WO2007039761A3 - Structure cristalline de cd44 et son utilisation - Google Patents
Structure cristalline de cd44 et son utilisation Download PDFInfo
- Publication number
- WO2007039761A3 WO2007039761A3 PCT/GB2006/003734 GB2006003734W WO2007039761A3 WO 2007039761 A3 WO2007039761 A3 WO 2007039761A3 GB 2006003734 W GB2006003734 W GB 2006003734W WO 2007039761 A3 WO2007039761 A3 WO 2007039761A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- crystal structure
- protein
- pharmaceuticals
- tables
- interaction
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 2
- 102100032912 CD44 antigen Human genes 0.000 abstract 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70585—CD44
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70585—CD44
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention concerne la structure cristalline de la molécule de la protéine CD44. Cette structure est présentée dans les tableaux de 1 à 4. On peut utiliser ladite structure pour modéliser l'interaction de composés, tels que des produits pharmaceutiques, avec la protéine et déterminer la structure des molécules associées.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0520365.8 | 2005-10-06 | ||
GBGB0520365.8A GB0520365D0 (en) | 2005-10-06 | 2005-10-06 | Crystal structure of CD44 and its use |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007039761A2 WO2007039761A2 (fr) | 2007-04-12 |
WO2007039761A3 true WO2007039761A3 (fr) | 2007-06-21 |
Family
ID=35429941
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2006/003734 WO2007039761A2 (fr) | 2005-10-06 | 2006-10-06 | Structure cristalline de cd44 et son utilisation |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB0520365D0 (fr) |
WO (1) | WO2007039761A2 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2010221168A1 (en) * | 2009-03-06 | 2011-10-06 | Angstrom Pharmaceuticals, Inc. | Compositions and methods for modulation of cell migration |
EP2542253A4 (fr) | 2010-03-05 | 2013-08-21 | Angstrom Pharmaceuticals Inc | Modulation du signalement intracellulaire |
EP4153192B8 (fr) | 2020-05-19 | 2024-09-04 | Institut Curie | Antagoniste de la voie cd44/acide hyaluronique pour utilisation dans une méthode de traitement du syndrome de libération de cytokines |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003094843A2 (fr) * | 2002-05-10 | 2003-11-20 | Incyte Corporation | Proteines d'adhesion cellulaire et a matrice extracellulaire |
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2005
- 2005-10-06 GB GBGB0520365.8A patent/GB0520365D0/en not_active Ceased
-
2006
- 2006-10-06 WO PCT/GB2006/003734 patent/WO2007039761A2/fr active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003094843A2 (fr) * | 2002-05-10 | 2003-11-20 | Incyte Corporation | Proteines d'adhesion cellulaire et a matrice extracellulaire |
Non-Patent Citations (6)
Title |
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BANERJI SUNEALE ET AL: "LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan", THE JOURNAL OF CELL BIOLOGY, ROCKEFELLER UNIVERSITY PRESS, US, vol. 144, no. 4, 22 February 1999 (1999-02-22), pages 789 - 801, XP002159438, ISSN: 0021-9525 * |
BLUNDELL T L ET AL: "HIGH-THROUGHPUT CRYSTALLOGRAPHY FOR LEAD DISCOVERY IN DRUG DESIGN", NATURE REVIEWS. DRUG DISCOVERY, NATURE PUBLISHING GROUP, BASINGSTOKE, GB, vol. 1, no. 1, January 2002 (2002-01-01), pages 45 - 54, XP009023187, ISSN: 1474-1784 * |
HUMPHRIES M J ET AL: "The structure of cell-adhesion molecules.", TRENDS IN CELL BIOLOGY FEB 1998, vol. 8, no. 2, February 1998 (1998-02-01), pages 78 - 83, XP009079851, ISSN: 0962-8924 * |
JACKSON DAVID GERALD ET AL: "Structure of the inflammatory homing receptor CD44 complexed with its pericellular matrix ligand hyaluronan.", FASEB JOURNAL, vol. 20, no. 5, Part 2, March 2006 (2006-03-01), & EXPERIMENTAL BIOLOGY 2006 MEETING; SAN FRANCISCO, CA, USA; APRIL 01 05, 2006, pages A915, XP009079901, ISSN: 0892-6638 * |
TAKEDA MITSUHIRO ET AL: "Ligand-induced structural changes of the CD44 hyaluronan-binding domain revealed by NMR.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 29 DEC 2006, vol. 281, no. 52, 29 December 2006 (2006-12-29), pages 40089 - 40095, XP002422616, ISSN: 0021-9258 * |
TERIETE PETER ET AL: "Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44.", MOLECULAR CELL 27 FEB 2004, vol. 13, no. 4, 27 February 2004 (2004-02-27), pages 483 - 496, XP002422615, ISSN: 1097-2765 * |
Also Published As
Publication number | Publication date |
---|---|
WO2007039761A2 (fr) | 2007-04-12 |
GB0520365D0 (en) | 2005-11-16 |
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