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WO2008088810A3 - Formulations pour des traitements cosmétiques et de parage comprenant des photosensibilisateurs en tant que marqueurs fluorescents - Google Patents

Formulations pour des traitements cosmétiques et de parage comprenant des photosensibilisateurs en tant que marqueurs fluorescents Download PDF

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Publication number
WO2008088810A3
WO2008088810A3 PCT/US2008/000537 US2008000537W WO2008088810A3 WO 2008088810 A3 WO2008088810 A3 WO 2008088810A3 US 2008000537 W US2008000537 W US 2008000537W WO 2008088810 A3 WO2008088810 A3 WO 2008088810A3
Authority
WO
WIPO (PCT)
Prior art keywords
fillers
photosensitizer
cosmetic
injected
injection
Prior art date
Application number
PCT/US2008/000537
Other languages
English (en)
Other versions
WO2008088810A2 (fr
Inventor
Wolfgang Neuberger
Susanna Grafe
Nikolay Nifantiev
Original Assignee
Ceramoptec Ind Inc
Wolfgang Neuberger
Susanna Grafe
Nikolay Nifantiev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/004,325 external-priority patent/US20090162423A1/en
Priority claimed from US12/006,911 external-priority patent/US20080214460A1/en
Application filed by Ceramoptec Ind Inc, Wolfgang Neuberger, Susanna Grafe, Nikolay Nifantiev filed Critical Ceramoptec Ind Inc
Publication of WO2008088810A2 publication Critical patent/WO2008088810A2/fr
Publication of WO2008088810A3 publication Critical patent/WO2008088810A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/42—Colour properties
    • A61K2800/43—Pigments; Dyes
    • A61K2800/434—Luminescent, Fluorescent; Optical brighteners; Photosensitizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des matériaux photoactifs, tels que des photosensibilisateurs, qui sont utilisés en tant que marqueurs fluorescents pour une détection in vivo de la répartition de la matière de remplissage injectée lors de traitements cosmétiques. Selon un mode préféré de réalisation, de la témoporfine liposomale formulée est utilisée, en tant que composant photoactif, en de très faibles concentrations ainsi que des matières de remplissage pour des applications cosmétiques et de cicatrisation de plaie. Des matières de remplissage qui peuvent être utilisées dans l'invention comprennent du collagène, des acides hyaluroniques et d'autres produits synthétiques ou naturels qui sont généralement utilisés pour la cicatrisation de plaie, la réduction de cicatrice et autres applications médicales semblables. Selon un mode préféré de réalisation, le photosensibilisateur formulé est couplé à la matière de remplissage, de sorte qu'un suivi est possible sur de plus longues périodes de temps. Un photosensibilisateur liposomal est injecté avec les matières de remplissage dans la zone de traitement, puis irradié avec une lumière laser peu de temps après l'injection. La fluorescence émise est mesurée par un dispositif non invasif particulier. Il est de ce fait possible de surveiller le lieu d'injection et la répartition de la solution injectée autour du lieu d'injection. Une fois irradiée avec le laser ou toute autre source lumineuse, la fluorescence du photosensibilisateur est détectée en utilisant un détecteur de fluorescence, ce qui permet de suivre la matière de remplissage au niveau du lieu d'injection et dans le volume d'injection.
PCT/US2008/000537 2007-01-18 2008-01-16 Formulations pour des traitements cosmétiques et de parage comprenant des photosensibilisateurs en tant que marqueurs fluorescents WO2008088810A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US88110707P 2007-01-18 2007-01-18
US60/881,107 2007-01-18
US12/004,325 US20090162423A1 (en) 2007-12-20 2007-12-20 Formulations for cosmetic and wound care treatments with photosensitizes as fluorescent markers
US12/004,325 2007-12-20
US12/006,911 US20080214460A1 (en) 2007-01-18 2008-01-07 Formulations for cosmetic and wound care treatments with photosensitizers as fluorescent markers
US12/006,911 2008-01-07

Publications (2)

Publication Number Publication Date
WO2008088810A2 WO2008088810A2 (fr) 2008-07-24
WO2008088810A3 true WO2008088810A3 (fr) 2008-12-18

Family

ID=39636569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/000537 WO2008088810A2 (fr) 2007-01-18 2008-01-16 Formulations pour des traitements cosmétiques et de parage comprenant des photosensibilisateurs en tant que marqueurs fluorescents

Country Status (1)

Country Link
WO (1) WO2008088810A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999048474A1 (fr) * 1998-03-20 1999-09-30 Mario Luca Russo Compositions pharmaceutiques ou cosmetiques contenant des substances photosensibles
US20030157026A1 (en) * 2001-06-27 2003-08-21 Katsuo Aizawa Photodynamic diagnosis and therapy for insulin-dependent diabetes mellitus
US20060127471A1 (en) * 2003-08-26 2006-06-15 Ceramoptec Industries, Inc. Pegylated liposomal formulations of hydrophobic photosensitizers for photodynamic therapy
US20070031482A1 (en) * 2005-08-02 2007-02-08 Ceramoptec Industries, Ind. PDT treatment method for cellulites and cosmetic use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999048474A1 (fr) * 1998-03-20 1999-09-30 Mario Luca Russo Compositions pharmaceutiques ou cosmetiques contenant des substances photosensibles
US20030157026A1 (en) * 2001-06-27 2003-08-21 Katsuo Aizawa Photodynamic diagnosis and therapy for insulin-dependent diabetes mellitus
US20060127471A1 (en) * 2003-08-26 2006-06-15 Ceramoptec Industries, Inc. Pegylated liposomal formulations of hydrophobic photosensitizers for photodynamic therapy
US20070031482A1 (en) * 2005-08-02 2007-02-08 Ceramoptec Industries, Ind. PDT treatment method for cellulites and cosmetic use

Also Published As

Publication number Publication date
WO2008088810A2 (fr) 2008-07-24

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