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WO2008076491A3 - Sensor for implantable medical device - Google Patents

Sensor for implantable medical device Download PDF

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Publication number
WO2008076491A3
WO2008076491A3 PCT/US2007/079248 US2007079248W WO2008076491A3 WO 2008076491 A3 WO2008076491 A3 WO 2008076491A3 US 2007079248 W US2007079248 W US 2007079248W WO 2008076491 A3 WO2008076491 A3 WO 2008076491A3
Authority
WO
WIPO (PCT)
Prior art keywords
ion
crown
medical device
sensor
implantable medical
Prior art date
Application number
PCT/US2007/079248
Other languages
French (fr)
Other versions
WO2008076491A2 (en
Inventor
Zhengrong Zhou
Qingshan Ye
Original Assignee
Medtronic Inc
Zhengrong Zhou
Qingshan Ye
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc, Zhengrong Zhou, Qingshan Ye filed Critical Medtronic Inc
Priority to EP07871092A priority Critical patent/EP2109767A2/en
Publication of WO2008076491A2 publication Critical patent/WO2008076491A2/en
Publication of WO2008076491A3 publication Critical patent/WO2008076491A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/333—Ion-selective electrodes or membranes
    • G01N27/3335—Ion-selective electrodes or membranes the membrane containing at least one organic component

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Electrochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Electrotherapy Devices (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

Ion sensors on a medical device lead is presented. An ion sensor includes an ion-selective working electrode and an ion-selective reference electrode. At least one of the electrodes includes a partially fluorinated organic compound based on bis [ (12-crown-4) methyl] malonates, bis [benzo-15-crown-5] amides and benzo-18-crown-6-amines as ionophore. Optical sensors incorporating these compounds are also disclosed.
PCT/US2007/079248 2006-09-21 2007-09-21 Sensor for implantable medical device WO2008076491A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07871092A EP2109767A2 (en) 2006-09-21 2007-09-21 Sensor for implantable medical device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82649306P 2006-09-21 2006-09-21
US60/826,493 2006-09-21

Publications (2)

Publication Number Publication Date
WO2008076491A2 WO2008076491A2 (en) 2008-06-26
WO2008076491A3 true WO2008076491A3 (en) 2008-12-31

Family

ID=39536932

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/079248 WO2008076491A2 (en) 2006-09-21 2007-09-21 Sensor for implantable medical device

Country Status (2)

Country Link
EP (1) EP2109767A2 (en)
WO (1) WO2008076491A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014179011A1 (en) * 2013-05-02 2014-11-06 Biochem Technology, Inc. Low drift ion selective electrode sensors
CN104710380B (en) * 2015-01-06 2017-08-08 南京工业大学 Vesicle probe for detecting lead ions, preparation method and application
CN108968976B (en) * 2017-05-31 2022-09-13 心脏起搏器股份公司 Implantable medical device with chemical sensor
WO2019023093A1 (en) 2017-07-26 2019-01-31 Cardiac Pacemakers, Inc. Systems and methods for disambiguation of posture
CN109381195B (en) 2017-08-10 2023-01-10 心脏起搏器股份公司 Systems and methods including electrolyte sensor fusion
CN109419515B (en) 2017-08-23 2023-03-24 心脏起搏器股份公司 Implantable chemical sensor with staged activation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0221508A1 (en) * 1985-10-30 1987-05-13 Hitachi, Ltd. Sodium ion selective electrode
JPH02237982A (en) * 1989-03-10 1990-09-20 Neos Co Ltd Fluorine-containing azacrown ether
JPH09208576A (en) * 1996-01-27 1997-08-12 Doujin Kagaku Kenkyusho:Kk Crown compound excellent in sodium ion selectivity
US6165796A (en) * 1997-11-26 2000-12-26 Beckman Coulter, Inc. Pipettable ion detector and method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0221508A1 (en) * 1985-10-30 1987-05-13 Hitachi, Ltd. Sodium ion selective electrode
JPH02237982A (en) * 1989-03-10 1990-09-20 Neos Co Ltd Fluorine-containing azacrown ether
JPH09208576A (en) * 1996-01-27 1997-08-12 Doujin Kagaku Kenkyusho:Kk Crown compound excellent in sodium ion selectivity
US6165796A (en) * 1997-11-26 2000-12-26 Beckman Coulter, Inc. Pipettable ion detector and method

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ELSHANI S ET AL: "Macrocyclic Ligands with Partially Fluorinated Sidearms: Synthesis and Metal Ion Complexation", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 56, no. 21, 1 May 2000 (2000-05-01), pages 3291 - 3301, XP004204439, ISSN: 0040-4020 *
ELSHANI S ET AL: "Synthesis of Macrocyclic Polyethers with Partially Fluorinated Side Arms", JOURNAL OF HETEROCYCLIC CHEMISTRY,, vol. 40, 1 May 2003 (2003-05-01), pages 451 - 458, XP009101979, ISSN: 0022-152x *

Also Published As

Publication number Publication date
WO2008076491A2 (en) 2008-06-26
EP2109767A2 (en) 2009-10-21

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