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WO2008002165A3 - A method, assay and kit for prediction and treatment of a human subject infected with a virus - Google Patents

A method, assay and kit for prediction and treatment of a human subject infected with a virus Download PDF

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Publication number
WO2008002165A3
WO2008002165A3 PCT/PL2007/000044 PL2007000044W WO2008002165A3 WO 2008002165 A3 WO2008002165 A3 WO 2008002165A3 PL 2007000044 W PL2007000044 W PL 2007000044W WO 2008002165 A3 WO2008002165 A3 WO 2008002165A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
human subject
virus
prediction
assay
Prior art date
Application number
PCT/PL2007/000044
Other languages
French (fr)
Other versions
WO2008002165A2 (en
Inventor
Krzysztof Kucharczyk
Radoslaw Kaczanowski
Original Assignee
Krzysztof Kucharczyk
Radoslaw Kaczanowski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krzysztof Kucharczyk, Radoslaw Kaczanowski filed Critical Krzysztof Kucharczyk
Publication of WO2008002165A2 publication Critical patent/WO2008002165A2/en
Publication of WO2008002165A3 publication Critical patent/WO2008002165A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Methods and reagents for determining of viral quasispecies diversity and number of different viral variants present in the sample useful in predicting human response to treatment are presented. The present invention is based on the discovery that in human subject infected with virus, there is a significant association between change of number of different viral quasispecies and their genetic and polypeptide diversity and the infected human subject response to treatment in the first weeks of treatment. Specifically, individuals in whom the number of different viral subspecies and their polypeptide diversity is reduced in the first weeks of treatment, will have an increased likelihood of sustained virologic response to treatment comprising interferon.
PCT/PL2007/000044 2006-06-30 2007-06-30 A method, assay and kit for prediction and treatment of a human subject infected with a virus WO2008002165A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81788806P 2006-06-30 2006-06-30
US60/817,888 2006-06-30

Publications (2)

Publication Number Publication Date
WO2008002165A2 WO2008002165A2 (en) 2008-01-03
WO2008002165A3 true WO2008002165A3 (en) 2008-05-29

Family

ID=38727463

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PL2007/000044 WO2008002165A2 (en) 2006-06-30 2007-06-30 A method, assay and kit for prediction and treatment of a human subject infected with a virus

Country Status (1)

Country Link
WO (1) WO2008002165A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2342363B1 (en) * 2008-10-06 2015-06-10 Janssen Diagnostics BVBA Method for determining drug resistance mutations in any of the non-structural protein regions ns3 to ns5b of hepatitis c virus (hcv) for genotypes 1 to 6
AU2013205064B2 (en) 2012-06-04 2015-07-30 Gen-Probe Incorporated Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
EP2754450A1 (en) 2013-01-11 2014-07-16 Österreichische Akademie der Wissenschaften Lactoferricin derived peptides
WO2024223883A1 (en) 2023-04-26 2024-10-31 Karl-Franzens-Universität Graz Peptides for cancer therapy
WO2024223887A1 (en) 2023-04-26 2024-10-31 Karl-Franzens-Universität Graz Peptides for antimicrobial therapy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998039487A1 (en) * 1997-03-05 1998-09-11 Ribogene, Inc. Novel screening methods to identify agents that selectively inhibit hepatitis c virus replication

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998039487A1 (en) * 1997-03-05 1998-09-11 Ribogene, Inc. Novel screening methods to identify agents that selectively inhibit hepatitis c virus replication

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ENOMOTO N ET AL: "COMPARISON OF FULL-LENGTH SEQUENCES OF INTERFERON-SENSITIVE AND RESISTANT HEPATITIS C VIRUS 1B. SENSITIVITY TO INTERFERON IS CONFERRED BY AMINO ACID SUBSTITUTIONS IN THE NS5A REGION", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 96, no. 1, 1 July 1995 (1995-07-01), pages 224 - 230, XP000196704, ISSN: 0021-9738 *
FARCI P ET AL: "THE OUTCOME OF ACUTE HEPATITIS C PREDICTED BY THE EVOLUTION OF THE VIRAL QUASISPECIES", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 288, 14 April 2000 (2000-04-14), pages 339 - 344, XP001183298, ISSN: 0036-8075 *
FARCI PATRIZIA ET AL: "Early changes in hepatitis C viral quasispecies during interferon therapy predict the therapeutic outcome", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 99, no. 5, 5 March 2002 (2002-03-05), pages 3081 - 3086, XP002474017, ISSN: 0027-8424 *
OKADA S ET AL: "THE DEGREE OF VARIABILITY IN THE AMINO TERMINAL REGION OF THE E2/NS1 PROTEIN OF HEPATITIS C VIRUS CORRELATES WITH RESPONSIVENESS TO INTERFERON THERAPY IN VIREMIC PATIENTS", HEPATOLOGY, WILLIAMS AND WILKINS, BALTIMORE, MD, US, vol. 16, no. 3, September 1992 (1992-09-01), pages 619 - 624, XP001018408, ISSN: 0270-9139 *

Also Published As

Publication number Publication date
WO2008002165A2 (en) 2008-01-03

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