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WO2008005942A3 - Sondes susceptibles d'être activées et procédés d'utilisation - Google Patents

Sondes susceptibles d'être activées et procédés d'utilisation Download PDF

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Publication number
WO2008005942A3
WO2008005942A3 PCT/US2007/072680 US2007072680W WO2008005942A3 WO 2008005942 A3 WO2008005942 A3 WO 2008005942A3 US 2007072680 W US2007072680 W US 2007072680W WO 2008005942 A3 WO2008005942 A3 WO 2008005942A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
tafps
activatable probes
detect
probes
Prior art date
Application number
PCT/US2007/072680
Other languages
English (en)
Other versions
WO2008005942A2 (fr
Inventor
Hisataka Kobayashi
Peter L Choyke
Yasuteru Urano
Original Assignee
Govt Of The Usa As Represented
Hisataka Kobayashi
Peter L Choyke
Yasuteru Urano
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Govt Of The Usa As Represented, Hisataka Kobayashi, Peter L Choyke, Yasuteru Urano filed Critical Govt Of The Usa As Represented
Publication of WO2008005942A2 publication Critical patent/WO2008005942A2/fr
Publication of WO2008005942A3 publication Critical patent/WO2008005942A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

La présente invention concerne des sondes fluorescentes, susceptibles d'activation et spécifiques d'une cible, (SFSASC), qui comportent des groupements de marquage et des groupements de ciblage. L'invention concerne également des procédés d'utilisation des SFSASC permettant de détecter des cellules biologiquement, ainsi que des exemples d'utilisation desdits procédés pour détecter des tumeurs in vitro et in vivo.
PCT/US2007/072680 2006-06-30 2007-07-02 Sondes susceptibles d'être activées et procédés d'utilisation WO2008005942A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US81813406P 2006-06-30 2006-06-30
US60/818,134 2006-06-30
US92280107P 2007-04-10 2007-04-10
US60/922,801 2007-04-10

Publications (2)

Publication Number Publication Date
WO2008005942A2 WO2008005942A2 (fr) 2008-01-10
WO2008005942A3 true WO2008005942A3 (fr) 2008-07-31

Family

ID=38895422

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/072680 WO2008005942A2 (fr) 2006-06-30 2007-07-02 Sondes susceptibles d'être activées et procédés d'utilisation

Country Status (1)

Country Link
WO (1) WO2008005942A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8258171B2 (en) 2006-11-15 2012-09-04 The University Of Tokyo pH-sensitive fluorescent probe
EP2151249A1 (fr) * 2008-07-28 2010-02-10 Canon Kabushiki Kaisha Indicateur de pH comprenant un polymère et un fluorophore
US8524239B2 (en) 2010-07-09 2013-09-03 The United States of America as represented by the Secrectary, Department of Health and Human Services Photosensitizing antibody-fluorophore conjugates
WO2013162502A1 (fr) * 2012-04-23 2013-10-31 Empire Technology Development Llc Visualisation de tissu pour une résection
US10588972B2 (en) 2014-06-02 2020-03-17 Li-Cor, Inc. Phthalocyanine probes and uses thereof
ES2743458T5 (es) 2014-08-08 2023-06-08 Us Health Eliminación fotocontrolada de dianas in vitro e in vivo
CN116421721A (zh) * 2022-11-17 2023-07-14 深圳市罗湖区人民医院 一种β-半乳糖苷酶激活的光敏剂、制备方法及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996005863A1 (fr) * 1994-08-19 1996-02-29 La Region Wallonne Composes, composition pharmaceutique et dispositif de diagnostic les comprenant et leur utilisation
WO2002056670A2 (fr) * 2001-01-05 2002-07-25 The General Hospital Corporation Sondes d'imagerie activables
WO2004028449A2 (fr) * 2002-09-24 2004-04-08 The General Hospital Corporation Sondes fluorescentes dans le proche infrarouge a extinction par des dimeres d'azulene
WO2007010128A1 (fr) * 2005-07-21 2007-01-25 Commissariat A L'energie Atomique Vecteur cible avec fonction d'imagerie activable
WO2007070680A2 (fr) * 2005-12-16 2007-06-21 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Sondes detectables optiquement pour l’identification et le traitement de tumeurs

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996005863A1 (fr) * 1994-08-19 1996-02-29 La Region Wallonne Composes, composition pharmaceutique et dispositif de diagnostic les comprenant et leur utilisation
WO2002056670A2 (fr) * 2001-01-05 2002-07-25 The General Hospital Corporation Sondes d'imagerie activables
WO2004028449A2 (fr) * 2002-09-24 2004-04-08 The General Hospital Corporation Sondes fluorescentes dans le proche infrarouge a extinction par des dimeres d'azulene
WO2007010128A1 (fr) * 2005-07-21 2007-01-25 Commissariat A L'energie Atomique Vecteur cible avec fonction d'imagerie activable
WO2007070680A2 (fr) * 2005-12-16 2007-06-21 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Sondes detectables optiquement pour l’identification et le traitement de tumeurs

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
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BREMER CHRISTOPH ET AL: "Optical-based molecular imaging: contrast agents and potential medical applications.", EUROPEAN RADIOLOGY FEB 2003, vol. 13, no. 2, February 2003 (2003-02-01), pages 231 - 243, XP002480501, ISSN: 0938-7994 *
HAMA ET AL: "Targeted optical imaging of cancer cells using lectin-binding BODIPY conjugated avidin", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 348, no. 3, 29 September 2006 (2006-09-29), pages 807 - 813, XP005599056, ISSN: 0006-291X *
HAMA Y ET AL: "A Comparison of the Emission Efficiency of Four Common Green Fluorescence Dyes after Internalization into Cancer Cells", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 17, 17 October 2006 (2006-10-17), pages 1426 - 1431, XP002455986, ISSN: 1043-1802 *
HAMA Y ET AL: "In Vivo Spectral Fluorescence Imaging of Submillimeter Peritoneal Cancer Implants Using a Lectin-Targeted Optical Agent", NEOPLASIA, DOYMA, BARCELONA, ES, vol. 8, no. 7, 1 July 2006 (2006-07-01), pages 607 - 612, XP002455987, ISSN: 0212-9787 *
HAMA YUKIHIRO ET AL: "A target cell-specific activatable fluorescence probe for in vivo molecular imaging of cancer based on a self-quenched avidin-rhodamine conjugate.", CANCER RESEARCH 15 MAR 2007, vol. 67, no. 6, 15 March 2007 (2007-03-15), pages 2791 - 2799, XP002480503, ISSN: 0008-5472 *
HAMA YUKIHIRO ET AL: "Activatable fluorescent molecular imaging of peritoneal metastases following pretargeting with a biotinylated monoclonal antibody.", CANCER RESEARCH 15 APR 2007, vol. 67, no. 8, 15 April 2007 (2007-04-15), pages 3809 - 3817, XP002480504, ISSN: 0008-5472 *
QIN ET AL: "Photophysical properties of an on/off fluorescent pH indicator excitable with visible light based on a borondipyrromethene-linked phenol", JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY, A: CHEMISTRY, ELSEVIER SEQUOIA, LAUSANNE, CH, vol. 183, no. 1-2, 30 September 2006 (2006-09-30), pages 190 - 197, XP005615308, ISSN: 1010-6030 *
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TEXIER ET AL: "Activatable probes for non-invasive small animal fluorescence imaging", NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH, SECTION - A:ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT, ELSEVIER, AMSTERDAM, NL, vol. 571, no. 1-2, 26 January 2007 (2007-01-26), pages 165 - 168, XP005737911, ISSN: 0168-9002 *
WALL D A ET AL: "Endocytic uptake, transport, and catabolism of proteins by epithelial cells.", THE AMERICAN JOURNAL OF PHYSIOLOGY JAN 1985, vol. 248, no. 1 Pt 1, January 1985 (1985-01-01), pages C12 - C20, XP009100030, ISSN: 0002-9513 *
WEISSLEDER R ET AL: "IN VIVO IMAGING OF TUMORS WITH PROTEASE-ACTIVATED NEAR-INFRARED FLUORESCENT PROBES", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 17, 1 January 1999 (1999-01-01), pages 375 - 378, XP008058609, ISSN: 1087-0156 *
YAO Z ET AL: "Imaging of intraperitoneal tumors with technetium-99m GSA", ANNALS OF NUCLEAR MEDICINE, JAPANESE SOCIETY OF NUCLEAR MEDICINE, TOKYO, JP, vol. 12, no. 2, 1 January 1998 (1998-01-01), pages 115 - 118, XP008085056, ISSN: 0914-7187 *

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