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WO2008060368A3 - Transglutaminase-binding peptides and methods of use - Google Patents

Transglutaminase-binding peptides and methods of use Download PDF

Info

Publication number
WO2008060368A3
WO2008060368A3 PCT/US2007/021163 US2007021163W WO2008060368A3 WO 2008060368 A3 WO2008060368 A3 WO 2008060368A3 US 2007021163 W US2007021163 W US 2007021163W WO 2008060368 A3 WO2008060368 A3 WO 2008060368A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
transglutaminase
binding peptides
compositions
subject matter
Prior art date
Application number
PCT/US2007/021163
Other languages
French (fr)
Other versions
WO2008060368A2 (en
Inventor
Mark W Dewhirst
Zahid N Rabbani
Zeljko Vujaskovic
Charles S Greenberg
John C Kirkpatrick
Hong Yuan
Original Assignee
Univ Duke
Mark W Dewhirst
Zahid N Rabbani
Zeljko Vujaskovic
Charles S Greenberg
John C Kirkpatrick
Hong Yuan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke, Mark W Dewhirst, Zahid N Rabbani, Zeljko Vujaskovic, Charles S Greenberg, John C Kirkpatrick, Hong Yuan filed Critical Univ Duke
Publication of WO2008060368A2 publication Critical patent/WO2008060368A2/en
Publication of WO2008060368A3 publication Critical patent/WO2008060368A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The presently disclosed subject matter discloses diagnostic and prognostic techniques and compositions for the detection and evaluation of a pathologic disorder. Particularly, the presently disclosed subject matter relates to compositions and methods for evaluating the presence of transglutaminase expression in a pathologic condition compared to normal, healthy expression to diagnose, treat and effectively monitor the pathologic condition.
PCT/US2007/021163 2006-10-02 2007-10-02 Transglutaminase-binding peptides and methods of use WO2008060368A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84871006P 2006-10-02 2006-10-02
US60/848,710 2006-10-02

Publications (2)

Publication Number Publication Date
WO2008060368A2 WO2008060368A2 (en) 2008-05-22
WO2008060368A3 true WO2008060368A3 (en) 2008-09-25

Family

ID=39402167

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/021163 WO2008060368A2 (en) 2006-10-02 2007-10-02 Transglutaminase-binding peptides and methods of use

Country Status (1)

Country Link
WO (1) WO2008060368A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060052308A1 (en) * 2003-11-18 2006-03-09 The Board Of Trustees Of The Leland Stanford Junior University Transglutaminase inhibitors and methods of use thereof
US20060083689A1 (en) * 2001-01-05 2006-04-20 Duke University Contrast enhancement agent for magnetic resonance imaging
US7049289B1 (en) * 1998-05-15 2006-05-23 Amersham Plc Labelled glutamine and lysine analogues

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7049289B1 (en) * 1998-05-15 2006-05-23 Amersham Plc Labelled glutamine and lysine analogues
US20060083689A1 (en) * 2001-01-05 2006-04-20 Duke University Contrast enhancement agent for magnetic resonance imaging
US20060052308A1 (en) * 2003-11-18 2006-03-09 The Board Of Trustees Of The Leland Stanford Junior University Transglutaminase inhibitors and methods of use thereof

Also Published As

Publication number Publication date
WO2008060368A2 (en) 2008-05-22

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