+

WO2007030975A1 - Procédé de réalisation de synchronisation de commandes dans la prise en charge d'un système de fichiers de mémoire non volatile à traitement multifils - Google Patents

Procédé de réalisation de synchronisation de commandes dans la prise en charge d'un système de fichiers de mémoire non volatile à traitement multifils Download PDF

Info

Publication number
WO2007030975A1
WO2007030975A1 PCT/CN2005/001574 CN2005001574W WO2007030975A1 WO 2007030975 A1 WO2007030975 A1 WO 2007030975A1 CN 2005001574 W CN2005001574 W CN 2005001574W WO 2007030975 A1 WO2007030975 A1 WO 2007030975A1
Authority
WO
WIPO (PCT)
Prior art keywords
tremella
heteropolysaccharide
extract
lactobacillus
food
Prior art date
Application number
PCT/CN2005/001574
Other languages
English (en)
Chinese (zh)
Inventor
Guiyun Liu
Feng Luo
Bin Luo
Original Assignee
Shanghai Wenda Biotech Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Wenda Biotech Inc. filed Critical Shanghai Wenda Biotech Inc.
Priority to JP2008530295A priority Critical patent/JP5498698B2/ja
Publication of WO2007030975A1 publication Critical patent/WO2007030975A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Definitions

  • the present invention relates to the use of a heteropolysaccharide; in particular, to the use of a Tremella heteropolysaccharide or an extract thereof for promoting the growth and/or reproduction of probiotics, and the use thereof for improving constipation function and detoxifying beauty function.
  • Bifidobacteria are physiological bacteria in the human body. They are Gram-positive, non-spore-free, non-exercise, and strictly anaerobic. They are dominant in the human intestine. The ultimate survival lies in the human body. It is closely related to human health. It is a kind of human body. A beneficial bacteria with many important physiological functions. With the rapid development of microbiology, the clinical health effects of bifidobacteria have gradually been recognized and accepted. Human physiology, immunity, nutrition, digestion, anti-tumor, anti-aging, drug efficacy, etc.
  • bifidobacteria in the human intestinal tract has disease treatment, disease-free anti-aging and health care.
  • the role for example, bifidobacteria can form a physiological barrier, prevent the colonization and invasion of pathogenic bacteria, protect the host from pathogenic bacteria, improve protein metabolism, provide a variety of B vitamins, promote calcium and iron absorption, improve immunity, and enhance Anti-tumor ability and other effects. If the deficiency of bifidobacteria in the human body means that the human body has a health crisis, it needs to be replenished in time.
  • Lactobacillus is also an important physiological bacterium in the human body. It is Gram-positive, non-spore-free, non-exercise, and strictly anaerobic. It has various physiological functions. Lactobacillus maintains the balance of the intestinal and genital flora and plays a key role in removing certain carcinogens or preventing carcinogenesis. The reduction of lactobacilli may lead to dysregulation of the intestinal flora, and the pathogens multiply in large numbers, and some bacterial enzymes in the metabolites can catalyze the conversion of carcinogenic precursor substances to carcinogens.
  • Lactobacillus can restore the balance of intestinal flora, resist the growth of pathogenic bacteria in the intestinal tract, inhibit the production of bacterial enzymes and reduce its activity. It can also be combined with carcinogens to excrete with feces, reducing its chances of formation, activation and retention.
  • Prebiotics are a class of non-digestible substances, but can be used as a substrate by the normal intestinal flora, which can selectively stimulate the growth and reproduction of one or several beneficial bacteria in the intestine, inhibit the growth of harmful bacteria, and host Health has beneficial effects, such as stachymile, oligofructose (including isomalto-oligosaccharides, galactose oligosaccharides, fructooligosaccharides, etc..
  • bifidus factor oligofructose is an internationally recognized bifidus factor, but they are all oligosaccharides with a relatively small molecular weight. Promote body by taking prebiotics. The growth and/or reproduction of probiotics can further improve the function of the human digestion and absorption system, help to improve constipation and promote human metabolism, and the toxins in the body are discharged in time, and the effect of beauty and beauty can be achieved.
  • Tremella faciformis Berk also known as white fungus, mulberry goose, and Qing dynasty. It belongs to Tremellales, Tremellacease, Tremella. It has the effects of nourishing yin and moistening the lungs, benefiting Qi and blood.
  • Tremella fuciformis is an acidic heteropolysaccharide extracted from the fungus fruit body (or its microbial fermentation broth). Since ancient times, China has called white fungus high-grade supplements and medicines. The best for medicine and food is the court's finest tonic food.
  • Tremella fuciformis which indicates that Tremella fuciformis has improved immunity and resistance. Tumor, anti-aging, blood sugar lowering, blood lipids, protein nucleic acid synthesis, antithrombotic and other pharmacological effects. Japan has applied it extensively to health products, cosmetics, and pharmaceuticals.
  • the development and application of Tremella has aroused great interest in the scientific community, and has received extensive attention in the international pharmaceutical and cosmetic fields, and has become a hot topic in current research and development.
  • Tremella polysaccharides and the corresponding functions have rarely been reported so far.
  • the applicant uses a special separation and purification process to refine the active polysaccharide in Tremella fuciformis, which is identified by modern analytical techniques.
  • the structure of the Tremella heteropolysaccharide is ⁇ - ( 1-3 ) mannose as the main chain, mainly by weight percentage 70- 93% neutral total sugar, 6-28% glucuronic acid, 0.1-3% binding protein; the average molecular weight of the Tremella heteropolysaccharide is 85-1.6 million Daltons, of which the molecular weight is greater than 6000 Daltons. 90% (by weight) or more, as described in the patent application No.
  • the object of the present invention is to provide a silver fungus heteropolysaccharide or a tremella polysaccharide extract of the trade name WSK in the patent application No. 200510023427.4 for the preparation of a pharmaceutical, food or drink or health supplement for promoting the growth and/or reproduction of probiotics. Use in.
  • Another object of the present invention is to provide a Tremella heteropolysaccharide or a Tremella polysaccharide extract of the trade name WSK in the patent application No. 200510023427.4 for the preparation of a medicine, a food or drink or a health care product having an improved constipation function. Use in the product.
  • a further object of the present invention is to provide a silver fungus heteropolysaccharide or a silver fungus heteropolysaccharide extract having the trade name WSK in the application No. 200510023427.4, in the preparation of a medicine, a food or drink or a health care product having a detoxifying beauty function. use.
  • the structure of the Tremella heteropolysaccharide according to the present invention is mainly composed of ⁇ -(1-3) mannose, mainly composed of 70-93% by weight of neutral total sugar, 6-28% of glucuronic acid, 0.1- 3% of the binding protein composition; the average molecular weight of the Tremella heteropolysaccharide is 85-1.6 million Daltons, wherein more than 90% by weight of the molecular weight is greater than 6000 Daltons.
  • the neutral total sugar mainly comprises the following content of glycosyl: 35-60% mannose, 10-25% fucose, 8-18% xylose and 5-15% glucose, the above content is white fungus Heteropolysaccharide weight meter.
  • the side chain of the tremella heteropolysaccharide has a plurality of different combinations of changes, one of which has been determined by X-ray diffraction as a structural unit represented by the following structural formula I -
  • the structural unit has a molecular weight of 2578.5 or 2724.7.
  • the sugar structure is composed of ⁇ -(1-3) mannose (Manp) as the main chain skeleton, and two ⁇ -(1-2) xylose (Xylp) and three ⁇ -glucose are attached to the two carbon atoms.
  • Aldehydic acid (GlcAp), 1 or 2 fucose (Fuc), 1 mannose is a side chain.
  • the Tremella heteropolysaccharide extract of the present invention mainly comprises 80-98% by weight of the above-mentioned Tremella heteropolysaccharide, 0.1-3.3% of free protein and 0.5-8% of ash; the average molecular weight of the Tremella heteropolysaccharide extract is 75-1.4 million Daltons, of which 75-98% by weight of molecular weight greater than 6000 Daltons.
  • the Tremella heteropolysaccharide extract of the present invention can be obtained by the following preparation method - 1) The raw material of the tremella fruit body is stirred with water at 80-100 ° C to obtain a crude extract ⁇ ,
  • the raw material of the white fungus fruit body is a dry raw material of the tremella fruit body, and the dried tremella fruit material is soaked, expanded and cleaned with water (including a yellow-brown base), 20-100 times each time, and multiple times of extraction. Not more than 200 times by weight of the dried fermented fruit body material amount of water is stirred and extracted at 80-100 ° C to obtain a crude extract.
  • the raw material of the white fungus fruit body may also be a raw material of fresh white fungus fruit body, fresh frozen fungus fruit raw material or frozen fresh white fungus fruit material, and the raw material of the white fungus fruit body is removed to a yellow-brown base and cleaned, and each time 2- 15 times, multiple extractions, no more than 30 times (by weight) of the amount of water of the raw material of the fungus fruit body is stirred and extracted at 80-100 ° C to obtain a crude extract.
  • Tremella heteropolysaccharide extract of the present invention comprises the following steps -
  • the method for preparing the Tremella heteropolysaccharide of the present invention comprises the step of further purifying the extract obtained by the above preparation method.
  • the purification was carried out by the Sevag method and the dialysis method.
  • other polysaccharide purification methods such as chromatographic separation methods, can also produce the Tremella heteropolysaccharide of the present invention.
  • the probiotic may be a variety of probiotics, mainly bifidobacteria and / or lactobacilli; preferably bifidobacteria and / or lactobacilli in the digestive system (such as the intestine), or the reproductive system (such as Lactobacillus in the reproductive tract).
  • the Bifidobaterinm is an obligate anaerobes of irregular shape, and there are 32 species, preferably Bifidobacterium bifidum, Bifidobacterium adolescentis or Bifidobacterium infantis, more preferably Bifidobacterium bifidum; Bifidobacterium bifidum The best is Bifidobacterium ATCC 2952.
  • the Lactobacillus is a Gram-positive Bacillus-free bacterium, and there are 56 species, preferably Lactobacillus delbrueckii, Lactobacillus casei, and Lactobacillus brevis, more preferably Lactobacillus delbrueckii; Preferably, it is a Lactobacillus delbrueckii subsp. bulgaricus, more preferably Lactobacillus bulgaricus ATCC 11480.
  • the medicine may be various dosage forms in the prior art, such as powders, tablets, capsules (including soft and hard capsules), liquids, suspensions, emulsions, oral liquids, jelly or granules;
  • the food and drink includes drinks and foods, and is a drink or food containing a concentrate and/or a dried product of Tremella heteropolysaccharide or Tremella heteropolysaccharide extract, and the application of the food or drink is not limited, and may be various dosage forms in the prior art.
  • the health care products can be prior art
  • Various dosage forms such as powders, tablets, capsules (including soft and hard capsules), liquids, suspensions, emulsions, oral liquids, jelly or granules, and the like.
  • the pharmaceutical, food or health supplement may further contain other prebiotics which promote the growth and/or reproduction of the probiotic.
  • the food or drink or health supplement may also contain various other edible nutrients for better nutrition and health care.
  • the Tremella heteropolysaccharide according to the present invention may be crude crude Tremella heteropolysaccharide containing impurities or pure Tremella polysaccharide.
  • a further object of the present invention is to provide a use of the Tremella heteropolysaccharide or Tremella polysaccharide extract of the trade name WSK in the patent application No. 200510023427.4 for promoting the growth and/or propagation of probiotics in vitro.
  • the action or function of the promoter is similar to the bifidus factor, and the difference is that: the bifidus factor is a substance that promotes the growth and/or reproduction of bifidobacteria, and the promoter promotes probiotics. (including bifidobacteria) substances that grow and/or reproduce.
  • the accelerator according to the present invention is added to medicines, foods, and health care products, and can promote the growth and reproduction of probiotics in the body after administration; and the promotion of the present invention is added to medicines, foods, and health care products containing probiotics. Agents can enhance the efficacy of such products.
  • the accelerator of the present invention can be used, for example, in a culture medium to culture probiotics in vitro, so that more beneficial bacteria can be cultured in a faster manner, thereby reducing costs.
  • the probiotics may be various probiotics, mainly bifidobacteria and/or lactobacilli.
  • the Bifidobacterium is preferably Bifidobacterium bifidum B. bifidum, more preferably Bifidobacterium ATCC 2952;
  • the Lactobacillus is preferably Lactobacillus delbrueckii, more preferably the Lactobacillus delbrueckii subsp. bulgaricus, most preferably Lactobacillus bulgaricus ATCC 11480.
  • Tremella fuciformis extract and Tremella fuciformis promote the growth and/or reproduction of probiotics, such as direct regulation of human intestinal bacteria, proliferation of bifidobacteria and/or lactic acid in vivo. Bacillus, will have a broader development prospects. Moreover, the proliferative effect of Tremella polysaccharides on probiotics such as bifidobacteria and lactobacilli will be further developed as a promoter (similar to the function or action of bifidus factors) and promote the development of microecology.
  • the medicine, food or health care product containing the extract of Tremella heteropolysaccharide or Tremella heteropolysaccharide of the present invention has the function of improving constipation and the function of detoxifying beauty and beauty after oral administration, which excretes toxins in the body and absorbs nutrients in the silver fungus heteropolysaccharide Can play a role in beauty and beauty.
  • Figure 1 is a comparison of the effects of sugar-free, oligosaccharide and tremella heteropolysaccharide on the growth and reproduction of Bifidobacterium ATCC 2952;
  • Figure 2A is a photograph of the growth and reproduction of Bifidobacterium ATCC 2952 in control group 1;
  • FIG. 2B is a photograph showing the growth and reproduction of Bifidobacterium ATCC 2952 in the experimental group (Tremella heteropolysaccharide group);
  • FIG. 3 is a comparison chart showing the effects of sugar-free, oligosaccharide and Tremella heteropolysaccharide on the growth and reproduction of Lactobacillus bulgaricus ATCC 11480;
  • Figure 4A is a photograph showing the growth and reproduction of Lactobacillus bulgaricus ATCC 11480 of Control Group 1;
  • Fig. 4B is a photograph showing the growth and reproduction of Lactobacillus bulgaricus ATCC 11480 in the experimental group (the Tremella heteropolysaccharide group);
  • Fig. 5 is a schematic view showing the improvement effect of the different concentrations of Tremella fuciformis on constipation;
  • Figure 6 is a schematic diagram of the lubricating effect of different concentrations of Tremella heteropolysaccharide solution on constipation patients and normal human stools.
  • Figure 7 is a schematic diagram showing the effect of different concentrations of Tremella fuciformis extract (WSK-1) on constipation;
  • Figure 8 is the lubrication effect of different concentrations of Tremella fuciformis extract (WSK-1) solution on constipation patients and normal stools Schematic diagram.
  • Tremella heteropolysaccharide extract and Tremella heteropolysaccharide are prepared according to the preparation method in the applicant's patent application No. 200510023427.4, which is described in detail as follows: Example 1
  • the Tremella fermentation broth obtained by microbial fermentation is heated at 100 ° C for 0.5 h, filtered conventionally, and the filter residue is discarded.
  • the supernatant is finally passed through a filter having a pore diameter of 0.1-1 ⁇ m; the filtrate and the ethanol are thoroughly mixed under uniform stirring.
  • the final concentration of ethanol in the mixed liquid was 85%, the precipitate was collected, dehydrated by dehydration with 100% ethanol, and the precipitate was collected; -40 ⁇ freeze-dried, and pulverized to obtain a white fungus heteropolysaccharide extract.
  • Product yield 0.55% (based on the weight of the fermentation broth).
  • aqueous phase was concentrated under reduced pressure to one-third, and the concentrate was thoroughly mixed with 3 times (volume ratio) of 95% ethanol in the aqueous phase, and centrifuged at 4000 r/min for 30 minutes to obtain a precipitate.
  • the precipitate was dissolved in 100 times by weight of deionized water, centrifuged, and insoluble, and the supernatant was placed in a 30 cm long dialysis bag (dialysis bag can pass 5000 molecular weight or less) Qualitatively perform dialysis (both ends are placed in a bottle filled with deionized water and rinsed with deionized water for 12 hours) to collect 5000 molecular weight or higher substances.
  • the dialyzed supernatant was thoroughly mixed with 3 times (volume) pure B, and centrifuged again at 4000 r/min for 30 minutes to obtain a precipitate.
  • the precipitate was dehydrated with absolute ethanol and dried under vacuum at 60 ° C to obtain pure silver ear polysaccharide. (WSK).
  • Tremella heteropolysaccharide promotes the growth and/or reproduction of bifidobacteria
  • Test strain Bifidobacteria ATCC 2952, purchased from the American Type Culture Collection
  • Sterilization method Sterilize at 90 ° C for 30 minutes
  • the experimental treatment was divided into the following three items - control group 1: medium 6.3 mL + bacterial solution 0.3 mL
  • Control group 2 medium 6.0 mL + oligofructose 0.3 mL + bacterial solution 0.3 mL (the mass ratio of oligofructose: cultivating medium in the medium is 1: 80)
  • Detection method Liquid quantitative limiting dilution method.
  • the experimental results show that the addition of Tremella heteropolysaccharide (1:80 dilution) to the liquid medium can promote the growth and reproduction of Bifidobacterium, and the effect is remarkable.
  • the Tremella fuciformis polysaccharide can significantly increase the amount of Bifidobacterium in the fermentation broth, and the promotion of the growth and reproduction of Bifidobacterium by the Tremella polysaccharides Even more than the oligofructose currently used as a prebiotic in the market.
  • Bifidobacterium ATCC 2952 The culture time in the MRS broth medium was advanced from 48 hours to 24 hours; and by smear staining, compared with the control group 1, the bacteria in the experimental group were enlarged and thick, and the density of the bacteria in the same field of view was markedly Increase 3 ⁇ 4, see Figure 2A and Figure
  • Test strain Lactobacillus ATCC 11480, purchased from the Institute of Microbiology, Chinese Academy of Sciences. Medium: MRS Broth Medium
  • the experimental processing is divided into the following three items:
  • Control group 1 medium 6.3 mL + bacterial solution 0.3 mL
  • Control group 2 Medium 6.0 mL + oligofructose 0.3 mL + bacterial solution 0.3 mL (The ratio of oligofructose: medium in the medium was 1: 80)
  • Lactobacillus 02 added with anaerobic bacteria basal medium (Shanghai Institute of Biological Products) vitamin K to a concentration of 0.1wt%, is made of the liquid medium, in a conventional culture incubator 37 ° C, stationary for 48 hours.
  • anaerobic bacteria basal medium Shanghai Institute of Biological Products
  • Detection method Liquid quantitative limiting dilution method.
  • the experimental results show that the addition of Tremella heteropolysaccharide (1:80 dilution) to the liquid medium can promote the growth and reproduction of Lactobacillus, and the effect is remarkable.
  • the Tremella polysaccharide compared with the sugar-free medium in the control group 1, the Tremella polysaccharide can significantly increase the amount of Lactobacillus in the fermentation broth, and the promotion effect of the Tremella polysaccharide on the growth and reproduction of Lactobacillus even More than the oligofructose currently used as a prebiotic in the market.
  • Subjects 16 patients with constipation, the symptoms were 3 times/week of bowel movements or dry stools, gender age is not limited, divided into 3 groups, Al, A2, A3 group, taking 0.1wt%, 0.2wt%, 0.5wt% respectively.
  • the Tremella heteropolysaccharide solution was used to observe changes in stool condition and facial skin luster.
  • Sixteen patients with normal bowel movements were divided into three groups, Bl, B2, and B3, taking 0.1 wt%, 0.2 wt%, and 0.5 wt Q / respectively.
  • the Tremella heteropolysaccharide solution was used to observe changes in stool condition and facial skin gloss.
  • Tremella Heteropolysaccharide Solution Sterile treatment to ensure the health and safety of the drinker, and to eliminate the influence of bacteria on the test results;
  • Tremella heteropolysaccharide (WSK) obtained in Example 4;
  • Bottle (PE bottle) cleaning method 75% alcohol soaking, clean room 24 hours to dry;
  • Groups A1 and B1 Each dose is 100mL, 2 times a day;
  • Group A2 and B2 Each dose is lOOmL, 2 times a day;
  • Groups A3 and B3 Each dose is 100mL, 2 times a day;
  • Tremella heteropolysaccharide has no side effects on normal people, no bloating, and the stool is relatively lubricated;
  • Tremella fuciformis has a beauty-enhancing effect of improving skin luster, and the improvement effect is markedly increased with the increase of the concentration of the tremella heteropolysaccharide.
  • Effect Example 4 The effect of the extract of Tremella fuciformis on constipation in constipation patients (whether it is improved) and the oral effect on normal people and the change in skin gloss on the face after taking (whether or not it has a beauty and beauty function) were tested.
  • Subjects 18 patients with constipation, the symptoms were bowel movements 3 times / week or dry stool, gender age is not limited, divided into 3 groups, Cl, C2, C3 group, taking 0.1wt%, 0.2wt%, 0.5wt% Tremella heteropolysaccharide extract solution, observe changes in stool condition and facial skin luster; 18 normal bowel movements, divided into 3 groups, Dl, D2, D3 group, respectively, taking 0.1wt%, 0.2wt%, 0.5wt% Tremella heteropolysaccharide extract solution, observe stool status and Changes in the luster of the skin on the face.
  • Tremella Heteropolysaccharide Extract Solution Sterile treatment, ensuring the health and safety of the user, and eliminating the influence of bacteria on the test results;
  • the Tremella heteropolysaccharide extract is the Tremella fuciformis extract (WSK-1) obtained in Example 1, The purity of Tremella fuciformis polysaccharide is 80%;
  • Bottle (PE bottle) cleaning method 75% alcohol soaking, clean room 24 hours to dry;
  • Group C1 and D1 Each dose is 100 mL, 2 times a day;
  • Group C2 and D2 100 mL per dose, 2 times a day;
  • Group C3 and D3 Each dose is lOOmL, 2 times a day;
  • Tremella fuciformis extract improves constipation Group C1 C2 C3 Tremella polysaccharides 0.1% 0.2% 0.5% concentration of extract
  • Tremella fuciformis polysaccharide extract has the function of lubricating stool and can improve constipation;
  • Tremella fuciformis extract has no side effects on normal people, no bloating, and the stool is relatively lubricated;
  • Tremella heteropolysaccharide extract has the effect of improving the skin's luster and improving the effect, and the effect of the increase is higher with the increase of the concentration of the tremella polysaccharide extract.
  • Tremella fuciformis extract and Tremella fuciformis are good promoters for promoting the growth and/or reproduction of probiotics, and also a good probiotic for promoting digestive or reproductive systems.
  • a promoting factor for growth and/or reproduction of bacteria that regulates the balance of microbial flora in the large intestine.
  • the white fungus heteropolysaccharide extract and the white fungus heteropolysaccharide also have a laxative effect, which may be caused by promoting the growth and/or reproduction of probiotics in the digestive system, the white fungus heteropolysaccharide extract and the white fungus miscellaneous
  • the polysaccharide can excrete toxins through the laxative and absorb the nutrients of the tremella polysaccharides to achieve the purpose of detoxification and beauty. Therefore, Tremella fuciformis extract and Tremella fuciformis (WSK) are healthy and nutritious foods.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention concerne un procédé pouvant être utilisé dans un système de fichiers de mémoire non volatile à traitement multifils. Le procédé comprend les étapes consistant à créer une structure de données pour stocker des informations d'avancement sur une ou plusieurs opérations simultanées pour accéder à un système de fichiers d'une mémoire non volatile ; et exécuter ladite ou lesdites opérations simultanées sur la base des informations d'avancement.
PCT/CN2005/001574 2005-09-16 2005-09-26 Procédé de réalisation de synchronisation de commandes dans la prise en charge d'un système de fichiers de mémoire non volatile à traitement multifils WO2007030975A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008530295A JP5498698B2 (ja) 2005-09-16 2005-09-26 シロキクラゲ雑多糖またはその抽出物の新用途

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB2005100297451A CN100484964C (zh) 2005-09-16 2005-09-16 银耳杂多糖或其提取物的新用途
CN200510029745.1 2005-09-16

Publications (1)

Publication Number Publication Date
WO2007030975A1 true WO2007030975A1 (fr) 2007-03-22

Family

ID=37864612

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2005/001574 WO2007030975A1 (fr) 2005-09-16 2005-09-26 Procédé de réalisation de synchronisation de commandes dans la prise en charge d'un système de fichiers de mémoire non volatile à traitement multifils

Country Status (3)

Country Link
JP (1) JP5498698B2 (fr)
CN (1) CN100484964C (fr)
WO (1) WO2007030975A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8435541B2 (en) 2010-09-02 2013-05-07 Bath & Body Works Brand Management, Inc. Topical compositions for inhibiting matrix metalloproteases and providing antioxidative activities
CN115005442A (zh) * 2022-06-15 2022-09-06 中国科学院新疆理化技术研究所 一种天山雪莲多糖提取物制备方法与应用
CN115299537A (zh) * 2022-07-05 2022-11-08 北京吉澳医学科技有限责任公司 一种具有美容养颜、改善便秘的饮品及其制备方法和应用
CN116874632A (zh) * 2023-08-02 2023-10-13 浙江省农业科学院 一种戊糖乳杆菌多糖及应用
CN118160918A (zh) * 2024-03-25 2024-06-11 山东九赐方生物科技有限公司 一种木耳复合发酵液的制备方法

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101579117B (zh) * 2009-03-26 2013-06-19 大山合集团有限公司 一种银耳软胶囊健康食品
CN102370004A (zh) * 2010-08-24 2012-03-14 上海辉文生物技术有限公司 一种银耳杂多糖或其提取物在液体乳制品中的应用
CN102336840B (zh) * 2011-10-17 2012-11-21 浙江大学 一种三股螺旋银耳多糖及其制备方法和应用
TW201345537A (zh) * 2012-05-10 2013-11-16 Univ Asia 保護視網膜細胞之銀耳多醣及其製造方法
JP2017195830A (ja) * 2016-04-28 2017-11-02 日本食菌工業株式会社 脂肪蓄積予防用の食品組成物
JP6969067B2 (ja) * 2016-05-10 2021-11-24 丸善製薬株式会社 抗炎症剤、抗老化剤および美白剤
JP6670166B2 (ja) * 2016-05-10 2020-03-18 丸善製薬株式会社 化粧料
CN105949337A (zh) * 2016-05-13 2016-09-21 福建农林大学 一种促双歧杆菌增殖的鲜银耳多糖提取方法
CN107019657A (zh) * 2016-12-14 2017-08-08 上海辉文生物技术股份有限公司 一种美白保湿组合物及其制备方法和使用方法
CN110590968B (zh) * 2019-09-05 2021-09-28 浙江工业大学 一种银耳低聚糖的制备方法及其应用
JP7253283B2 (ja) * 2020-02-27 2023-04-06 丸善製薬株式会社 化粧料および飲食品組成物
CN113907366A (zh) * 2021-11-02 2022-01-11 桂林理工大学 一种郁金多糖在调控益生菌增殖方面的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1437899A (zh) * 2003-01-21 2003-08-27 解俊峰 天然低聚糖饮料

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5726757B2 (fr) * 1974-09-30 1982-06-07
JP3577146B2 (ja) * 1995-11-21 2004-10-13 花王株式会社 外用剤組成物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1437899A (zh) * 2003-01-21 2003-08-27 解俊峰 天然低聚糖饮料

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MEDICINE AND HEALTH CARE, vol. 56, no. 9, 2001 *
SHANDONG FOOD SCI & TECH., vol. 23, no. 6, 2002 *
TRANSACTIONS OF THE CSAE, vol. 18, no. 2, 2002, pages 96 - 100 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8435541B2 (en) 2010-09-02 2013-05-07 Bath & Body Works Brand Management, Inc. Topical compositions for inhibiting matrix metalloproteases and providing antioxidative activities
CN115005442A (zh) * 2022-06-15 2022-09-06 中国科学院新疆理化技术研究所 一种天山雪莲多糖提取物制备方法与应用
CN115005442B (zh) * 2022-06-15 2023-07-25 中国科学院新疆理化技术研究所 一种天山雪莲多糖提取物制备方法与应用
CN115299537A (zh) * 2022-07-05 2022-11-08 北京吉澳医学科技有限责任公司 一种具有美容养颜、改善便秘的饮品及其制备方法和应用
CN116874632A (zh) * 2023-08-02 2023-10-13 浙江省农业科学院 一种戊糖乳杆菌多糖及应用
CN118160918A (zh) * 2024-03-25 2024-06-11 山东九赐方生物科技有限公司 一种木耳复合发酵液的制备方法

Also Published As

Publication number Publication date
CN1931879A (zh) 2007-03-21
JP5498698B2 (ja) 2014-05-21
CN100484964C (zh) 2009-05-06
JP2009507863A (ja) 2009-02-26

Similar Documents

Publication Publication Date Title
CN110157647B (zh) 一种能够缓解焦虑、改善睡眠的短乳杆菌及其用途
WO2007030975A1 (fr) Procédé de réalisation de synchronisation de commandes dans la prise en charge d'un système de fichiers de mémoire non volatile à traitement multifils
JP7590587B2 (ja) 排便を促進する組成物及びその用途
CN107048360A (zh) 制备具有调理胃肠道润肠通便功能的植物酵素的发酵组合物及制法
JP2018153182A (ja) ラクトバチルスプランタルムｔｃｉ３７８、およびそれを用いた脂肪の減少および胃腸機能の改善における使用
CN108850397A (zh) 一种止腹泻的益生菌凝胶糖果及其制备方法
CN102618452B (zh) 唾液乳杆菌及其代谢物的制备方法和组合物以及应用
CN114452308B (zh) 一种益生菌保护剂及其制备的微生态制剂和用途
CN109380733A (zh) 一种益生菌粉剂及其制备方法
CN103918792A (zh) 一种木糖醇益生菌羊奶片及其制备方法
CN115844019A (zh) 一种能够调节肠道的益生菌及应用
CN105707625A (zh) 一种益生菌发酵枇杷叶的组合物及其制备方法和应用
CN109662311A (zh) 具有润肠通便功能的酵素及其制备方法和应用
CN114470005B (zh) 益生菌和透明质酸钠的组合物及其应用
CN109169899A (zh) 一种含有猴头菇β-葡聚糖的护胃发酵乳的制备方法
JP2005013211A (ja) 乳酸菌含有食品組成物
US11969447B2 (en) Use of spray-dried powder derived from lactic acid bacterial strains and herbal extracts for promoting defecation
CN109527099A (zh) 一种枸杞复合益生菌羊奶片及其制备方法
CN118716405A (zh) 一种长双歧杆菌发酵乳及其制备方法和应用
CN113575964A (zh) 一种抗氧化和抗衰老的益生菌组合物及其制备方法
CN110313599A (zh) 一种降尿酸果冻及其制备方法
CN107647397A (zh) 一种益生菌粉及其制备方法
CN105663650A (zh) 一种治疗肺癌的益生菌发酵中药组合物及其制备方法
CN102742654B (zh) 一种养颜美容益生菌羊奶片及其制备方法
CN111603489A (zh) 一种改善便秘的菌剂及其制备方法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2008530295

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 05791984

Country of ref document: EP

Kind code of ref document: A1

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载