2008011625A3 publication Critical patent/WO2008011625A3/fr
Priority to US12/357,195 priority Critical patent/US20090182306A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00111—Tips, pillars, i.e. raised structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/055—Microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C2201/00—Manufacture or treatment of microstructural devices or systems
    • B81C2201/03—Processes for manufacturing substrate-free structures
    • B81C2201/034—Moulding

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des dispositifs à micro-aiguille(s) et des procédés de fabrication et d'utilisation de ceux-ci. Dans un mode de réalisation, l'invention concerne un dispositif permettant la libération prolongée d'un médicament à travers ou dans une barrière biologique telle que la peau. Ce dispositif peut comporter un substrat de base comprenant un médicament dispersé dans une matière de matrice, et une ou plusieurs micro-aiguilles s'étendant à partir du substrat de base, la ou les micro-aiguilles comportant une matière soluble ou gonflable dans l'eau, matière grâce à laquelle la ou les micro-aiguilles se dissolvent ou gonflent après avoir été introduites dans la barrière biologique, permettant ainsi le passage du médicament du substrat de base dans la barrière biologique.
PCT/US2007/074123 2006-07-21 2007-07-23 Dispositifs à micro-aiguille(s) et procédés d'administration de médicament ou de retrait de fluide WO2008011625A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/357,195 US20090182306A1 (en) 2006-07-21 2009-01-21 Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83247906P 2006-07-21 2006-07-21
US60/832,479 2006-07-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/357,195 Continuation-In-Part US20090182306A1 (en) 2006-07-21 2009-01-21 Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal

Publications (2)

Publication Number Publication Date
WO2008011625A2 WO2008011625A2 (fr) 2008-01-24
WO2008011625A3 true WO2008011625A3 (fr) 2008-12-04

Family

ID=38957686

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/074123 WO2008011625A2 (fr) 2006-07-21 2007-07-23 Dispositifs à micro-aiguille(s) et procédés d'administration de médicament ou de retrait de fluide

Country Status (1)

Country Link
WO (1) WO2008011625A2 (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
EP1893130A4 (fr) 2005-06-17 2015-08-26 Georgia Tech Res Inst Microstructures revetues et procede de fabrication de celles-ci
US7699819B2 (en) 2006-02-21 2010-04-20 The Hong Kong University Of Science And Technology Molecular sieve and zeolite microneedles and preparation thereof
WO2008091602A2 (fr) 2007-01-22 2008-07-31 Corium International, Inc. Applicateurs pour micro-aiguilles
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
AU2014200648B2 (en) * 2007-04-16 2015-09-24 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
CA2686093C (fr) 2007-04-16 2018-05-08 Corium International, Inc. Reseaux de micro-aiguilles coulees dans un solvant contenant un actif
EP2205169B1 (fr) 2007-09-28 2016-11-16 The Queen's University of Belfast Méthode et dispositif d'administration
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
AU2008341030B2 (en) 2007-12-24 2014-04-17 Vaxxas Pty Limited Coating method
WO2009097660A1 (fr) 2008-02-07 2009-08-13 The University Of Queensland Fabrication de timbre transdermique
US20090234322A1 (en) 2008-03-12 2009-09-17 Ultradent Products, Inc. Method of dental tissue injection using an array of micro-needles
JP5584202B2 (ja) * 2008-05-21 2014-09-03 セラジェクト， インコーポレイテッド 固溶体穿孔器パッチの製造方法及びその使用
AU2009250341A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection using a needle projection patch
JP5879126B2 (ja) * 2008-10-07 2016-03-08 ジン・トゥオＪＩＮ Ｔｕｏ 相転移ポリマーマイクロニードル
WO2010071918A1 (fr) * 2008-12-22 2010-07-01 The University Of Queensland Production de pièce
AU2011248108B2 (en) 2010-05-04 2016-05-26 Corium Pharma Solutions, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
WO2012006677A1 (fr) 2010-07-14 2012-01-19 The University Of Queensland Appareil d'application de timbre transdermique
JP5770055B2 (ja) * 2010-09-29 2015-08-26 富士フイルム株式会社 針状アレイ経皮吸収シートの製造方法
GB201107642D0 (en) * 2011-05-09 2011-06-22 Univ Cork Method
US11179553B2 (en) 2011-10-12 2021-11-23 Vaxxas Pty Limited Delivery device
US11052231B2 (en) * 2012-12-21 2021-07-06 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
WO2014112854A1 (fr) * 2013-01-21 2014-07-24 부경약품 ㈜ Micro-aiguille, moule pour sa production et son procédé de production
CN105142711B (zh) 2013-03-12 2019-01-22 考里安国际公司 微突起施加器
WO2014144973A1 (fr) 2013-03-15 2014-09-18 Corium International, Inc. Micro-réseau pour administrer un agent thérapeutique, procédés d'utilisation et procédés de fabrication
CA2906541C (fr) 2013-03-15 2022-06-21 Corium International, Inc. Microreseau pour l'administration d'un agent therapeutique et ses procedes d'utilisation
WO2014150285A2 (fr) 2013-03-15 2014-09-25 Corium International, Inc. Applicateurs de microprojection d'impacts multiples et procédés d'utilisation
AU2014237279B2 (en) 2013-03-15 2018-11-22 Corium Pharma Solutions, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
CN106573155A (zh) 2014-02-26 2017-04-19 鲁玛治疗公司 紫外光疗设备和方法
JP6579099B2 (ja) * 2014-04-03 2019-09-25 凸版印刷株式会社 穿刺注入器具
WO2016036866A1 (fr) 2014-09-04 2016-03-10 Corium International, Inc. Matrice de microstructures, procédé de production et procédés d'utilisation
CA2975275C (fr) 2015-02-02 2023-08-29 Vaxxas Pty Limited Applicateur a reseau de microprojections et procede
BR112017022535A2 (pt) * 2015-04-21 2018-07-10 Univ North Carolina State sistema de liberação de insulina responsivo à glicose usando nanocompósitos sensíveis à hipóxia.
WO2017004067A1 (fr) 2015-06-29 2017-01-05 Corium International, Inc. Micro-réseau pour l'administration d'un agent thérapeutique, procédés d'utilisation, et procédés de fabrication
US11103259B2 (en) 2015-09-18 2021-08-31 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
EP3355981A4 (fr) 2015-09-28 2019-05-22 Vaxxas Pty Limited Réseau de microsaillies ayant des propriétés de pénétration de la peau améliorées et procédés associés
EP4324404A3 (fr) * 2016-01-13 2024-04-24 The General Hospital Corporation DBA Massachusetts Procédés permettant d'éliminer les particules exogènes de la peau d'un patient
KR20180134856A (ko) 2016-02-09 2018-12-19 루마 세러퓨틱스 인코포레이티드 광선요법에 의해 건선을 치료하기 위한 방법, 조성물 및 장치
EP3606760B1 (fr) 2017-03-31 2023-09-27 Vaxxas Pty Limited Dispositif et procédé de revêtement de surfaces
CA3065371A1 (fr) 2017-06-13 2018-12-20 Vaxxas Pty Limited Controle de la qualite de revetements de substrats
EP4218893A1 (fr) 2017-08-04 2023-08-02 Vaxxas Pty Limited Actionneur à stockage d'énergie mécanique élevé compact et à force de déclenchement faible pour l'administration de patchs à réseaux de microprojections (prm)
CN108837238B (zh) * 2018-07-13 2023-09-01 江苏省人民医院（南京医科大学第一附属医院） 一种玻尿酸注射针
CN111588689B (zh) * 2020-06-20 2023-08-11 温州医科大学 一种角膜微创可溶性微针贴片及其制备方法与应用
US20220105029A1 (en) * 2020-10-07 2022-04-07 The Board Of Trustees Of The University Of Arkansas Biodegradable chitosan microneedle patch for transdermal delivery for livestock pain management
EP4291282A4 (fr) * 2021-02-11 2025-04-16 10X Tech Llc Procédé et appareil de fabrication de micro-aiguille cassante
EP4297723A4 (fr) * 2021-02-27 2025-01-29 Brigham & Womens Hospital Inc Compositions de micro-aiguilles et méthodes d'administration les utilisant

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US20020177839A1 (en) * 2001-04-20 2002-11-28 Cormier Michel J. N. Microprojection array having a beneficial agent containing coating

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US20020177839A1 (en) * 2001-04-20 2002-11-28 Cormier Michel J. N. Microprojection array having a beneficial agent containing coating

Also Published As

Publication number Publication date
WO2008011625A2 (fr) 2008-01-24

Similar Documents

Publication Publication Date Title
WO2008011625A3 (fr) Dispositifs à micro-aiguille(s) et procédés d'administration de médicament ou de retrait de fluide
WO2006015299A3 (fr) Dispositif multi-reservoir pour la delivrance de medicament transdermique et la detection
TW200618830A (en) Micorprojection apparatus and system with low infection potential
WO2009147641A3 (fr) Dispositif et système pour l'administration d'un matériel biologique
WO2008024141A3 (fr) Structures de nanofibres présentes sur des aspérités destinées à séquestrer, porter et transférer des substances
TW200613029A (en) System and method for drug delivery and microfluidic applications using microneedles
EP1976492B8 (fr) Système d'administration de médicaments comprenant des médicaments faiblement basiques et des acides organiques
WO2007019539A3 (fr) Procedes et dispositifs d'administration d'agents a travers des barrieres biologiques
WO2007146426A3 (fr) Nanobilles pour délivrance de médicament
WO2008005176A3 (fr) Marqueur radio-opaque polymère électroactif
AR072492A1 (es) Dispositivo y administracion transdermica de estrogeno
AR044964A1 (es) Formulaciones para microproyecciones recubiertas que contienen contra-iones no volatiles
MX2017012321A (es) Parche de microagujas para administrar un ingrediente activo a la piel.
WO2009021048A3 (fr) Réseaux de microaiguilles formés à partir de films polymères
IL189750A0 (en) Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof
WO2007089435A3 (fr) Dispositifs médicaux destinés à l'administration d'agent thérapeutique et dotés de zones polymères qui contiennent des copolymères présentant à la fois des segments souples et des segments durs de même longueur
DK2612645T3 (da) Lægemiddellagrings- og dispenseringsindretninger og systemer omfattende samme
WO2006023130A3 (fr) Dispositif biodegradable de diffusion d'un agent bioactif a liberation lente
ATE485072T1 (de) Katheter mit distaler wirkstofffreisetzungseinheit
EP2053589A4 (fr) Substrat à matrice active et dispositif d'affichage doté du substrat
WO2008011194A3 (fr) Dispositifs d'administration transmuqueuse avec absorption accrue
EP2010246A4 (fr) Dispositif et procede de liberation de medicament
IL202614A0 (en) Intravaginal drug delivery devices for the delivery of macromolecules and water soluble drugs
WO2007133776A3 (fr) Administration active et réorientation de flux : nouveaux dispositifs et méthode d'administration de substances à des patients
DK2902053T3 (da) Anordninger, systemer og fremgangsmåder til væskefremføring

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07813231

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

NENP Non-entry into the national phase

Ref country code: RU

122 Ep: pct application non-entry in european phase

Ref document number: 07813231

Country of ref document: EP

Kind code of ref document: A2

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载