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WO2007017585A3 - Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Download PDF

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Publication number
WO2007017585A3
WO2007017585A3 PCT/FR2006/001901 FR2006001901W WO2007017585A3 WO 2007017585 A3 WO2007017585 A3 WO 2007017585A3 FR 2006001901 W FR2006001901 W FR 2006001901W WO 2007017585 A3 WO2007017585 A3 WO 2007017585A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
preparation
pharmaceutical compositions
compositions containing
camptothecin analogues
Prior art date
Application number
PCT/FR2006/001901
Other languages
English (en)
Other versions
WO2007017585A2 (fr
Inventor
Gilbert Lavielle
Patrick Hautefaye
Alain Pierre
John Hickman
Stephane Leonce
Original Assignee
Servier Lab
Gilbert Lavielle
Patrick Hautefaye
Alain Pierre
John Hickman
Stephane Leonce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab, Gilbert Lavielle, Patrick Hautefaye, Alain Pierre, John Hickman, Stephane Leonce filed Critical Servier Lab
Priority to JP2008524549A priority Critical patent/JP2009503039A/ja
Priority to AU2006277863A priority patent/AU2006277863A1/en
Priority to US11/990,065 priority patent/US20100168149A1/en
Priority to EA200800393A priority patent/EA014689B1/ru
Priority to MX2008001560A priority patent/MX2008001560A/es
Priority to CA2617957A priority patent/CA2617957C/fr
Priority to EP06794288A priority patent/EP1910377A2/fr
Priority to BRPI0614608A priority patent/BRPI0614608A2/pt
Publication of WO2007017585A2 publication Critical patent/WO2007017585A2/fr
Publication of WO2007017585A3 publication Critical patent/WO2007017585A3/fr
Priority to NO20081169A priority patent/NO20081169L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Composé de formule (I) (I) dans laquelle : • R1, R2, R3, R4, R5, R80, R90, R81, R91, AIk et G sont tels que définis dans la description. Médicaments.
PCT/FR2006/001901 2005-08-05 2006-08-04 Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent WO2007017585A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP2008524549A JP2009503039A (ja) 2005-08-05 2006-08-04 新規カンプトセシン類似体化合物、その製造法、および該化合物を含有する薬学的組成物
AU2006277863A AU2006277863A1 (en) 2005-08-05 2006-08-04 Novel camptothecin analogues compounds, a method for the preparation thereof and pharmaceutical compositions containing said compounds
US11/990,065 US20100168149A1 (en) 2005-08-05 2006-08-04 Camptothecin Analogue Compounds, a Process for Their Preparation and Pharmaceutical Compositions Containing Them
EA200800393A EA014689B1 (ru) 2005-08-05 2006-08-04 Новые соединения - аналоги камптотецина, способ их получения и фармацевтические композиции, которые их содержат
MX2008001560A MX2008001560A (es) 2005-08-05 2006-08-04 Nuevos compuestos analogos de la camptotecina, un procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
CA2617957A CA2617957C (fr) 2005-08-05 2006-08-04 Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP06794288A EP1910377A2 (fr) 2005-08-05 2006-08-04 Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
BRPI0614608A BRPI0614608A2 (pt) 2005-08-05 2006-08-04 análogos de camptotecina, um processo para a preparação dos mesmos e composições farmacêuticas que contêm os ditos compostos
NO20081169A NO20081169L (no) 2005-08-05 2008-03-05 Nye camptothecinanalogforbindelser, en fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0508364A FR2889527A1 (fr) 2005-08-05 2005-08-05 Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR0508364 2005-08-05

Publications (2)

Publication Number Publication Date
WO2007017585A2 WO2007017585A2 (fr) 2007-02-15
WO2007017585A3 true WO2007017585A3 (fr) 2007-04-12

Family

ID=36216903

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2006/001901 WO2007017585A2 (fr) 2005-08-05 2006-08-04 Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (19)

Country Link
US (1) US20100168149A1 (fr)
EP (1) EP1910377A2 (fr)
JP (1) JP2009503039A (fr)
KR (1) KR20080032007A (fr)
CN (1) CN101238133A (fr)
AR (1) AR056189A1 (fr)
AU (1) AU2006277863A1 (fr)
BR (1) BRPI0614608A2 (fr)
CA (1) CA2617957C (fr)
EA (1) EA014689B1 (fr)
FR (1) FR2889527A1 (fr)
GE (1) GEP20115243B (fr)
MA (1) MA29653B1 (fr)
MX (1) MX2008001560A (fr)
MY (1) MY150497A (fr)
NO (1) NO20081169L (fr)
UA (1) UA95253C2 (fr)
WO (1) WO2007017585A2 (fr)
ZA (1) ZA200801991B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2889528B1 (fr) * 2005-08-05 2007-09-07 Servier Lab Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2900652C (fr) 2013-02-15 2021-05-04 Kala Pharmaceuticals, Inc. Composes therapeutiques et utilisations de ceux-ci
EP2958895B1 (fr) 2013-02-20 2020-08-19 Kala Pharmaceuticals, Inc. Composés thérapeutiques et leurs utilisations
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
US9458169B2 (en) 2013-11-01 2016-10-04 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CN106188079A (zh) * 2016-07-09 2016-12-07 兰州大学 喜树碱7‑位哌嗪硫脲类化合物、制备方法和用途
CA3036340A1 (fr) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Formes cristallines de composes therapeutiques et leurs utilisations
AU2017324251A1 (en) 2016-09-08 2019-03-21 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
AU2017324713B2 (en) 2016-09-08 2020-08-13 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
CN110357897A (zh) * 2019-07-26 2019-10-22 上海健康医学院 一种具有抗肿瘤活性的喜树碱衍生物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1101765A2 (fr) * 1999-11-18 2001-05-23 Adir Et Compagnie Nouveaux composés analogues de la camptothécine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
US20030105109A1 (en) * 1999-11-18 2003-06-05 Gilbert Lavielle New campothecin analogue compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6111107A (en) * 1997-11-20 2000-08-29 Enzon, Inc. High yield method for stereoselective acylation of tertiary alcohols
US6403604B1 (en) * 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6933302B2 (en) * 2002-06-03 2005-08-23 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
CN100443486C (zh) * 2002-09-11 2008-12-17 中国医学科学院药物研究所 7-酯化和7,20-双酯化的喜树碱衍生物及其制法和其药物组合物与用途
FR2889528B1 (fr) * 2005-08-05 2007-09-07 Servier Lab Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1101765A2 (fr) * 1999-11-18 2001-05-23 Adir Et Compagnie Nouveaux composés analogues de la camptothécine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
US20030105109A1 (en) * 1999-11-18 2003-06-05 Gilbert Lavielle New campothecin analogue compounds

Also Published As

Publication number Publication date
CA2617957A1 (fr) 2007-02-15
US20100168149A1 (en) 2010-07-01
CA2617957C (fr) 2011-09-20
MX2008001560A (es) 2008-02-15
MA29653B1 (fr) 2008-07-01
EP1910377A2 (fr) 2008-04-16
AU2006277863A1 (en) 2007-02-15
MY150497A (en) 2014-01-30
EA014689B1 (ru) 2010-12-30
KR20080032007A (ko) 2008-04-11
CN101238133A (zh) 2008-08-06
GEP20115243B (en) 2011-06-27
EA200800393A1 (ru) 2008-08-29
WO2007017585A2 (fr) 2007-02-15
FR2889527A1 (fr) 2007-02-09
UA95253C2 (ru) 2011-07-25
AR056189A1 (es) 2007-09-26
BRPI0614608A2 (pt) 2016-11-16
JP2009503039A (ja) 2009-01-29
NO20081169L (no) 2008-03-05
ZA200801991B (en) 2009-08-26

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