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WO2007031621B1 - Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation - Google Patents

Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation

Info

Publication number
WO2007031621B1
WO2007031621B1 PCT/FR2006/002038 FR2006002038W WO2007031621B1 WO 2007031621 B1 WO2007031621 B1 WO 2007031621B1 FR 2006002038 W FR2006002038 W FR 2006002038W WO 2007031621 B1 WO2007031621 B1 WO 2007031621B1
Authority
WO
WIPO (PCT)
Prior art keywords
mass
metronidazole
emulsions
production
dermatological foam
Prior art date
Application number
PCT/FR2006/002038
Other languages
English (en)
Other versions
WO2007031621A2 (fr
WO2007031621A3 (fr
Inventor
Dov Tamarkin
Doron Friedman
Original Assignee
Galderma Sa
Dov Tamarkin
Doron Friedman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Sa, Dov Tamarkin, Doron Friedman filed Critical Galderma Sa
Priority to CA2619474A priority Critical patent/CA2619474C/fr
Priority to EP06808066A priority patent/EP1928417A2/fr
Publication of WO2007031621A2 publication Critical patent/WO2007031621A2/fr
Publication of WO2007031621A3 publication Critical patent/WO2007031621A3/fr
Publication of WO2007031621B1 publication Critical patent/WO2007031621B1/fr
Priority to US12/076,114 priority patent/US20090053146A1/en
Priority to US13/154,478 priority patent/US20110237638A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/122—Foams; Dry foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des émulsions comprenant, en pourcentage en masse par rapport à la masse totale de la composition : (a) 72% à 76% d'eau ; (b) 0,1% à 5% d'un agent gélifiant de la phase aqueuse de l’émulsion ; (c) 0,75% à 2% de métronidazole ; (d) 5% à 10% d'huile minérale ; (e) 0,5% à 10% d'un agent tensioactif ; (f) 0,5% à 5% d'un acide gras ; (g) 0% à 4% d'un promoteur d'absorption du métronidazole (c) ; et (h) 0,1% à 5% d'un agent conservateur choisi parmi le groupe constitué par le méthylparabène, le propylparabène, le phénoxyéthanol et leurs mélanges. L'invention concerne également des mousses à base de métronidazole obtenues à partir de ces émulsions, ainsi que leur utilisation dermatologique.

Claims

39REVENDICATIONS MODIFIÉES reçues par le Bureau international le 15 mars 2007 (15.03.2007)
1. Composition à base de métronidazole choisie parmi les compositions suivantes :
Figure imgf000002_0001
40
Figure imgf000003_0001
41
Figure imgf000004_0001
2. Utilisation d'une composition selon la revendication 1, pour la préparation d'une mousse dermatologique destinée au traitement prophylactique ou thérapeutique d'une affection cutanée, par voie topique.
3. Utilisation selon la revendication 2, pour la préparation d'une mousse dermatologique destinée au traitement de la rosacée.
PCT/FR2006/002038 2005-09-13 2006-09-05 Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation WO2007031621A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA2619474A CA2619474C (fr) 2005-09-13 2006-09-05 Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation
EP06808066A EP1928417A2 (fr) 2005-09-13 2006-09-05 Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation
US12/076,114 US20090053146A1 (en) 2005-09-13 2008-03-13 Metronidazole-based dermatological foams and emulsions for the preparation thereof
US13/154,478 US20110237638A1 (en) 2005-09-13 2011-06-07 Metronidazole-based dermatological foam and emulsions for the preparation thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0509340 2005-09-13
FR0509340A FR2890559B1 (fr) 2005-09-13 2005-09-13 Mousses dermatologiques a base de metronidazole et emulsions pour la preparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/076,114 Continuation US20090053146A1 (en) 2005-09-13 2008-03-13 Metronidazole-based dermatological foams and emulsions for the preparation thereof

Publications (3)

Publication Number Publication Date
WO2007031621A2 WO2007031621A2 (fr) 2007-03-22
WO2007031621A3 WO2007031621A3 (fr) 2007-05-03
WO2007031621B1 true WO2007031621B1 (fr) 2007-06-21

Family

ID=36592928

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2006/002038 WO2007031621A2 (fr) 2005-09-13 2006-09-05 Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation

Country Status (5)

Country Link
US (2) US20090053146A1 (fr)
EP (1) EP1928417A2 (fr)
CA (1) CA2619474C (fr)
FR (1) FR2890559B1 (fr)
WO (1) WO2007031621A2 (fr)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8435498B2 (en) 2002-10-25 2013-05-07 Foamix Ltd. Penetrating pharmaceutical foam
US8486375B2 (en) 2003-04-28 2013-07-16 Foamix Ltd. Foamable compositions
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
US8518376B2 (en) 2007-12-07 2013-08-27 Foamix Ltd. Oil-based foamable carriers and formulations
US8518378B2 (en) 2003-08-04 2013-08-27 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US8618081B2 (en) 2009-10-02 2013-12-31 Foamix Ltd. Compositions, gels and foams with rheology modulators and uses thereof
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US8709385B2 (en) 2008-01-14 2014-04-29 Foamix Ltd. Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
US8722021B2 (en) 2002-10-25 2014-05-13 Foamix Ltd. Foamable carriers
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US9072667B2 (en) 2009-07-29 2015-07-07 Foamix Pharmaceuticals Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
US9101662B2 (en) 2003-08-04 2015-08-11 Foamix Pharmaceuticals Ltd. Compositions with modulating agents
US9161916B2 (en) 2007-12-07 2015-10-20 Foamix Pharmaceuticals Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
US9167813B2 (en) 2009-07-29 2015-10-27 Foamix Pharmaceuticals Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US9320705B2 (en) 2002-10-25 2016-04-26 Foamix Pharmaceuticals Ltd. Sensation modifying topical composition foam
US9439857B2 (en) 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
US9539208B2 (en) 2002-10-25 2017-01-10 Foamix Pharmaceuticals Ltd. Foam prepared from nanoemulsions and uses

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US8119109B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Foamable compositions, kits and methods for hyperhidrosis
US8119150B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Non-flammable insecticide composition and uses thereof
US8486376B2 (en) 2002-10-25 2013-07-16 Foamix Ltd. Moisturizing foam containing lanolin
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
JP2010528098A (ja) * 2007-05-31 2010-08-19 シントピックス グループ パブリック リミティド カンパニー ジアルキル・スルホスクシナート及びカルバニリド抗菌剤を含んでなる抗菌製剤
US20120087872A1 (en) 2009-04-28 2012-04-12 Foamix Ltd. Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
CA3054236A1 (fr) 2011-06-28 2013-01-03 Chemo Research Sl Formulations de gel a base de metronidazole aqueux mucoadhesif a dosage eleve et leur utilisation pour traiter une vaginose bacterienne
CA2978573A1 (fr) 2016-09-08 2018-03-08 Foamix Pharmaceuticals Ltd. Compositions et methodes de traitement de la rosacee et de l'acnee
US11278025B2 (en) 2017-05-17 2022-03-22 The General Hospital Corporation Antibiotic compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837378A (en) * 1986-01-15 1989-06-06 Curatek Pharmaceuticals, Inc. Topical metronidazole formulations and therapeutic uses thereof
US5536743A (en) * 1988-01-15 1996-07-16 Curatek Pharmaceuticals Limited Partnership Intravaginal treatment of vaginal infections with buffered metronidazole compositions
US5300491A (en) * 1991-10-31 1994-04-05 Apothekernes Laboratorium A.S. Treatment of protozoal infection
US6468989B1 (en) * 2000-07-13 2002-10-22 Dow Pharmaceutical Sciences Gel compositions containing metronidazole
US20060140984A1 (en) * 2002-10-25 2006-06-29 Foamix Ltd. Cosmetic and pharmaceutical foam
KR20060113657A (ko) * 2003-08-25 2006-11-02 포믹스 리미티드 침투성 약제용 거품제
US20050255048A1 (en) * 2004-05-15 2005-11-17 Collegium Pharmaceutical, Inc. Sprayable formulations for the treatment of acute inflammatory skin conditions
US20060024243A1 (en) * 2004-08-02 2006-02-02 Agis Industries (1983) Ltd. Foamable compositions containing nitro-imidazoles, processes for preparing same and methods of treatment utilizing same

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US9539208B2 (en) 2002-10-25 2017-01-10 Foamix Pharmaceuticals Ltd. Foam prepared from nanoemulsions and uses
US9492412B2 (en) 2002-10-25 2016-11-15 Foamix Pharmaceuticals Ltd. Penetrating pharmaceutical foam
US9320705B2 (en) 2002-10-25 2016-04-26 Foamix Pharmaceuticals Ltd. Sensation modifying topical composition foam
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US8435498B2 (en) 2002-10-25 2013-05-07 Foamix Ltd. Penetrating pharmaceutical foam
US8722021B2 (en) 2002-10-25 2014-05-13 Foamix Ltd. Foamable carriers
US8741265B2 (en) 2002-10-25 2014-06-03 Foamix Ltd. Penetrating pharmaceutical foam
US8840869B2 (en) 2002-10-25 2014-09-23 Foamix Ltd. Body cavity foams
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US8486375B2 (en) 2003-04-28 2013-07-16 Foamix Ltd. Foamable compositions
US8703105B2 (en) 2003-08-04 2014-04-22 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US9050253B2 (en) 2003-08-04 2015-06-09 Foamix Pharmaceuticals Ltd. Oleaginous pharmaceutical and cosmetic foam
US8518378B2 (en) 2003-08-04 2013-08-27 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US9101662B2 (en) 2003-08-04 2015-08-11 Foamix Pharmaceuticals Ltd. Compositions with modulating agents
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US9439857B2 (en) 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
US9161916B2 (en) 2007-12-07 2015-10-20 Foamix Pharmaceuticals Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
US8518376B2 (en) 2007-12-07 2013-08-27 Foamix Ltd. Oil-based foamable carriers and formulations
US9549898B2 (en) 2007-12-07 2017-01-24 Foamix Pharmaceuticals Ltd. Oil and liquid silicone foamable carriers and formulations
US8709385B2 (en) 2008-01-14 2014-04-29 Foamix Ltd. Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
US9072667B2 (en) 2009-07-29 2015-07-07 Foamix Pharmaceuticals Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
US9167813B2 (en) 2009-07-29 2015-10-27 Foamix Pharmaceuticals Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US9572775B2 (en) 2009-07-29 2017-02-21 Foamix Pharmaceuticals Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US8992896B2 (en) 2009-10-02 2015-03-31 Foamix Pharmaceuticals Ltd. Topical tetracycline compositions
US8945516B2 (en) 2009-10-02 2015-02-03 Foamix Pharmaceuticals Ltd. Surfactant-free water-free foamable compositions, breakable foams and gels and their uses
US8618081B2 (en) 2009-10-02 2013-12-31 Foamix Ltd. Compositions, gels and foams with rheology modulators and uses thereof
US8871184B2 (en) 2009-10-02 2014-10-28 Foamix Ltd. Topical tetracycline compositions
US8865139B1 (en) 2009-10-02 2014-10-21 Foamix Pharmaceuticals Ltd. Topical tetracycline compositions

Also Published As

Publication number Publication date
EP1928417A2 (fr) 2008-06-11
FR2890559A1 (fr) 2007-03-16
WO2007031621A2 (fr) 2007-03-22
CA2619474C (fr) 2012-01-10
US20090053146A1 (en) 2009-02-26
CA2619474A1 (fr) 2007-03-22
WO2007031621A3 (fr) 2007-05-03
US20110237638A1 (en) 2011-09-29
FR2890559B1 (fr) 2011-06-24

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