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WO2008006001A3 - Genetic polymorphisms associated with scoliosis and use thereof - Google Patents

Genetic polymorphisms associated with scoliosis and use thereof Download PDF

Info

Publication number
WO2008006001A3
WO2008006001A3 PCT/US2007/072785 US2007072785W WO2008006001A3 WO 2008006001 A3 WO2008006001 A3 WO 2008006001A3 US 2007072785 W US2007072785 W US 2007072785W WO 2008006001 A3 WO2008006001 A3 WO 2008006001A3
Authority
WO
WIPO (PCT)
Prior art keywords
scoliosis
risk
polymorphisms associated
genetic polymorphisms
developing
Prior art date
Application number
PCT/US2007/072785
Other languages
French (fr)
Other versions
WO2008006001A2 (en
Inventor
Lesa M Nelson
Kenneth Ward
Original Assignee
Axial Biotech Inc
Lesa M Nelson
Kenneth Ward
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axial Biotech Inc, Lesa M Nelson, Kenneth Ward filed Critical Axial Biotech Inc
Publication of WO2008006001A2 publication Critical patent/WO2008006001A2/en
Priority to US12/024,495 priority Critical patent/US20090035772A1/en
Publication of WO2008006001A3 publication Critical patent/WO2008006001A3/en
Priority to US12/339,011 priority patent/US20090104620A1/en
Priority to US12/341,289 priority patent/US8123787B2/en
Priority to US13/357,800 priority patent/US8641738B1/en
Priority to US13/526,876 priority patent/US20120258884A1/en
Priority to US13/848,772 priority patent/US20130310261A1/en
Priority to US13/852,932 priority patent/US20130288913A1/en
Priority to US14/170,691 priority patent/US9370431B2/en
Priority to US15/186,914 priority patent/US9623152B2/en
Priority to US15/488,870 priority patent/US9757152B2/en
Priority to US15/700,036 priority patent/US11020147B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to novel polymorphisms associated with scoliosis, risk of developing scoliosis and risk of scoliosis curve progression, and methods and materials for determining whether a human subject has scoliosis, is at risk of developing scoliosis or is at risk of scoliosis curve progression.
PCT/US2007/072785 2004-10-28 2007-07-03 Genetic polymorphisms associated with scoliosis and use thereof WO2008006001A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
US12/024,495 US20090035772A1 (en) 2007-07-03 2008-02-01 Genetic Markers Associated With Scoliosis And Uses Thereof
US12/339,011 US20090104620A1 (en) 2007-07-03 2008-12-18 Simplified Method of Determining Predisposition to Scoliosis
US12/341,289 US8123787B2 (en) 2004-10-28 2008-12-22 Method of treating scoliosis using a biological implant
US13/357,800 US8641738B1 (en) 2004-10-28 2012-01-25 Method of treating scoliosis using a biological implant
US13/526,876 US20120258884A1 (en) 2004-10-28 2012-06-19 Method of Determining Predisposition to Scoliosis
US13/848,772 US20130310261A1 (en) 2006-07-03 2013-03-22 Simplified Method of Determining Predisposition to Scoliosis
US13/852,932 US20130288913A1 (en) 2004-10-28 2013-03-28 Method of determining predisposition to scoliosis
US14/170,691 US9370431B2 (en) 2004-10-28 2014-02-03 Method of treating scoliosis using a biological implant
US15/186,914 US9623152B2 (en) 2004-10-28 2016-06-20 Method of treating scoliosis using a biological implant to scoliosis
US15/488,870 US9757152B2 (en) 2004-10-28 2017-04-17 Method of treating scoliosis using a biological implant
US15/700,036 US11020147B2 (en) 2004-10-28 2017-09-08 Method of treating scoliosis using a biological implant

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80649806P 2006-07-03 2006-07-03
US60/806,498 2006-07-03
US82526006P 2006-09-11 2006-09-11
US60/825,260 2006-09-11

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US13/357,800 Continuation-In-Part US8641738B1 (en) 2004-10-28 2012-01-25 Method of treating scoliosis using a biological implant

Related Child Applications (5)

Application Number Title Priority Date Filing Date
US11/259,941 Continuation-In-Part US20060155279A1 (en) 2004-10-28 2005-10-26 Apparatus and method for concave scoliosis expansion
PCT/US2007/078127 Continuation WO2008033813A1 (en) 2006-07-03 2007-09-11 Genetic markers on chromosome 7 associated with scoliosis and use thereof
US11/968,074 Continuation US20090035769A1 (en) 2004-10-28 2007-12-31 Genetic Markers Associated with Scoliosis and Uses Thereof
US11/968,046 Continuation US20090035768A1 (en) 2004-10-28 2007-12-31 Method of Determining Predisposition to Scoliosis and Uses Thereof
US11/968,046 A-371-Of-International US20090035768A1 (en) 2004-10-28 2007-12-31 Method of Determining Predisposition to Scoliosis and Uses Thereof

Publications (2)

Publication Number Publication Date
WO2008006001A2 WO2008006001A2 (en) 2008-01-10
WO2008006001A3 true WO2008006001A3 (en) 2008-05-22

Family

ID=38895454

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/072785 WO2008006001A2 (en) 2004-10-28 2007-07-03 Genetic polymorphisms associated with scoliosis and use thereof

Country Status (1)

Country Link
WO (1) WO2008006001A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8641738B1 (en) 2004-10-28 2014-02-04 James W. Ogilvie Method of treating scoliosis using a biological implant

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
COCKETT N.E. ET AL.: "Localization of the locus causing spider lamb syndrome to the distal end of ovine chromosome 6", MAMMALIAN GENOME, vol. 10, no. 1, January 1999 (1999-01-01), pages 35 - 38 *
GRUNDBERG E.: "Genetic variability in human bone phenotypes", ACTA UNIVERSITATIS UPSALIENSIS UPPSALA 2006, DIGITAL COMPREHENSIVE SUMMARIES OF UPPSALA DISSERATIONS FROM THE FACULTY OF MEDICINE, vol. 135, 26 March 2006 (2006-03-26) *
MILLER N.H. ET AL.: "Linkage analysis of genetic loci for kyphoscoliosis on chromosomes 5p13, 13q13.3 and 13q32", AMERICAN JOURNAL OF MEDICAL GENETICS PART A, vol. 140A, no. 10, 4 April 2006 (2006-04-04), pages 1059 - 1068 *
SHARIPOV R.N. ET AL.: "Polymorphism of the aggrecan gene in families with idiopathic scoliosis", MOLECULAR BIOLOGY, vol. 40, no. 3, March 2006 (2006-03-01), pages 493 - 495, XP019403388, DOI: doi:10.1134/S0026893306030174 *

Also Published As

Publication number Publication date
WO2008006001A2 (en) 2008-01-10

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