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WO2008050198A2 - Méthode cosmétique pour tonifier le derme - Google Patents

Méthode cosmétique pour tonifier le derme Download PDF

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Publication number
WO2008050198A2
WO2008050198A2 PCT/IB2007/003091 IB2007003091W WO2008050198A2 WO 2008050198 A2 WO2008050198 A2 WO 2008050198A2 IB 2007003091 W IB2007003091 W IB 2007003091W WO 2008050198 A2 WO2008050198 A2 WO 2008050198A2
Authority
WO
WIPO (PCT)
Prior art keywords
toning
dermis
cosmetic method
zone
fibroblasts
Prior art date
Application number
PCT/IB2007/003091
Other languages
English (en)
Other versions
WO2008050198A3 (fr
Inventor
Clelia Barini
Original Assignee
Clelia Barini
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clelia Barini filed Critical Clelia Barini
Publication of WO2008050198A2 publication Critical patent/WO2008050198A2/fr
Publication of WO2008050198A3 publication Critical patent/WO2008050198A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/81—Preparation or application process involves irradiation

Definitions

  • the invention refers to a cosmetic method for toning up the dermis, in particular the dermis of human beings .
  • the surface layer o f epidermis is removed in the areas where the rejuvenation treatment of the skin is wanted using a laser beam emitted by a speci fic emitter apparatus so wrinkles and other superficial epidermis defects can no longer be seen because they have been completely removed.
  • the dermi s that is the part of the tissue immediately under the epidermis, is toned up stimulating the production o f collagens in various ways by the cells of the connective tissue, named fibroblasts .
  • the fibroblasts are stimul ated by causing a traum a in a zone of the dermis where toning up is wanted and this trauma can be caused in different ways, that is, ways that are able to modify the homoeo stasis of the zone o f the dermis .
  • a zone of the dermis where toning up i s wanted undergoes mechanical compression by means of a manual instrument that comprises a roller that has elements in relief on its outer surface and which is made to roll over this zone repeatedly.
  • the fibroblasts in the zone activate spontaneously producing type 1 collagen, that is, the type which is part of the dermis composition .
  • the collagens produced by this stimulation via thi s compression, effects the dermi s increasing its consi stency, toning it up as wanted .
  • an instrument is used to stimulate the fibroblasts, emitting monopolar radiofrequency waves radiating a zone where to tone up the dermis is wi shed .
  • This instrument which i s known by the name o f Thermacool® and produced by the American company Thermage Inc . , emits monopol ar radio frequency waves that go through the various l ayers o f the dermi s which are progressively more resistant as the waves reach the dermi s in depth.
  • This resistance for the known law of OHM, generates heat and the fibroblasts in the radiated zone are stimulated by this heat traum a to produce type 1 collagens .
  • the trauma causes a change in the intermolecular structure o f the collagens which breaks the intramolecular bonds resulting in the formation o f shorter and more compact molecules .
  • a first drawback i that the method known as ablative i s painful so people undergoing this treatment are given drugs to relieve the pain plus the fact it leaves scabs which have to be bandaged for protection; the bandages can only be taken off when the epidermis has completely healed.
  • a second drawback with the method that uses Thermacool® is that in some cases, most likely due to very few fibroblasts in the zone undergoing the skin rej uvenation treatment with Thermacool®, the results are unsati sfactory because not enough type 1 coll agens is produced .
  • Another drawback is that in some cases after treatment, even when the desired toning up of the dermis is achieved, there is a gradual regression until the dermis i s almost as it was prior to treatment.
  • One obj ect of the invention i s to improve the prior art.
  • Another obj ect o f this invention is to perfect a cosmetic method for toning up the dermis that i s not painful for people who undergo the skin rej uvenation treatment.
  • Another obj ect o f this invention i s to perfect a cosmetic method for toning up the dermi s that allows to achieve results of toning up the dermis in all the zones undergoing the treatment, avoiding any unsatisfactory result.
  • Another obj ect of this invention is to perfect a cosmetic method for toning up the dermis that allows to maintain the skin rejuvenation effects of the treatment for a long time afterwards .
  • a cosmeti c method for toning up the dermis comprising the following phases : provoke a traum a in at least one zone of the dermis to tone up ; induce, with said trauma, cells o f the dermis known as fibroblasts, that are in at least said one zone, to produce collagens in at least said one zone; characterised in that prior to said provoking a trauma, the concentration of fibroblasts in at least said one zone are to b e increased .
  • the cosmetic method for toning up the dermis allows to achieve the desired toning up results in all cases where the skin rej uvenation treatment is carried out and to maintain these same results prolonged over time.
  • the cosmeti c method for toning up the dermis comprises a first phase, defined bio-revitalisation, where a mixture of four amino acids is inserted in a zone of the dermis where toning up is desired.
  • This mixture of amino acids comprises : Proline, Leucine, Lysine and Glycine.
  • the insertion o f thi s mixture o f amino acids causes a spontaneous migration of fibroblasts, called "chemotaxis", from the surrounding zones towards the zone where the insertion was made due to a tendency of the fibrobl asts to concentrate where there is a higher concentration of amino acids seeing as they are a nutriment for such cell s .
  • the zone of the dermis is radiated with a device that emits monopolar radiofrequency waves like, for example, a Thermacool® appliance, according to a treatment known as "Thermage" and with which the fibroblasts are stimul ated to produce type 1 collagens .
  • a device that emits monopolar radiofrequency waves like, for example, a Thermacool® appliance, according to a treatment known as "Thermage” and with which the fibroblasts are stimul ated to produce type 1 collagens .
  • the cosmetic method for toning up the dermis entails increasing the concentration of fibroblasts in the zones of the dermis where the toning up is desired, before being radiated with monopolar radiofrequency waves with, for example, a Thermacool® appliance.
  • the increased concentration of fibroblasts allows, on one hand, to increase the quantity o f collagens in the chosen zone of the dermis, specifically type 1 collagens, produced by these cells in a way directly proportional to the increased concentration of the same and, on the other hand, to supply a necessary quantity of amino acids to guarantee that the activated fibrobl asts will have enough of these amino acids to be able to withstand an increased production of type 1 coll agens and/or to make up for some inert fibroblasts that fail to produce coll agens .
  • a so call ed "systemic suppl ement" i s entailed that is, a daily dose o f at least three of the amino acids that the mixture is made o f to be taken by mouth, and more specifically Glycine, Proline and Lysine in a drinkable form .
  • This dose can be integrated with the addition of vitamin, specifically vitamin "C” , at the quantity o f one gram in the morning and one gram in the evening.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne une méthode cosmétique destinée à tonifier le derme et consistant à produire un trauma dans au moins une zone du derme à tonifier, puis à induire dans cette zone, au moyen du trauma, une production de collagène par les cellules du derme, connues sous le nom de fibroblastes, présentes dans ladite zone, la concentration des fibroblastes étant augmentée dans la zone avant la production du trauma.
PCT/IB2007/003091 2006-10-23 2007-10-17 Méthode cosmétique pour tonifier le derme WO2008050198A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMO20060339 ITMO20060339A1 (it) 2006-10-23 2006-10-23 Metodo cosmetico di tonificazione del derma
ITMO2006A000339 2006-10-23

Publications (2)

Publication Number Publication Date
WO2008050198A2 true WO2008050198A2 (fr) 2008-05-02
WO2008050198A3 WO2008050198A3 (fr) 2008-06-19

Family

ID=39271612

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/003091 WO2008050198A2 (fr) 2006-10-23 2007-10-17 Méthode cosmétique pour tonifier le derme

Country Status (2)

Country Link
IT (1) ITMO20060339A1 (fr)
WO (1) WO2008050198A2 (fr)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436228A (en) * 1990-12-12 1995-07-25 Postlethwaite; Arnold E. Chemotactic wound healing peptides
JP2002504933A (ja) * 1997-06-30 2002-02-12 タイム ブロック インコーポレイテッド 皮膚の老化及び傷の治療に用いられる細胞移動剤
AUPS052802A0 (en) * 2002-02-15 2002-03-07 Praxis Pharmaceuticals International Pty Ltd Carbohydrate-based anti-wrinkle and tissue remodelling compounds
JP4815752B2 (ja) * 2004-04-01 2011-11-16 味の素株式会社 アミノ酸含有飲食品
US20060058238A1 (en) * 2004-09-15 2006-03-16 Lee Laurent-Applegate Fetal skin cell protein compositions for the treatment of skin conditions, disorders or diseases and methods of making and using the same
US20060235370A1 (en) * 2005-04-04 2006-10-19 Oblong John E Method of regulating mammalian keratinous tissue

Also Published As

Publication number Publication date
ITMO20060339A1 (it) 2008-04-24
WO2008050198A3 (fr) 2008-06-19

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