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WO2008002929A3 - Heterologous cross-sensitization for improved agonist activity - Google Patents

Heterologous cross-sensitization for improved agonist activity Download PDF

Info

Publication number
WO2008002929A3
WO2008002929A3 PCT/US2007/072147 US2007072147W WO2008002929A3 WO 2008002929 A3 WO2008002929 A3 WO 2008002929A3 US 2007072147 W US2007072147 W US 2007072147W WO 2008002929 A3 WO2008002929 A3 WO 2008002929A3
Authority
WO
WIPO (PCT)
Prior art keywords
sensitization
agonist activity
heterologous cross
improved agonist
heterologous
Prior art date
Application number
PCT/US2007/072147
Other languages
French (fr)
Other versions
WO2008002929A2 (en
Inventor
Richard A Bond
Original Assignee
Inverseon Inc
Richard A Bond
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inverseon Inc, Richard A Bond filed Critical Inverseon Inc
Publication of WO2008002929A2 publication Critical patent/WO2008002929A2/en
Publication of WO2008002929A3 publication Critical patent/WO2008002929A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Methods for improving the effectiveness of prostacyclin agonists by heterologous sensitization by co-administering beta adrenergic inverse agonists are provided for the treatment of pulmonary hypertension and other diseases treated by chronic prostacyclin treatment.
PCT/US2007/072147 2006-06-26 2007-06-26 Heterologous cross-sensitization for improved agonist activity WO2008002929A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81668706P 2006-06-26 2006-06-26
US60/816,687 2006-06-26

Publications (2)

Publication Number Publication Date
WO2008002929A2 WO2008002929A2 (en) 2008-01-03
WO2008002929A3 true WO2008002929A3 (en) 2008-07-10

Family

ID=38846479

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/072147 WO2008002929A2 (en) 2006-06-26 2007-06-26 Heterologous cross-sensitization for improved agonist activity

Country Status (1)

Country Link
WO (1) WO2008002929A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9371264B2 (en) 2013-01-11 2016-06-21 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9394227B1 (en) 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US10246403B2 (en) 2015-06-17 2019-04-02 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050043391A1 (en) * 2003-07-17 2005-02-24 Fong Benson M. Combination therapies for treatment of hypertension and complications in patients with diabetes or metabolic syndrome
US20060104913A1 (en) * 2003-06-27 2006-05-18 Merck Patent Gmbh Inhalable formulations for treating pulmonary hypertension and methods of using same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060104913A1 (en) * 2003-06-27 2006-05-18 Merck Patent Gmbh Inhalable formulations for treating pulmonary hypertension and methods of using same
US20050043391A1 (en) * 2003-07-17 2005-02-24 Fong Benson M. Combination therapies for treatment of hypertension and complications in patients with diabetes or metabolic syndrome

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MIGGIN ET AL.: "Investigation of the Mechanism of G Protein: Effector Coupling by the Human and Mouse Prostacyclin Receptors", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, 2002, pages 27053 - 27064 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9371264B2 (en) 2013-01-11 2016-06-21 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9394227B1 (en) 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US10053414B2 (en) 2015-06-17 2018-08-21 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US10246403B2 (en) 2015-06-17 2019-04-02 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof

Also Published As

Publication number Publication date
WO2008002929A2 (en) 2008-01-03

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