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WO2008006969A3 - Novel tetracyclic derivatives, process for the preparation thereof and pharmaceutical compositions which contain them - Google Patents

Novel tetracyclic derivatives, process for the preparation thereof and pharmaceutical compositions which contain them Download PDF

Info

Publication number
WO2008006969A3
WO2008006969A3 PCT/FR2007/001174 FR2007001174W WO2008006969A3 WO 2008006969 A3 WO2008006969 A3 WO 2008006969A3 FR 2007001174 W FR2007001174 W FR 2007001174W WO 2008006969 A3 WO2008006969 A3 WO 2008006969A3
Authority
WO
WIPO (PCT)
Prior art keywords
contain
preparation
pharmaceutical compositions
novel tetracyclic
tetracyclic derivatives
Prior art date
Application number
PCT/FR2007/001174
Other languages
French (fr)
Other versions
WO2008006969A2 (en
Inventor
Helgoual Ch Jean-Martial L
Naour Morgan Le
Pascal Berthelot
Nicolas Lebegue
Veronique Leclerc
Pascal Carato
Catherine Dacquet
Alain Ktorza
Daniel-Henri Caignard
Original Assignee
Servier Lab
Helgoual Ch Jean-Martial L
Naour Morgan Le
Pascal Berthelot
Nicolas Lebegue
Veronique Leclerc
Pascal Carato
Catherine Dacquet
Alain Ktorza
Daniel-Henri Caignard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab, Helgoual Ch Jean-Martial L, Naour Morgan Le, Pascal Berthelot, Nicolas Lebegue, Veronique Leclerc, Pascal Carato, Catherine Dacquet, Alain Ktorza, Daniel-Henri Caignard filed Critical Servier Lab
Publication of WO2008006969A2 publication Critical patent/WO2008006969A2/en
Publication of WO2008006969A3 publication Critical patent/WO2008006969A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compounds of formula (I): in which: > R1, R2 and R3, as described in the description, form a ring of formula (II) where R6 is a hydrogen or halogen atom, or an alkyl, alkoxy, amino, alkylamino or dialkylamino group, and X is a hydrogen atom or an N-OR7 group, > R4 and R5 are a hydrogen or halogen atom, or an alkyl, alkoxy, alkylamino or dialkylamino group, > A is as defined in the description, > B is an alkyl or alkenyl group substituted with a [-CHR8R9 group.
PCT/FR2007/001174 2006-07-10 2007-07-09 Novel tetracyclic derivatives, process for the preparation thereof and pharmaceutical compositions which contain them WO2008006969A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR06.06247 2006-07-10
FR0606247A FR2903404B1 (en) 2006-07-10 2006-07-10 NOVEL TETRACYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Publications (2)

Publication Number Publication Date
WO2008006969A2 WO2008006969A2 (en) 2008-01-17
WO2008006969A3 true WO2008006969A3 (en) 2008-05-15

Family

ID=37722239

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2007/001174 WO2008006969A2 (en) 2006-07-10 2007-07-09 Novel tetracyclic derivatives, process for the preparation thereof and pharmaceutical compositions which contain them

Country Status (3)

Country Link
AR (1) AR061835A1 (en)
FR (1) FR2903404B1 (en)
WO (1) WO2008006969A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
WO2011107494A1 (en) 2010-03-03 2011-09-09 Sanofi Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof
DE102010015123A1 (en) 2010-04-16 2011-10-20 Sanofi-Aventis Deutschland Gmbh New benzylamidic diphenylazetidinone compounds, useful for treating lipid disorders, hyperlipidemia, atherosclerotic manifestations or insulin resistance, and for reducing serum cholesterol levels
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013068486A1 (en) 2011-11-08 2013-05-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of male infertility

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001057002A1 (en) * 2000-02-02 2001-08-09 Les Laboratoires Servier Novel heterocyclic derivatives, preparation method and pharmaceutical compositions containing same
US7071221B2 (en) * 2003-07-28 2006-07-04 Les Laboratoires Servier Heterocyclic oxime compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001057002A1 (en) * 2000-02-02 2001-08-09 Les Laboratoires Servier Novel heterocyclic derivatives, preparation method and pharmaceutical compositions containing same
US7071221B2 (en) * 2003-07-28 2006-07-04 Les Laboratoires Servier Heterocyclic oxime compounds

Also Published As

Publication number Publication date
AR061835A1 (en) 2008-09-24
FR2903404A1 (en) 2008-01-11
WO2008006969A2 (en) 2008-01-17
FR2903404B1 (en) 2008-08-22

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