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WO2007039761A3 - Structure cristalline de cd44 et son utilisation - Google Patents

Structure cristalline de cd44 et son utilisation Download PDF

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Publication number
WO2007039761A3
WO2007039761A3 PCT/GB2006/003734 GB2006003734W WO2007039761A3 WO 2007039761 A3 WO2007039761 A3 WO 2007039761A3 GB 2006003734 W GB2006003734 W GB 2006003734W WO 2007039761 A3 WO2007039761 A3 WO 2007039761A3
Authority
WO
WIPO (PCT)
Prior art keywords
crystal structure
protein
pharmaceuticals
tables
interaction
Prior art date
Application number
PCT/GB2006/003734
Other languages
English (en)
Other versions
WO2007039761A2 (fr
Inventor
David G Jackson
Suneale Banerji
Martin Noble
Anthony J Day
Original Assignee
Medical Res Council
David G Jackson
Suneale Banerji
Martin Noble
Anthony J Day
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Res Council, David G Jackson, Suneale Banerji, Martin Noble, Anthony J Day filed Critical Medical Res Council
Publication of WO2007039761A2 publication Critical patent/WO2007039761A2/fr
Publication of WO2007039761A3 publication Critical patent/WO2007039761A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70585—CD44
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70585—CD44
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne la structure cristalline de la molécule de la protéine CD44. Cette structure est présentée dans les tableaux de 1 à 4. On peut utiliser ladite structure pour modéliser l'interaction de composés, tels que des produits pharmaceutiques, avec la protéine et déterminer la structure des molécules associées.
PCT/GB2006/003734 2005-10-06 2006-10-06 Structure cristalline de cd44 et son utilisation WO2007039761A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0520365.8A GB0520365D0 (en) 2005-10-06 2005-10-06 Crystal structure of CD44 and its use
GB0520365.8 2005-10-06

Publications (2)

Publication Number Publication Date
WO2007039761A2 WO2007039761A2 (fr) 2007-04-12
WO2007039761A3 true WO2007039761A3 (fr) 2007-06-21

Family

ID=35429941

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/003734 WO2007039761A2 (fr) 2005-10-06 2006-10-06 Structure cristalline de cd44 et son utilisation

Country Status (2)

Country Link
GB (1) GB0520365D0 (fr)
WO (1) WO2007039761A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2754482A1 (fr) * 2009-03-06 2010-09-10 Angstrom Pharmaceuticals, Inc. Compositions et procedes de modulation de la migration cellulaire
CA2795698A1 (fr) 2010-03-05 2011-09-09 Angstrom Pharmaceuticals, Inc. Modulation du signalement intracellulaire
JP2023526529A (ja) 2020-05-19 2023-06-21 アンスティテュ・クリー サイトカイン放出症候群の診断及び処置の方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003094843A2 (fr) * 2002-05-10 2003-11-20 Incyte Corporation Proteines d'adhesion cellulaire et a matrice extracellulaire

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003094843A2 (fr) * 2002-05-10 2003-11-20 Incyte Corporation Proteines d'adhesion cellulaire et a matrice extracellulaire

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BANERJI SUNEALE ET AL: "LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan", THE JOURNAL OF CELL BIOLOGY, ROCKEFELLER UNIVERSITY PRESS, US, vol. 144, no. 4, 22 February 1999 (1999-02-22), pages 789 - 801, XP002159438, ISSN: 0021-9525 *
BLUNDELL T L ET AL: "HIGH-THROUGHPUT CRYSTALLOGRAPHY FOR LEAD DISCOVERY IN DRUG DESIGN", NATURE REVIEWS. DRUG DISCOVERY, NATURE PUBLISHING GROUP, BASINGSTOKE, GB, vol. 1, no. 1, January 2002 (2002-01-01), pages 45 - 54, XP009023187, ISSN: 1474-1784 *
HUMPHRIES M J ET AL: "The structure of cell-adhesion molecules.", TRENDS IN CELL BIOLOGY FEB 1998, vol. 8, no. 2, February 1998 (1998-02-01), pages 78 - 83, XP009079851, ISSN: 0962-8924 *
JACKSON DAVID GERALD ET AL: "Structure of the inflammatory homing receptor CD44 complexed with its pericellular matrix ligand hyaluronan.", FASEB JOURNAL, vol. 20, no. 5, Part 2, March 2006 (2006-03-01), & EXPERIMENTAL BIOLOGY 2006 MEETING; SAN FRANCISCO, CA, USA; APRIL 01 05, 2006, pages A915, XP009079901, ISSN: 0892-6638 *
TAKEDA MITSUHIRO ET AL: "Ligand-induced structural changes of the CD44 hyaluronan-binding domain revealed by NMR.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 29 DEC 2006, vol. 281, no. 52, 29 December 2006 (2006-12-29), pages 40089 - 40095, XP002422616, ISSN: 0021-9258 *
TERIETE PETER ET AL: "Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44.", MOLECULAR CELL 27 FEB 2004, vol. 13, no. 4, 27 February 2004 (2004-02-27), pages 483 - 496, XP002422615, ISSN: 1097-2765 *

Also Published As

Publication number Publication date
WO2007039761A2 (fr) 2007-04-12
GB0520365D0 (en) 2005-11-16

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