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WO2008010238A3 - Nouveaux composés antidiabétiques - Google Patents

Nouveaux composés antidiabétiques Download PDF

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Publication number
WO2008010238A3
WO2008010238A3 PCT/IN2007/000298 IN2007000298W WO2008010238A3 WO 2008010238 A3 WO2008010238 A3 WO 2008010238A3 IN 2007000298 W IN2007000298 W IN 2007000298W WO 2008010238 A3 WO2008010238 A3 WO 2008010238A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
hexan
antidiabetic
azabicyclo
stereoisomers
Prior art date
Application number
PCT/IN2007/000298
Other languages
English (en)
Other versions
WO2008010238A2 (fr
Inventor
Sudershan Kumar Arora
Neelima Sinha
Prathap S Nair
Ajay R Tilekar
Nabendu N Saha
Talha H Khan
Reeba Vikramadithyan
Rajesh Gupta
Sai Kumar Chakka
Navnath Popat Karche
Prasad Purushottam Dixit
Original Assignee
Lupin Ltd
Sudershan Kumar Arora
Neelima Sinha
Prathap S Nair
Ajay R Tilekar
Nabendu N Saha
Talha H Khan
Reeba Vikramadithyan
Rajesh Gupta
Sai Kumar Chakka
Navnath Popat Karche
Prasad Purushottam Dixit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd, Sudershan Kumar Arora, Neelima Sinha, Prathap S Nair, Ajay R Tilekar, Nabendu N Saha, Talha H Khan, Reeba Vikramadithyan, Rajesh Gupta, Sai Kumar Chakka, Navnath Popat Karche, Prasad Purushottam Dixit filed Critical Lupin Ltd
Priority to GB0902845A priority Critical patent/GB2454615A/en
Priority to AU2007274598A priority patent/AU2007274598A1/en
Publication of WO2008010238A2 publication Critical patent/WO2008010238A2/fr
Publication of WO2008010238A3 publication Critical patent/WO2008010238A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention porte sur de nouveaux composés antidiabétiques de formule générale (I) à usage médical dont les symboles sont définis dans la description, sur leurs sels pharmacocompatibles, sur leurs formes tautomères, sur leurs stéréoisomères, sur des préparations pharmaceutiques les contenant, sur leur procédé et leurs intermédiaires de fabrication, et sur leurs méthodes d'utilisation à des fins thérapeutiques pour le traitement du diabète de maladies associées.
PCT/IN2007/000298 2006-07-21 2007-07-20 Nouveaux composés antidiabétiques WO2008010238A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB0902845A GB2454615A (en) 2006-07-21 2007-07-20 Antidiabetic azabicyclo (3.1.0) hexan compounds
AU2007274598A AU2007274598A1 (en) 2006-07-21 2007-07-20 Antidiabetic azabicyclo [3. 1. 0] hexan compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN730/KOL/2006 2006-07-21
IN730KO2006 2006-07-21

Publications (2)

Publication Number Publication Date
WO2008010238A2 WO2008010238A2 (fr) 2008-01-24
WO2008010238A3 true WO2008010238A3 (fr) 2008-04-17

Family

ID=38812084

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000298 WO2008010238A2 (fr) 2006-07-21 2007-07-20 Nouveaux composés antidiabétiques

Country Status (3)

Country Link
AU (1) AU2007274598A1 (fr)
GB (1) GB2454615A (fr)
WO (1) WO2008010238A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2025674A1 (fr) 2007-08-15 2009-02-18 sanofi-aventis Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
FR2932479A1 (fr) * 2008-06-13 2009-12-18 Servier Lab Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
WO2011107494A1 (fr) 2010-03-03 2011-09-09 Sanofi Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation
DE102010015123A1 (de) 2010-04-16 2011-10-20 Sanofi-Aventis Deutschland Gmbh Benzylamidische Diphenylazetidinone, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
WO2011157827A1 (fr) 2010-06-18 2011-12-22 Sanofi Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (fr) 2011-09-12 2013-03-21 Sanofi Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
WO2013041621A1 (fr) 2011-09-20 2013-03-28 Basf Se Modulateurs à faible masse moléculaire du récepteur sensible au froid et au menthol trpm8, et leur utilisation
EP2760862B1 (fr) 2011-09-27 2015-10-21 Sanofi Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique utilisés comme inhibiteurs de kinase
WO2013068486A1 (fr) 2011-11-08 2013-05-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes pour le diagnostic et le traitement de l'infertilité masculine
MX2021014443A (es) 2019-05-31 2022-01-06 Ikena Oncology Inc Inhibidores del dominio asociado mejorador de la transcripcion (tead) y usos de los mismos.
KR20220034739A (ko) 2019-05-31 2022-03-18 이케나 온콜로지, 인코포레이티드 Tead 억제제 및 이의 용도
CN110237045A (zh) * 2019-07-11 2019-09-17 广西大学 一种胶囊剂

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999062872A1 (fr) * 1998-06-04 1999-12-09 Astrazeneca Ab Nouveaux derives (i) d'acide 3-aryl-2-hydroxypropionique
WO2004089898A1 (fr) * 2003-04-09 2004-10-21 Ranbaxy Laboratories Limited Derives d'azabicyclo hexane substitues en tant qu'antagonistes de recepteurs muscariniques

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999062872A1 (fr) * 1998-06-04 1999-12-09 Astrazeneca Ab Nouveaux derives (i) d'acide 3-aryl-2-hydroxypropionique
WO2004089898A1 (fr) * 2003-04-09 2004-10-21 Ranbaxy Laboratories Limited Derives d'azabicyclo hexane substitues en tant qu'antagonistes de recepteurs muscariniques

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KUHN ET AL: "Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 16, no. 15, 5 June 2006 (2006-06-05), pages 4016 - 4020, XP005508765, ISSN: 0960-894X *
SAUERBERG PER ET AL: "Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.", JOURNAL OF MEDICINAL CHEMISTRY 14 FEB 2002, vol. 45, no. 4, 14 February 2002 (2002-02-14), pages 789 - 804, XP002468039, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
GB2454615A (en) 2009-05-13
GB0902845D0 (en) 2009-04-08
AU2007274598A1 (en) 2008-01-24
WO2008010238A2 (fr) 2008-01-24

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