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WO2008053358A3 - A common gene expression signature in dilated cardiomyopathy - Google Patents

A common gene expression signature in dilated cardiomyopathy Download PDF

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Publication number
WO2008053358A3
WO2008053358A3 PCT/IB2007/004191 IB2007004191W WO2008053358A3 WO 2008053358 A3 WO2008053358 A3 WO 2008053358A3 IB 2007004191 W IB2007004191 W IB 2007004191W WO 2008053358 A3 WO2008053358 A3 WO 2008053358A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene expression
dilated cardiomyopathy
expression signature
common gene
cardiomyopathy
Prior art date
Application number
PCT/IB2007/004191
Other languages
French (fr)
Other versions
WO2008053358A2 (en
WO2008053358A8 (en
Inventor
Ruprecht Kuner
Holger Sueltmann
Markus Ruschhaupt
Andreas Buness
Andreas Barth
Michael Nabauer
Annemarie Poustka
Original Assignee
Deutsches Krebsforsch
Ruprecht Kuner
Holger Sueltmann
Markus Ruschhaupt
Andreas Buness
Andreas Barth
Michael Nabauer
Annemarie Poustka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforsch, Ruprecht Kuner, Holger Sueltmann, Markus Ruschhaupt, Andreas Buness, Andreas Barth, Michael Nabauer, Annemarie Poustka filed Critical Deutsches Krebsforsch
Priority to EP07866600A priority Critical patent/EP2046997A2/en
Priority to JP2009521384A priority patent/JP2009544306A/en
Publication of WO2008053358A2 publication Critical patent/WO2008053358A2/en
Publication of WO2008053358A3 publication Critical patent/WO2008053358A3/en
Publication of WO2008053358A8 publication Critical patent/WO2008053358A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides a convenient and highly effective microarray tool and method for diagnosing a cardiomyopathy state, especially dilated cardiomyopathy, in a subject, with a high degree of accuracy.
PCT/IB2007/004191 2006-07-25 2007-07-24 A common gene expression signature in dilated cardiomyopathy WO2008053358A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07866600A EP2046997A2 (en) 2006-07-25 2007-07-24 A common gene expression signature in dilated cardiomyopathy
JP2009521384A JP2009544306A (en) 2006-07-25 2007-07-24 Common gene expression signature for dilated cardiomyopathy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83295906P 2006-07-25 2006-07-25
US60/832,959 2006-07-25

Publications (3)

Publication Number Publication Date
WO2008053358A2 WO2008053358A2 (en) 2008-05-08
WO2008053358A3 true WO2008053358A3 (en) 2008-11-20
WO2008053358A8 WO2008053358A8 (en) 2009-08-27

Family

ID=39344668

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/004191 WO2008053358A2 (en) 2006-07-25 2007-07-24 A common gene expression signature in dilated cardiomyopathy

Country Status (3)

Country Link
EP (1) EP2046997A2 (en)
JP (1) JP2009544306A (en)
WO (1) WO2008053358A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2274622B1 (en) * 2008-04-30 2014-10-08 The Governing Council of the University of Toronto Use of sfrp-3 in the assessment of heart failure
AU2018222743B2 (en) 2017-02-17 2024-05-02 Bristol-Myers Squibb Company Antibodies to alpha-synuclein and uses thereof
CN110809718A (en) * 2017-06-21 2020-02-18 韩国生命工学研究院 Method and kit for diagnosing muscle weakness-related diseases using blood biomarkers
CN113355332B (en) * 2021-07-22 2022-09-06 青岛市妇女儿童医院 HEG1 Gene Mutants and Their Applications

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024571A2 (en) * 1997-11-10 1999-05-20 Curagen Corporation Differentially expressed genes in cardiac hypertrophy and their uses in treatment and diagnosis
WO2003006687A2 (en) * 2001-07-10 2003-01-23 Medigene Ag Novel target genes for diseases of the heart
WO2003040407A2 (en) * 2001-11-09 2003-05-15 Max-Planck-Gesellschaft Novel markers for cardiopathies
WO2005060656A2 (en) * 2003-12-16 2005-07-07 Hare Joshua M Identification of a gene expression profile that differentiates ischemic and nonischemic cardiomyopathy

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024571A2 (en) * 1997-11-10 1999-05-20 Curagen Corporation Differentially expressed genes in cardiac hypertrophy and their uses in treatment and diagnosis
WO2003006687A2 (en) * 2001-07-10 2003-01-23 Medigene Ag Novel target genes for diseases of the heart
WO2003040407A2 (en) * 2001-11-09 2003-05-15 Max-Planck-Gesellschaft Novel markers for cardiopathies
WO2005060656A2 (en) * 2003-12-16 2005-07-07 Hare Joshua M Identification of a gene expression profile that differentiates ischemic and nonischemic cardiomyopathy
US20050158756A1 (en) * 2003-12-16 2005-07-21 Joshua Hare Identification of a gene expression profile that differentiates ischemic and nonischemic cardiomyopathy

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"Affimetrix GeneChip Human Genome U133 Array Set HG-U133A", GEO,, 1 January 1900 (1900-01-01), XP002254749 *
BOHELER ET AL: "Gene expression in cardiac hypertrophy", DS IN CARDIOVASCULAR MEDICINE, ELSEVIER SCIENCE, NEW YORK, NY, US, vol. 2, no. 5, 1 September 1992 (1992-09-01), pages 176 - 182, XP002096139, ISSN: 1050-1738 *
HWANG JUEY-JEN ET AL: "Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure", PHYSIOLOGICAL GENOMICS, vol. 10, October 2002 (2002-10-01), pages 31 - 44, XP002488465, ISSN: 1094-8341 *
TAN F-L ET AL: "The gene expression fingerprint of human heart failure", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, vol. 99, no. 17, 20 August 2002 (2002-08-20), pages 11387 - 11392, XP002970100, ISSN: 0027-8424 *
YUNG C K ET AL: "Gene expression profiles in end-stage human idiopathic dilated cardiomyopathy: altered expression of apoptotic and cytoskeletal genes", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 83, no. 2, 1 February 2004 (2004-02-01), pages 281 - 297, XP004482956, ISSN: 0888-7543 *

Also Published As

Publication number Publication date
WO2008053358A2 (en) 2008-05-08
EP2046997A2 (en) 2009-04-15
JP2009544306A (en) 2009-12-17
WO2008053358A8 (en) 2009-08-27

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