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WO2007019119A3 - Rna complexes methods of their production and sensors and analytical methods involving same - Google Patents

Rna complexes methods of their production and sensors and analytical methods involving same Download PDF

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Publication number
WO2007019119A3
WO2007019119A3 PCT/US2006/029810 US2006029810W WO2007019119A3 WO 2007019119 A3 WO2007019119 A3 WO 2007019119A3 US 2006029810 W US2006029810 W US 2006029810W WO 2007019119 A3 WO2007019119 A3 WO 2007019119A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding sites
rna
methods
sensors
production
Prior art date
Application number
PCT/US2006/029810
Other languages
French (fr)
Other versions
WO2007019119A2 (en
Inventor
Neocles Leontis
Original Assignee
Univ Bowling Green State
Neocles Leontis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/196,003 external-priority patent/US7553945B2/en
Application filed by Univ Bowling Green State, Neocles Leontis filed Critical Univ Bowling Green State
Publication of WO2007019119A2 publication Critical patent/WO2007019119A2/en
Publication of WO2007019119A3 publication Critical patent/WO2007019119A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nanotechnology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention includes RNA complexes comprising at least three monomeric units of an RNA molecule, each monomeric unit comprising an RNA polymer having first and second helical domains that have respective first and second binding sites, wherein the first binding sites are adapted to binding to one another and are not adapted to bind to the second binding sites, and the second binding sites are adapted to binding to one another and are not adapted to bind to the first binding sites; such that the at least three monomeric units are adapted to self-assemble by forming pairs of cognate interactions and so as to form the RNA complex in a circular closed complex. The invention also includes derivatives of these complexes including aptamers, and analytical methods and devices using same.
PCT/US2006/029810 2005-08-03 2006-08-01 Rna complexes methods of their production and sensors and analytical methods involving same WO2007019119A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US70504105P 2005-08-03 2005-08-03
US60/705,041 2005-08-03
US11/196,003 2005-08-03
US11/196,003 US7553945B2 (en) 2005-08-03 2005-08-03 RNA complexes and methods of their production

Publications (2)

Publication Number Publication Date
WO2007019119A2 WO2007019119A2 (en) 2007-02-15
WO2007019119A3 true WO2007019119A3 (en) 2008-01-17

Family

ID=37727856

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/029810 WO2007019119A2 (en) 2005-08-03 2006-08-01 Rna complexes methods of their production and sensors and analytical methods involving same

Country Status (1)

Country Link
WO (1) WO2007019119A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030065155A1 (en) * 2000-03-06 2003-04-03 Nassim Usman Nucleic acid sensor molecules
US6866819B1 (en) * 2001-11-13 2005-03-15 Raytheon Company Sensor for detecting small concentrations of a target matter

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030065155A1 (en) * 2000-03-06 2003-04-03 Nassim Usman Nucleic acid sensor molecules
US6866819B1 (en) * 2001-11-13 2005-03-15 Raytheon Company Sensor for detecting small concentrations of a target matter

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JAEGER ET AL.: "Tecto-RNA: One-Dimensional Self-Assembly through Tertiary Interactions", ANGEW. CHEM. INT. ED., vol. 39, no. 14, July 2000 (2000-07-01), pages 2521 - 2524 *
SAYER ET AL.: "Structural characterization of a 20F-RNA aptamer that binds a HIV-1 SU glycoprotein, gp120", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 293, no. 3, May 2002 (2002-05-01), pages 924 - 931, XP002363739, DOI: doi:10.1016/S0006-291X(02)00308-X *
SHU ET AL.: "Bottom-up Assembly of RNA Arrays and Superstructures as Potential Parts in Nanotechnology", NANO LETTERS, vol. 4, no. 9, August 2004 (2004-08-01), Retrieved from the Internet <URL:http://www.pubs.acs.org/cgi-bin/article.cgi/nalefd/2004/4/i09/pdf/nl0494497.pdf> *

Also Published As

Publication number Publication date
WO2007019119A2 (en) 2007-02-15

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