WO2008006105A3 - Marqueurs génétiques dans le gène du récepteur de la tachykinine nk1 (tacr1) correspondant à des troubles asthmatiques - Google Patents
Marqueurs génétiques dans le gène du récepteur de la tachykinine nk1 (tacr1) correspondant à des troubles asthmatiques Download PDFInfo
- Publication number
- WO2008006105A3 WO2008006105A3 PCT/US2007/073066 US2007073066W WO2008006105A3 WO 2008006105 A3 WO2008006105 A3 WO 2008006105A3 US 2007073066 W US2007073066 W US 2007073066W WO 2008006105 A3 WO2008006105 A3 WO 2008006105A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- gene
- asthma
- tacr1
- tachykinin
- correlate
- Prior art date
Links
- 208000006673 asthma Diseases 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 title 1
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 title 1
- 102000003141 Tachykinin Human genes 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002068 genetic effect Effects 0.000 title 1
- 108060008037 tachykinin Proteins 0.000 title 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 208000013931 susceptibility to asthma Diseases 0.000 abstract 2
- 101000600903 Homo sapiens Substance-P receptor Proteins 0.000 abstract 1
- 238000012098 association analyses Methods 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 102000054765 polymorphisms of proteins Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Les polymorphismes du gène TACR1 faisant l'objet de la présente invention se révèlent, par analyse associative, analogues à un gène de sensibilité à l'asthme. L'invention concerne également des procédés permettant de diagnostiquer une sensibilité à l'asthme, une sensibilité réduite à l'asthme et une protection contre l'asthme, de même que des procédés de traitement de l'asthme.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81919806P | 2006-07-07 | 2006-07-07 | |
US60/819,198 | 2006-07-07 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2008006105A2 WO2008006105A2 (fr) | 2008-01-10 |
WO2008006105A9 WO2008006105A9 (fr) | 2008-04-03 |
WO2008006105A3 true WO2008006105A3 (fr) | 2008-08-14 |
Family
ID=38670544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/073066 WO2008006105A2 (fr) | 2006-07-07 | 2007-07-09 | Marqueurs génétiques dans le gène du récepteur de la tachykinine nk1 (tacr1) correspondant à des troubles asthmatiques |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008006105A2 (fr) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002016399A2 (fr) * | 2000-08-25 | 2002-02-28 | Genaissance Pharmaceuticals, Inc. | Haplotypes du gene tacr1 |
EP1262565A2 (fr) * | 2001-05-25 | 2002-12-04 | Pfizer Products Inc. | Polymorphismes génétiques dans le gène humain du récepteur de la neurokinine 1 et leurs usages dans diagnostic et traitement de maladies |
JP2003259875A (ja) * | 2002-03-08 | 2003-09-16 | Japan Science & Technology Corp | ヒト遺伝子の一塩基多型(4) |
WO2005100986A1 (fr) * | 2004-04-15 | 2005-10-27 | Bayer Healthcare Ag | Diagnostics et methodes therapeutiques pour des maladies associees au recepteur de la tachykinine (tacr1) |
-
2007
- 2007-07-09 WO PCT/US2007/073066 patent/WO2008006105A2/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002016399A2 (fr) * | 2000-08-25 | 2002-02-28 | Genaissance Pharmaceuticals, Inc. | Haplotypes du gene tacr1 |
EP1262565A2 (fr) * | 2001-05-25 | 2002-12-04 | Pfizer Products Inc. | Polymorphismes génétiques dans le gène humain du récepteur de la neurokinine 1 et leurs usages dans diagnostic et traitement de maladies |
JP2003259875A (ja) * | 2002-03-08 | 2003-09-16 | Japan Science & Technology Corp | ヒト遺伝子の一塩基多型(4) |
WO2005100986A1 (fr) * | 2004-04-15 | 2005-10-27 | Bayer Healthcare Ag | Diagnostics et methodes therapeutiques pour des maladies associees au recepteur de la tachykinine (tacr1) |
Non-Patent Citations (4)
Title |
---|
ADCOCK I M ET AL: "Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids.", JOURNAL OF MOLECULAR ENDOCRINOLOGY AUG 1993, vol. 11, no. 1, August 1993 (1993-08-01), pages 1 - 7, XP009092353, ISSN: 0952-5041 * |
ALMEIDA T A ET AL: "Tachykinins and tachykinin receptors: structure and activity relationships.", CURRENT MEDICINAL CHEMISTRY AUG 2004, vol. 11, no. 15, August 2004 (2004-08-01), pages 2045 - 2081, XP002459773, ISSN: 0929-8673 * |
DATABASE EMBL [online] ebi; 6 May 2004 (2004-05-06), "human SNP", XP002479802, retrieved from EMBL Database accession no. ADK91051 * |
DATABASE SNP [online] nih; 17 February 2004 (2004-02-17), XP002459774, retrieved from NCBI.NLM.NIH.GOV Database accession no. ss16811250 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008006105A9 (fr) | 2008-04-03 |
WO2008006105A2 (fr) | 2008-01-10 |
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