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WO2007031345A3 - Verfahren zur verkapselung und kontrollierten freisetzung von schwer wasserlöslichen (hydrophoben) flüssigen und festen wirkstoffen - Google Patents

Verfahren zur verkapselung und kontrollierten freisetzung von schwer wasserlöslichen (hydrophoben) flüssigen und festen wirkstoffen Download PDF

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Publication number
WO2007031345A3
WO2007031345A3 PCT/EP2006/009063 EP2006009063W WO2007031345A3 WO 2007031345 A3 WO2007031345 A3 WO 2007031345A3 EP 2006009063 W EP2006009063 W EP 2006009063W WO 2007031345 A3 WO2007031345 A3 WO 2007031345A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrophobic
active ingredients
encapsulation
release
soluble
Prior art date
Application number
PCT/EP2006/009063
Other languages
English (en)
French (fr)
Other versions
WO2007031345A2 (de
Inventor
Lars Daehne
Steffi Senst
Barbara Baude
Andreas Voigt
Original Assignee
Capsulution Nanoscience Ag
Lars Daehne
Steffi Senst
Barbara Baude
Andreas Voigt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Capsulution Nanoscience Ag, Lars Daehne, Steffi Senst, Barbara Baude, Andreas Voigt filed Critical Capsulution Nanoscience Ag
Priority to JP2008530434A priority Critical patent/JP2009507592A/ja
Priority to US11/992,083 priority patent/US20090304756A1/en
Priority to CA002622196A priority patent/CA2622196A1/en
Priority to EP06805755A priority patent/EP1928432A2/de
Publication of WO2007031345A2 publication Critical patent/WO2007031345A2/de
Publication of WO2007031345A3 publication Critical patent/WO2007031345A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

Die Erfindung betrifft die Befüllung von hydrophoben oder hydrophob modifizierten porösen Mikropartikeln mit hydrophoben Substanzen mit anschließender Verkapselung der entstehenden hydrophoben Partikel mit der Layer-by-Layer (LbL) Polyelektrolyt Technologie zum Zweck der Herstellung homogener Suspensionen in Wasser sowie zur kontrollierten Freisetzung der verkapselten Wirkstoffe. Durch eine spezifische Modifizierung der LbL-Oberfläche kann ein bevorzugtes Haften am Zielort realisiert werden.
PCT/EP2006/009063 2005-09-16 2006-09-18 Verfahren zur verkapselung und kontrollierten freisetzung von schwer wasserlöslichen (hydrophoben) flüssigen und festen wirkstoffen WO2007031345A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2008530434A JP2009507592A (ja) 2005-09-16 2006-09-18 難水溶性（疎水性）液体および固体活性成分のカプセル化および放出制御のための方法
US11/992,083 US20090304756A1 (en) 2005-09-16 2006-09-18 Method for the Encapsulation and Controlled Release of Poorly Water-Soluble (Hyprophobic) Liquid and Solid Active Ingredients
CA002622196A CA2622196A1 (en) 2005-09-16 2006-09-18 Process for the encapsulation and controlled release of sparingly water-soluble (hydrophobic) liquid and solid active ingredients
EP06805755A EP1928432A2 (de) 2005-09-16 2006-09-18 Verfahren zur verkapselung und kontrollierten freisetzung von schwer wasserlöslichen (hydrophoben) flüssigen und festen wirkstoffen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005044400.8 2005-09-16
DE102005044400A DE102005044400A1 (de) 2005-09-16 2005-09-16 Verfahren zur Verkapselung und kontrollierten Freisetzung von schwer wasserlöslichen (hydrophoben) flüssigen und festen Wirkstoffen

Publications (2)

Publication Number Publication Date
WO2007031345A2 WO2007031345A2 (de) 2007-03-22
WO2007031345A3 true WO2007031345A3 (de) 2007-07-19

Family

ID=37775792

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/009063 WO2007031345A2 (de) 2005-09-16 2006-09-18 Verfahren zur verkapselung und kontrollierten freisetzung von schwer wasserlöslichen (hydrophoben) flüssigen und festen wirkstoffen

Country Status (6)

Country Link
US (1) US20090304756A1 (de)
EP (1) EP1928432A2 (de)
JP (1) JP2009507592A (de)
CA (1) CA2622196A1 (de)
DE (1) DE102005044400A1 (de)
WO (1) WO2007031345A2 (de)

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US8771162B2 (en) 2010-04-23 2014-07-08 Eckert & Ziegler Bebig S. A. Spacers for use in brachytherapy, radiotherapy, and other medical therapy
AU2009234332B2 (en) 2008-01-15 2013-10-03 Wisconsin Alumni Research Foundation Oil emulsions and methods for manufacture and use thereof
GB0817936D0 (en) 2008-09-30 2008-11-05 Intrinsiq Materials Global Ltd Porous materials
EP2172193A1 (de) 2008-10-02 2010-04-07 Capsulution Nanoscience AG Verbesserte Nanopartikel-Zusammensetzungen schlecht löslicher Verbindungen
JP5253974B2 (ja) * 2008-11-14 2013-07-31 株式会社コーセー 多層被覆粒子及びその製造方法並びにそれを含有する皮膚外用剤
DE102009004368A1 (de) 2009-01-08 2010-07-15 Heraeus Kulzer Gmbh Dentalmaterialien enthaltend antimikrobielle Wirkstoffe zur Verhinderung von Plaque-Anlagerungen
GB201011905D0 (en) 2010-07-15 2010-09-01 Unilever Plc Benefit delivery particle,process for preparing said particle,compositions comprising said particles and a method for treating substrates
US9603784B2 (en) 2010-09-30 2017-03-28 Merck Patent Gmbh Process for treating sol-gel capsules
US10221445B2 (en) 2011-08-11 2019-03-05 Qiagen Gmbh Cell- or virus simulating means comprising encapsulated marker molecules
US8883717B2 (en) 2012-03-30 2014-11-11 Artificial Cell Technologies, Inc. Antigenic compositions and methods
US9433671B2 (en) 2012-03-30 2016-09-06 Artificial Cell Technologies, Inc. Anti-malaria compositions and methods
WO2013153210A1 (en) 2012-04-13 2013-10-17 Nanoscape Ag Sustained-release formulation
EP2906645A4 (de) * 2012-10-15 2016-04-20 Ultra Ink Inc Entfernbare tätowierungstinte und verwendung davon
US9675953B2 (en) 2013-10-09 2017-06-13 Nanocomposix, Inc. Encapsulated particles
EP2939653A1 (de) * 2014-04-30 2015-11-04 L'Oréal Zusammensetzung mit Mikrokapseln mit Partikeln mit einem hohen Nasspunkt
CN106659668A (zh) * 2014-05-28 2017-05-10 荷兰联合利华有限公司 用于处理基底的有益递送颗粒
US10729641B2 (en) * 2015-06-12 2020-08-04 Regents Of The University Of Minnesota Ordered macroporous materials
WO2017048689A1 (en) 2015-09-16 2017-03-23 Artificial Cell Technologies, Inc. Anti-malaria compositions and methods
EP3532593B1 (de) * 2016-10-26 2021-05-26 ELC Management LLC Abgabesysteme und verfahren mit verzögerter freisetzung
US10661244B2 (en) 2016-10-26 2020-05-26 Elc Management Llc Delayed release delivery systems and methods
ES2932283T3 (es) * 2016-10-26 2023-01-17 Elc Man Llc Sistemas y métodos de suministro de liberación retardada
ES2859726T3 (es) * 2016-10-26 2021-10-04 Elc Man Llc Sistemas y métodos de administración de liberación retardada
JP2020033324A (ja) * 2018-08-31 2020-03-05 テイカ株式会社 紫外線防御用複合材料およびこの紫外線防御用複合材料を用いた分散液並びに化粧料

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JPH08277216A (ja) * 1995-02-09 1996-10-22 Makoto Otsuka 粉末剤および薬物の放出速度制御方法
TW520440B (en) * 1997-03-28 2003-02-11 Shiseido Co Ltd A liquid chromatography apparatus and a packing material for the chromatographic column
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US20040013721A1 (en) * 2000-08-28 2004-01-22 Alexei Antipov Controlled and sustained release properties of polyelectrolyte multilayer capsules
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Also Published As

Publication number Publication date
JP2009507592A (ja) 2009-02-26
CA2622196A1 (en) 2007-03-22
WO2007031345A2 (de) 2007-03-22
DE102005044400A1 (de) 2007-03-22
US20090304756A1 (en) 2009-12-10
EP1928432A2 (de) 2008-06-11

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