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WO2007016377A3 - Dialysis solution including water-soluble polyelectrolyte osmotic agent - Google Patents

Dialysis solution including water-soluble polyelectrolyte osmotic agent Download PDF

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Publication number
WO2007016377A3
WO2007016377A3 PCT/US2006/029494 US2006029494W WO2007016377A3 WO 2007016377 A3 WO2007016377 A3 WO 2007016377A3 US 2006029494 W US2006029494 W US 2006029494W WO 2007016377 A3 WO2007016377 A3 WO 2007016377A3
Authority
WO
WIPO (PCT)
Prior art keywords
dialysis
subject
osmotic
osmotic agents
dialysis solution
Prior art date
Application number
PCT/US2006/029494
Other languages
French (fr)
Other versions
WO2007016377A2 (en
Inventor
Alan D Strickland
Jaime Simon
Original Assignee
Dow Global Technologies Inc
Alan D Strickland
Jaime Simon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Global Technologies Inc, Alan D Strickland, Jaime Simon filed Critical Dow Global Technologies Inc
Publication of WO2007016377A2 publication Critical patent/WO2007016377A2/en
Publication of WO2007016377A3 publication Critical patent/WO2007016377A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • External Artificial Organs (AREA)

Abstract

Dialysis solutions comprising aqueous solutions including physiologically acceptable salts and a polyelectrolyte osmotic agent are disclosed. The subject solutions provide an improved osmotic gradient resulting in reduced dialysis times and/or reduced volumes of required dialysis solution. Moreover, the subject osmotic agents do not significantly migrate into the patient's blood over the time period of dialysis nor are the subject osmotic agents as susceptible to forming detrimental degradation products during gamma sterilization. The subject osmotic agents are much less susceptible to microbial contamination than currently available osmotic agents used in dialysis. The use of free radical scavengers is also described along with the use of a filter to reduce the introduction of bacteria into the peritoneal cavity.
PCT/US2006/029494 2005-07-28 2006-07-27 Dialysis solution including water-soluble polyelectrolyte osmotic agent WO2007016377A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70348605P 2005-07-28 2005-07-28
US60/703,486 2005-07-28

Publications (2)

Publication Number Publication Date
WO2007016377A2 WO2007016377A2 (en) 2007-02-08
WO2007016377A3 true WO2007016377A3 (en) 2007-07-19

Family

ID=37709225

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/029494 WO2007016377A2 (en) 2005-07-28 2006-07-27 Dialysis solution including water-soluble polyelectrolyte osmotic agent

Country Status (1)

Country Link
WO (1) WO2007016377A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102012002372B4 (en) * 2012-02-08 2013-11-21 Fresenius Medical Care Deutschland Gmbh Concentrate for a dialysis fluid and dialysis fluid prepared therefrom
US10898631B2 (en) * 2017-05-24 2021-01-26 Sequana Medical Nv Direct sodium removal method, solution and apparatus to reduce fluid overload in heart failure patients
CN115624566B (en) * 2022-12-22 2023-03-10 广东省人民医院 A kind of peritoneal dialysis fluid and its preparation method and application

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020146386A1 (en) * 2000-11-20 2002-10-10 Jaime Simon In vivo use of water absorbent polymers
US20030202958A1 (en) * 1999-10-15 2003-10-30 Strickland Alan D. Dialysis solution including polyglycol osmotic agent

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030202958A1 (en) * 1999-10-15 2003-10-30 Strickland Alan D. Dialysis solution including polyglycol osmotic agent
US20020146386A1 (en) * 2000-11-20 2002-10-10 Jaime Simon In vivo use of water absorbent polymers

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
TWARDOWSKI Z J ET AL: "COMPARISON OF GLUCOSE AND POLY ACRYLATE AS OSMOTIC AGENTS FOR PERITONEAL DIALYSIS IN-VITRO AND RAT STUDIES", CLINICAL RESEARCH, vol. 29, no. 5, 1981, & ANNUAL MEETING OF THE SOUTHERN SOCIETY FOR CLINICAL INVESTIGATION, NEW ORLEANS, LA., USA, JAN. 14-16, pages 874A, XP009081107, ISSN: 0009-9279 *
TWARDOWSKI Z J ET AL: "LONG DWELL PERITONEAL DIALYSIS EXCHANGES IN RATS WITH POLY ACRYLATE AND GLUCOSE AS OSMOTIC AGENTS", CLINICAL RESEARCH, vol. 30, no. 1, 1982, & ANNUAL MEETING OF THE WESTERN SECTION OF THE AMERICAN FEDERATION FOR CLINICAL RESEARCH, CARMEL, CALI, pages 80A, XP009081106, ISSN: 0009-9279 *
TWARDOWSKI Z J ET AL: "POLY ANIONS AND GLUCOSE AS OSMOTIC AGENTS IN SIMULATED PERITONEAL DIALYSIS", ARTIFICIAL ORGANS, vol. 7, no. 4, 1983, pages 420 - 427, XP009081105, ISSN: 0160-564X *

Also Published As

Publication number Publication date
WO2007016377A2 (en) 2007-02-08

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