WO2007110765A3 - Procedes de preparation d'octreotide - Google Patents
Procedes de preparation d'octreotide Download PDFInfo
- Publication number
- WO2007110765A3 WO2007110765A3 PCT/IB2007/000800 IB2007000800W WO2007110765A3 WO 2007110765 A3 WO2007110765 A3 WO 2007110765A3 IB 2007000800 W IB2007000800 W IB 2007000800W WO 2007110765 A3 WO2007110765 A3 WO 2007110765A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- octreotide
- processes
- preparation
- pharmaceutically acceptable
- acceptable salts
- Prior art date
Links
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 title abstract 6
- 108010016076 Octreotide Proteins 0.000 title abstract 6
- 229960002700 octreotide Drugs 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
La présente invention concerne des procédés de préparation d'octréotide pur ou de ses sels pharmaceutiquement acceptables. L'invention concerne également une forme amorphe d'octréotide et des procédés de préparation de la forme amorphe d'octréotide ou de ses sels pharmaceutiquement acceptables. L'invention concerne également des compositions pharmaceutiques qui comprennent l'octréotide pur ou l'octréotide amorphe ou leurs sels pharmaceutiquement acceptables.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07734124A EP2013226A2 (fr) | 2006-03-28 | 2007-03-28 | Procédés de préparation d'octréotide |
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN457MU2006 | 2006-03-28 | ||
| IN454/MUM/2006 | 2006-03-28 | ||
| IN455MU2006 | 2006-03-28 | ||
| IN454MU2006 | 2006-03-28 | ||
| IN455/MUM/2006 | 2006-03-28 | ||
| IN456/MUM/2006 | 2006-03-28 | ||
| IN456MU2006 | 2006-03-28 | ||
| IN457/MUM/2006 | 2006-03-28 | ||
| IN1382MU2006 | 2006-08-31 | ||
| IN1382/MUM/2006 | 2006-08-31 | ||
| IN1372MU2006 | 2006-08-31 | ||
| IN1372/MUM/2006 | 2006-08-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2007110765A2 WO2007110765A2 (fr) | 2007-10-04 |
| WO2007110765A3 true WO2007110765A3 (fr) | 2009-04-16 |
Family
ID=38541506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IB2007/000800 WO2007110765A2 (fr) | 2006-03-28 | 2007-03-28 | Procedes de preparation d'octreotide |
Country Status (2)
| Country | Link |
|---|---|
| EP (1) | EP2013226A2 (fr) |
| WO (1) | WO2007110765A2 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2435780C1 (ru) * | 2010-07-08 | 2011-12-10 | Закрытое Акционерное Общество "Фарм-Синтез" | Способ получения циклического пептида - октреотида |
| RU2441018C1 (ru) * | 2010-09-28 | 2012-01-27 | Закрытое Акционерное Общество "Фарм-Синтез" | Способ хроматографической очистки октреотида |
| WO2013046233A2 (fr) | 2011-09-30 | 2013-04-04 | Mylan Laboratories Ltd | Procédé de préparation d'acétate d'octréotide |
| WO2013132505A1 (fr) | 2012-03-09 | 2013-09-12 | Natco Pharma Limited | Procédé amélioré pour la préparation d'octréotide par une synthèse peptidique en phase solution |
| CN104513293A (zh) * | 2013-09-26 | 2015-04-15 | 深圳信立泰药业股份有限公司 | 一种多肽疫苗的盐及其制备方法和含有该盐的药物制品 |
| WO2017175107A1 (fr) * | 2016-04-04 | 2017-10-12 | Emcure Pharmaceuticals Limited | Procédé de préparation d'acétate d'octréotide |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4395403A (en) * | 1979-11-27 | 1983-07-26 | Sandoz Ltd. | Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use |
| US6987167B2 (en) * | 2002-05-22 | 2006-01-17 | Wockhardt Limited | Process for production of the somatostatin analog, octreotide |
-
2007
- 2007-03-28 WO PCT/IB2007/000800 patent/WO2007110765A2/fr active Application Filing
- 2007-03-28 EP EP07734124A patent/EP2013226A2/fr not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4395403A (en) * | 1979-11-27 | 1983-07-26 | Sandoz Ltd. | Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use |
| US6987167B2 (en) * | 2002-05-22 | 2006-01-17 | Wockhardt Limited | Process for production of the somatostatin analog, octreotide |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2013226A2 (fr) | 2009-01-14 |
| WO2007110765A2 (fr) | 2007-10-04 |
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