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WO2008003320A3 - Three-dimensional cell scaffolds - Google Patents

Three-dimensional cell scaffolds Download PDF

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Publication number
WO2008003320A3
WO2008003320A3 PCT/DK2007/000340 DK2007000340W WO2008003320A3 WO 2008003320 A3 WO2008003320 A3 WO 2008003320A3 DK 2007000340 W DK2007000340 W DK 2007000340W WO 2008003320 A3 WO2008003320 A3 WO 2008003320A3
Authority
WO
WIPO (PCT)
Prior art keywords
dimensional cell
present
scaffolds
dimensional
methods
Prior art date
Application number
PCT/DK2007/000340
Other languages
French (fr)
Other versions
WO2008003320A2 (en
Inventor
Michael Ulrich-Vinther
Carsten Stengaard
Kjeld Soeballe
Brian Elmengaard
Original Assignee
Region Midtjylland
Univ Aarhus
Michael Ulrich-Vinther
Carsten Stengaard
Kjeld Soeballe
Brian Elmengaard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Region Midtjylland, Univ Aarhus, Michael Ulrich-Vinther, Carsten Stengaard, Kjeld Soeballe, Brian Elmengaard filed Critical Region Midtjylland
Publication of WO2008003320A2 publication Critical patent/WO2008003320A2/en
Publication of WO2008003320A3 publication Critical patent/WO2008003320A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/43—Hormones, e.g. dexamethasone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The present invention relates to three-dimensional cell scaffolds that can be used for repairing or regenerating damaged tissue, for example bone and cartilage. The three-dimensional cell scaffold of the present invention comprises a scaffold material and a coating. The coating material comprises a biological agent that aids in the regeneration of cell growth. The present invention further relates to a method of producing three-dimensional scaffolds. Moreover, methods for producing ready-for use implants and methods for regenerating tissue are also within the scope of this invention.
PCT/DK2007/000340 2006-07-05 2007-07-04 Three-dimensional cell scaffolds WO2008003320A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200600928 2006-07-05
DKPA200600928 2006-07-05

Publications (2)

Publication Number Publication Date
WO2008003320A2 WO2008003320A2 (en) 2008-01-10
WO2008003320A3 true WO2008003320A3 (en) 2009-02-26

Family

ID=38603380

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2007/000340 WO2008003320A2 (en) 2006-07-05 2007-07-04 Three-dimensional cell scaffolds

Country Status (1)

Country Link
WO (1) WO2008003320A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0820492D0 (en) 2008-11-07 2008-12-17 Sportcell Cell compositions and uses thereof
WO2011004388A2 (en) * 2009-07-08 2011-01-13 Sridhar K Narasimhachar An apparatus and method of culturing tubular autologous tissue graft
CN101703798B (en) * 2009-11-05 2013-03-20 上海纳米技术及应用国家工程研究中心有限公司 Nano hydroxyapatite coating and preparation method thereof and electrostatic atomization device
KR101067827B1 (en) * 2010-03-19 2011-09-27 포항공과대학교 산학협력단 3D artificial scaffold and its manufacturing method
WO2012052020A1 (en) * 2010-10-19 2012-04-26 Aarhus Universitet Tissue scaffold with controlled drug release
CN102205149B (en) * 2011-05-10 2013-10-02 中国科学院合肥物质科学研究院 Hydroxylapatite (HA)/chitosan/polylactic acid compound bone repair material and preparation method thereof
LT2753346T (en) 2011-09-07 2020-08-10 Mount Sinai School Of Medicine Ceramidase and cell differentiation
IL300460A (en) * 2012-07-24 2023-04-01 Nissan Chemical Corp Culture medium composition, and method for culturing cell or tissue using said composition
CN104740692B (en) * 2013-12-31 2017-09-05 上海微创骨科医疗科技有限公司 Fixation implant and preparation method thereof in a kind of bone
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
CN105363073B (en) * 2014-12-29 2019-11-12 浙江星月生物科技股份有限公司 Tissue engineering bone/cartilage bracket containing bioactie agent and the preparation method and application thereof
CN106492281B (en) * 2016-11-17 2022-02-08 温州医科大学 Biocompatible bone graft and preparation method thereof
CN107412886A (en) * 2017-08-02 2017-12-01 北京华信佳音医疗科技发展有限责任公司 A kind of preparation method of the biomaterial of sclerosed collagen composite polylactic acid
JP2021522938A (en) 2018-05-09 2021-09-02 ザ ジョンズ ホプキンス ユニバーシティ Nanofiber-hydrogel complex for cell and tissue delivery
BR112020022853A2 (en) 2018-05-09 2021-02-23 The Johns Hopkins University microsphere population, formulation, biomaterial, kit, method for performing a procedure, microsphere complex
CN109432509A (en) * 2018-09-17 2019-03-08 陈元峰 A kind of anti-inflammatory and bioactive bracket for facilitating cartilage differentiation and its preparation method and application
CN109437826B (en) * 2018-11-29 2021-03-23 广州润虹医药科技股份有限公司 Magnesium phosphate bone cement capable of being printed in 3D mode and preparation method and application thereof
KR102179902B1 (en) * 2019-08-08 2020-11-17 단국대학교 천안캠퍼스 산학협력단 Scaffolds for differentiation of odontoblast and method for differentiation of odontoblast using the same
CN115518198B (en) * 2022-10-11 2024-01-16 青岛大学 Vascular repair stent loaded with bidirectional gradient ECM coating and preparation method thereof
CN115944776B (en) * 2022-12-30 2024-07-09 中国科学院上海硅酸盐研究所 Bioprinting tendon-bone imitation multi-cell scaffold and preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
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WO2000016817A1 (en) * 1998-09-24 2000-03-30 Korea Atomic Energy Research Institute Dermal scaffold using neutralized chitosan sponge or neutralized chitosan/collagen mixed sponge
WO2003070186A2 (en) * 2002-02-20 2003-08-28 The Cleveland Clinic Foundation Composition and method for inducing bone growth and healing
US20040126405A1 (en) * 2002-12-30 2004-07-01 Scimed Life Systems, Inc. Engineered scaffolds for promoting growth of cells
US20060039947A1 (en) * 1998-09-11 2006-02-23 Gerhard Schmidmaier Biologically active implants

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060039947A1 (en) * 1998-09-11 2006-02-23 Gerhard Schmidmaier Biologically active implants
WO2000016817A1 (en) * 1998-09-24 2000-03-30 Korea Atomic Energy Research Institute Dermal scaffold using neutralized chitosan sponge or neutralized chitosan/collagen mixed sponge
WO2003070186A2 (en) * 2002-02-20 2003-08-28 The Cleveland Clinic Foundation Composition and method for inducing bone growth and healing
US20040126405A1 (en) * 2002-12-30 2004-07-01 Scimed Life Systems, Inc. Engineered scaffolds for promoting growth of cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A. ZHU ET AL: "Covalent immobilization of chitosan/heparin complex with a photosensitive hetero-functional crosslinking reagent on PLA surface", BIOMATERIALS, vol. 23, 2002, pages 4657 - 4665, XP004377538 *

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Publication number Publication date
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