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WO2008059009A3 - Factor v mutants for hemostasis in hemophilia - Google Patents

Factor v mutants for hemostasis in hemophilia Download PDF

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Publication number
WO2008059009A3
WO2008059009A3 PCT/EP2007/062366 EP2007062366W WO2008059009A3 WO 2008059009 A3 WO2008059009 A3 WO 2008059009A3 EP 2007062366 W EP2007062366 W EP 2007062366W WO 2008059009 A3 WO2008059009 A3 WO 2008059009A3
Authority
WO
WIPO (PCT)
Prior art keywords
hemophilia
factor
hemostasis
mutants
patient
Prior art date
Application number
PCT/EP2007/062366
Other languages
French (fr)
Other versions
WO2008059009A2 (en
Inventor
Dirk Jan Elbertus Opstelten
Christopher Adam Yallop
Cornelis Erik Hack
Josephus Cornelis Maria Meijers
Original Assignee
Crucell Holland Bv
Dirk Jan Elbertus Opstelten
Christopher Adam Yallop
Cornelis Erik Hack
Meijers Josephus Cornelis Mari
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crucell Holland Bv, Dirk Jan Elbertus Opstelten, Christopher Adam Yallop, Cornelis Erik Hack, Meijers Josephus Cornelis Mari filed Critical Crucell Holland Bv
Publication of WO2008059009A2 publication Critical patent/WO2008059009A2/en
Publication of WO2008059009A3 publication Critical patent/WO2008059009A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides a method for preventing or treating bleeding in joints, muscle and/or soft tissues in a hemophilia patient, comprising administering to the patient an effective hemostatic amount of APC-resistant Factor V.
PCT/EP2007/062366 2006-11-16 2007-11-15 Factor v mutants for hemostasis in hemophilia WO2008059009A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US85930606P 2006-11-16 2006-11-16
US60/859,306 2006-11-16
EP06124261.6 2006-11-16
EP06124261 2006-11-16
US94349607P 2007-06-12 2007-06-12
US60/943,496 2007-06-12

Publications (2)

Publication Number Publication Date
WO2008059009A2 WO2008059009A2 (en) 2008-05-22
WO2008059009A3 true WO2008059009A3 (en) 2009-02-26

Family

ID=39402037

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/062366 WO2008059009A2 (en) 2006-11-16 2007-11-15 Factor v mutants for hemostasis in hemophilia

Country Status (1)

Country Link
WO (1) WO2008059009A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110230645A1 (en) 2008-12-16 2011-09-22 Crucell Holland B.V. Purification of factor v
WO2011131774A1 (en) * 2010-04-21 2011-10-27 Erik Berntorp Genetic factors associated with inhibitor development in hemophilia a
GB201322091D0 (en) 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995029259A1 (en) * 1994-04-22 1995-11-02 Stichting Centraal Laboratorium Van De Bloedtransfusiedienst Van Het Nederlandse Rode Kruis Method and means for detecting and treating disorders in the blood coagulation cascade

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995029259A1 (en) * 1994-04-22 1995-11-02 Stichting Centraal Laboratorium Van De Bloedtransfusiedienst Van Het Nederlandse Rode Kruis Method and means for detecting and treating disorders in the blood coagulation cascade
EP0756638A1 (en) * 1994-04-22 1997-02-05 Stichting Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis Method and means for detecting and treating disorders in the blood coagulation cascade

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BLOOD, vol. 102, no. 11, 16 November 2003 (2003-11-16), 45TH ANNUAL MEETING OF THE AMERICAN SOCIETY OF HEMATOLOGY; SAN DIEGO, CA, USA; DECEMBER 06-09, 2003, pages 550a, ISSN: 0006-4971 *
BOS M H A ET AL: "Does activated protein C-resistant factor V contribute to thrombin generation in hemophilic plasma?", JOURNAL OF THROMBOSIS AND HAEMOSTASIS : JTH MAR 2005, vol. 3, no. 3, March 2005 (2005-03-01), pages 522 - 530, XP008078605, ISSN: 1538-7933 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2003 (2003-11-16), MERTENS KOEN ET AL: "Factor V variants that are resistant against activated protein C may compensate for defects upstream in the coagulation cascade.", XP002432590, Database accession no. PREV200400147341 *

Also Published As

Publication number Publication date
WO2008059009A2 (en) 2008-05-22

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