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WO2008011588A3 - Glycoconjugués d'alkylateurs de phosphoramidate pour le traitement du cancer - Google Patents

Glycoconjugués d'alkylateurs de phosphoramidate pour le traitement du cancer Download PDF

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Publication number
WO2008011588A3
WO2008011588A3 PCT/US2007/074012 US2007074012W WO2008011588A3 WO 2008011588 A3 WO2008011588 A3 WO 2008011588A3 US 2007074012 W US2007074012 W US 2007074012W WO 2008011588 A3 WO2008011588 A3 WO 2008011588A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
treatment
glycoconjugates
bromoglufosfamide
glufosfamide
Prior art date
Application number
PCT/US2007/074012
Other languages
English (en)
Other versions
WO2008011588A2 (fr
Inventor
Jian-Xin Duan
Jason Lewis
Hailong Jiao
Original Assignee
Threshold Pharmaceuticals Inc
Jian-Xin Duan
Jason Lewis
Hailong Jiao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Threshold Pharmaceuticals Inc, Jian-Xin Duan, Jason Lewis, Hailong Jiao filed Critical Threshold Pharmaceuticals Inc
Publication of WO2008011588A2 publication Critical patent/WO2008011588A2/fr
Publication of WO2008011588A3 publication Critical patent/WO2008011588A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C07H11/04—Phosphates; Phosphites; Polyphosphates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne le bromoglufosfamide et des composés apparentés qui utiles dans le traitement du cancer et autres maladies hyperprolifératives. Le glufosfamide et le bromoglufosfamide sont synthétisés par la réaction des dérivés tétraacétylés correspondants avec MeOH et une quantité catalytique de MeO(-). Le tétraacétyl glufosfamide est obtenu par la réaction d'un intermédiaire tétraacétyl trichloroacétamidate de glucose, l'ifosfamide moutarde, et d'un acide dans un solvant polaire anhydre.
PCT/US2007/074012 2006-07-20 2007-07-20 Glycoconjugués d'alkylateurs de phosphoramidate pour le traitement du cancer WO2008011588A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US83242906P 2006-07-20 2006-07-20
US60/832,429 2006-07-20
US87852607P 2007-01-03 2007-01-03
US60/878,526 2007-01-03

Publications (2)

Publication Number Publication Date
WO2008011588A2 WO2008011588A2 (fr) 2008-01-24
WO2008011588A3 true WO2008011588A3 (fr) 2008-09-12

Family

ID=38957664

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/074012 WO2008011588A2 (fr) 2006-07-20 2007-07-20 Glycoconjugués d'alkylateurs de phosphoramidate pour le traitement du cancer

Country Status (1)

Country Link
WO (1) WO2008011588A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200507752B (en) 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
BRPI0612845A8 (pt) 2005-06-29 2018-01-23 Threshold Pharmaceuticals Inc composto, formulação farmacêutica, métodos para tratar câncer e para sintetizar um composto de fórmula alq-dispasador
US8552048B2 (en) 2006-12-26 2013-10-08 Threshold Pharmaceuticals, Inc. Phosphoramidate alkylator prodrugs for the treatment of cancer
CN101481394B (zh) * 2008-01-09 2013-01-30 苏州天人合生物技术有限公司 2,3,4,6-四-o-乙酰基-d-吡喃葡萄糖基-[n, n′-双(2-氯乙基)]-磷酸二酰胺的制备方法
CN102115483B (zh) 2009-12-30 2014-12-17 苏州天人合生物技术有限公司 卤代双去氧糖衍生物及其制备方法与应用
WO2019118486A1 (fr) * 2017-12-11 2019-06-20 Cerecor Inc. Promédicaments à base de phosphoramidate de monosaccharide
WO2025026214A1 (fr) * 2023-07-28 2025-02-06 深圳艾欣达伟医药科技有限公司 Traitement de la mutation du gène p53 ou de patients atteints d'un cancer négatif et d'une tumeur

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5306727A (en) * 1993-04-30 1994-04-26 Research Corporation Technologies, Inc. Phosphoramidates useful as antitumor agents
US5622936A (en) * 1988-10-20 1997-04-22 Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts Tumor inhibiting saccharide conjugates
US6506739B1 (en) * 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622936A (en) * 1988-10-20 1997-04-22 Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts Tumor inhibiting saccharide conjugates
US5306727A (en) * 1993-04-30 1994-04-26 Research Corporation Technologies, Inc. Phosphoramidates useful as antitumor agents
US6506739B1 (en) * 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents

Also Published As

Publication number Publication date
WO2008011588A2 (fr) 2008-01-24

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