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WO2008011538A3 - Méthodes d'utilisation de flavonoïdes pour améliorer la mémoire - Google Patents

Méthodes d'utilisation de flavonoïdes pour améliorer la mémoire Download PDF

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Publication number
WO2008011538A3
WO2008011538A3 PCT/US2007/073925 US2007073925W WO2008011538A3 WO 2008011538 A3 WO2008011538 A3 WO 2008011538A3 US 2007073925 W US2007073925 W US 2007073925W WO 2008011538 A3 WO2008011538 A3 WO 2008011538A3
Authority
WO
WIPO (PCT)
Prior art keywords
flavonoids
methods
desoxy
enhance memory
fisetin
Prior art date
Application number
PCT/US2007/073925
Other languages
English (en)
Other versions
WO2008011538A2 (fr
Inventor
Pamela A Maher
Original Assignee
Salk Inst For Biological Studi
Pamela A Maher
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Inst For Biological Studi, Pamela A Maher filed Critical Salk Inst For Biological Studi
Publication of WO2008011538A2 publication Critical patent/WO2008011538A2/fr
Publication of WO2008011538A3 publication Critical patent/WO2008011538A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des flavonoïdes (par ex., des 5-désoxy flavones et/ou des 5-désoxy flavonols), notamment, entre autres, la fisétine et ses dérivés) qui activent l'ERKet induisent la phosphorylation de CREB dans des cultures neuronales, facilitent la potentialisation à long terme dans des tranches hippocampiques et améliorent la reconnaissance d'objets in vivo. L'invention concerne également l'utilisation desdits flavonoïdes, par exemple, pour améliorer la mémoire.
PCT/US2007/073925 2006-07-19 2007-07-19 Méthodes d'utilisation de flavonoïdes pour améliorer la mémoire WO2008011538A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80780506P 2006-07-19 2006-07-19
US60/807,805 2006-07-19

Publications (2)

Publication Number Publication Date
WO2008011538A2 WO2008011538A2 (fr) 2008-01-24
WO2008011538A3 true WO2008011538A3 (fr) 2008-11-13

Family

ID=38957636

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/073925 WO2008011538A2 (fr) 2006-07-19 2007-07-19 Méthodes d'utilisation de flavonoïdes pour améliorer la mémoire

Country Status (2)

Country Link
US (1) US7897637B2 (fr)
WO (1) WO2008011538A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2677892A1 (fr) * 2007-02-14 2008-12-04 Mars, Incorporated Composes neurogeniques
BRPI0801239A2 (pt) * 2008-04-01 2009-11-17 Ache Lab Farmaceuticos Sa uso de um ou mais benzopiranonas, composição farmacêutica e método de prevenção ou tratamento de doenças, disfunções e distúrbios associados a monoamino oxidase
US8034838B2 (en) * 2008-05-29 2011-10-11 Daryl Lee Thompson Composition and method for the treatment of neurological disorders
JP2010270095A (ja) * 2008-05-30 2010-12-02 Yamaha Motor Co Ltd 認知行動能力向上剤
CN103533933A (zh) * 2009-09-11 2014-01-22 雀巢产品技术援助有限公司 用于增强动物认知和相关功能的组合物和方法
WO2011156479A2 (fr) 2010-06-09 2011-12-15 Emory University Agonistes trkb et leurs procédés d'utilisation
WO2013025498A1 (fr) * 2011-08-12 2013-02-21 Schubert David R Analogues du polyphénol neuroprotecteurs
EP2827711B1 (fr) * 2012-03-19 2019-06-19 Buck Institute for Research on Aging Inhibiteurs de bace spécifiques de l'app (asbi) et leurs utilisations
US9593125B2 (en) 2012-07-27 2017-03-14 Emory University Heterocyclic flavone derivatives, compositions, and methods related thereto
ES2795665T3 (es) 2012-09-14 2020-11-24 Abbott Lab Procedimientos para aumentar la funcionalidad cerebral utilizando 2-fucosil-lactosa
ES2572831T3 (es) 2012-09-14 2016-06-02 Abbott Laboratories Composiciones nutricionales para su uso en métodos para modular los niveles de corticosterona en individuos con estrés psicológico
TR201908822T4 (tr) * 2012-10-11 2019-07-22 Armaron Bio Pty Ltd Yeni flavonoid bileşikleri ve bunların kullanımları.
US10123991B2 (en) 2015-05-15 2018-11-13 Global Biolife Inc. Electrophilically enhanced phenolic compounds for treating inflammatory related diseases and disorders
WO2017096049A1 (fr) 2015-12-03 2017-06-08 The University Of North Carolina At Pembroke Substances pour l'amélioration de la cathépsine b et méthodes d'utilisation
AU2020395610A1 (en) * 2019-12-06 2022-06-30 Gretals Australia Pty Ltd Neurologically active flavonoid compositions and methods of use thereof
CN115025081A (zh) * 2022-01-27 2022-09-09 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） 漆黄素在制备铁死亡抑制剂中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010047032A1 (en) * 1999-12-30 2001-11-29 Castillo Gerardo M. Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases
US20030194453A1 (en) * 2002-04-15 2003-10-16 Coleman Henry D. Dietary supplement
US20060111307A1 (en) * 2004-11-16 2006-05-25 Wendye Robbins Methods and compositions for treating pain

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2543550B1 (fr) 1983-04-01 1985-08-09 Cortial Nouveaux derives de la tetrahydroxy-3', 4',5,7 flavone, leur methode de preparation et leur emploi therapeutique
WO2002076473A1 (fr) 2001-03-26 2002-10-03 Academy Of Military Medical Sciences Institute Of Pharmacology And Toxicology Derive de quercetine et son utilisation medicinale
US7763588B2 (en) 2003-06-13 2010-07-27 The Salk Institute For Biological Studies Method for increasing cognitive function and neurogenesis
US20070105109A1 (en) 2003-07-02 2007-05-10 Geesaman Bard J Sirt1 and genetic disorders
RU2392957C2 (ru) 2003-09-02 2010-06-27 Юниджен Фармасьютиклз, Инк. Композиция, содержащая смесь флавоноидов со свободным кольцом и флаванов, которая предназначена для предупреждения и лечения ухудшения когнитивной способности и связанных с возрастом ослаблений памяти
US7629006B2 (en) 2004-09-09 2009-12-08 AZI Company, Ltd Process for preparing extract from rhus verniciflua and pharmaceutical composition containing the same
WO2006076681A2 (fr) 2005-01-13 2006-07-20 Sirtris Pharmaceuticals, Inc. Compositions nouvelles pour le traitement des troubles de la neurodegenerescence et de la coagulation du sang
WO2006138418A2 (fr) 2005-06-14 2006-12-28 President And Fellows Of Harvard College Amelioration de la performance cognitive avec des activateurs de sirtuine
US20070248590A1 (en) 2005-12-02 2007-10-25 Sirtris Pharmaceuticals, Inc. Modulators of CDC2-like kinases (CLKS) and methods of use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010047032A1 (en) * 1999-12-30 2001-11-29 Castillo Gerardo M. Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases
US20030194453A1 (en) * 2002-04-15 2003-10-16 Coleman Henry D. Dietary supplement
US20060111307A1 (en) * 2004-11-16 2006-05-25 Wendye Robbins Methods and compositions for treating pain

Also Published As

Publication number Publication date
US20080021096A1 (en) 2008-01-24
WO2008011538A2 (fr) 2008-01-24
US7897637B2 (en) 2011-03-01

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